CR11524A - Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno - Google Patents

Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno

Info

Publication number
CR11524A
CR11524A CR11524A CR11524A CR11524A CR 11524 A CR11524 A CR 11524A CR 11524 A CR11524 A CR 11524A CR 11524 A CR11524 A CR 11524A CR 11524 A CR11524 A CR 11524A
Authority
CR
Costa Rica
Prior art keywords
treatment
affections
androgen
receiver
bicycle derivatives
Prior art date
Application number
CR11524A
Other languages
English (en)
Inventor
Robert Hugh Bradbury
Neil James Hales
Alfred Arthur Rabow
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR11524A publication Critical patent/CR11524A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a los compuestos biciclicos de formula I donde los numeros enteros X1, X2, X3, el anillo A, R4, R5 y m son como los definidos en la descripcion.
CR11524A 2007-12-21 2010-06-21 Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno CR11524A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1575507P 2007-12-21 2007-12-21
US9609008P 2008-09-11 2008-09-11
US10780408P 2008-10-23 2008-10-23

Publications (1)

Publication Number Publication Date
CR11524A true CR11524A (es) 2010-08-05

Family

ID=40428336

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11524A CR11524A (es) 2007-12-21 2010-06-21 Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno

Country Status (23)

Country Link
US (1) US8003649B2 (es)
EP (1) EP2235010A1 (es)
JP (1) JP2011507824A (es)
KR (1) KR20100099742A (es)
CN (1) CN101952286A (es)
AR (1) AR069911A1 (es)
AU (1) AU2008339572B2 (es)
BR (1) BRPI0821676A2 (es)
CA (1) CA2709514A1 (es)
CL (1) CL2008003846A1 (es)
CO (1) CO6331441A2 (es)
CR (1) CR11524A (es)
DO (1) DOP2010000195A (es)
EA (1) EA017144B1 (es)
EC (1) ECSP10010291A (es)
IL (1) IL206284A0 (es)
NI (1) NI201000110A (es)
NZ (1) NZ586913A (es)
PE (1) PE20091157A1 (es)
TW (1) TW200927121A (es)
UY (1) UY31559A1 (es)
WO (1) WO2009081197A1 (es)
ZA (1) ZA201004227B (es)

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DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
BRPI0907844B8 (pt) 2008-02-22 2021-05-25 Radius Health Inc compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
EA019320B1 (ru) 2008-12-22 2014-02-28 Мерк Патент Гмбх Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения
WO2010092371A1 (en) * 2009-02-10 2010-08-19 Astrazeneca Ab Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer
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WO2011008543A2 (en) * 2009-06-29 2011-01-20 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
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EP2491031B1 (en) 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as orexin receptor modulators
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JP5964756B2 (ja) 2010-02-04 2016-08-03 ラジウス ヘルス，インコーポレイテッド 選択的アンドロゲン受容体モジュレーター
PL2568806T3 (pl) 2010-05-12 2017-03-31 Radius Health, Inc. Schematy lecznicze
CN103221404B (zh) 2010-05-13 2015-12-16 安姆根有限公司 可用作pde10抑制剂的不饱和氮杂环化合物
US9006450B2 (en) 2010-07-01 2015-04-14 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
US9422290B2 (en) * 2012-11-13 2016-08-23 Boehringer Ingelheim International Gmbh Triazolopyridazine
US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
HUP1300139A2 (en) * 2013-03-06 2014-09-29 Richter Gedeon Nyrt Phenoxypiperidine h3 antagonists
JP6376707B2 (ja) 2013-05-13 2018-08-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節剤としての置換架橋尿素類似体
EP3009424B1 (en) * 2013-06-10 2017-12-20 Astellas Pharma Inc. Bicyclic nitrogen-containing aromatic heterocyclic amide compound
NO2719005T3 (es) * 2014-07-28 2018-01-20
EP3034499A1 (en) * 2014-12-17 2016-06-22 Gilead Sciences, Inc. Novel FXR (NR1H4) modulating compounds
EP3034501A1 (en) * 2014-12-17 2016-06-22 Gilead Sciences, Inc. Hydroxy containing FXR (NR1H4) modulating compounds
WO2016161125A1 (en) * 2015-03-31 2016-10-06 University Of Vermont And State Agricultural College Methods for treating cryptosporidiosis using triazolopyridazines
KR20230116948A (ko) 2016-03-10 2023-08-04 얀센 파마슈티카 엔.브이. 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법
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CN109942574B (zh) * 2019-01-11 2022-04-01 成都阿奇生物医药科技有限公司 天奇替尼及其制备方法和用途
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Also Published As

Publication number Publication date
AR069911A1 (es) 2010-03-03
ECSP10010291A (es) 2010-07-30
KR20100099742A (ko) 2010-09-13
CO6331441A2 (es) 2011-10-20
NZ586913A (en) 2012-06-29
AU2008339572B2 (en) 2012-05-10
EP2235010A1 (en) 2010-10-06
BRPI0821676A2 (pt) 2015-06-16
CN101952286A (zh) 2011-01-19
US20100016279A1 (en) 2010-01-21
DOP2010000195A (es) 2010-08-31
JP2011507824A (ja) 2011-03-10
UY31559A1 (es) 2009-08-03
WO2009081197A1 (en) 2009-07-02
EA201000946A1 (ru) 2010-12-30
US8003649B2 (en) 2011-08-23
EA017144B1 (ru) 2012-10-30
TW200927121A (en) 2009-07-01
AU2008339572A1 (en) 2009-07-02
CA2709514A1 (en) 2009-07-02
ZA201004227B (en) 2011-10-26
IL206284A0 (en) 2010-12-30
NI201000110A (es) 2012-05-14
PE20091157A1 (es) 2009-09-03
CL2008003846A1 (es) 2010-02-05

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)