CR20140229A - Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona - Google Patents

Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona

Info

Publication number
CR20140229A
CR20140229A CR20140229A CR20140229A CR20140229A CR 20140229 A CR20140229 A CR 20140229A CR 20140229 A CR20140229 A CR 20140229A CR 20140229 A CR20140229 A CR 20140229A CR 20140229 A CR20140229 A CR 20140229A
Authority
CR
Costa Rica
Prior art keywords
dihidroisoquinolin
ona
bicyclic derivatives
new bicyclic
new
Prior art date
Application number
CR20140229A
Other languages
English (en)
Inventor
Johannes Aebi
Kurt Amrein
Wenming Chen
Benoit Hornsperger
Bernd Kuhn
Yongfu Liu
Hans P Maerki
Alexander V Mayweg
Peter Mohr
Xuefei Tan
Zhanguo Wang
Mingwei Zhou
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20140229A publication Critical patent/CR20140229A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona nuevos compuestos, que tienen la fórmula general (I).
CR20140229A 2011-11-30 2014-05-15 Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona CR20140229A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011083229 2011-11-30

Publications (1)

Publication Number Publication Date
CR20140229A true CR20140229A (es) 2014-06-19

Family

ID=47297189

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140229A CR20140229A (es) 2011-11-30 2014-05-15 Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona

Country Status (33)

Country Link
US (1) US9133158B2 (es)
EP (2) EP3587401B1 (es)
JP (1) JP6382108B2 (es)
KR (1) KR102089927B1 (es)
CN (1) CN103958478B (es)
AR (1) AR088989A1 (es)
AU (1) AU2012344041B2 (es)
BR (1) BR112014013136B1 (es)
CA (1) CA2850700C (es)
CL (1) CL2014001389A1 (es)
CO (1) CO6920296A2 (es)
CR (1) CR20140229A (es)
DK (1) DK2785695T3 (es)
EA (1) EA035454B1 (es)
ES (1) ES2811806T3 (es)
HR (1) HRP20201277T1 (es)
HU (1) HUE050431T2 (es)
IL (1) IL232570B (es)
LT (1) LT2785695T (es)
MA (1) MA35664B1 (es)
MX (1) MX350717B (es)
MY (1) MY178867A (es)
PE (1) PE20141283A1 (es)
PH (1) PH12014501179B1 (es)
PL (1) PL2785695T3 (es)
PT (1) PT2785695T (es)
RS (1) RS60660B1 (es)
SG (1) SG11201402199QA (es)
SI (1) SI2785695T1 (es)
TW (1) TWI583678B (es)
UA (1) UA112565C2 (es)
WO (1) WO2013079452A1 (es)
ZA (1) ZA201402908B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN105358534A (zh) * 2013-04-23 2016-02-24 斯洛文尼亚莱柯制药股份有限公司 8-氯-1-甲基-苯并[d]吖庚因的新合成方法、新的中间体及其生产方法
PE20151951A1 (es) * 2013-05-17 2015-12-26 Hoffmann La Roche Heteroarildihidropirimidinas unidas por puentes en 6 para el tratamiento y la profilaxis de infeccion por el virus de la hepatitis b
AR096423A1 (es) 2013-05-27 2015-12-30 Hoffmann La Roche Compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona
MY176401A (en) * 2014-04-24 2020-08-05 Mitsubishi Tanabe Pharma Corp Novel disubstituted 1,2,4-triazine compound
CR20170118A (es) * 2014-10-08 2017-07-10 Hoffmann La Roche Derivados espirodiamina como inhibidores de la aldosterona sintasa
KR102441634B1 (ko) * 2014-10-15 2022-09-13 베링거 인겔하임 인터내셔날 게엠베하 알도스테론 신타아제 억제제
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
WO2016089800A1 (en) * 2014-12-02 2016-06-09 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors
CN104529729B (zh) * 2014-12-31 2016-03-30 浙江永太科技股份有限公司 一种2-氟-3-氯苯甲醛的制备方法
JP6314196B2 (ja) * 2015-10-22 2018-04-18 田辺三菱製薬株式会社 医薬組成物
JP6545275B2 (ja) * 2015-10-23 2019-07-17 田辺三菱製薬株式会社 新規含窒素芳香族複素環化合物
TWI804987B (zh) 2015-12-24 2023-06-11 日商協和麒麟股份有限公司 α、β不飽和醯胺化合物
KR102537985B1 (ko) * 2016-09-12 2023-05-30 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 단환형 화합물
WO2018049328A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Bicyclic compounds useful as gpr120 modulators
WO2018133865A1 (zh) * 2017-01-22 2018-07-26 福建广生堂药业股份有限公司 Ask1抑制剂及其制备方法和应用
CN109071498B (zh) * 2017-02-16 2021-03-30 四川科伦博泰生物医药股份有限公司 激酶抑制剂及其制备方法和用途
SG11201912770SA (en) 2017-06-23 2020-01-30 Kyowa Kirin Co Ltd a, ß-UNSATURATED AMIDE COMPOUND
WO2019016112A1 (en) 2017-07-17 2019-01-24 AbbVie Deutschland GmbH & Co. KG SUBSTITUTED QUINOLINE COMPOUNDS IN POSITIONS 1, 2, 3 AND 4 AS MODULATORS OF S1P
CN109810171B (zh) * 2017-11-21 2020-12-01 首都医科大学 二氢异喹啉-3-甲酰-LARGD(aa)aa,其制备,抗静脉血栓活性和应用
US11434249B1 (en) 2018-01-02 2022-09-06 Seal Rock Therapeutics, Inc. ASK1 inhibitor compounds and uses thereof
KR102613340B1 (ko) * 2018-06-26 2023-12-14 쩌지앙 빔그린 파머슈티컬스, 엘티디 A2a 수용체 길항제로서의 트리아졸로 트리아진 유도체
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
CN113767095A (zh) 2019-05-01 2021-12-07 勃林格殷格翰国际有限公司 (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯
EP4017850A1 (en) * 2019-08-21 2022-06-29 Kalvista Pharmaceuticals Limited Enzyme inhibitors
WO2021224818A1 (en) * 2020-05-08 2021-11-11 Pfizer Inc. Isoindolone compounds as hpk1 inhibitors
CN112079826B (zh) * 2020-09-17 2022-07-29 广州中医药大学(广州中医药研究院) 一类甾体合成酶抑制剂及其治疗应用
WO2023063851A1 (en) * 2021-10-13 2023-04-20 «Target Medicals» Limited Liability Company Inhibitors of human aldosterone synthase (cyp11b2)
US12213973B2 (en) 2021-10-18 2025-02-04 Northwestern University Bacterial nitric oxide synthase inhibitors
AU2022415313A1 (en) 2021-12-14 2024-05-02 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors for treating chronic kidney disease
EP4448513A4 (en) * 2021-12-16 2025-11-05 Beigene Switzerland Gmbh 3,4-DIHYDROISOQUINOLINE-1(2H)-ONE DERIVATIVES AS STING ANTAGONISTS AND THEIR USE
CN119894905A (zh) * 2022-09-23 2025-04-25 广州威诺森医药科技有限公司 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用
AU2023378302A1 (en) * 2022-11-10 2025-04-10 «Target Medicals» Limited Liability Company Inhibitors of human aldosterone synthase (cyp11b2)
CN117247371B (zh) * 2023-09-18 2026-03-10 上海相辉医药科技有限公司 一种cyp11b2抑制剂baxdrostat的制备方法
WO2025098465A1 (zh) * 2023-11-10 2025-05-15 上海齐鲁制药研究中心有限公司 稠环衍生物、其制备方法及其在医药上的应用
TW202535378A (zh) 2023-12-22 2025-09-16 大陸商上海翊石醫藥科技有限公司 一種芳雜環化合物及其製備方法和應用
AU2024414094A1 (en) * 2023-12-29 2026-07-16 Shenzhen Salubris Pharmaceuticals Co., Ltd Aldosterone synthetase inhibitor, and preparation method therefor and use thereof
CN120289471B (zh) * 2024-03-01 2025-10-17 浙江扬厉医药技术有限公司 吡喃并吡啶类化合物、其制备方法、药物组合物及应用
WO2026138983A1 (zh) * 2024-12-26 2026-07-02 深圳信立泰药业股份有限公司 一种化合物a或其可药用盐的医药用途
WO2026138971A1 (zh) * 2024-12-26 2026-07-02 深圳信立泰药业股份有限公司 一种化合物a或其盐的医药用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710507A (en) 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
JP2000072751A (ja) * 1998-08-26 2000-03-07 Tanabe Seiyaku Co Ltd イソキノリノン誘導体
JP4361273B2 (ja) * 2001-02-27 2009-11-11 アメリカ合衆国 潜在的な血管形成阻害剤としてのサリドマイド類似体
AR049126A1 (es) * 2004-05-28 2006-06-28 Speedel Experimenta Ag Derivados de 5, 6, 7, 8 - tetrahidroimidazo[1,5a]piridina con actividad inhibitoria de la aldosterona sintasa, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del hiperaldosterismo y del sindrome de cushing.
BRPI0709678A2 (pt) * 2006-03-29 2011-07-19 Novartis Ag compostos orgánicos
WO2008027284A1 (en) * 2006-08-25 2008-03-06 Novartis Ag Fused imidazole derivatives for the treatment of disorders mediated by aldosterone synthase and/or 11-beta-hydroxylase and/or aromatase
BRPI0814441A2 (pt) * 2007-07-19 2015-07-14 Schering Corp Compostos de amida heterocíclica como inibidores de proteína cinase
TW200918062A (en) * 2007-09-12 2009-05-01 Wyeth Corp Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
AU2010247412A1 (en) * 2009-05-15 2011-11-24 Novartis Ag 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1
EP2627648A1 (en) * 2010-09-16 2013-08-21 Novartis AG 17aHYDROXYLASE/C17,20-LYASE INHIBITORS

Also Published As

Publication number Publication date
PT2785695T (pt) 2020-08-20
ZA201402908B (en) 2017-04-26
BR112014013136A2 (pt) 2017-06-13
ES2811806T3 (es) 2021-03-15
MA35664B1 (fr) 2014-11-01
CA2850700C (en) 2019-11-12
HRP20201277T1 (hr) 2020-11-13
EA035454B1 (ru) 2020-06-18
WO2013079452A1 (en) 2013-06-06
SI2785695T1 (sl) 2020-10-30
IL232570A0 (en) 2014-06-30
MY178867A (en) 2020-10-21
DK2785695T3 (da) 2020-08-24
KR20140104000A (ko) 2014-08-27
EA201491018A1 (ru) 2014-09-30
SG11201402199QA (en) 2014-09-26
EP3587401B1 (en) 2026-08-19
US9133158B2 (en) 2015-09-15
TW201329066A (zh) 2013-07-16
HUE050431T2 (hu) 2020-12-28
MX2014005833A (es) 2014-06-04
AU2012344041B2 (en) 2017-08-17
CN103958478A (zh) 2014-07-30
EP2785695A1 (en) 2014-10-08
UA112565C2 (uk) 2016-09-26
CA2850700A1 (en) 2013-06-06
CL2014001389A1 (es) 2014-10-03
PL2785695T3 (pl) 2020-11-16
PE20141283A1 (es) 2014-10-01
EP2785695B1 (en) 2020-06-17
JP2014533736A (ja) 2014-12-15
JP6382108B2 (ja) 2018-08-29
LT2785695T (lt) 2020-08-25
IL232570B (en) 2018-02-28
BR112014013136B1 (pt) 2020-05-26
US20130143863A1 (en) 2013-06-06
PH12014501179A1 (en) 2014-09-08
CO6920296A2 (es) 2014-04-10
CN103958478B (zh) 2017-08-01
AU2012344041A1 (en) 2014-04-10
TWI583678B (zh) 2017-05-21
MX350717B (es) 2017-09-14
KR102089927B1 (ko) 2020-03-18
PH12014501179B1 (en) 2018-10-26
RS60660B1 (sr) 2020-09-30
AR088989A1 (es) 2014-07-23
EP3587401A1 (en) 2020-01-01

Similar Documents

Publication Publication Date Title
CR20150120A (es) Nuevos derivados bicíclicos
JOP20180103A1 (ar) مركب صيدلاني
MX2018006148A (es) Inhibidores de cxcr2.
CR20130539A (es) Triazolopiridinas
CR20130045A (es) Compuestos terapéuticos
CR20140468A (es) Inhibidores de diacilglicerol aciltransferasa 2
UY34445A (es) Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a
EA201492223A1 (ru) Новые диазаспироциклоалканы и азаспироциклоалканы
EA201490567A1 (ru) Новые бициклические производные дигидрохинолин-2-она
CR20180057A (es) Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
UY34156A (es) Compuestos inhibidores de metaloenzimas
CO6852084A2 (es) Nuevos compuestos sustituidos con halógeno
CR20140106A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
UY34602A (es) ?Derivados de bencimidazolil- e imidazopiridinil-metilamina?
UY34472A (es) Derivados modificados de 4-fenil-piridina
PH12016500676A1 (en) Pyrimidine fgfr4 inhibitors
CR20180072A (es) Nuevos compuestos biciclicos como inhibidores de atx
UA108101C2 (xx) Похідні n3-заміщених n1-сульфоніл-5-фторпіримідинонів
EA201590224A1 (ru) Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы
UY34216A (es) Nuevos compuestos que inhiben la actividad de la Lp-PLA2
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
CR20140135A (es) Nuevos derivados de aril-quinolina
CR20120637A (es) Triazolopiridinas sustituidas
CR20180143A (es) Nuevos compuestos biciclicos como inhibidores duales de atx/ca
CR20140306A (es) Fluormetil -5,6-dihidro-4h-[1,3] oxazinas