CR20160178A - Derivados de desoxinojirimicina y sus métodos de uso - Google Patents

Derivados de desoxinojirimicina y sus métodos de uso

Info

Publication number
CR20160178A
CR20160178A CR20160178A CR20160178A CR20160178A CR 20160178 A CR20160178 A CR 20160178A CR 20160178 A CR20160178 A CR 20160178A CR 20160178 A CR20160178 A CR 20160178A CR 20160178 A CR20160178 A CR 20160178A
Authority
CR
Costa Rica
Prior art keywords
derivatives
virus
deoxinojirimicine
methods
deoxinojirimycin
Prior art date
Application number
CR20160178A
Other languages
English (en)
Inventor
Raju Penmasta
Urban Ramstedt
Tam Nguyen
Hitesh Batra
Original Assignee
Emergent Virology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Virology Llc filed Critical Emergent Virology Llc
Publication of CR20160178A publication Critical patent/CR20160178A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente solicitud proporciona iminoazúcares novedosos y su uso en el tratamiento de infecciones virales, tales como infección de Dengue e infección de Influeza A. Los presentes inventores descubrieron que ciertos derivados de desoxinojirimicina pueden ser efectivos contra uno o más virus, los cuales pueden ser, por ejemplo, un virus de Dengue y/o un virus que pertenece a la familia Orthomyxoviridae, tal como un virus de Influenza A. En particular, estos derivados de desoxinojirimicina pueden ser útiles para tratar una enfermedad o condición causada por o asociada con uno o más virus.
CR20160178A 2013-09-16 2014-09-15 Derivados de desoxinojirimicina y sus métodos de uso CR20160178A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361878286P 2013-09-16 2013-09-16
PCT/US2014/055599 WO2015039010A2 (en) 2013-09-16 2014-09-15 Deoxynojirimycin derivatives and methods of their using

Publications (1)

Publication Number Publication Date
CR20160178A true CR20160178A (es) 2016-08-08

Family

ID=52666528

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160178A CR20160178A (es) 2013-09-16 2014-09-15 Derivados de desoxinojirimicina y sus métodos de uso

Country Status (18)

Country Link
US (1) US10144727B2 (es)
EP (1) EP3046558B1 (es)
JP (1) JP6456393B2 (es)
KR (1) KR20160055916A (es)
CN (1) CN105636589B (es)
AP (1) AP2016009125A0 (es)
AU (1) AU2014318488B2 (es)
BR (1) BR112016005417A8 (es)
CA (1) CA2924026C (es)
CL (1) CL2016000597A1 (es)
CR (1) CR20160178A (es)
HK (1) HK1222129A1 (es)
IL (1) IL244446A0 (es)
MX (1) MX2016003323A (es)
PH (1) PH12016500465A1 (es)
RU (1) RU2702133C2 (es)
SG (1) SG11201601646YA (es)
WO (1) WO2015039010A2 (es)

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US9682914B2 (en) 2014-01-13 2017-06-20 P2 Science, Inc. Terpene-derived acids and esters and methods for preparing and using same
WO2015196019A1 (en) 2014-06-20 2015-12-23 P2 Science, Inc. Film ozonolysis in a tubular or multitubular reactor
US20170247314A1 (en) * 2014-08-06 2017-08-31 P2 Science, Inc. Fragrances from the esters of fatty acids
CA2966893C (en) 2014-11-05 2023-10-24 Emergent Virology Llc Iminosugars
WO2017201030A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating viral infection
US20190282558A1 (en) * 2016-05-16 2019-09-19 Emergent Virology Llc Methods of Treating Zika Virus Infection
CA3026192A1 (en) 2016-06-21 2017-12-28 P2 Science, Inc. Flow-through reactors for the continuous quenching of peroxide mixtures and methods comprising the same
US10696605B2 (en) 2016-09-16 2020-06-30 P2 Science, Inc. Uses of vanadium to oxidize aldehydes and ozonides
CN111904959A (zh) * 2020-08-21 2020-11-10 牡丹江医学院 α-L-岩藻糖苷酶抑制剂在制备治疗小儿肺炎的药物中的用途

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Also Published As

Publication number Publication date
AP2016009125A0 (en) 2016-04-30
AU2014318488A2 (en) 2016-04-28
JP6456393B2 (ja) 2019-01-23
WO2015039010A2 (en) 2015-03-19
PH12016500465B1 (en) 2016-05-16
RU2016111704A (ru) 2017-10-23
AU2014318488A1 (en) 2016-04-21
CA2924026C (en) 2021-12-28
JP2016530332A (ja) 2016-09-29
IL244446A0 (en) 2016-04-21
BR112016005417A8 (pt) 2020-02-18
US10144727B2 (en) 2018-12-04
CL2016000597A1 (es) 2017-02-24
MX2016003323A (es) 2016-08-12
PH12016500465A1 (en) 2016-05-16
US20160221993A1 (en) 2016-08-04
CA2924026A1 (en) 2015-03-19
RU2016111704A3 (es) 2018-06-09
EP3046558A2 (en) 2016-07-27
AU2014318488B2 (en) 2019-03-07
EP3046558A4 (en) 2017-06-07
HK1222129A1 (zh) 2017-06-23
KR20160055916A (ko) 2016-05-18
CN105636589B (zh) 2019-07-23
SG11201601646YA (en) 2016-04-28
RU2702133C2 (ru) 2019-10-04
CN105636589A (zh) 2016-06-01
WO2015039010A3 (en) 2015-05-07
EP3046558B1 (en) 2019-08-14

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