ECSP12011982A - Aminopirimidinas como inhibidores de syk - Google Patents

Aminopirimidinas como inhibidores de syk

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Publication number
ECSP12011982A
ECSP12011982A ECSP12011982A ECSP12011982A EC SP12011982 A ECSP12011982 A EC SP12011982A EC SP12011982 A ECSP12011982 A EC SP12011982A EC SP12011982 A ECSP12011982 A EC SP12011982A
Authority
EC
Ecuador
Prior art keywords
aminopirimidins
syk inhibitors
copd
asthma
enzyme
Prior art date
Application number
Other languages
English (en)
Inventor
Daniel Guay
Jacques Yves Gauthier
Ryan D Otte
Kenneth L Arrington
Bernard Cote
Alan B Northrup
Francesco Maria Emilia Di
B Wesley Trotter
Michael D Altman
Brian M Andresen
Kaleen Konrad Childers
Anthony Donofrio
Jhon Michael Ellis
Christian Fischer
David Joseph Guerin
Andrew M Haidle
Salomon Kattar
Sandra Lee Knowles
Chaomin Li
Jongwon Lim
Eric Romeo
Tony Siu
Brandon M Taoka
Hua Zhou
Jason Burch
Kristina Dupont-Gaudet
Jean-Francois Fournier
Joel S Robichaud
Michelle R Machacek
Boyle Brendan M O
Alessia Petrocchi
Michael H Reutershan
Original Assignee
Merck Sharp & Dohme
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43502894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011982(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Merck Canada Inc filed Critical Merck Sharp & Dohme
Publication of ECSP12011982A publication Critical patent/ECSP12011982A/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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Abstract

La presente invención proporciona nuevas pirimidina aminas de fórmula (I) que son potentes inhibidores de la tirosina quinasa del bazo, y son útiles en el tratamiento y prevención de enfermedades mediadas por dicha enzima, tales como asma, COPD y artritis reumatoide.
ECSP12011982 2009-12-17 2012-06-19 Aminopirimidinas como inhibidores de syk ECSP12011982A (es)

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US28726709P 2009-12-17 2009-12-17

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ECSP12011982A true ECSP12011982A (es) 2012-07-31

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ECSP12011982 ECSP12011982A (es) 2009-12-17 2012-06-19 Aminopirimidinas como inhibidores de syk

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EP (1) EP2513098B1 (es)
JP (2) JP5242857B2 (es)
KR (1) KR101445012B1 (es)
CN (1) CN102858767B (es)
AR (1) AR080672A1 (es)
AU (1) AU2010331927B2 (es)
BR (1) BR112012014703B1 (es)
CA (1) CA2782889C (es)
CL (1) CL2012001627A1 (es)
CO (1) CO6551728A2 (es)
CR (1) CR20120331A (es)
DO (1) DOP2012000166A (es)
EA (1) EA022790B1 (es)
EC (1) ECSP12011982A (es)
ES (1) ES2609040T3 (es)
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GT (1) GT201200202A (es)
MA (1) MA33926B1 (es)
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Families Citing this family (93)

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Publication number Priority date Publication date Assignee Title
EP2512246B1 (en) 2009-12-17 2015-09-30 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
AU2010331927B2 (en) * 2009-12-17 2013-10-10 Merck Canada Inc. Aminopyrimidines as Syk inhibitors
EP2516434B1 (en) 2009-12-23 2015-05-27 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors
CN102812022B (zh) 2010-01-12 2016-02-03 Ab科学有限公司 噻唑和噁唑激酶抑制剂
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
WO2012151137A1 (en) * 2011-05-04 2012-11-08 Merck Sharp & Dohme Corp. Amino-pyridine-containing spleen tyrosine kinase (syk) inhibitors
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