CR20130431A - 5-(fenil)/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores de mglur5 - Google Patents

5-(fenil)/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores de mglur5

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Publication number
CR20130431A
CR20130431A CR20130431A CR20130431A CR20130431A CR 20130431 A CR20130431 A CR 20130431A CR 20130431 A CR20130431 A CR 20130431A CR 20130431 A CR20130431 A CR 20130431A CR 20130431 A CR20130431 A CR 20130431A
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CR
Costa Rica
Prior art keywords
carboxamidas
etinil
pirimidina
piridinil
piridina
Prior art date
Application number
CR20130431A
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English (en)
Inventor
Georg Jaeschke
Synese Jolidon
Lothar Lindemann
Antonio Ricci
Daniel Rueher
Heinz Stadler
Eric Vieira
Original Assignee
Hoffmann La Roche
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45954677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20130431(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20130431A publication Critical patent/CR20130431A/es

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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a derivados de etinilo de la fórmula I.
CR20130431A 2011-04-19 2013-08-30 5-(fenil)/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores de mglur5 CR20130431A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11162945 2011-04-19
EP11185137 2011-10-14

Publications (1)

Publication Number Publication Date
CR20130431A true CR20130431A (es) 2013-12-09

Family

ID=45954677

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130431A CR20130431A (es) 2011-04-19 2013-08-30 5-(fenil)/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores de mglur5

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Country Link
US (1) US8772300B2 (es)
EP (1) EP2699547B1 (es)
JP (1) JP5753625B2 (es)
KR (1) KR101573998B1 (es)
CN (1) CN103582629B (es)
AR (1) AR086024A1 (es)
AU (1) AU2012244870B2 (es)
BR (1) BR112013021848A2 (es)
CA (1) CA2825971C (es)
CL (1) CL2013002971A1 (es)
CO (1) CO6741199A2 (es)
CR (1) CR20130431A (es)
CY (1) CY1116388T1 (es)
DK (1) DK2699547T3 (es)
EA (1) EA023369B1 (es)
EC (1) ECSP13012980A (es)
ES (1) ES2534086T3 (es)
HR (1) HRP20150569T1 (es)
HU (1) HUE025033T2 (es)
IL (1) IL227662A (es)
MA (1) MA35113B1 (es)
MX (1) MX338631B (es)
MY (1) MY161403A (es)
PE (1) PE20140984A1 (es)
PH (1) PH12013501572A1 (es)
PL (1) PL2699547T3 (es)
PT (1) PT2699547E (es)
RS (1) RS53909B1 (es)
SG (1) SG194513A1 (es)
SI (1) SI2699547T1 (es)
TW (1) TWI458720B (es)
WO (1) WO2012143340A1 (es)

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UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
MX2015002823A (es) * 2012-10-18 2015-05-15 Hoffmann La Roche Derivados de etilinilo como moduladores de la actividad del receptor de glutamato metabotropico 5 (mglur5).
JP5989253B2 (ja) * 2012-10-18 2016-09-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ｍＧｌｕＲ５受容体活性のモジュレータとしてのエチニル誘導体
CA2921427A1 (en) * 2013-08-16 2015-02-19 Duke University Substituted hydroxamic acid compounds
LT3303316T (lt) 2015-06-03 2020-05-11 F. Hoffmann-La Roche Ag Etinilo dariniai
ES2733468T3 (es) 2015-07-15 2019-11-29 Hoffmann La Roche Derivados de etinilo como moduladores de los receptores metabotrópicos de glutamato
WO2018015235A1 (en) 2016-07-18 2018-01-25 F. Hoffmann-La Roche Ag Ethynyl derivatives
WO2022025636A1 (ko) 2020-07-29 2022-02-03 주식회사 비보존 Mglur5 및 5-ht2a 수용체의 이중 조절제 및 이의 용도
WO2025080252A1 (en) * 2023-10-13 2025-04-17 Allyx Therapeutics, Inc. Methods of use of (4r,5r)-5-(2-chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one
WO2026072192A1 (en) 2024-09-27 2026-04-02 Alto Neuroscience, Inc. Effective treatment of depression in patients having poor cognition or impaired learning and/or memory with a mglur5 positive allosteric modulator

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TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
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