MA33447B1 - Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires - Google Patents
Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoiresInfo
- Publication number
- MA33447B1 MA33447B1 MA34555A MA34555A MA33447B1 MA 33447 B1 MA33447 B1 MA 33447B1 MA 34555 A MA34555 A MA 34555A MA 34555 A MA34555 A MA 34555A MA 33447 B1 MA33447 B1 MA 33447B1
- Authority
- MA
- Morocco
- Prior art keywords
- compound used
- inflammatory diseases
- novel compound
- diseases
- treat degenerative
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003412 degenerative effect Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000036244 malformation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000007306 turnover Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne un composé représenté par la formule (I). Ce composé peut être préparé comme une composition pharmaceutique, et peut être utilisé pour prévenir et traiter une variété d'états chez les mammifères, en particulier chez l'homme, comprenant à titre d'exemple notamment et de manière non restrictive, les états inflammatoires, les maladies auto-immunes, les maladies prolifératives, les rejets de transplantation, les maladies impliquant l'incapacité de renouvellement du cartilage, les malformations congénitales du cartilage, et/ou les maladies associées à l'hypersécrétion de IL6.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22068509P | 2009-06-26 | 2009-06-26 | |
| US29818810P | 2010-01-25 | 2010-01-25 | |
| PCT/EP2010/059067 WO2010149771A1 (fr) | 2009-06-26 | 2010-06-25 | Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33447B1 true MA33447B1 (fr) | 2012-07-03 |
Family
ID=42340530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34555A MA33447B1 (fr) | 2009-06-26 | 2010-06-25 | Nouveau composé utilisé pour traiter les maladies dégénératives et inflammatoires |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8796457B2 (fr) |
| EP (2) | EP2792677B1 (fr) |
| JP (1) | JP5486084B2 (fr) |
| KR (1) | KR101712561B1 (fr) |
| CN (1) | CN102459261B (fr) |
| AR (1) | AR077221A1 (fr) |
| AU (1) | AU2010264635B2 (fr) |
| BR (1) | BRPI1014759A2 (fr) |
| CA (1) | CA2765988C (fr) |
| CL (1) | CL2011003276A1 (fr) |
| CO (1) | CO6491039A2 (fr) |
| CR (1) | CR20110673A (fr) |
| CY (1) | CY1119711T1 (fr) |
| DK (2) | DK2445912T3 (fr) |
| DO (1) | DOP2011000378A (fr) |
| EA (1) | EA020111B1 (fr) |
| ES (2) | ES2634325T3 (fr) |
| HR (2) | HRP20141057T1 (fr) |
| HU (1) | HUE034205T2 (fr) |
| IL (1) | IL216618A (fr) |
| JO (1) | JO3030B1 (fr) |
| LT (1) | LT2792677T (fr) |
| MA (1) | MA33447B1 (fr) |
| ME (1) | ME01916B (fr) |
| MX (1) | MX2011013451A (fr) |
| NZ (1) | NZ596836A (fr) |
| PE (1) | PE20120494A1 (fr) |
| PL (2) | PL2445912T3 (fr) |
| PT (2) | PT2792677T (fr) |
| RS (1) | RS53617B1 (fr) |
| SG (1) | SG177359A1 (fr) |
| SI (2) | SI2792677T1 (fr) |
| SM (2) | SMT201700333T1 (fr) |
| TW (1) | TWI469981B (fr) |
| UY (1) | UY32741A (fr) |
| WO (1) | WO2010149771A1 (fr) |
| ZA (1) | ZA201109502B (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| JP6129155B2 (ja) | 2011-04-12 | 2017-05-17 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 同種移植片拒絶反応を抑制する方法 |
| HRP20180299T1 (hr) * | 2011-10-11 | 2018-04-20 | Sanofi Biotechnology | Pripravci za liječenje reumatoidnog artritisa i postupci za njihovo korištenje |
| TWI589299B (zh) * | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| HUE038878T2 (hu) * | 2012-06-22 | 2018-12-28 | Galapagos Nv | Aminotriazolopirimidin gyulladás kezelésében történõ alkalmazásra és gyógyászati készítményeik |
| MA38884A1 (fr) | 2013-09-05 | 2017-06-30 | Hoffmann La Roche | Composé de triazolopyridine, compositions et procédés d'utilisation associés |
| ES2654051T3 (es) | 2013-12-05 | 2018-02-12 | Pfizer Inc. | Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinil acrilamidas |
| GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| RS64677B1 (sr) * | 2015-04-13 | 2023-11-30 | Galapagos Nv | Metode lečenja kardiovaskularnih poremećaja |
| WO2018019223A1 (fr) | 2016-07-26 | 2018-02-01 | 张文燕 | Composé en tant qu'inhibiteur sélectif jak, son sel et son utilisation thérapeutique |
| CN111479810B (zh) * | 2018-01-31 | 2022-11-22 | 珠海联邦制药股份有限公司 | Jak抑制剂及其应用 |
| MA53481A (fr) | 2018-08-29 | 2021-07-07 | Regeneron Pharma | Méthodes et compositions pour le traitement de sujets ayant une polyarthrite rhumatoïde |
| JP7542543B2 (ja) | 2019-01-31 | 2024-08-30 | サノフィ・バイオテクノロジー | 若年性特発性関節炎を治療するための抗il-6受容体抗体 |
| CN114651010A (zh) | 2019-04-24 | 2022-06-21 | 赛诺菲生物技术公司 | 类风湿性关节炎的诊断和治疗方法 |
| KR20230061198A (ko) | 2019-06-04 | 2023-05-08 | 사노피 바이오테크놀로지 | 류마티스성 관절염을 갖는 대상체에서 통증을 치료하기 위한 조성물 및 방법 |
| CN111072655B (zh) * | 2019-12-30 | 2021-12-10 | 深圳市坤健创新药物研究院 | 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用 |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE283840T1 (de) | 1999-01-29 | 2004-12-15 | Chugai Pharmaceutical Co Ltd | Chondrogonese promotoren und indolin-2-on derivate |
| US20040138285A1 (en) | 2001-04-27 | 2004-07-15 | Makoto Okazaki | Chondrogenesis promoters |
| US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| AU2003231880A1 (en) * | 2002-05-30 | 2003-12-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of jak and cdk2 protein kinases |
| JP2006517580A (ja) | 2003-02-14 | 2006-07-27 | ファイザー・プロダクツ・インク | 抗炎症化合物としてのトリアゾロピリジン |
| US20050222171A1 (en) * | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
| JP2008503712A (ja) | 2004-06-21 | 2008-02-07 | ガラパゴス・ナムローゼ・フェンノートシャップ | 骨関節炎治療の方法及び手段 |
| JP2008509987A (ja) | 2004-08-18 | 2008-04-03 | ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー | トリアゾロピリジン化合物 |
| MX2007004179A (es) | 2004-10-07 | 2007-06-07 | Warner Lambert Co | Derivados de triazolpiridina como agentes antibacterianos. |
| GB0515026D0 (en) | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| ES2549862T3 (es) * | 2006-08-30 | 2015-11-02 | Cellzome Limited | Derivados de triazol como inhibidores de quinasa |
| CL2008001626A1 (es) | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
| EP2178868A1 (fr) | 2007-07-18 | 2010-04-28 | Novartis Ag | Composés hétéroaryliques bicycliques et leur utilisation comme inhibiteurs de kinase |
| WO2009017954A1 (fr) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibiteurs de kinase jak2 |
| MX2010002312A (es) | 2007-08-31 | 2010-03-18 | Merck Serono Sa | Compuestos de triazolopiridina y su uso como inhibidores de cinasa reguladora de señal de apoptosis. |
| GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US20090217316A1 (en) * | 2008-02-22 | 2009-08-27 | Binita Gupta | Systems and Methods for Advertising Insertion Notification in a Real-Time Streaming Media Service |
| US20100035875A1 (en) | 2008-06-20 | 2010-02-11 | Bing-Yan Zhu | Triazolopyridine jak inhibitor compounds and methods |
| WO2010010184A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4]triazolo[1, 5-a]pyridines utilisées comme inhibiteurs de jak |
| WO2010010188A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
| WO2010010186A1 (fr) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
| WO2010010187A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
| WO2010010189A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
| JO3041B1 (ar) * | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| NZ597140A (en) | 2009-06-05 | 2014-01-31 | Cephalon Inc | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
-
2010
- 2010-05-31 JO JOP/2010/0179A patent/JO3030B1/ar active
- 2010-06-23 TW TW99120587A patent/TWI469981B/zh not_active IP Right Cessation
- 2010-06-24 AR ARP100102236A patent/AR077221A1/es active IP Right Grant
- 2010-06-25 PT PT141758870T patent/PT2792677T/pt unknown
- 2010-06-25 AU AU2010264635A patent/AU2010264635B2/en not_active Ceased
- 2010-06-25 ES ES14175887.0T patent/ES2634325T3/es active Active
- 2010-06-25 RS RS20140614A patent/RS53617B1/sr unknown
- 2010-06-25 JP JP2012516762A patent/JP5486084B2/ja active Active
- 2010-06-25 WO PCT/EP2010/059067 patent/WO2010149771A1/fr not_active Ceased
- 2010-06-25 UY UY0001032741A patent/UY32741A/es not_active Application Discontinuation
- 2010-06-25 CA CA2765988A patent/CA2765988C/fr not_active Expired - Fee Related
- 2010-06-25 ME MEP-2014-132A patent/ME01916B/me unknown
- 2010-06-25 NZ NZ596836A patent/NZ596836A/xx not_active IP Right Cessation
- 2010-06-25 PT PT107286486T patent/PT2445912E/pt unknown
- 2010-06-25 DK DK10728648.6T patent/DK2445912T3/da active
- 2010-06-25 PL PL10728648T patent/PL2445912T3/pl unknown
- 2010-06-25 SM SM20170333T patent/SMT201700333T1/it unknown
- 2010-06-25 CN CN201080028413.0A patent/CN102459261B/zh active Active
- 2010-06-25 SI SI201031494T patent/SI2792677T1/sl unknown
- 2010-06-25 PE PE2011002144A patent/PE20120494A1/es active IP Right Grant
- 2010-06-25 MA MA34555A patent/MA33447B1/fr unknown
- 2010-06-25 EA EA201270076A patent/EA020111B1/ru not_active IP Right Cessation
- 2010-06-25 PL PL14175887T patent/PL2792677T3/pl unknown
- 2010-06-25 HR HRP20141057AT patent/HRP20141057T1/hr unknown
- 2010-06-25 LT LTEP14175887.0T patent/LT2792677T/lt unknown
- 2010-06-25 HU HUE14175887A patent/HUE034205T2/en unknown
- 2010-06-25 ES ES10728648.6T patent/ES2519170T3/es active Active
- 2010-06-25 SI SI201030775T patent/SI2445912T1/sl unknown
- 2010-06-25 MX MX2011013451A patent/MX2011013451A/es active IP Right Grant
- 2010-06-25 EP EP14175887.0A patent/EP2792677B1/fr active Active
- 2010-06-25 SG SG2011096179A patent/SG177359A1/en unknown
- 2010-06-25 EP EP10728648.6A patent/EP2445912B1/fr active Active
- 2010-06-25 BR BRPI1014759A patent/BRPI1014759A2/pt active Search and Examination
- 2010-06-25 US US12/823,682 patent/US8796457B2/en active Active
- 2010-06-25 DK DK14175887.0T patent/DK2792677T3/en active
- 2010-06-25 KR KR1020127002060A patent/KR101712561B1/ko not_active Expired - Fee Related
-
2011
- 2011-11-27 IL IL216618A patent/IL216618A/en not_active IP Right Cessation
- 2011-12-06 DO DO2011000378A patent/DOP2011000378A/es unknown
- 2011-12-14 CR CR20110673A patent/CR20110673A/es unknown
- 2011-12-22 CL CL2011003276A patent/CL2011003276A1/es unknown
- 2011-12-22 ZA ZA2011/09502A patent/ZA201109502B/en unknown
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2012
- 2012-01-16 CO CO12005375A patent/CO6491039A2/es active IP Right Grant
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2014
- 2014-08-04 US US14/451,127 patent/US9505754B2/en active Active
- 2014-11-10 SM SM201400169T patent/SMT201400169B/xx unknown
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2017
- 2017-07-04 HR HRP20171024TT patent/HRP20171024T1/hr unknown
- 2017-07-24 CY CY20171100784T patent/CY1119711T1/el unknown
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