ECSP099435A - AGINGIST COMPOUNDS OF RECEPTORS SPHINGOSINE-1-PHOSPHATE AND ANTAGONIST COMPOUNDS - Google Patents

AGINGIST COMPOUNDS OF RECEPTORS SPHINGOSINE-1-PHOSPHATE AND ANTAGONIST COMPOUNDS

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Publication number
ECSP099435A
ECSP099435A EC2009009435A ECSP099435A ECSP099435A EC SP099435 A ECSP099435 A EC SP099435A EC 2009009435 A EC2009009435 A EC 2009009435A EC SP099435 A ECSP099435 A EC SP099435A EC SP099435 A ECSP099435 A EC SP099435A
Authority
EC
Ecuador
Prior art keywords
compounds
receptors
agingist
sphingosine
phosphate
Prior art date
Application number
EC2009009435A
Other languages
Spanish (es)
Inventor
Grier A Wallace
Shannon R Fix-Stenzel
Martin E Hayes
Eric C Breinlinger
Thomas D Gordon
Graham K Ansell
Kevin P Cusak
Adrian D Hobson
Pintipa Grongsaard
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39562856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099435(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ECSP099435A publication Critical patent/ECSP099435A/en

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    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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Abstract

La presente invención esta dirigida a agentes nuevos, potentes y selectivos, los cuales son agonistas o antagonistas de uno o más de los receptores individuales de la familia de receptores S1P. Los compuestos de la invención son usados como terapia en el tratamiento de condiciones médicas asociadas con el agonismo o antagonismo de los receptores individuales de la familia de receptores S1P.The present invention is directed to new, potent and selective agents, which are agonists or antagonists of one or more of the individual receptors of the S1P receptor family. The compounds of the invention are used as therapy in the treatment of medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.

EC2009009435A 2006-12-21 2009-06-15 AGINGIST COMPOUNDS OF RECEPTORS SPHINGOSINE-1-PHOSPHATE AND ANTAGONIST COMPOUNDS ECSP099435A (en)

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PCT/US2007/026263 WO2008079382A1 (en) 2006-12-21 2007-12-21 Sphingosine-1 -phosphate receptor agonist and antagonist compounds

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