CR11436A - Moduladores enlazados a amida y-secretasa - Google Patents

Moduladores enlazados a amida y-secretasa

Info

Publication number
CR11436A
CR11436A CR11436A CR11436A CR11436A CR 11436 A CR11436 A CR 11436A CR 11436 A CR11436 A CR 11436A CR 11436 A CR11436 A CR 11436A CR 11436 A CR11436 A CR 11436A
Authority
CR
Costa Rica
Prior art keywords
secretasa
amida
modulators
linked
modulators linked
Prior art date
Application number
CR11436A
Other languages
English (en)
Inventor
Yung Ho Chin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR11436A publication Critical patent/CR11436A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A LOS COMPUESTOS DE LA FORMULA I COMO SE MUESTRAN A CONTINUACION, EN DONDE LAS DEFINICIONES DE A, R1, R2,R3, R4, R5, R6, R7 Y R8 SE PROPORCIONAN EN LA ESPECIFICACION. LOS COMPUESTOS DE LA FORMULA I SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON LA ACTIVIDAD DE LA Y-SECRETASA, QUE INCLUYE LA ENFERMEDAD DE ALZHEIMER.
CR11436A 2007-10-19 2010-05-17 Moduladores enlazados a amida y-secretasa CR11436A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98117007P 2007-10-19 2007-10-19

Publications (1)

Publication Number Publication Date
CR11436A true CR11436A (es) 2011-01-14

Family

ID=40091367

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11436A CR11436A (es) 2007-10-19 2010-05-17 Moduladores enlazados a amida y-secretasa

Country Status (18)

Country Link
US (1) US7951843B2 (es)
EP (1) EP2212280B1 (es)
JP (1) JP5543353B2 (es)
KR (1) KR20100090265A (es)
CN (1) CN101888990B (es)
AU (1) AU2008312653B2 (es)
BR (1) BRPI0817425A2 (es)
CA (1) CA2702835A1 (es)
CO (1) CO6280529A2 (es)
CR (1) CR11436A (es)
EA (1) EA017907B1 (es)
ES (1) ES2447842T3 (es)
IL (1) IL205044A (es)
MX (1) MX2010004308A (es)
NI (1) NI201000063A (es)
NZ (1) NZ584721A (es)
WO (1) WO2009052079A1 (es)
ZA (1) ZA201003518B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE543799T1 (de) * 2007-10-19 2012-02-15 Janssen Pharmaceutica Nv Piperidinyl- und piperazinylmodulatoren von g- sekretase
EP2212277B1 (en) * 2007-10-19 2016-08-31 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
US8692017B2 (en) * 2007-10-19 2014-04-08 Janssen Pharmaceutica, N.V. Carbon linked modulators of gamma-secretase
US20120129189A1 (en) * 2009-07-17 2012-05-24 Chulan Kwon Methods of Controlling Cell Proliferation
EP2499282B1 (en) * 2009-11-09 2015-04-22 NeuroGenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
CA2881078C (en) * 2004-06-24 2018-10-02 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
EP1650183A1 (en) 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
WO2007143745A2 (en) * 2006-06-09 2007-12-13 Icos Corporation Substituted phenyl acetic acids as dp-2 antagonists

Also Published As

Publication number Publication date
ES2447842T3 (es) 2014-03-13
NI201000063A (es) 2010-09-13
CA2702835A1 (en) 2009-04-23
JP2011500699A (ja) 2011-01-06
AU2008312653B2 (en) 2013-03-07
JP5543353B2 (ja) 2014-07-09
KR20100090265A (ko) 2010-08-13
ZA201003518B (en) 2012-07-25
EP2212280A1 (en) 2010-08-04
MX2010004308A (es) 2010-05-03
CO6280529A2 (es) 2011-05-20
BRPI0817425A2 (pt) 2015-06-16
US7951843B2 (en) 2011-05-31
EA201070494A1 (ru) 2010-12-30
US20090105345A1 (en) 2009-04-23
EA017907B1 (ru) 2013-04-30
EP2212280B1 (en) 2013-12-04
AU2008312653A1 (en) 2009-04-23
WO2009052079A1 (en) 2009-04-23
CN101888990A (zh) 2010-11-17
CN101888990B (zh) 2014-01-29
IL205044A0 (en) 2010-11-30
IL205044A (en) 2015-02-26
NZ584721A (en) 2011-11-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)