CR20110673A - Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias - Google Patents

Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias

Info

Publication number
CR20110673A
CR20110673A CR20110673A CR20110673A CR20110673A CR 20110673 A CR20110673 A CR 20110673A CR 20110673 A CR20110673 A CR 20110673A CR 20110673 A CR20110673 A CR 20110673A CR 20110673 A CR20110673 A CR 20110673A
Authority
CR
Costa Rica
Prior art keywords
treatment
degenerative
inflammatory diseases
diseases
useful compound
Prior art date
Application number
CR20110673A
Other languages
English (en)
Inventor
Christel Jeanne Marie Menet
Javier Blanc
Original Assignee
Galapagos Nv
Heinz Co H J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv, Heinz Co H J filed Critical Galapagos Nv
Publication of CR20110673A publication Critical patent/CR20110673A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Este compuesto puede prepararse como una composición farmacéutica, y puede usarse para la prevención y el tratamiento de una diversidad de afecciones en mamíferos, que incluyen humanos, que abarcan, a modo de ejemplo, sin limitación, afecciones inflamatorias, enfermedades autoinmunitarias, enfermedades proliferativas, rechazo de trasplantes, enfermedades que involucran el deterioro del recambio de cartílago, malformaciones congénitas del cartílago y enfermedades asociadas con la hipersecreción de IL6.
CR20110673A 2009-06-26 2011-12-14 Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias CR20110673A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22068509P 2009-06-26 2009-06-26
US29818810P 2010-01-25 2010-01-25

Publications (1)

Publication Number Publication Date
CR20110673A true CR20110673A (es) 2012-02-09

Family

ID=42340530

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110673A CR20110673A (es) 2009-06-26 2011-12-14 Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias

Country Status (37)

Country Link
US (2) US8796457B2 (es)
EP (2) EP2445912B1 (es)
JP (1) JP5486084B2 (es)
KR (1) KR101712561B1 (es)
CN (1) CN102459261B (es)
AR (1) AR077221A1 (es)
AU (1) AU2010264635B2 (es)
BR (1) BRPI1014759A2 (es)
CA (1) CA2765988C (es)
CL (1) CL2011003276A1 (es)
CO (1) CO6491039A2 (es)
CR (1) CR20110673A (es)
CY (1) CY1119711T1 (es)
DK (2) DK2792677T3 (es)
DO (1) DOP2011000378A (es)
EA (1) EA020111B1 (es)
ES (2) ES2634325T3 (es)
HR (2) HRP20141057T1 (es)
HU (1) HUE034205T2 (es)
IL (1) IL216618A (es)
JO (1) JO3030B1 (es)
LT (1) LT2792677T (es)
MA (1) MA33447B1 (es)
ME (1) ME01916B (es)
MX (1) MX2011013451A (es)
NZ (1) NZ596836A (es)
PE (1) PE20120494A1 (es)
PL (2) PL2792677T3 (es)
PT (2) PT2792677T (es)
RS (1) RS53617B1 (es)
SG (1) SG177359A1 (es)
SI (2) SI2445912T1 (es)
SM (2) SMT201700333T1 (es)
TW (1) TWI469981B (es)
UY (1) UY32741A (es)
WO (1) WO2010149771A1 (es)
ZA (1) ZA201109502B (es)

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TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
JP6129155B2 (ja) 2011-04-12 2017-05-17 ライジェル ファーマシューティカルズ， インコーポレイテッド 同種移植片拒絶反応を抑制する方法
TWI589299B (zh) * 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
KR20200039028A (ko) * 2011-10-11 2020-04-14 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 류마티스 관절염 치료를 위한 조성물 및 이의 이용방법
MX368511B (es) * 2012-06-22 2019-10-07 Galapagos Nv Aminotriazolopiridina para uso en tratamiento de inflamacion y composiciones farmaceuticas de la misma.
JP6472803B2 (ja) 2013-09-05 2019-02-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ トリアゾロピリジン化合物、その組成物及び使用方法
LT3077395T (lt) 2013-12-05 2018-02-12 Pfizer Inc. Pirolo[2,3-d]pirimidinilo, pirolo[2,3-b]pirazinilo ir pirolo[2,3-d]piridinilo akrilamidai
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402070D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
SMT202300328T1 (it) * 2015-04-13 2023-11-13 Galapagos Nv Metodi per il trattamento di disturbi cardiovascolari
EP3492468B1 (en) 2016-07-26 2022-02-23 Suzhou Longbiotech Pharmaceuticals Co., Ltd. Heterocyclic compound as jak inhibitor, and salts and therapeutic use thereof
CN111479810B (zh) 2018-01-31 2022-11-22 珠海联邦制药股份有限公司 Jak抑制剂及其应用
KR20260109977A (ko) 2018-08-29 2026-07-13 리제너론 파아마슈티컬스, 인크. 류마티스성 관절염을 갖는 대상체를 치료하기 위한 방법 및 조성물
JP7542543B2 (ja) 2019-01-31 2024-08-30 サノフィ・バイオテクノロジー 若年性特発性関節炎を治療するための抗ｉｌ－６受容体抗体
JP2022545312A (ja) 2019-04-24 2022-10-27 サノフィ・バイオテクノロジー 関節リウマチの診断及び処置の方法
CA3142710A1 (en) 2019-06-04 2020-12-10 Sanofi Biotechnology Compositions and methods for treating pain in subjects with rheumatoid arthritis
CN111072655B (zh) * 2019-12-30 2021-12-10 深圳市坤健创新药物研究院 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用
IL312785B2 (en) 2020-05-19 2026-06-01 Cybin Irl Ltd Deuterated tryptamine derivatives and methods of use
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

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WO2010010186A1 (en) * 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
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TWI462920B (zh) * 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات

Also Published As

Publication number Publication date
DK2445912T3 (da) 2014-11-10
US8796457B2 (en) 2014-08-05
DOP2011000378A (es) 2012-02-15
JP5486084B2 (ja) 2014-05-07
TW201103937A (en) 2011-02-01
PE20120494A1 (es) 2012-05-17
TWI469981B (zh) 2015-01-21
HRP20171024T1 (hr) 2017-10-06
EP2445912A1 (en) 2012-05-02
KR20120059487A (ko) 2012-06-08
EA201270076A1 (ru) 2012-08-30
RS53617B1 (sr) 2015-04-30
CY1119711T1 (el) 2018-06-27
EP2792677B1 (en) 2017-04-26
BRPI1014759A2 (pt) 2016-04-19
AR077221A1 (es) 2011-08-10
ZA201109502B (en) 2012-09-26
SG177359A1 (en) 2012-02-28
SI2445912T1 (sl) 2014-12-31
PL2792677T3 (pl) 2017-09-29
HUE034205T2 (en) 2018-01-29
SI2792677T1 (sl) 2017-08-31
SMT201700333T1 (it) 2017-09-07
CA2765988C (en) 2017-08-29
LT2792677T (lt) 2017-07-25
US20100331359A1 (en) 2010-12-30
SMT201400169B (it) 2015-01-15
KR101712561B1 (ko) 2017-03-06
IL216618A0 (en) 2012-02-29
HK1168098A1 (en) 2012-12-21
CO6491039A2 (es) 2012-07-31
CA2765988A1 (en) 2010-12-29
EA020111B1 (ru) 2014-08-29
PL2445912T3 (pl) 2015-02-27
AU2010264635A1 (en) 2011-12-22
EP2445912B1 (en) 2014-08-13
MX2011013451A (es) 2012-04-30
EP2792677A1 (en) 2014-10-22
JO3030B1 (ar) 2016-09-05
HK1202537A1 (en) 2015-10-02
US9505754B2 (en) 2016-11-29
HRP20141057T1 (en) 2015-03-13
JP2012530767A (ja) 2012-12-06
MA33447B1 (fr) 2012-07-03
CN102459261A (zh) 2012-05-16
ME01916B (me) 2015-05-20
WO2010149771A1 (en) 2010-12-29
CL2011003276A1 (es) 2012-08-31
PT2445912E (pt) 2014-11-07
NZ596836A (en) 2013-02-22
AU2010264635B2 (en) 2015-05-07
UY32741A (es) 2011-01-31
PT2792677T (pt) 2017-07-06
IL216618A (en) 2014-09-30
CN102459261B (zh) 2014-11-05
ES2634325T3 (es) 2017-09-27
ES2519170T3 (es) 2014-11-06
DK2792677T3 (en) 2017-07-10
US20150031671A1 (en) 2015-01-29

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