CR10872A - AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR - Google Patents

AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR

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Publication number
CR10872A
CR10872A CR10872A CR10872A CR10872A CR 10872 A CR10872 A CR 10872A CR 10872 A CR10872 A CR 10872A CR 10872 A CR10872 A CR 10872A CR 10872 A CR10872 A CR 10872A
Authority
CR
Costa Rica
Prior art keywords
sphingosine
agonist
antagonist compounds
phosphate receptor
receptor family
Prior art date
Application number
CR10872A
Other languages
Spanish (es)
Inventor
Grier A Wallace
Eric C Breinlinger
Kevin P Cusack
Shannon R Fix-Senzel
Thomas D Gordon
Adrian D Hobson
Martin E Hayes
Graham K Ansell
Pintipa Grongsaard
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39562856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR10872(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CR10872A publication Critical patent/CR10872A/en

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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/40—Esters thereof
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Abstract

La presente invencion se refiere a agentes novedosos, potentes y selectivos que son agonistas o antagonistas de los uno o mas receptores individuales de la familia de receptores S1P. Los compuestos de la invencion son utiles como agentes terapeuticos para el tratamiento de trastornos clinicos asociados con el agonismo o antagonismo de receptores individuales de la familia de receptore S1P.The present invention relates to novel, potent and selective agents that are agonists or antagonists of the one or more individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutic agents for the treatment of clinical disorders associated with agonism or antagonism of individual receptors of the S1P receptor family.

CR10872A 2006-12-21 2009-06-19 AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR CR10872A (en)

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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080086546A (en) * 2006-01-27 2008-09-25 유니버시티 오브 버지니아 페이턴트 파운데이션 Methods of treating neuropathic pain
WO2007092638A1 (en) 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
JP2010510251A (en) 2006-11-21 2010-04-02 ユニバーシティ オブ バージニア パテント ファンデーション Benzocycloheptyl analog having sphingosine = 1-phosphate receptor activity
JP2010510250A (en) 2006-11-21 2010-04-02 ユニバーシティ オブ バージニア パテント ファンデーション Sphingosine = 1-hydrindan analog having phosphate receptor agonist activity
EP2102145A4 (en) * 2006-12-21 2014-06-18 Abbott Lab Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane carboxylates
MX2009012685A (en) * 2007-05-31 2009-12-14 Sepracor Inc Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors.
CN104311472B9 (en) 2008-07-23 2020-03-17 艾尼纳制药公司 Substituted 1,2,3, 4-tetrahydrocyclopenta [ b ] indol-3-yl acetic acid derivatives
PL2342205T4 (en) 2008-08-27 2016-12-30 Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
CA2739901A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
CN102186845B (en) 2008-10-17 2016-09-07 阿卡制药有限公司 S1P receptor modulators and their uses
AR074062A1 (en) * 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc S1P RECEIVER AGONISTS FOR THE TREATMENT OF BRAIN MALARIA AND PHARMACEUTICAL FORM
AR074061A1 (en) * 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc S1P LIASA INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA AND PHARMACEUTICAL FORMULATION
ES2405054T3 (en) 2009-01-23 2013-05-30 Bristol-Myers Squibb Company Pyrazole-1,2,4-oxadiazole derivatives as sphingosine-1-phosphate agonists
EP2389377B1 (en) 2009-01-23 2014-07-16 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
WO2010085581A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
EP2528894A1 (en) 2010-01-27 2012-12-05 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CN105503882B (en) 2010-03-03 2019-07-05 艾尼纳制药公司 The method for preparing S1P1 receptor modulators and its crystal form
JP5735634B2 (en) 2010-04-23 2015-06-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 4- (5-Isoxazolyl or 5-pyrazolyl-1,2,4-oxadiazol-3-yl) -mandelic acid amide compounds as sphingosine-1-phosphate receptor 1 agonists
TWI522361B (en) 2010-07-09 2016-02-21 艾伯維公司 Fused heterocyclic derivative as S1P regulator
TW201643169A (en) 2010-07-09 2016-12-16 艾伯維股份有限公司 Spiro-piperidine derivatives as S1P modulators
TW201206893A (en) 2010-07-09 2012-02-16 Abbott Healthcare Products Bv Bisaryl (thio) morpholine derivatives as S1P modulators
WO2012040532A1 (en) 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
AR085749A1 (en) 2011-04-01 2013-10-23 Novartis Ag FORMULATIONS
TWI613182B (en) * 2013-02-21 2018-02-01 必治妥美雅史谷比公司 Bicyclic compound
WO2015009731A2 (en) 2013-07-15 2015-01-22 The Regents Of The University Of California Azacyclic constrained analogs of fty720
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
UY36274A (en) * 2014-08-20 2016-02-29 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware BICYCLIC COMPOUNDS REPLACED AS SELECTIVE AGONISTS OF S1P1 RECEPTOR ACTIVITY COUPLED TO PROTEIN G
CA3002540C (en) 2015-01-06 2023-11-07 Arena Pharmaceuticals, Inc. Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
JP6838744B2 (en) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド (R) -2- (7- (4-cyclopentyl-3- (trifluoromethyl) benzyloxy) -1,2,3,4-tetrahydrocyclopenta [b] indole-for use in S1P1 receptor-related disorders Crystalline L-arginine salt of 3-yl) acetic acid (Compound 1)
EP3352753A4 (en) * 2015-09-24 2019-03-13 The Regents of The University of California SYNTHETIC SPHINGOLIPID MOLECULES, MEDICAMENTS, METHODS FOR THEIR SYNTHESIS, AND METHODS OF TREATMENT
KR102482825B1 (en) * 2016-09-02 2022-12-29 브리스톨-마이어스 스큅 컴퍼니 Substituted tricyclic heterocyclic compounds
CN110520124A (en) 2017-02-16 2019-11-29 艾尼纳制药公司 For treating the Compounds and methods for of primary biliary cholangitis
KR20190113955A (en) 2017-02-16 2019-10-08 아레나 파마슈티칼스, 인크. Compounds and Methods for the Treatment of Inflammatory Bowel Disease With Extra-Intestinal Symptoms
KR101891051B1 (en) * 2018-01-29 2018-08-31 주식회사 세종바이오메드 Sphingosine-1-Phosphate analogue and synthetic method thereof
JP7397011B2 (en) 2018-06-06 2023-12-12 アリーナ ファーマシューティカルズ， インコーポレイテッド Methods of treating conditions associated with S1P1 receptors
EP3847158B1 (en) 2018-09-06 2026-06-24 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN110808093A (en) * 2019-09-16 2020-02-18 中山大学孙逸仙纪念医院 A predictive model for clinical prognosis of radiation encephalopathy and its construction method
MX2022005084A (en) 2019-10-31 2022-05-26 Escape Bio Inc SOLID FORMS OF A S1P A RECEIVER MODULATOR.
CN117007818B (en) * 2023-08-04 2024-04-09 徐州医科大学科技园发展有限公司 Application of S1PR1 as a target in developing or preparing drugs for preventing chronic pain-related memory impairment diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2807192A (en) * 1991-10-02 1993-05-03 Smithkline Beecham Corporation Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity
US5314896A (en) * 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
CA2596990A1 (en) * 2005-02-14 2006-08-24 University Of Virginia Patent Foundation Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups
BRPI0707957A2 (en) * 2006-02-21 2011-05-17 Univ Virginia Patent Found compound, and, method for preventing or treating a pathological condition or symptom in a mammal

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