CN202497219U - 带有介孔生物涂层的骨科螺钉 - Google Patents
带有介孔生物涂层的骨科螺钉 Download PDFInfo
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Abstract
一种带有介孔生物涂层的骨科螺钉，包括钉体，钉体的前端呈锥形，钉体的表面覆盖有一层介孔纳米微球生物涂层。介孔纳米微球生物涂层包围钉体。钉体上设置有螺纹，介孔纳米微球生物涂层覆盖螺纹的表面。介孔纳米微球生物涂层由复数个介孔硅纳米微球排列组成。钉体的表面覆盖有一层介孔纳米微球生物涂层，介孔纳米微球生物涂层可为携带生物活性物质如BMP、唑来膦酸等创造了良好条件。加载活性物质的介孔纳米微球生物涂层在完成骨折固定的同时，可以在骨折端释放活性物质，产生促进骨折愈合的生物学作用。本实用新型提高了骨折救治的成功率，降低了骨折不愈合及延迟愈合的发生率。
Description
技术领域:
本实用新型涉及人类生活用品，尤其涉及医疗器械，特别涉及骨科手术材料，具体的是一种带有介孔生物涂层的骨科螺钉。
背景技术:
骨折是人类常见的损伤，也是矫形外科治疗的重要方面。目前，切开复位加内固定已成为治疗骨折的重要方式。但是，依据骨折类型及受伤年龄不同，其愈后也各不相同，骨折不愈合或延迟愈合的病例仍然存在，骨折不愈合或延迟愈合可能造成患肢长期疼痛、无法负重及内固定失败等严重后果。
发明内容：
本实用新型的目的在于提供一种带有介孔生物涂层的骨科螺钉，所述的这种带有介孔生物涂层的骨科螺钉要解决现有技术中骨折不愈合或延迟愈合的技术问题。
本实用新型的这种带有介孔生物涂层的骨科螺钉，包括钉体，所述的钉体的前端呈锥形，其中，所述的钉体的表面覆盖有一层介孔纳米微球生物涂层。
进一步的，所述的介孔纳米微球生物涂层包围所述的钉体。
进一步的，所述的钉体上设置有螺纹，所述的介孔纳米微球生物涂层覆盖螺纹的表面。
进一步的，所述的介孔纳米微球生物涂层由复数个介孔硅纳米微球（mesoporous silica nanoparticulate，MSN）排列组成。所述的介孔硅纳米微球由SiO2-CaO-P2O3组成的。与传统的无机及有机高分子药物载体材料相比，介孔硅纳米微球具有较大的比表面积，可以提高生物活性；介孔孔道直径可以进行调控，表面进行化学改性，有利于不同分子量药物的装载；介孔孔道具有均一大小的规则孔道，较大的比表面积，能够实现较大量的药物装载；介孔的孔表面有丰富的化学基团，可以和很多药物分子形成化学键合，结合较为牢固，药物的释放通过孔道扩散，从而实现缓慢的可持续释放；介孔二氧化硅微球降解产物为水、钙、磷和硅离子，无任何毒性。
本实用新型的工作原理是：钉体的表面覆盖有一层介孔纳米微球生物涂层，介孔纳米微球生物涂层可为携带生物活性物质如BMP、唑来膦酸等创造了良好条件。加载活性物质的介孔纳米微球生物涂层在完成骨折固定的同时，可以在骨折端释放活性物质，产生促进骨折愈合的生物学作用。
本实用新型和已有技术相比较，其效果是积极和明显的。本实用新型在骨科螺钉的钉体表面覆盖一层介孔纳米微球生物涂层，利用该介孔纳米微球生物涂层，可携带生物活性物质如BMP、唑来膦酸等，在钉体植入体内并完成骨折固定时，介孔纳米微球生物涂层可在骨折端释放活性物质，产生促进骨折愈合的生物学作用，促进骨折愈合。本实用新型提高了骨折救治的成功率，降低了骨折不愈合及延迟愈合的发生率。
附图说明：
图1是本实用新型的带有介孔生物涂层的骨科螺钉的结构示意图。
具体实施方式：
实施例1:
如图1所示，本实用新型的带有介孔生物涂层的骨科螺钉，包括钉体1，所述的钉体1的前端呈锥形，其中，所述的钉体1的表面覆盖有一层介孔纳米微球生物涂层。
进一步的，所述的介孔纳米微球生物涂层包围所述的钉体1。
进一步的，所述的钉体1上设置有螺纹，所述的介孔纳米微球生物涂层覆盖螺纹的表面。
进一步的，所述的介孔纳米微球生物涂层由复数个介孔硅纳米微球（mesoporous silica nanoparticulate，MSN）排列组成。所述的介孔硅纳米微球由SiO2-CaO-P2O3组成的。与传统的无机及有机高分子药物载体材料相比，介孔硅纳米微球具有较大的比表面积，可以提高生物活性；介孔孔道直径可以进行调控，表面进行化学改性，有利于不同分子量药物的装载；介孔孔道具有均一大小的规则孔道，较大的比表面积，能够实现较大量的药物装载；介孔的孔表面有丰富的化学基团，可以和很多药物分子形成化学键合，结合较为牢固，药物的释放通过孔道扩散，从而实现缓慢的可持续释放；介孔二氧化硅微球降解产物为水、钙、磷和硅离子，无任何毒性。
本实施例的工作原理是：钉体1的表面覆盖有一层介孔纳米微球生物涂层，介孔纳米微球生物涂层可为携带生物活性物质如BMP、唑来膦酸等创造了良好条件。加载活性物质的介孔纳米微球生物涂层在完成骨折固定的同时，可以在骨折端释放活性物质，产生促进骨折愈合的生物学作用。
上述实施例为本实用新型较佳的实施方式，但本实用新型的实施方式并不受上述实施例的限制，其它的任何未背离本实用新型的精神实质与原理下所作的改变，修饰，替代，组合，简化均应为等效的置换方式，都包含在本实用新型的保护范围之内。
Claims (3)
1.一种带有介孔生物涂层的骨科螺钉，包括钉体，所述的钉体的前端呈锥形，其特征在于：所述的钉体的表面覆盖有一层介孔纳米微球生物涂层。
2.如权利要求1所述的带有介孔生物涂层的骨科螺钉，其特征在于：所述的介孔纳米微球生物涂层包围所述的钉体。
3.如权利要求1所述的带有介孔生物涂层的骨科螺钉，其特征在于：所述的钉体上设置有螺纹，所述的介孔纳米微球生物涂层覆盖螺纹的表面。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2505299C1 (ru) * | 2012-11-20 | 2014-01-27 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения скелетных осложнений у больных с литическими метастазами в длинные трубчатые кости |
| CN107412855A (zh) * | 2017-08-03 | 2017-12-01 | 华东理工大学 | 具有涂层的3d打印支架及其制备方法和应用 |
| CN107551329A (zh) * | 2017-10-20 | 2018-01-09 | 上海交通大学医学院附属第九人民医院 | 一种针对骨质疏松性骨折治疗的内固定装置及其制备方法 |
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2012
- 2012-02-27 CN CN2012200663595U patent/CN202497219U/zh not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2505299C1 (ru) * | 2012-11-20 | 2014-01-27 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения скелетных осложнений у больных с литическими метастазами в длинные трубчатые кости |
| CN107412855A (zh) * | 2017-08-03 | 2017-12-01 | 华东理工大学 | 具有涂层的3d打印支架及其制备方法和应用 |
| CN107551329A (zh) * | 2017-10-20 | 2018-01-09 | 上海交通大学医学院附属第九人民医院 | 一种针对骨质疏松性骨折治疗的内固定装置及其制备方法 |
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