CR20160178A - Derivados de desoxinojirimicina y sus métodos de uso - Google Patents

Derivados de desoxinojirimicina y sus métodos de uso

Info

Publication number
CR20160178A
CR20160178A CR20160178A CR20160178A CR20160178A CR 20160178 A CR20160178 A CR 20160178A CR 20160178 A CR20160178 A CR 20160178A CR 20160178 A CR20160178 A CR 20160178A CR 20160178 A CR20160178 A CR 20160178A
Authority
CR
Costa Rica
Prior art keywords
derivatives
virus
deoxinojirimicine
methods
deoxinojirimycin
Prior art date
Application number
CR20160178A
Other languages
English (en)
Inventor
Raju Penmasta
Urban Ramstedt
Tam Nguyen
Hitesh Batra
Original Assignee
Emergent Virology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Virology Llc filed Critical Emergent Virology Llc
Publication of CR20160178A publication Critical patent/CR20160178A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente solicitud proporciona iminoazúcares novedosos y su uso en el tratamiento de infecciones virales, tales como infección de Dengue e infección de Influeza A. Los presentes inventores descubrieron que ciertos derivados de desoxinojirimicina pueden ser efectivos contra uno o más virus, los cuales pueden ser, por ejemplo, un virus de Dengue y/o un virus que pertenece a la familia Orthomyxoviridae, tal como un virus de Influenza A. En particular, estos derivados de desoxinojirimicina pueden ser útiles para tratar una enfermedad o condición causada por o asociada con uno o más virus.
CR20160178A 2013-09-16 2014-09-15 Derivados de desoxinojirimicina y sus métodos de uso CR20160178A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361878286P 2013-09-16 2013-09-16
PCT/US2014/055599 WO2015039010A2 (en) 2013-09-16 2014-09-15 Deoxynojirimycin derivatives and methods of their using

Publications (1)

Publication Number Publication Date
CR20160178A true CR20160178A (es) 2016-08-08

Family

ID=52666528

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160178A CR20160178A (es) 2013-09-16 2014-09-15 Derivados de desoxinojirimicina y sus métodos de uso

Country Status (18)

Country Link
US (1) US10144727B2 (es)
EP (1) EP3046558B1 (es)
JP (1) JP6456393B2 (es)
KR (1) KR20160055916A (es)
CN (1) CN105636589B (es)
AP (1) AP2016009125A0 (es)
AU (1) AU2014318488B2 (es)
BR (1) BR112016005417A8 (es)
CA (1) CA2924026C (es)
CL (1) CL2016000597A1 (es)
CR (1) CR20160178A (es)
HK (1) HK1222129A1 (es)
IL (1) IL244446A0 (es)
MX (1) MX2016003323A (es)
PH (1) PH12016500465B1 (es)
RU (1) RU2702133C2 (es)
SG (1) SG11201601646YA (es)
WO (1) WO2015039010A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015106293A1 (en) 2014-01-13 2015-07-16 P2 Science, Inc. Terpene-derived acids and esters and methods for preparing and using same
JP6687547B2 (ja) 2014-06-20 2020-04-22 ピー２ サイエンス，インコーポレイティド 管式又は多管式反応器における膜オゾン分解
EP3177587A4 (en) * 2014-08-06 2018-01-17 P2 Science, Inc. Fragrances from the esters of fatty acids
SG11201703330YA (en) 2014-11-05 2017-05-30 Emergent Virology Llc Iminosugars useful for the treatment of viral diseases
WO2017201030A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating viral infection
WO2017201052A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating zika virus infection
JP7028457B2 (ja) 2016-06-21 2022-03-02 ピー２・サイエンス・インコーポレイテッド 過酸化物混合物の連続クエンチのためのフロースルー反応器およびそれを含む方法
EP3512631B1 (en) 2016-09-16 2022-03-23 P2 Science, Inc. Uses of vanadium to oxidize aldehydes and ozonides
CN111904959A (zh) * 2020-08-21 2020-11-10 牡丹江医学院 α-L-岩藻糖苷酶抑制剂在制备治疗小儿肺炎的药物中的用途

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2758025A1 (de) * 1977-12-24 1979-07-12 Bayer Ag Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung
DE2834122A1 (de) 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2853573A1 (de) 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3038901A1 (de) 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3611841A1 (de) 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US4994572A (en) 1989-10-12 1991-02-19 Monsanto Company Synthesis of nojirimycin derivatives
US5200523A (en) 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
WO1995022975A1 (en) 1994-02-25 1995-08-31 G.D. Searle & Co. Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
AU761748B2 (en) 1997-12-11 2003-06-12 Chancellor, Masters And Scholars Of The University Of Oxford, The Inhibition of membrane-associated viral replication
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
GB9828474D0 (en) 1998-12-24 1999-02-17 British Aerospace Surface topology inspection
ES2311921T3 (es) 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
HK1046869A1 (zh) 1999-08-10 2003-01-30 The Chancellor, Masters And Scholars Of The University Of Oxford 使用长链n烷基化合物及其恶衍生物作为抗病毒成分
US7427758B2 (en) 2003-05-28 2008-09-23 Opto-Knowledge Systems, Inc. Cryogenically cooled adjustable apertures for infra-red cameras
FR2861991B1 (fr) * 2003-11-07 2008-01-18 Centre Nat Rech Scient Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
CA2652958C (en) 2006-05-24 2015-11-17 United Therapeutics Corporation Deoxynojirimycin and d-arabinitol analogs and methods of using
KR20090040906A (ko) 2006-08-02 2009-04-27 유나이티드 세러퓨틱스 코오포레이션 바이러스 감염의 리포솜 치료
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
WO2009118658A2 (en) 2008-03-26 2009-10-01 University Of Oxford Endoplasmic reticulum targeting liposomes
US9040488B2 (en) * 2008-09-02 2015-05-26 Baruch S. Blumberg Institute Imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity
KR101755133B1 (ko) * 2009-02-23 2017-07-06 유나이티드 세러퓨틱스 코오포레이션 이미노슈가 및 바이러스성 질환을 치료하는 방법
CN102625660B (zh) 2009-02-24 2015-03-11 联合治疗公司 亚氨基糖以及治疗沙粒病毒感染的方法
EP2410989A2 (en) 2009-03-27 2012-02-01 The Chancellor, Masters and Scholars of the University of Oxford Cholesterol level lowering liposomes
CA2765086C (en) 2009-06-12 2015-12-15 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases
CN105748476A (zh) 2009-09-04 2016-07-13 联合治疗公司 亚氨基糖以及治疗丝状病毒性疾病的方法
WO2011028781A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating poxviral infections
KR101497194B1 (ko) * 2009-09-04 2015-02-27 유나이티드 세러퓨틱스 코오포레이션 오르토믹소바이러스 감염의 치료 방법
WO2014017915A2 (en) * 2012-07-27 2014-01-30 Universiteit Utrecht Holding B.V. Urea and guanidinium derivatives of iminosugars

Also Published As

Publication number Publication date
JP2016530332A (ja) 2016-09-29
AU2014318488A2 (en) 2016-04-28
WO2015039010A3 (en) 2015-05-07
MX2016003323A (es) 2016-08-12
CA2924026A1 (en) 2015-03-19
CN105636589B (zh) 2019-07-23
AU2014318488B2 (en) 2019-03-07
US20160221993A1 (en) 2016-08-04
RU2702133C2 (ru) 2019-10-04
HK1222129A1 (zh) 2017-06-23
SG11201601646YA (en) 2016-04-28
EP3046558A2 (en) 2016-07-27
CA2924026C (en) 2021-12-28
US10144727B2 (en) 2018-12-04
PH12016500465A1 (en) 2016-05-16
CL2016000597A1 (es) 2017-02-24
WO2015039010A2 (en) 2015-03-19
IL244446A0 (en) 2016-04-21
EP3046558B1 (en) 2019-08-14
RU2016111704A (ru) 2017-10-23
KR20160055916A (ko) 2016-05-18
AU2014318488A1 (en) 2016-04-21
AP2016009125A0 (en) 2016-04-30
CN105636589A (zh) 2016-06-01
EP3046558A4 (en) 2017-06-07
RU2016111704A3 (es) 2018-06-09
PH12016500465B1 (en) 2016-05-16
JP6456393B2 (ja) 2019-01-23
BR112016005417A8 (pt) 2020-02-18

Similar Documents

Publication Publication Date Title
CR20160178A (es) Derivados de desoxinojirimicina y sus métodos de uso
CL2016000493A1 (es) Inhibidores de polimerasa hcv.
CL2016000381A1 (es) Compuestos antivirales
CL2014003634A1 (es) Inhibidores del virus de la hepatitis c
CL2016000805A1 (es) Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
EA201791460A1 (ru) N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
CL2018000684A1 (es) Moduladores de la proteína de núcleo de la hepatitis b.
MX381896B (es) Compuestos de tiazolida para el tratamiento de infecciones virales.
ECSP14013315A (es) Inhibidores de aplicación viral
CL2015003615A1 (es) Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
CL2016001120A1 (es) Compuestos derivados de pirrolo1,2-f1,2,4triazina ,composición farmacéutica que los comprende y su uso en el tratamiento de una infección por virus sincicial compuestos intermediarios. pct
MX2011011331A (es) Moleculas de union humanas capaces de neutralizar el virus de la influenza h3n2 y usos de las mismas.
CL2015001916A1 (es) Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral.
EA201790266A1 (ru) Индолы для применения при инфекции, вызванной вирусом гриппа
EA201790571A1 (ru) Пирролопиримидины для применения при инфекции, вызванной вирусом гриппа
MX2015011473A (es) Compuesto de fosforamidato de nucleosido novedoso y su uso.
CL2012001959A1 (es) Compuestos derivados del acido tiofeno-2-carboxilico, inhibidores de virus flaviviridae; composicion farmaceutica que los comprende; y su uso para el tratamiento de una infeccion viral por flaviviridae.
MX2016003199A (es) Compuestos de azapiridona y usos de los mismos.
CO6761335A2 (es) Inhibidores del virus de la hepatitis c
DOP2016000336A (es) Derivados de isoindolina para uso en el tratamiento de una infeccion viral
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
PE20170185A1 (es) Composiciones farmaceuticas para tratar enfermedades infecciosas
BR112016024096A2 (pt) novo bacteriófago e composição compreendendo o mesmo
CL2016000300A1 (es) Métodos terapéuticos
CL2015003358A1 (es) Compuestos derivados de nucleósidos 4'-azido-3'-desoxi-3'-fluoro sustituidos; composición farmacéutica que comprende a dichos compuestos y el uso de los mismos para tratar una infección del virus de la hepatitis c (hcv).