TN2009000180A1 - NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF - Google Patents

NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF

Info

Publication number: TN2009000180A1
Authority: TN; Tunisia
Prior art keywords: compounds; benzothiepin; substituted; novel; benzyl groups
Prior art date: 2006-11-14

Application number

TNP2009000180A

Other languages

English (en)

Inventor

Wendelin Frick

Heiner Glombik

Stefan Theis

Hubert Heuer

Hans-Ludwig Schaefer

Werner Kramer

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-14

Filing date

2009-05-08

Publication date

2010-10-18

2009-05-08 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2010-10-18 Publication of TN2009000180A1 publication Critical patent/TN2009000180A1/fr

Links

150000001875 compounds Chemical class 0.000 title abstract 3
-1 BENZYL GROUPS Chemical group 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000000055 hyoplipidemic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Obesity (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TNP2009000180A 2006-11-14 2009-05-08 NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF TN2009000180A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102006053635A DE102006053635B4 (de)	2006-11-14	2006-11-14	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
PCT/EP2007/009393 WO2008058628A1 (fr)	2006-11-14	2007-10-30	Nouveaux dérivés de 1,4-benzothiépine-1,1-dioxyde substitués par des restes benzyle, procédé de production approprié, médicaments contenant lesdits composés et leur utilisation

Publications (1)

Publication Number	Publication Date
TN2009000180A1 true TN2009000180A1 (en)	2010-10-18

Family

ID=39092812

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2009000180A TN2009000180A1 (en)	2006-11-14	2009-05-08	NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF

Country Status (37)

Country	Link
US (1)	US7956085B2 (fr)
EP (1)	EP2084172B1 (fr)
JP (1)	JP5301453B2 (fr)
KR (1)	KR101489168B1 (fr)
CN (1)	CN101535326B (fr)
AR (2)	AR063786A1 (fr)
AT (1)	ATE492554T1 (fr)
AU (1)	AU2007321496B2 (fr)
BR (1)	BRPI0718813B8 (fr)
CA (2)	CA2669230C (fr)
CL (1)	CL2007003262A1 (fr)
CO (1)	CO6190534A2 (fr)
CR (1)	CR10733A (fr)
CY (1)	CY1111166T1 (fr)
DE (2)	DE102006053635B4 (fr)
DK (1)	DK2084172T3 (fr)
EC (1)	ECSP099327A (fr)
ES (1)	ES2358371T3 (fr)
GT (1)	GT200900125A (fr)
HR (1)	HRP20110197T1 (fr)
IL (1)	IL198718A (fr)
MA (1)	MA30883B1 (fr)
MX (1)	MX2009003958A (fr)
MY (1)	MY148429A (fr)
NI (1)	NI200900076A (fr)
NO (2)	NO342236B1 (fr)
NZ (1)	NZ576762A (fr)
PE (1)	PE20081493A1 (fr)
PL (1)	PL2084172T3 (fr)
PT (1)	PT2084172E (fr)
RU (1)	RU2456282C2 (fr)
SI (1)	SI2084172T1 (fr)
SV (1)	SV2009003216A (fr)
TN (1)	TN2009000180A1 (fr)
TW (1)	TWI414530B (fr)
UY (1)	UY30709A1 (fr)
WO (1)	WO2008058628A1 (fr)

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WO2011157827A1 (fr)	2010-06-18	2011-12-22	Sanofi	Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
RU2013114390A (ru)	2010-08-31	2014-10-10	СНУ Ар энд ДиБи ФАУНДЕЙШН	Применение фетального репрограммирования посредством ppar-дельта-агониста
PL3400944T3 (pl)	2010-11-04	2020-11-16	Albireo Ab	Inhibitory ibat w leczeniu chorób wątroby
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US10441605B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Oral cholestyramine formulation and use thereof
US10786529B2 (en)	2016-02-09	2020-09-29	Albireo Ab	Oral cholestyramine formulation and use thereof
CA3071182A1 (fr)	2017-08-09	2019-02-14	Albireo Ab	Pastilles de cholestyramine, formulations orales de cholestyramine et leur utilisation
JP2020530448A (ja)	2017-08-09	2020-10-22	アルビレオ・アクチボラグ	コレスチラミン顆粒、経口コレスチラミン製剤、及びそれらの使用
US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
ES2942443T3 (es)	2018-06-05	2023-06-01	Albireo Ab	Compuestos de benzotia(di)azepina y su uso como moduladores de ácidos biliares
BR112020024479A2 (pt)	2018-06-20	2021-03-02	Albireo Ab	hidrato cristalino, modificações cristalinas de odevixibat, solvato misto de odevixibat, uso de modificação cristalina de odevixibat, processo para a preparação de modificação cristalina de odevixibat, e, composição farmacêutica
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
JP2021534196A (ja)	2018-08-23	2021-12-09	シージェンインコーポレイテッド	抗ｔｉｇｉｔ抗体
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
HUE060905T2 (hu)	2019-02-06	2023-04-28	Albireo Ab	Benzotiadiazepin vegyületek és azok alkalmazása epesav modulátorként
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
PL3923943T3 (pl)	2019-02-12	2024-12-09	Mirum Pharmaceuticals, Inc.	Zależna od genotypu i dawki odpowiedź na asbti u pacjentów z niedoborem pompy eksportu soli żółciowych
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
ES2973549T3 (es)	2019-12-04	2024-06-20	Albireo Ab	Compuestos de benzoti(di)azepina y su uso como moduladores de los ácidos biliares
CN114786772B (zh)	2019-12-04	2024-04-09	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
CA3158184A1 (fr)	2019-12-04	2021-08-10	Albireo Ab	Composes de benzothiadiazepine et leur utilisation en tant que modulateurs de l'acide biliaire
CA3158181A1 (fr)	2019-12-04	2021-06-10	Albireo Ab	Composes de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
EP4188541B1 (fr)	2020-08-03	2024-12-25	Albireo AB	Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
JP2023549226A (ja)	2020-11-12	2023-11-22	アルビレオエービー	進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
JP2024500309A (ja)	2020-12-04	2024-01-09	アルビレオエービー	ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
JP2025516153A (ja)	2022-04-22	2025-05-27	アルビレオ・アクチボラグ	Ａｓｂｔ阻害剤の皮下投与
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MXPA04003524A (es)	2001-11-02	2004-07-23	Searle Llc	Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
GB0304194D0 (en)	2003-02-25	2003-03-26	Astrazeneca Ab	Chemical compounds
DE102005033099A1 (de)	2005-07-15	2007-01-18	Sanofi-Aventis Deutschland Gmbh	Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung

2006
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Also Published As

Publication number	Publication date
AR063786A1 (es)	2009-02-18
KR20090082396A (ko)	2009-07-30
PL2084172T3 (pl)	2011-06-30
US20100035961A1 (en)	2010-02-11
SV2009003216A (es)	2010-05-26
HK1137762A1 (en)	2010-08-06
MY148429A (en)	2013-04-30
CL2007003262A1 (es)	2008-05-30
CN101535326B (zh)	2012-10-31
JP5301453B2 (ja)	2013-09-25
BRPI0718813A2 (pt)	2013-12-03
NO20091893L (no)	2009-07-09
DE502007006055D1 (de)	2011-02-03
IL198718A (en)	2012-12-31
US7956085B2 (en)	2011-06-07
EP2084172B1 (fr)	2010-12-22
DK2084172T3 (da)	2011-04-04
NZ576762A (en)	2010-11-26
DE102006053635B4 (de)	2011-06-30
TW200837072A (en)	2008-09-16
ES2358371T3 (es)	2011-05-10
ATE492554T1 (de)	2011-01-15
UY30709A1 (es)	2008-07-03
GT200900125A (es)	2011-06-23
CR10733A (es)	2009-05-25
IL198718A0 (en)	2010-02-17
BRPI0718813B8 (pt)	2021-05-25
RU2456282C2 (ru)	2012-07-20
HRP20110197T1 (hr)	2011-04-30
PT2084172E (pt)	2011-02-10
MA30883B1 (fr)	2009-11-02
AU2007321496B2 (en)	2012-07-26
WO2008058628A1 (fr)	2008-05-22
PE20081493A1 (es)	2008-11-24
TWI414530B (zh)	2013-11-11
ECSP099327A (es)	2009-06-30
NO20180497A1 (no)	2009-07-09
CA2669230C (fr)	2015-01-13
NO342236B1 (no)	2018-04-23
CY1111166T1 (el)	2015-06-11
CA2865332A1 (fr)	2008-05-22
BRPI0718813B1 (pt)	2020-12-08
CA2669230A1 (fr)	2008-05-22
CA2865332C (fr)	2016-03-29
EP2084172A1 (fr)	2009-08-05
JP2010509379A (ja)	2010-03-25
AR109033A2 (es)	2018-10-24
NO344589B1 (no)	2020-02-03
CO6190534A2 (es)	2010-08-19
KR101489168B1 (ko)	2015-02-03
MX2009003958A (es)	2009-04-27
NI200900076A (es)	2010-01-29
SI2084172T1 (sl)	2011-03-31
CN101535326A (zh)	2009-09-16
AU2007321496A1 (en)	2008-05-22
DE102006053635A1 (de)	2008-05-15
RU2009122470A (ru)	2010-12-20

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