CR11245A - Mejoras en compuestos organicos o relacionadas con los mismos - Google Patents
Mejoras en compuestos organicos o relacionadas con los mismosInfo
- Publication number
- CR11245A CR11245A CR11245A CR11245A CR11245A CR 11245 A CR11245 A CR 11245A CR 11245 A CR11245 A CR 11245A CR 11245 A CR11245 A CR 11245A CR 11245 A CR11245 A CR 11245A
- Authority
- CR
- Costa Rica
- Prior art keywords
- same
- organic compounds
- ch3ch
- nr1r2
- cycloalkyl
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen
- A01N35/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
- A01N39/02—Aryloxy-carboxylic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
- A01N43/68—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms with two or three nitrogen atoms directly attached to ring carbon atoms
- A01N43/70—Diamino—1,3,5—triazines with only one oxygen, sulfur or halogen atom or only one cyano, thiocyano (—SCN), cyanato (—OCN) or azido (—N3) group directly attached to a ring carbon atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
- A01N45/02—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Una composicion que comprende un compuesto de formula I CH3CH(OH)C(=O)NR1R2 donde R1 y R2 son cada uno independientemente hidrogeno; o alquilo C1-6, alquenilo C2-6 o cicloalquilo C3-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0716592.1A GB0716592D0 (en) | 2007-08-24 | 2007-08-24 | Improvements in or relating to organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR11245A true CR11245A (es) | 2010-04-19 |
Family
ID=38599260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR11245A CR11245A (es) | 2007-08-24 | 2010-01-29 | Mejoras en compuestos organicos o relacionadas con los mismos |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US20110190129A1 (es) |
| EP (1) | EP2194778B1 (es) |
| JP (1) | JP5539873B2 (es) |
| KR (1) | KR20100065292A (es) |
| CN (1) | CN101784186B (es) |
| AP (1) | AP2713A (es) |
| AR (1) | AR068615A1 (es) |
| AU (1) | AU2008292009B2 (es) |
| BR (1) | BRPI0816238B1 (es) |
| CA (1) | CA2695171C (es) |
| CO (2) | CO6260004A2 (es) |
| CR (1) | CR11245A (es) |
| DK (1) | DK2194778T3 (es) |
| DO (1) | DOP2010000065A (es) |
| EA (1) | EA017314B1 (es) |
| EC (1) | ECSP109990A (es) |
| EG (1) | EG26581A (es) |
| ES (1) | ES2621360T3 (es) |
| GB (1) | GB0716592D0 (es) |
| GE (1) | GEP20156292B (es) |
| GT (1) | GT201000047A (es) |
| HN (1) | HN2010000355A (es) |
| HU (1) | HUE031139T2 (es) |
| IL (1) | IL203736A (es) |
| MA (1) | MA31621B1 (es) |
| MX (1) | MX2010001915A (es) |
| MY (1) | MY152080A (es) |
| NI (1) | NI201000026A (es) |
| NZ (1) | NZ583089A (es) |
| PL (1) | PL2194778T3 (es) |
| PT (1) | PT2194778T (es) |
| SV (1) | SV2010003495A (es) |
| TN (1) | TN2010000084A1 (es) |
| TW (1) | TW200913881A (es) |
| UA (1) | UA100529C2 (es) |
| WO (1) | WO2009027624A2 (es) |
| ZA (1) | ZA201000789B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0817513D0 (en) * | 2008-09-24 | 2008-10-29 | Syngenta Ltd | Co-crystals |
| GB0817976D0 (en) * | 2008-10-01 | 2008-11-05 | Syngenta Ltd | Co-crystals |
| EP2272346A1 (de) | 2009-07-08 | 2011-01-12 | LANXESS Deutschland GmbH | Penthiopyrad für den Holzschutz |
| FR2951447B1 (fr) | 2009-10-19 | 2012-10-19 | Rhodia Operations | Composes de type ether-amide et utilisattions |
| CA2798997C (en) | 2010-05-27 | 2018-05-15 | Akzo Nobel Chemicals International B.V. | Agricultural formulations with acyl morpholines and polar aprotic co-solvents |
| KR20130119900A (ko) * | 2010-06-07 | 2013-11-01 | 다우 아그로사이언시즈 엘엘씨 | 살진균제로서의 피라지닐 카르복스아미드 |
| CA2938806C (en) * | 2014-02-14 | 2022-05-10 | BASF Agro B.V. | Emulsifiable concentrate comprising pesticide, alkyl lactate, and lactamide |
| UA118214C2 (uk) * | 2014-02-14 | 2018-12-10 | Басф Агро Б.В. | Здатний до емульгування концентрат, що включає пестицид, жирний амід і лактамід |
| EP3364756B1 (en) * | 2015-10-21 | 2021-12-08 | Basf Se | Liquid pesticidal composition |
| WO2018143911A1 (en) | 2017-01-31 | 2018-08-09 | Kimberly-Clark Worldwide, Inc. | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same |
| US11805776B2 (en) * | 2018-01-16 | 2023-11-07 | The United States Of America, As Represented By The Secretary Of Agriculture | Compositions and methods for killing insect and non-insect pests |
| US12226505B2 (en) | 2018-10-25 | 2025-02-18 | The Procter & Gamble Company | Compositions having enhanced deposition of surfactant-soluble anti-dandruff agents |
| EP4171755A1 (en) | 2020-06-26 | 2023-05-03 | The Procter & Gamble Company | Synergistic anti-inflammatory compositions |
| US11701316B2 (en) | 2020-12-18 | 2023-07-18 | The Procter & Gamble Company | Synergistic anti-inflammatory compositions |
| US20220192956A1 (en) * | 2020-12-18 | 2022-06-23 | The Procter & Gamble Company | Superior efficacy of azoxystrobin and other strobilurins |
| CN117500903A (zh) * | 2021-06-21 | 2024-02-02 | 金伯利-克拉克环球有限公司 | 用于叶面使用的草丝兰提取物 |
| GB202114743D0 (en) * | 2021-10-15 | 2021-12-01 | Syngenta Crop Protection Ag | Composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1083501B (de) * | 1959-03-26 | 1960-06-15 | Merck Ag E | Verfahren zur Herstellung von Loesungen in Wasser schwer- oder unloeslicher Arzneimittel |
| US4837242A (en) * | 1987-01-20 | 1989-06-06 | Sumitomo Chemical Company, Limited | Thiazoles and pyrazoles as fungicides |
| DE4112873A1 (de) * | 1991-04-19 | 1992-10-22 | Richard H Dr Sehring | Fungicides pflanzenschutzmittel mit wirkung im zierpflanzen und obstbau sowie gegen echten mehltau an getreide, gurken, reben und hopfen |
| DE4130189A1 (de) * | 1991-04-19 | 1993-03-18 | Sehring Richard H Dr | Neue emulsionskonzentrate fuer den einsatz im pflanzenschutz |
| JP3066291B2 (ja) * | 1994-07-07 | 2000-07-17 | 麒麟麦酒株式会社 | 抗腫瘍薬物の用時調合型セット製剤 |
| AUPQ875700A0 (en) * | 2000-07-13 | 2000-08-03 | Reflex Research Limited | Combination compositions |
| GB0605780D0 (en) * | 2006-03-22 | 2006-05-03 | Syngenta Ltd | Formulations |
| EP1961301A1 (en) * | 2007-02-22 | 2008-08-27 | Cognis IP Management GmbH | Biocide compositions comprising a dialkylamide of a hydroxycarboxylic acid |
-
2007
- 2007-08-24 GB GBGB0716592.1A patent/GB0716592D0/en not_active Ceased
-
2008
- 2008-08-13 EP EP08788299.9A patent/EP2194778B1/en active Active
- 2008-08-13 MY MYPI20100781 patent/MY152080A/en unknown
- 2008-08-13 MX MX2010001915A patent/MX2010001915A/es not_active Application Discontinuation
- 2008-08-13 PL PL08788299T patent/PL2194778T3/pl unknown
- 2008-08-13 US US12/674,727 patent/US20110190129A1/en not_active Abandoned
- 2008-08-13 HU HUE08788299A patent/HUE031139T2/en unknown
- 2008-08-13 EA EA201070305A patent/EA017314B1/ru not_active IP Right Cessation
- 2008-08-13 CA CA2695171A patent/CA2695171C/en active Active
- 2008-08-13 WO PCT/GB2008/002730 patent/WO2009027624A2/en not_active Ceased
- 2008-08-13 BR BRPI0816238A patent/BRPI0816238B1/pt active IP Right Grant
- 2008-08-13 UA UAA201003389A patent/UA100529C2/ru unknown
- 2008-08-13 DK DK08788299.9T patent/DK2194778T3/en active
- 2008-08-13 NZ NZ583089A patent/NZ583089A/en unknown
- 2008-08-13 AP AP2010005160A patent/AP2713A/xx active
- 2008-08-13 AU AU2008292009A patent/AU2008292009B2/en active Active
- 2008-08-13 GE GEAP200811738A patent/GEP20156292B/en unknown
- 2008-08-13 ES ES08788299.9T patent/ES2621360T3/es active Active
- 2008-08-13 JP JP2010521463A patent/JP5539873B2/ja active Active
- 2008-08-13 CN CN200880104213.1A patent/CN101784186B/zh active Active
- 2008-08-13 PT PT87882999T patent/PT2194778T/pt unknown
- 2008-08-13 KR KR1020107004107A patent/KR20100065292A/ko not_active Ceased
- 2008-08-15 TW TW097131103A patent/TW200913881A/zh unknown
- 2008-08-22 AR ARP080103673A patent/AR068615A1/es active IP Right Grant
-
2010
- 2010-01-29 CR CR11245A patent/CR11245A/es not_active Application Discontinuation
- 2010-02-02 ZA ZA201000789A patent/ZA201000789B/xx unknown
- 2010-02-04 IL IL203736A patent/IL203736A/en active IP Right Grant
- 2010-02-11 CO CO10015213A patent/CO6260004A2/es active IP Right Grant
- 2010-02-16 NI NI201000026A patent/NI201000026A/es unknown
- 2010-02-18 CO CO10018962A patent/CO6260005A2/es active IP Right Grant
- 2010-02-19 MA MA32634A patent/MA31621B1/fr unknown
- 2010-02-19 TN TNP2010000084A patent/TN2010000084A1/fr unknown
- 2010-02-22 EG EG2010020292A patent/EG26581A/en active
- 2010-02-23 HN HN2010000355A patent/HN2010000355A/es unknown
- 2010-02-23 DO DO2010000065A patent/DOP2010000065A/es unknown
- 2010-02-23 GT GT201000047A patent/GT201000047A/es unknown
- 2010-02-23 EC EC2010009990A patent/ECSP109990A/es unknown
- 2010-02-24 SV SV2010003495A patent/SV2010003495A/es not_active Application Discontinuation
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