BRPI0814821A2 - Composto, composição farmacêutica, e, processo para preparar um composto - Google Patents

Composto, composição farmacêutica, e, processo para preparar um composto

Info

Publication number
BRPI0814821A2
BRPI0814821A2 BRPI0814821-0A2A BRPI0814821A BRPI0814821A2 BR PI0814821 A2 BRPI0814821 A2 BR PI0814821A2 BR PI0814821 A BRPI0814821 A BR PI0814821A BR PI0814821 A2 BRPI0814821 A2 BR PI0814821A2
Authority
BR
Brazil
Prior art keywords
compound
prepare
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
BRPI0814821-0A2A
Other languages
English (en)
Inventor
Bernard Christopher Barlaam
Richard Ducray
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0814821A2 publication Critical patent/BRPI0814821A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0814821-0A2A 2007-07-16 2008-07-14 Composto, composição farmacêutica, e, processo para preparar um composto BRPI0814821A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07301236 2007-07-16
PCT/GB2008/050562 WO2009010789A2 (en) 2007-07-16 2008-07-14 Pyrimidine derivatives 934

Publications (1)

Publication Number Publication Date
BRPI0814821A2 true BRPI0814821A2 (pt) 2015-02-03

Family

ID=40260140

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814821-0A2A BRPI0814821A2 (pt) 2007-07-16 2008-07-14 Composto, composição farmacêutica, e, processo para preparar um composto

Country Status (18)

Country Link
US (1) US7718653B2 (pt)
EP (1) EP2183242A2 (pt)
JP (1) JP2010533700A (pt)
KR (1) KR20100042272A (pt)
CN (1) CN101796046A (pt)
AU (1) AU2008277446A1 (pt)
BR (1) BRPI0814821A2 (pt)
CA (1) CA2693880A1 (pt)
CO (1) CO6260075A2 (pt)
CR (1) CR11220A (pt)
DO (1) DOP2010000022A (pt)
EA (1) EA201000101A1 (pt)
EC (1) ECSP109958A (pt)
MX (1) MX2010000658A (pt)
NI (1) NI201000011A (pt)
SV (1) SV2010003459A (pt)
WO (1) WO2009010789A2 (pt)
ZA (1) ZA201000107B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012029647A2 (pt) 2010-05-21 2016-08-02 Chemilia Ab novos derivados de pirimidinas
MX2013010898A (es) 2011-03-24 2013-12-06 Chemilia Ab Novedoso derivados de la pirimidina.
TWI548621B (zh) 2011-04-22 2016-09-11 標誌製藥公司 經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法
CN103890875B (zh) 2011-05-03 2018-01-19 菲尼克斯电气公司 用于利用包括平面的发送线圈的、耦合最小化的矩阵来无接触地传输能量的系统和方法
CN103222842B (zh) 2013-04-18 2015-09-09 安翰光电技术（武汉）有限公司 一种控制胶囊内窥镜在人体消化道运动的装置及方法
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
EP3712134B1 (en) 2014-12-16 2023-11-29 Signal Pharmaceuticals, LLC Salts of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide
US9513297B2 (en) 2014-12-16 2016-12-06 Signal Pharmaceuticals, Llc Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
EP3250557B1 (en) 2015-01-29 2024-11-20 Signal Pharmaceuticals, LLC Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
EP3325432B1 (en) 2015-07-24 2020-09-02 Celgene Corporation Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
CN106543089A (zh) * 2016-11-04 2017-03-29 山东铂源药业有限公司 一种达沙替尼中间体的合成方法
US20230227484A1 (en) * 2020-05-29 2023-07-20 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Pyrimidine compound as axl inhibitor
CN116178434A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的单对甲苯磺酸盐及其晶型
CN116178433A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的盐及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030024659A (ko) * 2000-02-17 2003-03-26 암겐 인코포레이티드 키나제 억제제
ES2286408T3 (es) 2002-03-05 2007-12-01 Astrazeneca Ab Sales de alquilamonio de omeprazol e esomeprazol.
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
ATE542801T1 (de) * 2003-08-15 2012-02-15 Novartis Ag Zur behandlung von neoplastischen krankheiten, entzündlichen erkrankungen und erkrankungen des immunsystems geeignete 2,4-pyrimidindiamine
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
GB0419161D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
WO2006101977A2 (en) 2005-03-16 2006-09-28 Targegen, Inc. Pyrimidine compounds and methods of use
WO2006129100A1 (en) * 2005-06-03 2006-12-07 Glaxo Group Limited Novel compounds
WO2007009681A1 (en) 2005-07-15 2007-01-25 Glaxo Group Limited 1 , 1-DIOXID0-2 , 3-DIHYDRO-l , 2-BENZISOTHIAZ0L-6-YL-1H-INDAZOL-4-YL-2 , 4-PYRIMIDINEDI AMINE DERIVATIVES
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
US20090149467A1 (en) 2005-09-15 2009-06-11 Merck & Co., Inc. Tyrosine Kinase Inhibitors
WO2007053452A1 (en) * 2005-11-01 2007-05-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
TW200736232A (en) 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
WO2007085540A1 (en) 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
TW200840581A (en) * 2007-02-28 2008-10-16 Astrazeneca Ab Novel pyrimidine derivatives
US7947698B2 (en) * 2007-03-23 2011-05-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
JP2010525047A (ja) 2007-04-27 2010-07-22 アストラゼネカ アクチボラグ 増殖状態の処置のためのＥｐｈＢ４キナーゼ阻害剤としてのＮ’−（フェニル）−Ｎ−（モルホリン−４−イル−ピリジン−２−イル）−ピリミジン−２，４−ジアミン誘導体

Also Published As

Publication number Publication date
ECSP109958A (es) 2010-03-31
AU2008277446A1 (en) 2009-01-22
SV2010003459A (es) 2010-04-30
MX2010000658A (es) 2010-03-26
WO2009010789A3 (en) 2009-05-07
KR20100042272A (ko) 2010-04-23
US20090023719A1 (en) 2009-01-22
CR11220A (es) 2010-05-20
EP2183242A2 (en) 2010-05-12
CA2693880A1 (en) 2009-01-22
NI201000011A (es) 2010-12-07
WO2009010789A2 (en) 2009-01-22
JP2010533700A (ja) 2010-10-28
CN101796046A (zh) 2010-08-04
DOP2010000022A (es) 2010-02-15
US7718653B2 (en) 2010-05-18
ZA201000107B (en) 2010-09-29
EA201000101A1 (ru) 2010-08-30
CO6260075A2 (es) 2011-03-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.