CR20140138A - Procedimiento para preparar 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]-amino}-1 (r)-hidroxietil)-8-hidroxiquinolin-2 (1h)-ona via un nuevo intermedio - Google Patents

Procedimiento para preparar 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]-amino}-1 (r)-hidroxietil)-8-hidroxiquinolin-2 (1h)-ona via un nuevo intermedio

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Publication number
CR20140138A
CR20140138A CR20140138A CR20140138A CR20140138A CR 20140138 A CR20140138 A CR 20140138A CR 20140138 A CR20140138 A CR 20140138A CR 20140138 A CR20140138 A CR 20140138A CR 20140138 A CR20140138 A CR 20140138A
Authority
CR
Costa Rica
Prior art keywords
difluoro
hydroxyethyl
amino
phenyletoxi
hexil
Prior art date
Application number
CR20140138A
Other languages
English (en)
Inventor
Hereu Iolanda Marchueta
Valls Enrique Moyes
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44785778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140138(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of CR20140138A publication Critical patent/CR20140138A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para preparar un compuesto 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]-amino}-1(R)-hidroxietil)-8-hidroxiquinolin-2(1H)-ona de fórmula (I) o una cualquiera de sus sales farmacéuticamente aceptables,
CR20140138A 2011-10-07 2014-03-25 Procedimiento para preparar 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]-amino}-1 (r)-hidroxietil)-8-hidroxiquinolin-2 (1h)-ona via un nuevo intermedio CR20140138A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11382316.5A EP2578570A1 (en) 2011-10-07 2011-10-07 Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
US201161561645P 2011-11-18 2011-11-18

Publications (1)

Publication Number Publication Date
CR20140138A true CR20140138A (es) 2014-05-20

Family

ID=44785778

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140138A CR20140138A (es) 2011-10-07 2014-03-25 Procedimiento para preparar 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]-amino}-1 (r)-hidroxietil)-8-hidroxiquinolin-2 (1h)-ona via un nuevo intermedio

Country Status (21)

Country Link
US (1) US9108918B2 (es)
EP (2) EP2578570A1 (es)
JP (1) JP2014532059A (es)
KR (1) KR20140072072A (es)
CN (1) CN103889958A (es)
AR (1) AR088243A1 (es)
AU (1) AU2012320612A1 (es)
BR (1) BR112014007891A2 (es)
CA (1) CA2846444A1 (es)
CL (1) CL2014000724A1 (es)
CO (1) CO6970590A2 (es)
CR (1) CR20140138A (es)
EA (1) EA201400425A1 (es)
IL (1) IL231284A0 (es)
MX (1) MX2014002970A (es)
PE (1) PE20141670A1 (es)
PH (1) PH12014500774A1 (es)
SG (1) SG11201400898XA (es)
UY (1) UY34334A (es)
WO (1) WO2013050375A1 (es)
ZA (1) ZA201401177B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.

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