CR11220A - Derivados de pirimidina 934 - Google Patents

Derivados de pirimidina 934

Info

Publication number
CR11220A
CR11220A CR11220A CR11220A CR11220A CR 11220 A CR11220 A CR 11220A CR 11220 A CR11220 A CR 11220A CR 11220 A CR11220 A CR 11220A CR 11220 A CR11220 A CR 11220A
Authority
CR
Costa Rica
Prior art keywords
pirimidine derivatives
pirimidine
derivatives
ring
condensed
Prior art date
Application number
CR11220A
Other languages
English (en)
Inventor
Berbard Christophe Barlaam
Richard Ducray
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR11220A publication Critical patent/CR11220A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de formula (i) en la que de A1, A2 o A3 es A3 es N y los otros se relacionan independientemente de CH o N; en anillo B es un anillo carbociclico o heterocicco de 5 o 6 miembros condensado que esta opcialmente sustituido como se define en la memoria descriptiva, y R1; R2, R3, R4 y n son como se define en la memoria decriptiva.
CR11220A 2007-07-16 2010-01-15 Derivados de pirimidina 934 CR11220A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07301236 2007-07-16

Publications (1)

Publication Number Publication Date
CR11220A true CR11220A (es) 2010-05-20

Family

ID=40260140

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11220A CR11220A (es) 2007-07-16 2010-01-15 Derivados de pirimidina 934

Country Status (18)

Country Link
US (1) US7718653B2 (es)
EP (1) EP2183242A2 (es)
JP (1) JP2010533700A (es)
KR (1) KR20100042272A (es)
CN (1) CN101796046A (es)
AU (1) AU2008277446A1 (es)
BR (1) BRPI0814821A2 (es)
CA (1) CA2693880A1 (es)
CO (1) CO6260075A2 (es)
CR (1) CR11220A (es)
DO (1) DOP2010000022A (es)
EA (1) EA201000101A1 (es)
EC (1) ECSP109958A (es)
MX (1) MX2010000658A (es)
NI (1) NI201000011A (es)
SV (1) SV2010003459A (es)
WO (1) WO2009010789A2 (es)
ZA (1) ZA201000107B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927547B2 (en) 2010-05-21 2015-01-06 Noviga Research Ab Pyrimidine derivatives
DK2688883T3 (en) 2011-03-24 2016-09-05 Noviga Res Ab pyrimidine
US9139534B2 (en) 2011-04-22 2015-09-22 Signal Pharmaceuticals, Llc Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
US9953761B2 (en) 2011-05-03 2018-04-24 Phoenix Contact Gmbh & Co. Kg Arrangement and method for contactless energy transmission with a coupling-minimized matrix of planar transmission coils
CN103222842B (zh) 2013-04-18 2015-09-09 安翰光电技术（武汉）有限公司 一种控制胶囊内窥镜在人体消化道运动的装置及方法
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US9513297B2 (en) 2014-12-16 2016-12-06 Signal Pharmaceuticals, Llc Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
CN107108524A (zh) 2014-12-16 2017-08-29 西格诺药品有限公司 2‑(叔丁基氨基)‑4‑((1r,3r,4r)‑3‑羟基‑4‑甲基环己基氨基)‑嘧啶‑5‑甲酰胺的配制物
EP3250557B1 (en) 2015-01-29 2024-11-20 Signal Pharmaceuticals, LLC Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
CN107922287B (zh) 2015-07-24 2021-04-09 细胞基因公司 合成(1r,2r,5r)-5-氨基-2-甲基环己醇盐酸盐的方法和其中可用的中间体
CN106543089A (zh) * 2016-11-04 2017-03-29 山东铂源药业有限公司 一种达沙替尼中间体的合成方法
WO2021239133A1 (zh) * 2020-05-29 2021-12-02 南京正大天晴制药有限公司 作为axl抑制剂的嘧啶类化合物
CN116178433A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的盐及其制备方法和用途
CN116178434A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的单对甲苯磺酸盐及其晶型

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3704101A (en) * 2000-02-17 2001-08-27 Amgen Inc Kinase inhibitors
ES2286408T3 (es) 2002-03-05 2007-12-01 Astrazeneca Ab Sales de alquilamonio de omeprazol e esomeprazol.
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
PT1660458E (pt) * 2003-08-15 2012-04-27 Novartis Ag 2,4-pirimidinodiaminas úteis no tratamento de doenças neoplásicas, desordens inflamatórias e do sistema imunitário
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
GB0419161D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
JP2008533166A (ja) 2005-03-16 2008-08-21 ターゲジェン インコーポレーティッド ピリミジン化合物および使用法
WO2006129100A1 (en) * 2005-06-03 2006-12-07 Glaxo Group Limited Novel compounds
TW200740805A (en) 2005-07-15 2007-11-01 Glaxo Group Ltd Novel compounds
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
US20090149467A1 (en) 2005-09-15 2009-06-11 Merck & Co., Inc. Tyrosine Kinase Inhibitors
JP5191391B2 (ja) * 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
TW200736232A (en) 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
WO2007085540A1 (en) 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
TW200840581A (en) 2007-02-28 2008-10-16 Astrazeneca Ab Novel pyrimidine derivatives
WO2008118822A1 (en) * 2007-03-23 2008-10-02 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2008132505A1 (en) 2007-04-27 2008-11-06 Astrazeneca Ab N' - (phenyl) -n- (morpholin-4-yl-pyridin-2-yl) -pyrimidine-2, 4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditions

Also Published As

Publication number Publication date
CO6260075A2 (es) 2011-03-22
US7718653B2 (en) 2010-05-18
AU2008277446A1 (en) 2009-01-22
BRPI0814821A2 (pt) 2015-02-03
WO2009010789A2 (en) 2009-01-22
MX2010000658A (es) 2010-03-26
SV2010003459A (es) 2010-04-30
US20090023719A1 (en) 2009-01-22
ZA201000107B (en) 2010-09-29
EP2183242A2 (en) 2010-05-12
ECSP109958A (es) 2010-03-31
EA201000101A1 (ru) 2010-08-30
CA2693880A1 (en) 2009-01-22
CN101796046A (zh) 2010-08-04
JP2010533700A (ja) 2010-10-28
DOP2010000022A (es) 2010-02-15
NI201000011A (es) 2010-12-07
WO2009010789A3 (en) 2009-05-07
KR20100042272A (ko) 2010-04-23

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)