CR20160165A - Acetato de 4-{4-[(1 e)-4-(2,9- diazaespiro [5.5] undec-2-il) but-1 -en-i -il]-2- metilbencil}-5-(propan-2-il) -1h-pirazol-3-ilo beta-d- glucopiranósido - Google Patents
Acetato de 4-{4-[(1 e)-4-(2,9- diazaespiro [5.5] undec-2-il) but-1 -en-i -il]-2- metilbencil}-5-(propan-2-il) -1h-pirazol-3-ilo beta-d- glucopiranósidoInfo
- Publication number
- CR20160165A CR20160165A CR20160165A CR20160165A CR20160165A CR 20160165 A CR20160165 A CR 20160165A CR 20160165 A CR20160165 A CR 20160165A CR 20160165 A CR20160165 A CR 20160165A CR 20160165 A CR20160165 A CR 20160165A
- Authority
- CR
- Costa Rica
- Prior art keywords
- metilbencil
- glucopiranoside
- diazaespiro
- acutate
- pirazol
- Prior art date
Links
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a un compuesto de Fórmula I: o hidrato del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361901488P | 2013-11-08 | 2013-11-08 | |
| PCT/US2014/063161 WO2015069541A1 (en) | 2013-11-08 | 2014-10-30 | 4-{4-[(1 e)-4-(2,9-diazaspiro[5.5]undec-2-yl)but-1 -en-1 -yl]-2-methylbenzyl}-5-(propan-2-yl)-1 h-pyrazol-3-yl beta-d- glucopyranoside acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20160165A true CR20160165A (es) | 2016-06-08 |
Family
ID=51982747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20160165A CR20160165A (es) | 2013-11-08 | 2016-04-06 | Acetato de 4-{4-[(1 e)-4-(2,9- diazaespiro [5.5] undec-2-il) but-1 -en-i -il]-2- metilbencil}-5-(propan-2-il) -1h-pirazol-3-ilo beta-d- glucopiranósido |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9573970B2 (es) |
| EP (1) | EP3066108B1 (es) |
| JP (1) | JP6197113B2 (es) |
| KR (1) | KR101858881B1 (es) |
| CN (1) | CN105705509B (es) |
| AP (1) | AP2016009180A0 (es) |
| AR (2) | AR098670A1 (es) |
| AU (1) | AU2014347065B2 (es) |
| CA (1) | CA2925128C (es) |
| CL (1) | CL2016000791A1 (es) |
| CR (1) | CR20160165A (es) |
| CY (1) | CY1121096T1 (es) |
| DK (1) | DK3066108T3 (es) |
| DO (1) | DOP2016000067A (es) |
| EA (1) | EA028801B1 (es) |
| ES (1) | ES2703944T3 (es) |
| HR (1) | HRP20182061T1 (es) |
| IL (1) | IL244899B (es) |
| JO (1) | JO3485B1 (es) |
| LT (1) | LT3066108T (es) |
| MA (1) | MA39019A1 (es) |
| MX (1) | MX368174B (es) |
| MY (1) | MY192242A (es) |
| NZ (1) | NZ718118A (es) |
| PE (1) | PE20160884A1 (es) |
| PH (1) | PH12016500851B1 (es) |
| PL (1) | PL3066108T3 (es) |
| PT (1) | PT3066108T (es) |
| RS (1) | RS58050B1 (es) |
| SI (1) | SI3066108T1 (es) |
| SV (1) | SV2016005190A (es) |
| TN (1) | TN2016000112A1 (es) |
| TW (1) | TWI655198B (es) |
| UA (1) | UA118767C2 (es) |
| WO (1) | WO2015069541A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3256156B1 (en) * | 2015-02-13 | 2025-02-12 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| JP2020523394A (ja) * | 2017-06-12 | 2020-08-06 | リグナメッド・エルエルシーＬｉｇｎａｍｅｄ，Ｌｌｃ | （ｓ，ｓ）−セコイソラリシレシノールジグルコシド及び（ｒ，ｒ）−セコイソラリシレシノールジグルコシドの製造方法 |
| CN110054657B (zh) * | 2018-01-18 | 2021-06-29 | 亚宝药业集团股份有限公司 | 吡喃葡萄糖取代的吡唑化合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0013667B8 (pt) | 1999-08-31 | 2021-05-25 | Kissei Pharmaceutical | derivados de glucopiranosiloxipirazol, composições medicinais contendo os mesmos e seus intermediários na produção deles |
| WO2002068439A1 (fr) | 2001-02-26 | 2002-09-06 | Kissei Pharmaceutical Co., Ltd. | Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci |
| EP1400529A4 (en) | 2001-05-30 | 2007-12-19 | Kissei Pharmaceutical | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL AND INTERMEDIARY USE THEREOF |
| ZA200501094B (en) * | 2002-08-08 | 2006-10-25 | Kissei Pharmaceutical | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof |
| BRPI0313290B1 (pt) | 2002-08-08 | 2016-12-06 | Kissei Pharmaceutical | derivados de pirazol, promedicamento, composição farmacêutica, agentes terapêuticos e uso medicinal |
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| DE102004028241B4 (de) * | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
| AR061026A1 (es) * | 2006-05-19 | 2008-07-30 | Taisho Pharmaceutical Co Ltd | Compuesto glicitol c-fenilo y preparacion farmaceutica |
| CA2709530C (en) | 2007-12-27 | 2016-02-23 | Kissei Pharmaceutical Co., Ltd. | Monosebacate of pyrazole derivative |
| MY155658A (en) | 2009-02-23 | 2015-11-13 | Taisho Pharmaceutical Co Ltd | A-isopropylphenyl glucitol compounds as sglti inhibitors |
| WO2011039338A2 (en) | 2009-10-02 | 2011-04-07 | Sanofi-Aventis | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| UA113086C2 (xx) * | 2012-05-10 | 2016-12-12 | Піразольні сполуки як інгібітори sglt1 |
-
2014
- 2014-10-24 AR ARP140104010A patent/AR098670A1/es not_active Application Discontinuation
- 2014-10-26 JO JOP/2014/0310A patent/JO3485B1/ar active
- 2014-10-27 TW TW103137067A patent/TWI655198B/zh active
- 2014-10-30 RS RS20181382A patent/RS58050B1/sr unknown
- 2014-10-30 LT LTEP14802974.7T patent/LT3066108T/lt unknown
- 2014-10-30 MX MX2016005999A patent/MX368174B/es active IP Right Grant
- 2014-10-30 DK DK14802974.7T patent/DK3066108T3/da active
- 2014-10-30 KR KR1020167011764A patent/KR101858881B1/ko active Active
- 2014-10-30 PL PL14802974T patent/PL3066108T3/pl unknown
- 2014-10-30 UA UAA201603973A patent/UA118767C2/uk unknown
- 2014-10-30 AP AP2016009180A patent/AP2016009180A0/en unknown
- 2014-10-30 WO PCT/US2014/063161 patent/WO2015069541A1/en not_active Ceased
- 2014-10-30 PT PT14802974T patent/PT3066108T/pt unknown
- 2014-10-30 TN TN2016000112A patent/TN2016000112A1/en unknown
- 2014-10-30 EA EA201690749A patent/EA028801B1/ru not_active IP Right Cessation
- 2014-10-30 MA MA39019A patent/MA39019A1/fr unknown
- 2014-10-30 CN CN201480060924.9A patent/CN105705509B/zh active Active
- 2014-10-30 AU AU2014347065A patent/AU2014347065B2/en active Active
- 2014-10-30 EP EP14802974.7A patent/EP3066108B1/en active Active
- 2014-10-30 ES ES14802974T patent/ES2703944T3/es active Active
- 2014-10-30 MY MYPI2016701635A patent/MY192242A/en unknown
- 2014-10-30 US US15/026,427 patent/US9573970B2/en active Active
- 2014-10-30 CA CA2925128A patent/CA2925128C/en active Active
- 2014-10-30 JP JP2016526778A patent/JP6197113B2/ja active Active
- 2014-10-30 SI SI201430941T patent/SI3066108T1/sl unknown
- 2014-10-30 HR HRP20182061TT patent/HRP20182061T1/hr unknown
- 2014-10-30 NZ NZ718118A patent/NZ718118A/en unknown
- 2014-10-30 PE PE2016000546A patent/PE20160884A1/es unknown
-
2016
- 2016-03-17 DO DO2016000067A patent/DOP2016000067A/es unknown
- 2016-04-04 IL IL24489916A patent/IL244899B/en active IP Right Grant
- 2016-04-06 CR CR20160165A patent/CR20160165A/es unknown
- 2016-04-06 CL CL2016000791A patent/CL2016000791A1/es unknown
- 2016-05-03 SV SV2016005190A patent/SV2016005190A/es unknown
- 2016-05-06 PH PH12016500851A patent/PH12016500851B1/en unknown
-
2018
- 2018-12-12 CY CY181101334T patent/CY1121096T1/el unknown
-
2021
- 2021-11-17 AR ARP210103177A patent/AR124083A2/es unknown
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