CR20120169A - Procesos para la preparación de 2-(1-feniletil)-isoindolin-1-ona - Google Patents

Procesos para la preparación de 2-(1-feniletil)-isoindolin-1-ona

Info

Publication number
CR20120169A
CR20120169A CR20120169A CR20120169A CR20120169A CR 20120169 A CR20120169 A CR 20120169A CR 20120169 A CR20120169 A CR 20120169A CR 20120169 A CR20120169 A CR 20120169A CR 20120169 A CR20120169 A CR 20120169A
Authority
CR
Costa Rica
Prior art keywords
isoindolin
preparation
pheniletil
ona
processes
Prior art date
Application number
CR20120169A
Other languages
English (en)
Inventor
Anthony J Frank
Hong-Wa Man
Chuangseng Ge
Manohar Saindaine
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CR20120169A publication Critical patent/CR20120169A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describen métodos para la preparación de compuestos de isoindolin-1-ona.
CR20120169A 2009-10-09 2012-04-09 Procesos para la preparación de 2-(1-feniletil)-isoindolin-1-ona CR20120169A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25042109P 2009-10-09 2009-10-09

Publications (1)

Publication Number Publication Date
CR20120169A true CR20120169A (es) 2012-07-30

Family

ID=43301314

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120169A CR20120169A (es) 2009-10-09 2012-04-09 Procesos para la preparación de 2-(1-feniletil)-isoindolin-1-ona

Country Status (21)

Country Link
US (1) US8415485B2 (es)
EP (1) EP2486012B1 (es)
JP (1) JP5753177B2 (es)
KR (1) KR20120084306A (es)
CN (1) CN102639498A (es)
AR (1) AR078581A1 (es)
AU (1) AU2010303243B2 (es)
BR (1) BR112012007737A2 (es)
CA (1) CA2775581A1 (es)
CR (1) CR20120169A (es)
EC (1) ECSP12011781A (es)
ES (1) ES2451350T3 (es)
IL (1) IL218898A0 (es)
MX (1) MX2012004024A (es)
MY (1) MY183201A (es)
NI (1) NI201200049A (es)
NZ (1) NZ599147A (es)
PH (1) PH12012500669A1 (es)
RU (1) RU2557236C2 (es)
WO (1) WO2011044479A1 (es)
ZA (1) ZA201202380B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
EP3539539B1 (en) 2013-06-17 2025-11-05 Amgen (Europe) GmbH Tablet formulations of (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
CN104447443B (zh) * 2014-12-05 2016-07-27 新发药业有限公司 一种阿普斯特及其中间体的制备方法
CN115850129B (zh) * 2023-02-28 2023-05-16 凯莱英生命科学技术(天津)有限公司 （s）-1-(3-乙氧基-4-甲氧基苯基)-2-（甲磺酰基）乙胺的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
US5703098A (en) * 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
US6020358A (en) 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US6667316B1 (en) 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US20100129363A1 (en) * 2002-05-17 2010-05-27 Zeldis Jerome B Methods and compositions using pde4 inhibitors for the treatment and management of cancers
BR0317885A (pt) * 2002-12-30 2005-12-06 Celgene Corp Composto, isÈmeros s e r enantiomericamente puros do mesmo, composição farmacêutica e métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa, de tratar ou prevenir mds, de tratar doença mieloproliferativa, angiogênese indesejada, câncer, uma doença, inflamação dos pulmões, depressão, distúrbio pulmonar obstrutivo crÈnico, doença inflamatória do intestino, dermatite atópica, psorìase, doença de crohn, artrite reumatóide, asma, eslcerose múltipla e doença cardìaca em um mamìfero e de tratar, prevenir ou controlar a sìndrome de dor regional complexa
JP4713465B2 (ja) * 2003-03-12 2011-06-29 セルジーン コーポレイション ７−アミド−イソインドリル化合物およびその薬学的使用
CH696542A5 (de) * 2003-07-09 2007-07-31 Siegfried Ltd Verfahren zur Herstellung von substituierten 2,6-Dioxopiperidin-3-yl-Verbindungen.
ATE386715T1 (de) * 2003-11-25 2008-03-15 Lilly Co Eli Modulatoren des peroxisomproliferatoraktivierten rezeptors
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
US7142423B2 (en) * 2004-10-26 2006-11-28 Comarco Wireless Technologies, Inc. Power adapter with fan assembly
JP5031745B2 (ja) * 2005-08-12 2012-09-26 アストラゼネカ アクチボラグ 代謝型グルタミン酸受容体増強性イソインドロン
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
EP2215074B1 (en) * 2007-09-27 2014-02-19 The United States of America, as Represented by the Secretary, Department of Health and Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
JP2011515469A (ja) * 2008-03-24 2011-05-19 セルジーン コーポレイション シクロプロピル−ｎ−｛２−［（１ｓ）−１−（３−エトキシ−４−メトキシフェニル）−２−（メチルスルホニル）エチル］−３−オキソイソインドリン−４−イル｝カルボキサミドを使用した乾癬又は乾癬性関節炎の治療

Also Published As

Publication number Publication date
RU2557236C2 (ru) 2015-07-20
AU2010303243A1 (en) 2012-05-03
HK1168596A1 (en) 2013-01-04
PH12012500669A1 (en) 2018-02-07
JP5753177B2 (ja) 2015-07-22
BR112012007737A2 (pt) 2015-09-15
CA2775581A1 (en) 2011-04-14
NZ599147A (en) 2014-03-28
US8415485B2 (en) 2013-04-09
WO2011044479A1 (en) 2011-04-14
AR078581A1 (es) 2011-11-16
MY183201A (en) 2021-02-18
US20110087033A1 (en) 2011-04-14
ES2451350T3 (es) 2014-03-26
EP2486012B1 (en) 2013-12-11
EP2486012A1 (en) 2012-08-15
IL218898A0 (en) 2012-06-28
MX2012004024A (es) 2012-05-08
JP2013507389A (ja) 2013-03-04
ECSP12011781A (es) 2012-07-31
CN102639498A (zh) 2012-08-15
ZA201202380B (en) 2013-06-26
NI201200049A (es) 2012-11-27
RU2012118615A (ru) 2013-11-20
KR20120084306A (ko) 2012-07-27
AU2010303243B2 (en) 2014-08-28

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