CR11485A - Tratamiento de cancer de mama con un inhibidor de parp solo o en combinacion con agentes anti-tumorales - Google Patents
Tratamiento de cancer de mama con un inhibidor de parp solo o en combinacion con agentes anti-tumoralesInfo
- Publication number
- CR11485A CR11485A CR11485A CR11485A CR11485A CR 11485 A CR11485 A CR 11485A CR 11485 A CR11485 A CR 11485A CR 11485 A CR11485 A CR 11485A CR 11485 A CR11485 A CR 11485A
- Authority
- CR
- Costa Rica
- Prior art keywords
- breast cancer
- combination
- parp inhibitor
- cancer treatment
- tumor agents
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 2
- 239000012661 PARP inhibitor Substances 0.000 title abstract 2
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
En un aspecto, la presente invencion proporciona un metodo para tratar el cancer de mama que es negativo para al menos uno de ER, PR, o HER2, que comprende administrar a un sujeto al menos un inhibidor de PARP.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98733307P | 2007-11-12 | 2007-11-12 | |
| US1236407P | 2007-12-07 | 2007-12-07 | |
| US5852808P | 2008-06-03 | 2008-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR11485A true CR11485A (es) | 2010-09-13 |
Family
ID=40639414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR11485A CR11485A (es) | 2007-11-12 | 2010-06-10 | Tratamiento de cancer de mama con un inhibidor de parp solo o en combinacion con agentes anti-tumorales |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US7732491B2 (es) |
| EP (1) | EP2217227B1 (es) |
| JP (1) | JP2011503111A (es) |
| KR (1) | KR20100102609A (es) |
| CN (2) | CN101917982B (es) |
| AR (1) | AR069291A1 (es) |
| AU (1) | AU2008321128A1 (es) |
| CA (1) | CA2705537A1 (es) |
| CO (1) | CO6290650A2 (es) |
| CR (1) | CR11485A (es) |
| DO (2) | DOP2010000141A (es) |
| EC (1) | ECSP10010240A (es) |
| GT (1) | GT201000140A (es) |
| IL (1) | IL205689A0 (es) |
| MA (1) | MA31909B1 (es) |
| MX (1) | MX2010005222A (es) |
| NI (1) | NI201000083A (es) |
| NZ (1) | NZ586125A (es) |
| RU (2) | RU2480211C2 (es) |
| SG (1) | SG185952A1 (es) |
| TN (1) | TN2010000208A1 (es) |
| TW (2) | TW200924739A (es) |
| WO (1) | WO2009064738A2 (es) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101242822B (zh) | 2005-07-18 | 2011-08-24 | 彼帕科学公司 | 治疗卵巢癌的药物 |
| AU2007354301A1 (en) * | 2006-06-12 | 2008-12-04 | Bipar Sciences, Inc. | Method of treating diseases with PARP inhibitors |
| US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
| WO2008030892A2 (en) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Drug design for tubulin inhibitors, compositions, and methods of treatment thereof |
| WO2008030883A2 (en) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
| US7994222B2 (en) * | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
| WO2008030887A2 (en) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Methods for designing parp inhibitors and uses thereof |
| US20120082659A1 (en) * | 2007-10-02 | 2012-04-05 | Hartmut Land | Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations |
| AU2008321128A1 (en) * | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
| MX2010005221A (es) * | 2007-11-12 | 2010-09-28 | Bipar Sciences Inc | Tratamiento de cancer de utero y cancer de ovario con un inhibidor de parp solo o en combinacion con agentes antitumorales. |
| US20090149397A1 (en) * | 2007-12-07 | 2009-06-11 | Bipar Sciences | Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors |
| US20090275608A1 (en) * | 2008-02-04 | 2009-11-05 | Bipar Sciences, Inc. | Methods of diagnosing and treating parp-mediated diseases |
| US8470312B2 (en) * | 2008-05-27 | 2013-06-25 | Oncolytics Biotech, Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| US8729239B2 (en) | 2009-04-09 | 2014-05-20 | Nuclea Biotechnologies, Inc. | Antibodies against fatty acid synthase |
| US8685891B2 (en) | 2009-08-27 | 2014-04-01 | Nuclea Biotechnologies, Inc. | Method and assay for determining FAS expression |
| US8710035B2 (en) | 2010-03-24 | 2014-04-29 | The University Of Chicago | Methods and compositions related to glucocorticoid receptor antagonists and breast cancer |
| EP2558866B1 (en) * | 2010-04-15 | 2016-08-17 | Tracon Pharmaceuticals, Inc. | Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| CA2802882C (en) * | 2010-06-18 | 2018-10-30 | Jerry Lanchbury | Methods and materials for assessing loss of heterozygosity |
| JP2013531068A (ja) * | 2010-07-19 | 2013-08-01 | バイパー サイエンシズ,インコーポレイティド | 4−ヨード−3−ニトロベンズアミドを抗腫瘍剤と組み合わせて用いる乳癌の治療方法 |
| AU2011293635B2 (en) | 2010-08-24 | 2015-11-26 | Children's Medical Center Corporation | Methods for predicting anti-cancer response |
| WO2013052006A1 (en) * | 2010-10-07 | 2013-04-11 | Agency For Science, Technology And Research (A*Star) | Parp-1 inhibitors |
| CN103221384B (zh) | 2010-11-05 | 2015-05-13 | 浙江海正药业股份有限公司 | 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途 |
| US9314473B2 (en) * | 2011-02-03 | 2016-04-19 | Pop Test Oncology Limited Liability Company | System and method for diagnosis and treatment |
| EP2670866A4 (en) * | 2011-04-05 | 2015-09-02 | Translational Genomics Res Inst | BIOMARKERS AND METHOD OF APPLICATION THEREFOR |
| WO2012155063A1 (en) * | 2011-05-11 | 2012-11-15 | Synta Pharmaceuticals Corp. | Treating cancer with an hsp90 inhibitory compound |
| EP2717911A1 (en) * | 2011-06-06 | 2014-04-16 | Novartis Forschungsstiftung, Zweigniederlassung | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer |
| JP6117194B2 (ja) | 2011-06-17 | 2017-04-19 | ミリアド・ジェネティックス・インコーポレイテッド | アレル不均衡を評価するための方法および材料 |
| US8933078B2 (en) | 2011-07-14 | 2015-01-13 | Research Cancer Institute Of America | Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances |
| CN110075316A (zh) * | 2011-08-15 | 2019-08-02 | 吉安特科技股份有限公司 | 特异性靶向癌细胞的输送系统及其使用方法 |
| FI20115876A0 (fi) * | 2011-09-06 | 2011-09-06 | Turun Yliopisto | Yhdistelmähoito |
| CA2849903A1 (en) * | 2011-09-26 | 2013-04-04 | Celgene Corporation | Combination therapy for chemoresistant cancers |
| BR112014007521A8 (pt) | 2011-10-14 | 2018-04-10 | Genentech Inc | método para estender a sobrevida livre de progressão em uma população com câncer de mama, artigo de fabricação, método para produção de um artigo de fabricação, para garantir o uso seguro e efetivo de pertuzumabe, de tratar câncer de mama, bolsa intravenosa, método de tratar câncer gástrico, de tratar adenocarcinoma do estômago e de melhora de sobrevida |
| JP2014532712A (ja) | 2011-11-02 | 2014-12-08 | シンタ ファーマシューティカルズ コーポレーション | トポイソメラーゼi阻害剤とhsp90阻害剤の組合せを使用する癌療法 |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| AU2012339679A1 (en) | 2011-11-14 | 2014-06-12 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with BRAF inhibitors |
| EP3660161B1 (en) | 2011-12-21 | 2024-07-31 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
| US8889707B2 (en) * | 2012-02-08 | 2014-11-18 | Malka COHEN-ARMON | Treatment of addiction |
| CA3080441C (en) | 2012-02-23 | 2026-01-06 | The Technical University Of Denmark | Methods for predicting anti-cancer response |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CN104507308A (zh) * | 2012-06-01 | 2015-04-08 | 博格有限责任公司 | 用辅酶q10治疗实体肿瘤的方法 |
| AU2013273466B2 (en) | 2012-06-07 | 2018-11-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors |
| WO2014160080A1 (en) | 2013-03-14 | 2014-10-02 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
| WO2014152330A1 (en) * | 2013-03-15 | 2014-09-25 | Stc.Unm | Arsenic-based treatment of cancers and inflammatory disorders |
| WO2014150840A1 (en) * | 2013-03-15 | 2014-09-25 | Medimmune, Llc | Methods of treating breast cancer |
| CA2909091C (en) | 2013-04-09 | 2021-11-02 | The Board Of Trustees Of The University Of Illinois | Tumor-selective combination therapy |
| ES2909899T3 (es) | 2013-12-09 | 2022-05-10 | Inst Curie | Métodos para detectar inactivación de la ruta de recombinación homóloga (BRCA1/2) en tumores humanos |
| JP6758195B2 (ja) * | 2014-01-14 | 2020-09-23 | ネクター セラピューティクス | 併用ベースの治療方法 |
| WO2015120458A1 (en) | 2014-02-10 | 2015-08-13 | Fred Hutchinson Cancer Research Center | Halogen treatment of heart attack and ischemic injury |
| EP3137076A4 (en) * | 2014-05-02 | 2017-12-06 | Emory University | Selective chemotherapy treatments and diagnostic methods related thereto |
| US9303069B2 (en) * | 2014-05-05 | 2016-04-05 | University Of Mississippi Medical Center | Peptides for treating cancer |
| JP6877334B2 (ja) | 2014-08-15 | 2021-05-26 | ミリアド・ジェネティックス・インコーポレイテッド | 相同組換え欠損を評価するための方法および材料 |
| ES2748005T3 (es) * | 2014-12-12 | 2020-03-12 | Medivation Prostate Therapeutics Llc | Método para predecir la respuesta a agentes terapéuticos de cáncer de mama y método de tratamiento de cáncer de mama |
| EP3265560B1 (en) | 2015-03-02 | 2021-12-08 | Sinai Health System | Homologous recombination factors |
| CN114927178A (zh) * | 2015-06-12 | 2022-08-19 | 格尼亚Ip控股私人有限公司 | 患者和生物样本识别和追踪的方法和系统 |
| US10828373B2 (en) | 2015-09-10 | 2020-11-10 | Tambo, Inc. | Bioorthogonal compositions |
| CN108348605B (zh) * | 2015-11-10 | 2023-06-09 | 帕拉卡林治疗公司 | 用pdgf-cc抑制剂和抗雌激素治疗er阴性乳癌 |
| AU2017206718B2 (en) * | 2016-01-11 | 2021-09-30 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| WO2017174879A1 (en) * | 2016-04-06 | 2017-10-12 | University Of Oulu | Compounds for use in the treatment of cancer |
| CN109219852A (zh) | 2016-05-01 | 2019-01-15 | 基因组研究有限公司 | 表征dna样品的方法 |
| GB201607629D0 (en) | 2016-05-01 | 2016-06-15 | Genome Res Ltd | Mutational signatures in cancer |
| US11890292B2 (en) | 2017-02-27 | 2024-02-06 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| CN110337450B (zh) | 2017-03-02 | 2023-07-25 | 豪夫迈·罗氏有限公司 | Her2阳性乳腺癌的辅助治疗 |
| US11369585B2 (en) | 2017-03-17 | 2022-06-28 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| CA3055076C (en) | 2017-03-31 | 2022-02-22 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| ES2983582T3 (es) | 2017-04-07 | 2024-10-23 | Tambo Inc | Composiciones bioortogonales |
| MA48637A (fr) * | 2017-05-09 | 2021-03-17 | Merck Sharp & Dohme | Polythérapies pour le traitement du cancer |
| MA49144A (fr) | 2017-05-18 | 2020-03-25 | Tesaro Inc | Polythérapies pour le traitement du cancer |
| WO2018237327A1 (en) | 2017-06-22 | 2018-12-27 | Triact Therapeutics, Inc. | Methods of treating glioblastoma |
| WO2019051025A2 (en) * | 2017-09-06 | 2019-03-14 | The Trustees Of Columbia University In The City Of New York | TREATMENT OF AGGRESSIVE CANCERS BY TARGETING C9ORF72 |
| WO2019067991A1 (en) | 2017-09-29 | 2019-04-04 | Triact Therapeutics, Inc. | INIPARIB FORMULATIONS AND USES THEREOF |
| SG11202002862RA (en) | 2017-09-30 | 2020-04-29 | Tesaro Inc | Combination therapies for treating cancer |
| JP2020536869A (ja) | 2017-10-06 | 2020-12-17 | テサロ, インコーポレイテッド | 併用療法およびその使用 |
| US20210047693A1 (en) * | 2017-11-15 | 2021-02-18 | The Regents Of The University Of California | Methods of treating extrachromosomal dna expressing cancers |
| WO2019099750A1 (en) | 2017-11-17 | 2019-05-23 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| AU2019219322A1 (en) * | 2018-02-12 | 2020-09-10 | Cinda Pharma Ab | Thioredoxin reductase inhibitors for use in the treatment of cancer |
| US10953209B2 (en) * | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| US20190375732A1 (en) | 2018-05-14 | 2019-12-12 | David Hung | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN113454080B (zh) | 2018-10-30 | 2025-10-28 | 修复治疗公司 | 化合物、药物组合物和制备化合物的方法以及其使用方法 |
| PT3897589T (pt) | 2018-12-19 | 2026-01-21 | Corcept Therapeutics Inc | Formulações farmacêuticas contendo relacorilant, um composto de azadecalina fundido com heteroaril-cetona |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| JP7789561B2 (ja) | 2019-02-22 | 2025-12-22 | コーセプト セラピューティクス, インコーポレイテッド | レラコリラント、ヘテロアリール-ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途 |
| MX2021013774A (es) | 2019-05-14 | 2021-12-10 | Nuvation Bio Inc | Compuestos anticancerigenos dirigidos a los receptores hormonales nucleares. |
| WO2020232133A1 (en) * | 2019-05-14 | 2020-11-19 | Georgetown University | Methods of treating gastrointestinal cancers and tumors thereof using combination therapy |
| KR20220101120A (ko) * | 2019-11-04 | 2022-07-19 | 패러데이 파마슈티컬스, 인코포레이티드 | 화학요법 연관 악액질 및 심장독성의 치료 및 예방을 위한 요오드 화합물의 용도 |
| US11952349B2 (en) | 2019-11-13 | 2024-04-09 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| JP2023508996A (ja) * | 2019-12-31 | 2023-03-06 | キネート バイオファーマ インク. | Cdk12/13阻害剤を用いる癌の処置 |
| CN111362828A (zh) * | 2020-03-30 | 2020-07-03 | 山西医科大学 | 一种18f标记的氟丙酰化鸟氨酸及其制备方法和应用 |
| WO2022070483A1 (ja) * | 2020-09-30 | 2022-04-07 | 地方独立行政法人東京都健康長寿医療センター | 前立腺癌又は乳癌治療用医薬組成物 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| EP4313991A1 (en) | 2021-03-23 | 2024-02-07 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| US12006314B2 (en) | 2021-05-03 | 2024-06-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| US12005092B2 (en) * | 2021-12-22 | 2024-06-11 | Laura Mann Kevehazi | Herbal composition for breast cancer prevention |
| WO2024016014A2 (en) * | 2022-07-15 | 2024-01-18 | Lantern Pharma Inc. | Method for treating breast cancers and parp resistant breast cancers |
| KR20250073629A (ko) | 2022-10-06 | 2025-05-27 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 글루코코르티코이드 수용체 조절제의 제형 |
| WO2024092195A1 (en) | 2022-10-28 | 2024-05-02 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
| WO2025106920A1 (en) * | 2023-11-15 | 2025-05-22 | Yale University | Parp pet imaging agents and methods of using the same |
Family Cites Families (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2669583A (en) | 1954-02-16 | X-amroo-zralkoxbbenzamdjes | ||
| US2006735A (en) | 1932-11-17 | 1935-07-02 | Gen Aniline Works Inc | Nitro-aryl amino-aryl amines |
| LU38172A1 (es) | 1957-11-25 | |||
| US3161564A (en) | 1960-10-03 | 1964-12-15 | Salsbury S Lab Dr | Veterinary composition containing halo-nitro-benzamides and methods of using same |
| US3228833A (en) | 1962-12-17 | 1966-01-11 | Sterling Drug Inc | Anticoccidial compositions and methods of using same |
| AR204004A1 (es) | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US5215738A (en) | 1985-05-03 | 1993-06-01 | Sri International | Benzamide and nicotinamide radiosensitizers |
| US5032617A (en) | 1985-05-03 | 1991-07-16 | Sri International | Substituted benzamide radiosensitizers |
| US5041653A (en) | 1985-05-03 | 1991-08-20 | Sri International | Substituted benzamide radiosensitizers |
| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| JP2534631B2 (ja) | 1986-01-17 | 1996-09-18 | プリベンティブ メディシン インスティテュート | Dnaが関連する病気にかかり易い体質または該病気に対する感受性を測定するための試験 |
| US5283352A (en) | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
| US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| US5177075A (en) | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| US4923885A (en) * | 1988-08-19 | 1990-05-08 | Merck & Co., Inc. | 5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs as antiproliferative agents |
| AU6518890A (en) | 1989-09-26 | 1991-04-28 | Regents Of The University Of California, The | 6-amino-1,2-benzopyrones useful for treatment of viral diseases |
| US5719151A (en) | 1990-05-04 | 1998-02-17 | Shall; Sydney | Substituted benzene compounds |
| US5633282A (en) | 1990-05-25 | 1997-05-27 | British Technology Group Limited | Inhibition of viral infection |
| US5637618A (en) | 1990-06-01 | 1997-06-10 | Bioresearch, Inc. | Specific eatable taste modifiers |
| US5631038A (en) | 1990-06-01 | 1997-05-20 | Bioresearch, Inc. | Specific eatable taste modifiers |
| US5232735A (en) | 1990-06-01 | 1993-08-03 | Bioresearch, Inc. | Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers |
| FI931384A7 (fi) | 1990-09-28 | 1993-03-26 | Smithkline Beecham Corp | Vesiliukoisia kamptotekiinianalogeja, prosesseja ja menetelmiä |
| US5484951A (en) | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
| US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
| US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
| US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| CA2085136C (en) | 1991-04-10 | 1997-03-18 | Ernest Kun | Method for inhibition of retroviral replication |
| US5473074A (en) | 1991-10-22 | 1995-12-05 | Octamer, Incorporated | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54 |
| US5753674A (en) | 1991-10-22 | 1998-05-19 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents |
| US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
| US5482975A (en) | 1991-10-22 | 1996-01-09 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents |
| US5464871A (en) | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
| US5877185A (en) * | 1991-10-22 | 1999-03-02 | Octamer, Inc. | Synergistic compositions useful as anti-tumor agents |
| CZ291047B6 (cs) | 1992-10-28 | 2002-12-11 | Genentech, Inc. | Farmaceutický prostředek obsahující antagonisty faktoru růstu vaskulárních endoteliálních buněk |
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| US5783599A (en) | 1993-02-24 | 1998-07-21 | Octamer Inc | Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
| DZ1781A1 (fr) | 1993-05-21 | 2002-02-17 | Radopah Ltd | Agents d'arylation. |
| US6015792A (en) | 1993-05-26 | 2000-01-18 | Bioresearch, Inc. | Specific eatable taste modifiers |
| US6008250A (en) | 1993-05-26 | 1999-12-28 | Bioresearch, Inc. | Specific eatable taste modifiers |
| GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| US5589483A (en) | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス.アー. | 白金化合物の製造方法 |
| CA2225465A1 (en) | 1995-08-02 | 1997-02-13 | Newcastle University Ventures Limited | Benzimidazole compounds |
| US5837729A (en) | 1996-04-26 | 1998-11-17 | Metatron, Inc. | Methods for treating and preventing HIV infection using acetaminophen and derivatives thereof |
| RU2103260C1 (ru) * | 1996-04-26 | 1998-01-27 | Государственный научный центр Российской Федерации "НИОПИК" | Способ получения 4-нитробензамида |
| US5736576A (en) | 1996-06-04 | 1998-04-07 | Octamer, Inc. | Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity |
| US6017958A (en) | 1996-06-04 | 2000-01-25 | Octamer, Inc. | Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity |
| GB9702701D0 (en) | 1997-02-01 | 1997-04-02 | Univ Newcastle Ventures Ltd | Quinazolinone compounds |
| US20050287120A1 (en) | 1997-03-21 | 2005-12-29 | Fisher Paul B | Cancer - targeted viral vectors |
| CA2285530A1 (en) | 1997-03-26 | 1998-10-01 | Biosource Technologies, Inc. | Di-aryl ethers and their derivatives as anti-cancer agents |
| US5908861A (en) | 1997-05-13 | 1999-06-01 | Octamer, Inc. | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors |
| US6121278A (en) | 1997-09-03 | 2000-09-19 | Guilford Pharmaceuticals, Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| US6235748B1 (en) | 1997-09-03 | 2001-05-22 | Guilford Pharmaceuticals Inc. | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
| US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US5922775A (en) | 1997-10-23 | 1999-07-13 | Octamer, Inc. | Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity |
| US6380193B1 (en) | 1998-05-15 | 2002-04-30 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds, methods and compositions for inhibiting PARP activity |
| US6395749B1 (en) | 1998-05-15 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, methods, and compositions for inhibiting PARP activity |
| EP1077944A1 (en) | 1998-05-15 | 2001-02-28 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, compositions, and methods for inhibiting parp activity |
| CO5070700A1 (es) | 1998-06-05 | 2001-08-28 | Basf Ag | Genes novedosos de (adp-ribosa) polimerasa |
| KR20010100977A (ko) | 1998-11-03 | 2001-11-14 | 스타르크, 카르크 | 치환된 2-페닐벤즈이미다졸, 그의 제조 및 그의 용도 |
| TR200101498T2 (tr) | 1998-11-27 | 2001-11-21 | Basf Aktiengesellschaft | İkameli benzimidazoller ve parp inhibitörleri olarak kullanımları |
| JP3552934B2 (ja) | 1998-12-24 | 2004-08-11 | セントラル硝子株式会社 | 安息香酸アミド類の製造方法 |
| US6326517B1 (en) | 1998-12-10 | 2001-12-04 | Central Glass Company, Limited | Method of producing benzamides |
| US6201020B1 (en) | 1998-12-31 | 2001-03-13 | Guilford Pharmaceuticals, Inc. | Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp |
| US6387902B1 (en) | 1998-12-31 | 2002-05-14 | Guilford Pharmaceuticals, Inc. | Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP |
| PL210415B1 (pl) | 1999-01-11 | 2012-01-31 | Agouron Pharma | Pochodne indolu, środek farmaceutyczny i zastosowanie pochodnych indolu |
| EP1148053A4 (en) | 1999-01-26 | 2002-03-06 | Ono Pharmaceutical Co | 2H-PHTHALAZIN-1-ON DERIVATIVES AND DRUG COMPOSITIONS THAT CONTAIN THESE DERIVATIVES AS ACTIVE INGREDIENTS |
| US6423696B1 (en) | 1999-04-16 | 2002-07-23 | The United States Of America, As Represented By The Department Of Health & Human Services | Inhibition of arylamine N-acetyl transferase |
| DE19921567A1 (de) | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
| TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| US6803457B1 (en) | 1999-09-30 | 2004-10-12 | Pfizer, Inc. | Compounds for the treatment of ischemia |
| US6476048B1 (en) | 1999-12-07 | 2002-11-05 | Inotek Pharamaceuticals Corporation | Substituted phenanthridinones and methods of use thereof |
| US6277990B1 (en) | 1999-12-07 | 2001-08-21 | Inotek Corporation | Substituted phenanthridinones and methods of use thereof |
| US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| US6723733B2 (en) | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
| ITMI20002358A1 (it) | 2000-10-31 | 2002-05-01 | Flavio Moroni | Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi |
| AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| US20040053888A1 (en) | 2001-01-04 | 2004-03-18 | Norio Suzuki | Cyclodextrin-containing pharmaceutical preparation |
| US20020164633A1 (en) | 2001-04-20 | 2002-11-07 | Inotek Pharmaceuticals Corporation | Cell-based assay for detecting activation of poly (ADP-ribose) polymerase |
| EP1397350B1 (en) | 2001-05-08 | 2007-02-28 | Kudos Pharmaceuticals Limited | Isoquinolinone derivatives as parp inhibitors |
| WO2003007955A2 (en) | 2001-07-20 | 2003-01-30 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
| CN1568187A (zh) | 2001-08-15 | 2005-01-19 | Icos股份有限公司 | 2h-2,3-二氮杂萘-1-酮和其使用方法 |
| US20050113283A1 (en) | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
| AUPS019702A0 (en) | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
| MXPA04009324A (es) | 2002-03-26 | 2005-01-25 | Banyu Pharma Co Ltd | Uso de derivado de indolopirrolocarbazol y otro agente anticanceroso en combinacion. |
| AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| US20040034078A1 (en) | 2002-06-14 | 2004-02-19 | Agouron Pharmaceuticals, Inc. | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase |
| PA8578001A1 (es) * | 2002-08-07 | 2004-05-07 | Warner Lambert Co | Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas |
| AU2003287526A1 (en) | 2002-11-06 | 2004-06-03 | Protein-stabilized liposomal formulations of pharmaceutical agents | |
| BRPI0408996A (pt) | 2003-03-31 | 2006-03-28 | Pfizer | saia de inibidores tricìclicos de poli(adpp-ribose) polimerases |
| ES2527871T3 (es) | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
| ES2396334T3 (es) | 2003-05-28 | 2013-02-20 | Eisai Inc. | Compuestos, métodos y composiciones farmacéuticas para la inhibición de PARP |
| US20050004038A1 (en) * | 2003-06-27 | 2005-01-06 | Lyon Robert P. | Bivalent inhibitors of Glutathione-S-Transferases |
| ATE454893T1 (de) | 2003-07-25 | 2010-01-15 | Cancer Rec Tech Ltd | Tricyclische parp-hemmer |
| WO2005018677A2 (en) | 2003-08-01 | 2005-03-03 | Wyeth Holdings Corporation | Use of combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer |
| CN1870991A (zh) | 2003-09-04 | 2006-11-29 | 安万特药物公司 | 作为多聚(adp-核糖)聚合酶(parp)抑制剂的被取代的吲哚类化合物 |
| WO2005023765A1 (en) | 2003-09-11 | 2005-03-17 | Pharmacia & Upjohn Company Llc | Method for catalyzing amidation reactions by the presence of co2 |
| KR101118582B1 (ko) | 2003-11-20 | 2012-02-27 | 얀센 파마슈티카 엔.브이. | 폴리(adp-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논 |
| EP1709011B1 (en) | 2003-11-20 | 2015-07-29 | Janssen Pharmaceutica NV | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| JP5545690B2 (ja) | 2003-12-01 | 2014-07-09 | クドス ファーマシューティカルズ リミテッド | 癌治療のためのdna損傷修復阻害剤 |
| NZ547193A (en) | 2003-12-05 | 2010-03-26 | Janssen Pharmaceutica Nv | 6-Substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| SG151250A1 (en) | 2003-12-10 | 2009-04-30 | Janssen Pharmaceutica Nv | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| US7439031B2 (en) * | 2003-12-15 | 2008-10-21 | The Trustees Of The University Of Pennsylvania | Method of identifying compounds that induce cell death by necrosis |
| US7680864B2 (en) | 2004-03-02 | 2010-03-16 | Intel Corporation | Method and apparatus for managing access to stored objects based on retention policy |
| PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| JP2005336083A (ja) | 2004-05-26 | 2005-12-08 | Sumitomo Chemical Co Ltd | 芳香族アミノ化合物の製造方法 |
| EA014955B1 (ru) | 2004-06-30 | 2011-04-29 | Янссен Фармацевтика Н. В. | Производные фталазина в качестве ингибиторов parp |
| UA85593C2 (uk) | 2004-06-30 | 2009-02-10 | Янссен Фармацевтика Н.В. | Похідні хіназолінону як інгібітори parp |
| MXPA06014541A (es) | 2004-06-30 | 2007-03-23 | Janssen Pharmaceutica Nv | Derivados de quinazolindiona como inhibidores de la poli(adp-ribosa) polimerasa. |
| US20060035890A1 (en) | 2004-08-10 | 2006-02-16 | Amit Banerjee | Compounds and methods for the treatment of ubiquitin conjugating disorders |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| ATE551345T1 (de) | 2004-09-22 | 2012-04-15 | Pfizer | Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on |
| MX2007003314A (es) | 2004-09-22 | 2007-08-06 | Pfizer | Combinaciones terapeuticas que comprenden inhibidor de poli(adp-ribosa)polimerasas. |
| DE102004050196A1 (de) | 2004-10-15 | 2006-04-20 | Sanofi-Aventis Deutschland Gmbh | Substituierte 2-Pyridon-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| EP1812439B2 (en) * | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US20060094676A1 (en) | 2004-10-29 | 2006-05-04 | Ronit Lahav | Compositions and methods for treating cancer using compositions comprising an inhibitor of endothelin receptor activity |
| BRPI0518068A (pt) | 2004-10-29 | 2008-10-28 | Banyu Pharma Co Ltd | composto ou um éster ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, inibidor seletivo de aurora a, agente anti-tumor, e, preparação combinada |
| CN1768733A (zh) | 2004-11-02 | 2006-05-10 | 上海富海科申药业有限公司 | 芳香硝基化合物在制备治疗艾滋病药物中的应用 |
| CN1768732A (zh) | 2004-11-02 | 2006-05-10 | 上海富海科申药业有限公司 | 芳香硝基化合物在制备治疗肿瘤药物中的应用 |
| US20070157330A1 (en) * | 2004-12-07 | 2007-07-05 | Min Wu | Reconstituted human breast tumor model |
| GB0428111D0 (en) | 2004-12-22 | 2005-01-26 | Kudos Pharm Ltd | Pthalazinone derivatives |
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| US7728026B2 (en) | 2005-04-11 | 2010-06-01 | Abbott Laboratories, Inc. | 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors |
| US20070015814A1 (en) | 2005-06-10 | 2007-01-18 | Ernest Kun | Parp Modulators and Treatment of Cancer |
| CN101242822B (zh) * | 2005-07-18 | 2011-08-24 | 彼帕科学公司 | 治疗卵巢癌的药物 |
| EP1957477B1 (en) * | 2005-09-29 | 2011-12-07 | Abbott Laboratories | 1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors |
| US20080293795A1 (en) | 2006-01-17 | 2008-11-27 | Abbott Laboratories | Combination therapy with parp inhibitors |
| PL2338487T3 (pl) * | 2006-01-17 | 2014-03-31 | Abbvie Bahamas Ltd | Terapia skojarzona z inhibitorami PARP |
| CA2646156C (en) | 2006-03-22 | 2016-05-24 | Medigene Ag | Treatment of triple receptor negative breast cancer |
| CA2647545C (en) * | 2006-04-03 | 2016-02-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors |
| WO2007113648A2 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| US20080262062A1 (en) | 2006-11-20 | 2008-10-23 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| AU2007354301A1 (en) | 2006-06-12 | 2008-12-04 | Bipar Sciences, Inc. | Method of treating diseases with PARP inhibitors |
| DE102006037399A1 (de) | 2006-08-10 | 2008-02-14 | Archimica Gmbh | Verfahren zur Herstellung von Arylaminen |
| WO2008030892A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Drug design for tubulin inhibitors, compositions, and methods of treatment thereof |
| WO2008030887A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Methods for designing parp inhibitors and uses thereof |
| US7994222B2 (en) | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
| WO2008030883A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
| CN101190211B (zh) | 2006-11-23 | 2011-08-10 | 上海富海科申药业有限公司 | 芳香硝基化合物在制备治疗病毒性肝炎药物中的应用 |
| AR064777A1 (es) | 2007-01-10 | 2009-04-22 | Inst Di Reserche D Biolog Mole | Indazoles sustituidos con amida como inhibidores de poli (adp- ribosa) polimerasa (parp) |
| RS52633B (sr) | 2007-01-16 | 2013-06-28 | Bipar Sciences Inc. | Formulacija za tretman kancera |
| AU2008223793B2 (en) | 2007-03-08 | 2012-08-23 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| EP2211854A4 (en) | 2007-10-19 | 2011-01-12 | Bipar Sciences Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS |
| AU2008321128A1 (en) | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
| MX2010005221A (es) * | 2007-11-12 | 2010-09-28 | Bipar Sciences Inc | Tratamiento de cancer de utero y cancer de ovario con un inhibidor de parp solo o en combinacion con agentes antitumorales. |
| US20090149397A1 (en) | 2007-12-07 | 2009-06-11 | Bipar Sciences | Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors |
-
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