CR20140216A - 5,7-imidazo[1,2-c]pirimidinas sustituidas - Google Patents

5,7-imidazo[1,2-c]pirimidinas sustituidas

Info

Publication number
CR20140216A
CR20140216A CR20140216A CR20140216A CR20140216A CR 20140216 A CR20140216 A CR 20140216A CR 20140216 A CR20140216 A CR 20140216A CR 20140216 A CR20140216 A CR 20140216A CR 20140216 A CR20140216 A CR 20140216A
Authority
CR
Costa Rica
Prior art keywords
pyrimidins
imidazo
substituted
solvates
stereoisomers
Prior art date
Application number
CR20140216A
Other languages
English (en)
Inventor
Mark Laurence Boys
Laurence E Burgess
C Todd Eary
Robert Groneberg
Bruno P Hache
Darren Harvey
Erik James Hicken
Christopher F Kraser
Ellen Laird
David A Moreno
Mark C Munson
Li Ren
John E Robinson
Stephen T Schlachter
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CR20140216A publication Critical patent/CR20140216A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de Fórmula I: y estereoisómeros y sales y solvatos farmacéuticamente aceptables de estos, donde R1, R2, R3, R4, R5, R6, X1 y X2 tienen los significados que se proporcionan en la memoria descriptiva, son inhibidores de una o más cinasas JAK y s
CR20140216A 2011-10-12 2014-05-09 5,7-imidazo[1,2-c]pirimidinas sustituidas CR20140216A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161546426P 2011-10-12 2011-10-12

Publications (1)

Publication Number Publication Date
CR20140216A true CR20140216A (es) 2014-08-21

Family

ID=47071473

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140216A CR20140216A (es) 2011-10-12 2014-05-09 5,7-imidazo[1,2-c]pirimidinas sustituidas

Country Status (20)

Country Link
US (1) US20140228349A1 (es)
EP (1) EP2766368A1 (es)
JP (1) JP2014528475A (es)
KR (1) KR20140076619A (es)
CN (1) CN103987713A (es)
AR (1) AR088304A1 (es)
AU (1) AU2012323399A1 (es)
BR (1) BR112014008865A2 (es)
CA (1) CA2851623A1 (es)
CL (1) CL2014000931A1 (es)
CO (1) CO6950483A2 (es)
CR (1) CR20140216A (es)
IL (1) IL231903A0 (es)
MX (1) MX2014004473A (es)
PH (1) PH12014500730A1 (es)
RU (1) RU2014118954A (es)
SG (1) SG11201401342VA (es)
TW (1) TW201326173A (es)
UY (1) UY34388A (es)
WO (1) WO2013055645A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2634185T3 (en) 2012-03-02 2016-03-21 Sareum Ltd Tyk2 kinase inhibitors
PH12021550330A1 (en) 2013-08-21 2022-09-28 Janssen Biopharma Inc Antiviral compounds
CN105793245B (zh) * 2013-09-03 2018-03-20 萨勒姆有限公司 药物化合物
EP3227297B1 (en) * 2014-12-05 2021-01-20 Array Biopharma, Inc. 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
AU2016208906B2 (en) 2015-01-20 2018-07-12 Wuxi Fortune Pharmaceutical Co., Ltd JAK inhibitor
UA119701C2 (uk) * 2015-04-29 2019-07-25 Вуксі Фортуне Фармасьютікал Ко., Лтд Піримідинові сполуки як jak-інгібітори
DK3305788T3 (da) 2015-05-29 2020-09-28 Wuxi Fortune Pharmaceutical Co Ltd Janus-kinase-hæmmer
ES2794779T3 (es) 2016-02-24 2020-11-19 Pfizer Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de JAK
GB201617871D0 (en) 2016-10-21 2016-12-07 Sareum Limited Pharmaceutical compounds
EP3668858A1 (en) 2017-08-14 2020-06-24 Pfizer Inc Pyrazolo[1,5-a]pyrazin-4-yl and related derivatives
WO2019233434A1 (zh) * 2018-06-06 2019-12-12 杭州澳津生物医药技术有限公司 一种吡唑嘧啶衍生物及其用途和药物组合物
TW202028209A (zh) * 2018-09-27 2020-08-01 大陸商重慶複創醫藥研究有限公司 作為RET激酶抑制劑的取代的咪唑[1,2-a]吡啶和[1,2,4]三唑[1,5-a]吡啶化合物
GB201816369D0 (en) 2018-10-08 2018-11-28 Sareum Ltd Pharmaceutical compounds
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
PE20211655A1 (es) 2018-10-31 2021-08-24 Gilead Sciences Inc Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1
CN111320624B (zh) * 2018-12-14 2023-05-12 中国医药研究开发中心有限公司 三唑并吡啶类和咪唑并吡啶类化合物及其制备方法和医药用途
PL3954689T3 (pl) * 2019-04-12 2024-08-05 Primegene (Beijing) Co., Ltd. Związki pochodne pirazolopirazyny, kompozycja farmaceutyczna i ich zastosowanie
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
CN111039963B (zh) * 2019-12-31 2021-03-19 卓和药业集团有限公司 Wxfl10203614水溶性类似物及其合成方法
WO2021173476A1 (en) * 2020-02-24 2021-09-02 The Trustees Of Columbia University In The City Of New York Compounds, pharmaceutical formulations, and methods for treatment of cancer
GB202005114D0 (en) 2020-04-07 2020-05-20 Sareum Ltd Crystalline Forms of a Pharmaceutical Compound
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
EP4244223A1 (en) * 2020-11-13 2023-09-20 Biogen MA Inc. Pyrazolo[1,5-a]pyrazine derivatives as btk inhibitors
TWI820622B (zh) 2021-03-04 2023-11-01 美商美國禮來大藥廠 Fgfr3抑制劑化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1105378B1 (en) 1998-08-21 2005-03-30 Parker Hughes Institute Quinazoline derivatives
JP2001302667A (ja) * 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
CN103214484B (zh) * 2005-12-13 2016-07-06 因塞特控股公司 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶
ES2560435T3 (es) * 2006-11-22 2016-02-19 Incyte Holdings Corporation Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa
DE102007012645A1 (de) * 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
CL2008001709A1 (es) * 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
JP2013523884A (ja) * 2010-04-14 2013-06-17 アレイ バイオファーマ、インコーポレイテッド ＪＡＫキナーゼの阻害剤としての５，７置換イミダゾ［１，２−ｃ］ピリミジン

Also Published As

Publication number Publication date
CL2014000931A1 (es) 2014-08-29
UY34388A (es) 2014-04-30
WO2013055645A1 (en) 2013-04-18
CO6950483A2 (es) 2014-05-20
PH12014500730A1 (en) 2018-01-17
JP2014528475A (ja) 2014-10-27
SG11201401342VA (en) 2014-09-26
TW201326173A (zh) 2013-07-01
CA2851623A1 (en) 2013-04-18
BR112014008865A2 (pt) 2017-04-25
RU2014118954A (ru) 2015-11-20
MX2014004473A (es) 2015-04-14
US20140228349A1 (en) 2014-08-14
AU2012323399A1 (en) 2014-05-29
CN103987713A (zh) 2014-08-13
IL231903A0 (en) 2014-05-28
KR20140076619A (ko) 2014-06-20
AR088304A1 (es) 2014-05-21
EP2766368A1 (en) 2014-08-20

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