CR10733A - Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof - Google Patents

Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof

Info

Publication number: CR10733A
Authority: CR; Costa Rica
Prior art keywords: benzothiepin; substituted; novel; compounds; benzyl groups
Prior art date: 2006-11-14

Application number

CR10733A

Other languages

English (en)

Inventor

Wendelln Frick

Heiner Glombik

Stefan Theis

Hubert Heuer

Hans-Ludwig Schaefer

Werner Kramer

Original Assignee

Sanofi Aventis Deutchsland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-14

Filing date

2009-04-20

Publication date

2009-05-25

2009-04-20 Application filed by Sanofi Aventis Deutchsland Gmbh filed Critical Sanofi Aventis Deutchsland Gmbh

2009-05-25 Publication of CR10733A publication Critical patent/CR10733A/es

Links

-1 BENZYL GROUPS Chemical group 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CR10733A 2006-11-14 2009-04-20 Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof CR10733A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102006053635A DE102006053635B4 (de)	2006-11-14	2006-11-14	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number	Publication Date
CR10733A true CR10733A (es)	2009-05-25

Family

ID=39092812

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CR10733A CR10733A (es)	2006-11-14	2009-04-20	Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof

Country Status (37)

Country	Link
US (1)	US7956085B2 (es)
EP (1)	EP2084172B1 (es)
JP (1)	JP5301453B2 (es)
KR (1)	KR101489168B1 (es)
CN (1)	CN101535326B (es)
AR (2)	AR063786A1 (es)
AT (1)	ATE492554T1 (es)
AU (1)	AU2007321496B2 (es)
BR (1)	BRPI0718813B8 (es)
CA (2)	CA2669230C (es)
CL (1)	CL2007003262A1 (es)
CO (1)	CO6190534A2 (es)
CR (1)	CR10733A (es)
CY (1)	CY1111166T1 (es)
DE (2)	DE102006053635B4 (es)
DK (1)	DK2084172T3 (es)
EC (1)	ECSP099327A (es)
ES (1)	ES2358371T3 (es)
GT (1)	GT200900125A (es)
HR (1)	HRP20110197T1 (es)
IL (1)	IL198718A (es)
MA (1)	MA30883B1 (es)
MX (1)	MX2009003958A (es)
MY (1)	MY148429A (es)
NI (1)	NI200900076A (es)
NO (2)	NO342236B1 (es)
NZ (1)	NZ576762A (es)
PE (1)	PE20081493A1 (es)
PL (1)	PL2084172T3 (es)
PT (1)	PT2084172E (es)
RU (1)	RU2456282C2 (es)
SI (1)	SI2084172T1 (es)
SV (1)	SV2009003216A (es)
TN (1)	TN2009000180A1 (es)
TW (1)	TWI414530B (es)
UY (1)	UY30709A1 (es)
WO (1)	WO2008058628A1 (es)

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PL2282991T3 (pl) *	2008-05-02	2018-07-31	Sanofi-Aventis Deutschland Gmbh	Sposób wytwarzania pochodnych 1,1-dwutlenku 1,4-benzotiepiny
EP2367554A4 (en)	2008-11-26	2020-03-25	Satiogen Pharmaceuticals, Inc.	Bile acid reflux inhibitor for the treatment of obesity and diabetes
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AU2011296737A1 (en)	2010-08-31	2013-04-11	Snu R&Db Foundation	Use of the fetal reprogramming of a PPAR delta agonist
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BR112014010223B8 (pt)	2011-10-28	2021-02-23	Lumena Pharmaceuticals Llc	uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica
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EP3413875B1 (en)	2016-02-09	2020-01-29	Albireo AB	Cholestyramine pellets and methods for preparation thereof
JP2020530448A (ja)	2017-08-09	2020-10-22	アルビレオ・アクチボラグ	コレスチラミン顆粒、経口コレスチラミン製剤、及びそれらの使用
CN110996915B (zh)	2017-08-09	2023-10-03	阿尔比里奥公司	考来烯胺丸粒、口服考来烯胺制剂及其用途
JP7391048B2 (ja)	2018-06-05	2023-12-04	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
MX2020013839A (es)	2018-06-20	2021-03-25	Albireo Ab	Formulacion farmaceutica de odevixibat.
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
BR112021003156A2 (pt)	2018-08-23	2021-05-11	Seagen, Inc.	composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit.
RS63899B1 (sr)	2019-02-06	2023-02-28	Albireo Ab	Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselina
TWI835997B (zh)	2019-02-06	2024-03-21	瑞典商艾爾比瑞歐公司	苯并噻氮呯化合物及其用作膽酸調節劑之用途
CA3129826A1 (en)	2019-02-12	2020-08-20	Mirum Pharmaceuticals, Inc.	Methods for treating cholestasis
CA3158181A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
EP4069359B1 (en)	2019-12-04	2024-01-03	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
JP7665620B2 (ja)	2019-12-04	2025-04-21	アルビレオ・アクチボラグ	ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
BR112022010505A2 (pt)	2019-12-04	2022-09-06	Albireo Ab	Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar
CA3186857A1 (en)	2020-08-03	2022-02-10	Per-Goran Gillberg	Benzothia(di)azepine compounds and their use as bile acid modulators
AU2021379076A1 (en)	2020-11-12	2023-06-08	Albireo Ab	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
AU2021390172A1 (en)	2020-12-04	2023-06-22	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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2006
- 2006-11-14 DE DE102006053635A patent/DE102006053635B4/de not_active Expired - Fee Related
2007
- 2007-10-30 AU AU2007321496A patent/AU2007321496B2/en active Active
- 2007-10-30 DK DK07819434.7T patent/DK2084172T3/da active
- 2007-10-30 KR KR1020097009914A patent/KR101489168B1/ko active Active
- 2007-10-30 HR HR20110197T patent/HRP20110197T1/hr unknown
- 2007-10-30 EP EP07819434A patent/EP2084172B1/de active Active
- 2007-10-30 MX MX2009003958A patent/MX2009003958A/es active IP Right Grant
- 2007-10-30 RU RU2009122470/04A patent/RU2456282C2/ru active
- 2007-10-30 AT AT07819434T patent/ATE492554T1/de active
- 2007-10-30 BR BRPI0718813A patent/BRPI0718813B8/pt active IP Right Grant
- 2007-10-30 DE DE502007006055T patent/DE502007006055D1/de active Active
- 2007-10-30 NZ NZ576762A patent/NZ576762A/en unknown
- 2007-10-30 JP JP2009536625A patent/JP5301453B2/ja active Active
- 2007-10-30 PT PT07819434T patent/PT2084172E/pt unknown
- 2007-10-30 ES ES07819434T patent/ES2358371T3/es active Active
- 2007-10-30 WO PCT/EP2007/009393 patent/WO2008058628A1/de not_active Ceased
- 2007-10-30 CA CA2669230A patent/CA2669230C/en active Active
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- 2007-10-30 SI SI200730487T patent/SI2084172T1/sl unknown
- 2007-10-30 PL PL07819434T patent/PL2084172T3/pl unknown
- 2007-10-30 NO NO20091893A patent/NO342236B1/no unknown
- 2007-10-30 CA CA2865332A patent/CA2865332C/en active Active
- 2007-10-30 CN CN2007800424399A patent/CN101535326B/zh active Active
- 2007-11-12 UY UY30709A patent/UY30709A1/es unknown
- 2007-11-12 TW TW096142599A patent/TWI414530B/zh active
- 2007-11-12 PE PE2007001553A patent/PE20081493A1/es not_active Application Discontinuation
- 2007-11-12 AR ARP070105027A patent/AR063786A1/es active IP Right Grant
- 2007-11-13 CL CL200703262A patent/CL2007003262A1/es unknown
2009
- 2009-04-03 SV SV2009003216A patent/SV2009003216A/es unknown
- 2009-04-20 CR CR10733A patent/CR10733A/es not_active Application Discontinuation
- 2009-05-04 NI NI200900076A patent/NI200900076A/es unknown
- 2009-05-06 CO CO09045559A patent/CO6190534A2/es not_active Application Discontinuation
- 2009-05-08 TN TNP2009000180A patent/TN2009000180A1/fr unknown
- 2009-05-12 IL IL198718A patent/IL198718A/en active IP Right Grant
- 2009-05-12 MA MA31864A patent/MA30883B1/fr unknown
- 2009-05-13 EC EC2009009327A patent/ECSP099327A/es unknown
- 2009-05-13 GT GT200900125A patent/GT200900125A/es unknown
- 2009-05-14 US US12/465,911 patent/US7956085B2/en active Active
2011
- 2011-02-04 CY CY20111100133T patent/CY1111166T1/el unknown
2017
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Also Published As

Publication number	Publication date
AU2007321496B2 (en)	2012-07-26
CA2865332C (en)	2016-03-29
PL2084172T3 (pl)	2011-06-30
DK2084172T3 (da)	2011-04-04
RU2456282C2 (ru)	2012-07-20
SI2084172T1 (sl)	2011-03-31
AU2007321496A1 (en)	2008-05-22
WO2008058628A1 (de)	2008-05-22
TWI414530B (zh)	2013-11-11
ECSP099327A (es)	2009-06-30
SV2009003216A (es)	2010-05-26
JP5301453B2 (ja)	2013-09-25
MY148429A (en)	2013-04-30
MX2009003958A (es)	2009-04-27
HK1137762A1 (en)	2010-08-06
NO342236B1 (no)	2018-04-23
CN101535326A (zh)	2009-09-16
US20100035961A1 (en)	2010-02-11
EP2084172B1 (de)	2010-12-22
IL198718A (en)	2012-12-31
NO20091893L (no)	2009-07-09
CA2865332A1 (en)	2008-05-22
IL198718A0 (en)	2010-02-17
CY1111166T1 (el)	2015-06-11
CA2669230C (en)	2015-01-13
CA2669230A1 (en)	2008-05-22
KR20090082396A (ko)	2009-07-30
KR101489168B1 (ko)	2015-02-03
PE20081493A1 (es)	2008-11-24
MA30883B1 (fr)	2009-11-02
BRPI0718813A2 (pt)	2013-12-03
RU2009122470A (ru)	2010-12-20
BRPI0718813B8 (pt)	2021-05-25
GT200900125A (es)	2011-06-23
DE102006053635B4 (de)	2011-06-30
BRPI0718813B1 (pt)	2020-12-08
DE502007006055D1 (de)	2011-02-03
TN2009000180A1 (en)	2010-10-18
HRP20110197T1 (hr)	2011-04-30
CN101535326B (zh)	2012-10-31
PT2084172E (pt)	2011-02-10
UY30709A1 (es)	2008-07-03
CL2007003262A1 (es)	2008-05-30
TW200837072A (en)	2008-09-16
NO20180497A1 (no)	2009-07-09
NO344589B1 (no)	2020-02-03
ATE492554T1 (de)	2011-01-15
US7956085B2 (en)	2011-06-07
NZ576762A (en)	2010-11-26
CO6190534A2 (es)	2010-08-19
ES2358371T3 (es)	2011-05-10
EP2084172A1 (de)	2009-08-05
NI200900076A (es)	2010-01-29
JP2010509379A (ja)	2010-03-25
AR109033A2 (es)	2018-10-24
AR063786A1 (es)	2009-02-18
DE102006053635A1 (de)	2008-05-15

Legal Events

Date	Code	Title	Description
2014-04-24	FA	Abandonment or withdrawal (granting procedure)

Publication	Publication Date	Title
IL198718A0 (en)	2010-02-17	Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof
CY2014042I2 (el)	2015-12-09	Γλυκοπυρανοζυλο-υποκατεστημενα παραγωγα βενζολιου, φαρμακα που περιεχουν τις ενωσεις αυτες, χρηση αυτων και μεθοδος για την παραγωγη τους
HUS1900034I1 (hu)	2019-07-29	6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok
EP1973405A4 (en)	2011-06-01	HYDROXYALKYLARYLAMID DERIVATIVES
ATE481383T1 (de)	2010-10-15	3-aza-bicycloä3.1.0ühexanderivate
BRPI0810646A2 (pt)	2014-11-04	" compostos farmacêuticos ".
ATE484499T1 (de)	2010-10-15	Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
DK1940467T3 (da)	2017-02-13	Lægemiddelsammensætning med langvarig frigivelse
HUS1400051I1 (hu)	2016-10-28	Lurazidont tartalmazó gyógyászati készítmény
BRPI0810928A2 (pt)	2019-09-24	"composição farmacêutica"
BRPI0811718A2 (pt)	2014-11-18	Derivados de 3,3-espiroindolinona
ATE469145T1 (de)	2010-06-15	4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-
ATE460401T1 (de)	2010-03-15	1,2,4,5-tetrahydro-3h-benzazepinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
DE602007001681D1 (de)	2009-09-03	1,3-dioxan-carboxylsäuren
ATE502024T1 (de)	2011-04-15	Diosmetin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
MA29033B1 (fr)	2007-11-01	Composes organiques
ITMO20050343A1 (it)	2007-06-24	Supporto per medicazione
BRPI0819202A2 (pt)	2015-05-05	Derivado heterocíclico, e, composição farmacêutica
ATE462408T1 (de)	2010-04-15	Pharmazeutische zusammensetzungen, enthaltend valatograst, und verfahren zu deren herstellung
DE602006018590D1 (de)	2011-01-13	Heteroarylharnstoffderivate zur hemmung von chk1
ATE430142T1 (de)	2009-05-15	Phenylpiperazin-methanon-derivate
DK1910325T3 (da)	2011-01-24	Nye farmaceutisk forbindelser
EP2060563A4 (en)	2010-12-22	CYCLIC AMINO ALKYL CY CARBOXYL AMIDE DERIVATIVE
ATE372992T1 (de)	2007-09-15	Indanyl-piperazinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen