CR20180060A - Proteínas inhibidores de insectos novedosas. - Google Patents
Proteínas inhibidores de insectos novedosas.Info
- Publication number
- CR20180060A CR20180060A CR20180060A CR20180060A CR20180060A CR 20180060 A CR20180060 A CR 20180060A CR 20180060 A CR20180060 A CR 20180060A CR 20180060 A CR20180060 A CR 20180060A CR 20180060 A CR20180060 A CR 20180060A
- Authority
- CR
- Costa Rica
- Prior art keywords
- tic5290
- nucleic acid
- recombinant nucleic
- novedous
- insects
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 241000238631 Hexapoda Species 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 241000254173 Coleoptera Species 0.000 abstract 3
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 241000258937 Hemiptera Species 0.000 abstract 2
- 241000255777 Lepidoptera Species 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/22—Bacillus
- A01N63/23—B. thuringiensis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pest Control & Pesticides (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Insects & Arthropods (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Botany (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
Se describe una clase de proteína pesticida que presenta actividad tóxica contra especies de plagas de coleópteros, lepidópteros y hemípteros, e incluye, entre otros, TIC5290. Se proporcionan construcciones de ADN que contienen una secuencia de ácido nucleico recombinante que codifica TIC5290. Se proporcionan plantas, células de plantas, semillas y partes de plantas transgénicas que contienen secuencias de ácido nucleico recombinante que codifican TIC5290. También se proporcionan métodos para detectar la presencia de las secuencias de ácido nucleico recombinante o TIC5290 en una muestra biológica, y métodos para controlar plagas de especies de coleópteros, lepidópteros y hemípteros que utilizan TIC5290.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199024P | 2015-07-30 | 2015-07-30 | |
| PCT/US2016/044296 WO2017019787A1 (en) | 2015-07-30 | 2016-07-27 | Novel insect inhibitory proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20180060A true CR20180060A (es) | 2018-07-09 |
Family
ID=57885446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20180060A CR20180060A (es) | 2015-07-30 | 2016-07-27 | Proteínas inhibidores de insectos novedosas. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10100330B2 (es) |
| EP (1) | EP3328187B1 (es) |
| JP (1) | JP6933641B2 (es) |
| CN (1) | CN107849571B (es) |
| AR (1) | AR105768A1 (es) |
| BR (1) | BR112018001379B1 (es) |
| CA (1) | CA2992084A1 (es) |
| CL (1) | CL2018000227A1 (es) |
| CO (1) | CO2018000801A2 (es) |
| CR (1) | CR20180060A (es) |
| EC (1) | ECSP18006878A (es) |
| ES (1) | ES2904255T3 (es) |
| HR (1) | HRP20211858T1 (es) |
| HU (1) | HUE057364T2 (es) |
| MX (1) | MX378742B (es) |
| NI (1) | NI201800013A (es) |
| PE (1) | PE20180775A1 (es) |
| PY (1) | PY1648650A (es) |
| RU (1) | RU2765310C2 (es) |
| SV (1) | SV2018005620A (es) |
| UA (1) | UA126327C2 (es) |
| WO (1) | WO2017019787A1 (es) |
| ZA (1) | ZA201800227B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20180775A1 (es) * | 2015-07-30 | 2018-05-07 | Monsanto Technology Llc | Proteinas inhibidoras de insectos novedosas |
| CN109952024B (zh) * | 2016-10-10 | 2023-11-03 | 孟山都技术公司 | 新型昆虫抑制蛋白 |
| EP3691453A4 (en) | 2017-10-02 | 2021-07-07 | Syngenta Participations AG | MANIPULATED PESTICIDE PROTEINS AND METHODS OF CONTROLLING PLANT PESTURES |
| WO2019126479A1 (en) * | 2017-12-22 | 2019-06-27 | AgBiome, Inc. | Pesticidal genes and methods of use |
| CA3100392A1 (en) * | 2018-09-25 | 2020-04-02 | Monsanto Technology Llc | Novel insect inhibitory proteins |
| CN115426875A (zh) | 2020-04-24 | 2022-12-02 | 孟山都技术公司 | 转基因玉米事件mon95275以及其检测方法和用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849870A (en) * | 1993-03-25 | 1998-12-15 | Novartis Finance Corporation | Pesticidal proteins and strains |
| AU5098398A (en) * | 1996-10-30 | 1998-05-22 | Mycogen Corporation | Novel pesticidal toxins and nucleotide sequences which encode these toxins |
| US6551962B1 (en) | 2000-10-06 | 2003-04-22 | Monsanto Technology Llc | Method for deploying a transgenic refuge |
| US7304162B2 (en) * | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| CN1849397B (zh) * | 2003-07-07 | 2014-06-04 | 孟山都技术有限公司 | 苏云金芽孢杆菌分泌的杀虫蛋白及其应用 |
| MXPA06007005A (es) * | 2003-12-16 | 2008-02-14 | Monsanto Technology Llc | Composiciones de proteinas y genes secretados de bacillus thuringiensis y usos de las mismas. |
| US8946510B2 (en) | 2004-04-09 | 2015-02-03 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
| ATE505548T1 (de) * | 2005-08-31 | 2011-04-15 | Monsanto Technology Llc | Insektizidzusammensetzungen und verfahren zur herstellung von insektenbeständigen transgenen pflanzen |
| CL2007002135A1 (es) | 2006-07-21 | 2008-03-14 | Pioneer Hi Bred Int | Acido nucleico de bacillus thuringiensis que codifican polipeptidos con actividad plaguicida; construccion de adn y celula huesped que lo comprenden; metodo de proteccion de una planta contra una plaga; polipeptidos y metodo de produccion; y composic |
| KR20090054965A (ko) | 2006-07-21 | 2009-06-01 | 파이어니어 하이-브레드 인터내셔날 인코포레이티드 | 신규한 유전자를 동정하는 방법 |
| US7772465B2 (en) | 2007-06-26 | 2010-08-10 | Pioneer Hi-Bred International, Inc. | Bacillus thuringiensis gene with lepidopteran activity |
| US8283524B2 (en) | 2008-05-15 | 2012-10-09 | Pioneer Hi-Bred International, Inc | Bacillus thuringiensis gene with lepidopteran activity |
| CN102076858B (zh) | 2008-06-11 | 2013-10-30 | 先锋国际良种公司 | 具有鳞翅目活性的新的苏云金芽孢杆菌基因 |
| US8445749B2 (en) | 2008-09-19 | 2013-05-21 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
| US20100077507A1 (en) | 2008-09-22 | 2010-03-25 | Pioneer Hi-Bred International, Inc. | Novel Bacillus Thuringiensis Gene with Lepidopteran Activity |
| WO2010085295A2 (en) | 2009-01-23 | 2010-07-29 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| CA3081727A1 (en) * | 2009-02-27 | 2010-09-02 | BASF Agricultural Solutions Seed US LLC | Pesticidal proteins and methods for their use |
| CA2780540A1 (en) | 2009-11-12 | 2011-05-19 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| US8586832B2 (en) | 2009-12-21 | 2013-11-19 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with Lepidopteran activity |
| CA2807375A1 (en) | 2010-08-19 | 2012-02-23 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| WO2012092106A1 (en) | 2010-12-28 | 2012-07-05 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
| AU2012214420B2 (en) * | 2011-02-11 | 2017-03-02 | Monsanto Technology Llc | Pesticidal nucleic acids and proteins and uses thereof |
| BR112013025834B1 (pt) | 2011-04-07 | 2021-10-05 | Monsanto Technology Llc | Molécula de ácido nucleico recombinante codificadora de proteína pesticida, composição inibidora de insetos, e método para controlar uma praga de espécies de lepidóptero e/ou hemíptero |
| CA2844913A1 (en) * | 2011-08-19 | 2013-02-28 | Synthetic Genomics, Inc. | Integrated method for high-throughput identification of novel pesticidal compositions and uses therefor |
| US9974302B2 (en) * | 2013-08-09 | 2018-05-22 | Monsanto Technology Llc | Pesticidal toxin active against coleopteran and/or hemipteran insects |
| PE20180775A1 (es) * | 2015-07-30 | 2018-05-07 | Monsanto Technology Llc | Proteinas inhibidoras de insectos novedosas |
-
2016
- 2016-07-27 PE PE2018000135A patent/PE20180775A1/es unknown
- 2016-07-27 ES ES16831304T patent/ES2904255T3/es active Active
- 2016-07-27 RU RU2018107162A patent/RU2765310C2/ru active
- 2016-07-27 CN CN201680043100.XA patent/CN107849571B/zh active Active
- 2016-07-27 WO PCT/US2016/044296 patent/WO2017019787A1/en not_active Ceased
- 2016-07-27 BR BR112018001379-0A patent/BR112018001379B1/pt active IP Right Grant
- 2016-07-27 CA CA2992084A patent/CA2992084A1/en active Pending
- 2016-07-27 EP EP16831304.7A patent/EP3328187B1/en active Active
- 2016-07-27 MX MX2018001258A patent/MX378742B/es unknown
- 2016-07-27 JP JP2018504868A patent/JP6933641B2/ja active Active
- 2016-07-27 CR CR20180060A patent/CR20180060A/es unknown
- 2016-07-27 HR HRP20211858TT patent/HRP20211858T1/hr unknown
- 2016-07-27 US US15/221,544 patent/US10100330B2/en active Active
- 2016-07-27 HU HUE16831304A patent/HUE057364T2/hu unknown
- 2016-07-27 UA UAA201802018A patent/UA126327C2/uk unknown
- 2016-07-29 PY PY201601648650A patent/PY1648650A/es unknown
- 2016-07-29 AR ARP160102316A patent/AR105768A1/es unknown
-
2018
- 2018-01-12 ZA ZA2018/00227A patent/ZA201800227B/en unknown
- 2018-01-26 CO CONC2018/0000801A patent/CO2018000801A2/es unknown
- 2018-01-26 NI NI201800013A patent/NI201800013A/es unknown
- 2018-01-26 SV SV2018005620A patent/SV2018005620A/es unknown
- 2018-01-26 CL CL2018000227A patent/CL2018000227A1/es unknown
- 2018-01-29 EC ECIEPI20186878A patent/ECSP18006878A/es unknown
- 2018-06-07 US US16/002,994 patent/US20180346925A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20211858T1 (hr) | 2022-03-04 |
| BR112018001379A2 (pt) | 2018-09-11 |
| RU2018107162A (ru) | 2019-08-28 |
| US10100330B2 (en) | 2018-10-16 |
| HUE057364T2 (hu) | 2022-05-28 |
| US20170044568A1 (en) | 2017-02-16 |
| WO2017019787A1 (en) | 2017-02-02 |
| MX378742B (es) | 2025-03-10 |
| RU2018107162A3 (es) | 2020-01-28 |
| SV2018005620A (es) | 2018-08-31 |
| EP3328187A4 (en) | 2019-01-09 |
| EP3328187A1 (en) | 2018-06-06 |
| CL2018000227A1 (es) | 2018-04-27 |
| UA126327C2 (uk) | 2022-09-21 |
| NI201800013A (es) | 2018-06-12 |
| PE20180775A1 (es) | 2018-05-07 |
| ZA201800227B (en) | 2018-12-19 |
| RU2765310C2 (ru) | 2022-01-28 |
| PY1648650A (es) | 2018-10-01 |
| JP6933641B2 (ja) | 2021-09-08 |
| CN107849571B (zh) | 2022-04-19 |
| US20180346925A1 (en) | 2018-12-06 |
| MX2018001258A (es) | 2018-04-20 |
| CN107849571A (zh) | 2018-03-27 |
| CA2992084A1 (en) | 2017-02-02 |
| ECSP18006878A (es) | 2018-04-30 |
| AR105768A1 (es) | 2017-11-08 |
| BR112018001379B1 (pt) | 2024-04-30 |
| JP2018525987A (ja) | 2018-09-13 |
| CO2018000801A2 (es) | 2018-04-10 |
| ES2904255T3 (es) | 2022-04-04 |
| EP3328187B1 (en) | 2021-11-10 |
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