CR20120331A - Aminopirimidinas como inhibidores de syk - Google Patents

Aminopirimidinas como inhibidores de syk

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Publication number
CR20120331A
CR20120331A CR20120331A CR20120331A CR20120331A CR 20120331 A CR20120331 A CR 20120331A CR 20120331 A CR20120331 A CR 20120331A CR 20120331 A CR20120331 A CR 20120331A CR 20120331 A CR20120331 A CR 20120331A
Authority
CR
Costa Rica
Prior art keywords
aminopirimidins
syk inhibitors
copd
asthma
enzyme
Prior art date
Application number
CR20120331A
Other languages
English (en)
Inventor
Michael D Altman
Brian M Andresen
Kenneth L Arrington
Kaleen Konrad Childers
Francesco Maria Emilia Di
Anthony Donofrio
John Michael Ellis
Christian Fischer
David Joseph Guerin
Andrew M Haidle
Solomon Kattar
Sandra Lee Knowles
Chaomin Li
Jongwon Lim
Michelle R Machacek
Alan B Northrup
Brendan M O'boyle
Ryan D Otte
Alessia Petrocchi
Michael H Reutershan
Eric Romeo
Tony Siu
Brandon M Taoka
B Wesley Trotter
Hua Zhou
Jason Burch
Bernard Cote
Kristina Dupont-Gaudet
Jean-Francois Fournier
Jacques Yves Gauthier
Daniel Guay
Joel S Robichaud
Original Assignee
Merck Sharp & Dohme
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43502894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120331(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Merck Canada Inc filed Critical Merck Sharp & Dohme
Publication of CR20120331A publication Critical patent/CR20120331A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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Abstract

La presente invención proporciona nuevas pirimidina amidas de fórmula (I) que son potentes inhibidores de la tirosina quinasa del bazo y son útiles en el tratamiento y prevención de enfermedades mediadas por dicha enzima, tales como asma, COPD y artritis 5 reumatoide.
CR20120331A 2009-12-17 2012-06-18 Aminopirimidinas como inhibidores de syk CR20120331A (es)

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US28726709P 2009-12-17 2009-12-17

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CR20120331A true CR20120331A (es) 2012-08-01

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US (3) US8759366B2 (es)
EP (1) EP2513098B1 (es)
JP (2) JP5242857B2 (es)
KR (1) KR101445012B1 (es)
CN (1) CN102858767B (es)
AR (1) AR080672A1 (es)
AU (1) AU2010331927B2 (es)
BR (1) BR112012014703B1 (es)
CA (1) CA2782889C (es)
CL (1) CL2012001627A1 (es)
CO (1) CO6551728A2 (es)
CR (1) CR20120331A (es)
DO (1) DOP2012000166A (es)
EA (1) EA022790B1 (es)
EC (1) ECSP12011982A (es)
ES (1) ES2609040T3 (es)
GE (1) GEP20146125B (es)
GT (1) GT201200202A (es)
MA (1) MA33926B1 (es)
MX (1) MX2012007154A (es)
NI (1) NI201200108A (es)
NZ (1) NZ600673A (es)
PE (1) PE20121480A1 (es)
PH (1) PH12012501225A1 (es)
SG (1) SG181803A1 (es)
TN (1) TN2012000288A1 (es)
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Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2512246B1 (en) 2009-12-17 2015-09-30 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
AU2010331927B2 (en) * 2009-12-17 2013-10-10 Merck Canada Inc. Aminopyrimidines as Syk inhibitors
EP2516434B1 (en) 2009-12-23 2015-05-27 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors
CN102812022B (zh) 2010-01-12 2016-02-03 Ab科学有限公司 噻唑和噁唑激酶抑制剂
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
WO2012151137A1 (en) * 2011-05-04 2012-11-08 Merck Sharp & Dohme Corp. Amino-pyridine-containing spleen tyrosine kinase (syk) inhibitors
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