MA33447B1 - Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires - Google Patents

Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires

Info

Publication number
MA33447B1
MA33447B1 MA34555A MA34555A MA33447B1 MA 33447 B1 MA33447 B1 MA 33447B1 MA 34555 A MA34555 A MA 34555A MA 34555 A MA34555 A MA 34555A MA 33447 B1 MA33447 B1 MA 33447B1
Authority
MA
Morocco
Prior art keywords
compound used
inflammatory diseases
novel compound
diseases
treat degenerative
Prior art date
Application number
MA34555A
Other languages
Arabic (ar)
English (en)
Inventor
Christel Jeanne Marie Menet
Javier Blanc
Original Assignee
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Publication of MA33447B1 publication Critical patent/MA33447B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un composé représenté par la formule (I). Ce composé peut être préparé comme une composition pharmaceutique, et peut être utilisé pour prévenir et traiter une variété d'états chez les mammifères, en particulier chez l'homme, comprenant à titre d'exemple notamment et de manière non restrictive, les états inflammatoires, les maladies auto-immunes, les maladies prolifératives, les rejets de transplantation, les maladies impliquant l'incapacité de renouvellement du cartilage, les malformations congénitales du cartilage, et/ou les maladies associées à l'hypersécrétion de IL6.
MA34555A 2009-06-26 2010-06-25 Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires MA33447B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22068509P 2009-06-26 2009-06-26
US29818810P 2010-01-25 2010-01-25
PCT/EP2010/059067 WO2010149771A1 (fr) 2009-06-26 2010-06-25 Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires

Publications (1)

Publication Number Publication Date
MA33447B1 true MA33447B1 (fr) 2012-07-03

Family

ID=42340530

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34555A MA33447B1 (fr) 2009-06-26 2010-06-25 Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires

Country Status (37)

Country Link
US (2) US8796457B2 (fr)
EP (2) EP2792677B1 (fr)
JP (1) JP5486084B2 (fr)
KR (1) KR101712561B1 (fr)
CN (1) CN102459261B (fr)
AR (1) AR077221A1 (fr)
AU (1) AU2010264635B2 (fr)
BR (1) BRPI1014759A2 (fr)
CA (1) CA2765988C (fr)
CL (1) CL2011003276A1 (fr)
CO (1) CO6491039A2 (fr)
CR (1) CR20110673A (fr)
CY (1) CY1119711T1 (fr)
DK (2) DK2445912T3 (fr)
DO (1) DOP2011000378A (fr)
EA (1) EA020111B1 (fr)
ES (2) ES2634325T3 (fr)
HR (2) HRP20141057T1 (fr)
HU (1) HUE034205T2 (fr)
IL (1) IL216618A (fr)
JO (1) JO3030B1 (fr)
LT (1) LT2792677T (fr)
MA (1) MA33447B1 (fr)
ME (1) ME01916B (fr)
MX (1) MX2011013451A (fr)
NZ (1) NZ596836A (fr)
PE (1) PE20120494A1 (fr)
PL (2) PL2445912T3 (fr)
PT (2) PT2792677T (fr)
RS (1) RS53617B1 (fr)
SG (1) SG177359A1 (fr)
SI (2) SI2792677T1 (fr)
SM (2) SMT201700333T1 (fr)
TW (1) TWI469981B (fr)
UY (1) UY32741A (fr)
WO (1) WO2010149771A1 (fr)
ZA (1) ZA201109502B (fr)

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JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
JP6129155B2 (ja) 2011-04-12 2017-05-17 ライジェル ファーマシューティカルズ, インコーポレイテッド 同種移植片拒絶反応を抑制する方法
HRP20180299T1 (hr) * 2011-10-11 2018-04-20 Sanofi Biotechnology Pripravci za liječenje reumatoidnog artritisa i postupci za njihovo korištenje
TWI589299B (zh) * 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
HUE038878T2 (hu) * 2012-06-22 2018-12-28 Galapagos Nv Aminotriazolopirimidin gyulladás kezelésében történõ alkalmazásra és gyógyászati készítményeik
MA38884A1 (fr) 2013-09-05 2017-06-30 Hoffmann La Roche Composé de triazolopyridine, compositions et procédés d'utilisation associés
ES2654051T3 (es) 2013-12-05 2018-02-12 Pfizer Inc. Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinil acrilamidas
GB201402070D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
RS64677B1 (sr) * 2015-04-13 2023-11-30 Galapagos Nv Metode lečenja kardiovaskularnih poremećaja
WO2018019223A1 (fr) 2016-07-26 2018-02-01 张文燕 Composé en tant qu'inhibiteur sélectif jak, son sel et son utilisation thérapeutique
CN111479810B (zh) * 2018-01-31 2022-11-22 珠海联邦制药股份有限公司 Jak抑制剂及其应用
MA53481A (fr) 2018-08-29 2021-07-07 Regeneron Pharma Méthodes et compositions pour le traitement de sujets ayant une polyarthrite rhumatoïde
JP7542543B2 (ja) 2019-01-31 2024-08-30 サノフィ・バイオテクノロジー 若年性特発性関節炎を治療するための抗il-6受容体抗体
CN114651010A (zh) 2019-04-24 2022-06-21 赛诺菲生物技术公司 类风湿性关节炎的诊断和治疗方法
KR20230061198A (ko) 2019-06-04 2023-05-08 사노피 바이오테크놀로지 류마티스성 관절염을 갖는 대상체에서 통증을 치료하기 위한 조성물 및 방법
CN111072655B (zh) * 2019-12-30 2021-12-10 深圳市坤健创新药物研究院 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

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ATE283840T1 (de) 1999-01-29 2004-12-15 Chugai Pharmaceutical Co Ltd Chondrogonese promotoren und indolin-2-on derivate
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JP2006517580A (ja) 2003-02-14 2006-07-27 ファイザー・プロダクツ・インク 抗炎症化合物としてのトリアゾロピリジン
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WO2010010184A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv [1, 2, 4]triazolo[1, 5-a]pyridines utilisées comme inhibiteurs de jak
WO2010010188A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
WO2010010186A1 (fr) * 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
WO2010010187A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
WO2010010189A1 (fr) 2008-07-25 2010-01-28 Galapagos Nv Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires
JO3041B1 (ar) * 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
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JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物

Also Published As

Publication number Publication date
CN102459261A (zh) 2012-05-16
TWI469981B (zh) 2015-01-21
CY1119711T1 (el) 2018-06-27
HK1168098A1 (en) 2012-12-21
CO6491039A2 (es) 2012-07-31
JP5486084B2 (ja) 2014-05-07
DK2445912T3 (da) 2014-11-10
LT2792677T (lt) 2017-07-25
ES2519170T3 (es) 2014-11-06
ME01916B (me) 2015-05-20
DK2792677T3 (en) 2017-07-10
US8796457B2 (en) 2014-08-05
ES2634325T3 (es) 2017-09-27
HRP20171024T1 (hr) 2017-10-06
EP2792677B1 (fr) 2017-04-26
PE20120494A1 (es) 2012-05-17
EP2792677A1 (fr) 2014-10-22
HK1202537A1 (en) 2015-10-02
EP2445912A1 (fr) 2012-05-02
AU2010264635B2 (en) 2015-05-07
CA2765988A1 (fr) 2010-12-29
MX2011013451A (es) 2012-04-30
US9505754B2 (en) 2016-11-29
SG177359A1 (en) 2012-02-28
SMT201700333T1 (it) 2017-09-07
ZA201109502B (en) 2012-09-26
SI2792677T1 (sl) 2017-08-31
TW201103937A (en) 2011-02-01
KR101712561B1 (ko) 2017-03-06
CN102459261B (zh) 2014-11-05
US20150031671A1 (en) 2015-01-29
CL2011003276A1 (es) 2012-08-31
PL2445912T3 (pl) 2015-02-27
AU2010264635A1 (en) 2011-12-22
JO3030B1 (ar) 2016-09-05
EA201270076A1 (ru) 2012-08-30
PT2792677T (pt) 2017-07-06
HUE034205T2 (en) 2018-01-29
NZ596836A (en) 2013-02-22
IL216618A0 (en) 2012-02-29
BRPI1014759A2 (pt) 2016-04-19
HRP20141057T1 (en) 2015-03-13
AR077221A1 (es) 2011-08-10
UY32741A (es) 2011-01-31
WO2010149771A1 (fr) 2010-12-29
KR20120059487A (ko) 2012-06-08
IL216618A (en) 2014-09-30
CR20110673A (es) 2012-02-09
CA2765988C (fr) 2017-08-29
EP2445912B1 (fr) 2014-08-13
SI2445912T1 (sl) 2014-12-31
RS53617B1 (sr) 2015-04-30
EA020111B1 (ru) 2014-08-29
PL2792677T3 (pl) 2017-09-29
DOP2011000378A (es) 2012-02-15
US20100331359A1 (en) 2010-12-30
JP2012530767A (ja) 2012-12-06
PT2445912E (pt) 2014-11-07
SMT201400169B (it) 2015-01-15

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