CR20190204A - Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer - Google Patents

Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer

Info

Publication number
CR20190204A
CR20190204A CR20190204A CR20190204A CR20190204A CR 20190204 A CR20190204 A CR 20190204A CR 20190204 A CR20190204 A CR 20190204A CR 20190204 A CR20190204 A CR 20190204A CR 20190204 A CR20190204 A CR 20190204A
Authority
CR
Costa Rica
Prior art keywords
treatment
pyrazolo
tetrahydro
cancer
derivatives useful
Prior art date
Application number
CR20190204A
Other languages
English (en)
Inventor
James Stewart Scott
Johannes Wilhelmus Maria Nissink
Samantha Jayne HUGHES
Bernard Christophe Barlaam
Bin Yang
Thomas Andrew MOSS
Daniel Hillebrand O'DONOVAN
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR20190204A publication Critical patent/CR20190204A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La memoria descriptiva se refiere a compuestos de Fórmula (I):(I) y a sales farmacéuticamente aceptables de los mismos, a procesos e intermedios usados para su preparación, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos proliferativos celulares.The specification relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.
CR20190204A 2016-10-24 2017-10-13 Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer CR20190204A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662411799P 2016-10-24 2016-10-24
US201662435159P 2016-12-16 2016-12-16
PCT/EP2017/076191 WO2018077630A1 (en) 2016-10-24 2017-10-13 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer

Publications (1)

Publication Number Publication Date
CR20190204A true CR20190204A (es) 2019-06-11

Family

ID=60083331

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190204A CR20190204A (es) 2016-10-24 2017-10-13 Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer

Country Status (36)

Country Link
US (5) US10131663B2 (es)
EP (2) EP3433256B1 (es)
JP (2) JP6744489B2 (es)
KR (1) KR102178692B1 (es)
CN (2) CN114656464B (es)
AU (1) AU2017349797B2 (es)
CL (1) CL2019001077A1 (es)
CO (1) CO2019003950A2 (es)
CR (1) CR20190204A (es)
CY (2) CY1122566T1 (es)
DK (2) DK3640251T3 (es)
DO (1) DOP2019000104A (es)
EC (1) ECSP19028657A (es)
ES (2) ES2751902T3 (es)
HR (1) HRP20220255T1 (es)
HU (2) HUE057524T2 (es)
IL (1) IL266245B (es)
JO (1) JOP20190090B1 (es)
LT (2) LT3640251T (es)
ME (1) ME03547B (es)
MX (1) MX382331B (es)
MY (1) MY205300A (es)
NI (1) NI201900039A (es)
NZ (1) NZ753459A (es)
PE (1) PE20191078A1 (es)
PH (1) PH12019500830A1 (es)
PL (2) PL3433256T3 (es)
PT (2) PT3640251T (es)
RS (1) RS59445B1 (es)
SG (1) SG11201903182XA (es)
SI (2) SI3640251T1 (es)
SM (2) SMT202200098T1 (es)
TW (1) TWI735681B (es)
UA (1) UA125824C2 (es)
WO (1) WO2018077630A1 (es)
ZA (1) ZA201900694B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102710603B1 (ko) 2015-10-01 2024-09-27 올레마 파마슈티컬스 인코포레이티드 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물
US9969732B2 (en) * 2016-04-08 2018-05-15 Genentech, Inc. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof
US10125135B2 (en) 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
WO2018019793A1 (en) 2016-07-25 2018-02-01 Astrazeneca Ab N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer
TWI735681B (zh) 2016-10-24 2021-08-11 瑞典商阿斯特捷利康公司 化合物
LT3555097T (lt) 2016-12-16 2022-08-25 Janssen Pharmaceutica Nv Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
PT3494116T (pt) 2017-01-30 2020-01-28 Astrazeneca Ab Moduladores de recetores de estrogénio
WO2019002442A1 (en) * 2017-06-29 2019-01-03 Astrazeneca Ab CHEMICAL COMPOUNDS
WO2019002441A1 (en) * 2017-06-29 2019-01-03 Astrazeneca Ab CHEMICAL COMPOUNDS
US11236088B2 (en) 2017-11-14 2022-02-01 Kind Pharmaceutical Heterocyclic compounds and their application in medicine
IL279348B2 (en) 2018-06-15 2026-01-01 Reata Pharmaceuticals Inc Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
CA3109090A1 (en) 2018-08-17 2020-02-20 F. Hoffmann-La Roche Ag Diagnostic and therapeutic methods for the treatment of breast cancer
CN109053524A (zh) * 2018-09-11 2018-12-21 山东谛爱生物技术有限公司 一种N-Boc-3-羟基氮杂环丁烷的制备方法
MX2022000279A (es) 2019-07-07 2022-02-03 Olema Pharmaceuticals Inc Regimenes de antagonistas del receptor de estrogeno.
WO2021127039A1 (en) * 2019-12-20 2021-06-24 Recurium Ip Holdings, Llc Combinations
CN114746424B (zh) * 2020-01-10 2023-06-16 江苏恒瑞医药股份有限公司 三环四氢异喹啉类衍生物、其制备方法及其在医药上的应用
WO2021214253A1 (en) * 2020-04-24 2021-10-28 Astrazeneca Ab Dosage regimen for the treatment of cancer
PE20221838A1 (es) * 2020-04-24 2022-11-29 Astrazeneca Ab Formulaciones farmaceuticas
AU2021269612A1 (en) 2020-05-15 2023-01-05 Jiangsu Simcere Pharmaceutical Co., Ltd. Pyrrolidine compound and use thereof
WO2021249533A1 (zh) * 2020-06-12 2021-12-16 江苏先声药业有限公司 雌激素受体调节剂化合物及其用途
EP4174059A4 (en) * 2020-06-28 2024-07-03 Medshine Discovery Inc. INDAZOLE FUSED CYCLIC COMPOUND
CN114105977B (zh) * 2020-08-28 2023-09-01 先声再明医药有限公司 雌激素受体调节剂化合物及其用途
KR20220107752A (ko) 2021-01-26 2022-08-02 충북대학교 산학협력단 피라졸로퀴놀린 유도체 및 이의 항암제로서의 용도
CN116669729A (zh) * 2021-02-08 2023-08-29 贝达药业股份有限公司 杂芳基并哌啶类衍生物及其药物组合物和应用
BR112023018286A2 (pt) 2021-03-11 2023-10-31 Janssen Pharmaceutica Nv Lorpucitinib para uso no tratamento de distúrbios mediados por jak
US12410155B2 (en) 2021-12-28 2025-09-09 Zhejiang Yangli Pharmaceutical Technology Co., Ltd. Salt form and crystal form of tetrahydrocyclohepta indazole compound
WO2024083716A1 (en) 2022-10-17 2024-04-25 Astrazeneca Ab Combinations of a serd for the treatment of cancer
EP4615431A1 (en) 2022-11-11 2025-09-17 Astrazeneca AB Combination therapies for the treatment of cancer
US20240180893A1 (en) * 2022-11-17 2024-06-06 Astrazeneca Ab Methods of treatment of breast cancer
EP4709386A1 (en) 2023-05-11 2026-03-18 Astrazeneca AB Combination of a parp1 inhibitor and a selective estrogen degrader for treating cancer
WO2025175249A1 (en) * 2024-02-14 2025-08-21 Olema Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
TW202543650A (zh) 2024-03-08 2025-11-16 美商海爾達醫療運營公司 異雙官能化合物及其在治療疾病中之用途

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ES2349762T3 (es) 2000-08-10 2011-01-11 Pfizer Italia S.R.L. Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
TW200716628A (en) 2005-03-22 2007-05-01 Astrazeneca Ab Novel compounds
FR2884252B1 (fr) 2005-04-08 2007-05-18 Aventis Pharma Sa Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90
AR058223A1 (es) 2005-11-25 2008-01-23 Palau Pharma Sa Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto
EP2223925A1 (en) 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20120157401A1 (en) 2009-05-27 2012-06-21 Ptc Therapeutics, Inc. Methods for treating neurofibromatosis
US20120157402A1 (en) 2009-05-27 2012-06-21 Liangxian Cao Methods for treating brain tumors
MX373926B (es) 2009-05-27 2020-07-10 Ptc Therapeutics Inc Metodos para tratar cancer y estados no neoplasicos.
HUE033581T2 (hu) 2010-06-10 2017-12-28 Seragon Pharmaceuticals Inc Ösztrogén receptor modulátorok és alkalmazásaik
US8853423B2 (en) 2010-06-17 2014-10-07 Seragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
CA2819299A1 (en) 2010-12-24 2012-06-28 Merck Sharp & Dohme B.V. N-substituted azetidine derivatives
JP6112625B2 (ja) 2011-12-14 2017-04-12 セラゴン ファーマシューティカルズ，インク． フッ素化したエストロゲン受容体モジュレーターおよびその使用
TWI653235B (zh) 2013-05-28 2019-03-11 阿斯特捷利康公司 作為抗癌劑之吲哚衍生物
BR112015030595A2 (pt) 2013-06-19 2017-07-25 Seragon Pharmaceuticals Inc moduladores de receptor de estrogênio de azetidina e usos dos mesmos
EA031077B1 (ru) 2013-06-19 2018-11-30 Серагон Фармасьютикалз, Инк. Модулятор рецептора эстрогена и его применения
WO2015092634A1 (en) 2013-12-16 2015-06-25 Novartis Ag 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders
CN107406424B (zh) * 2014-12-18 2020-08-25 豪夫迈·罗氏有限公司 雌激素受体调节剂及其用途
KR102785474B1 (ko) * 2014-12-18 2025-03-26 에프. 호프만-라 로슈 아게 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도
EP3233818A1 (en) 2014-12-18 2017-10-25 F. Hoffmann-La Roche AG Derivatives of 2,3-diphenylchromene useful for the treatment of cancer
WO2016174551A1 (en) 2015-04-27 2016-11-03 Pfizer Inc. Anti-estrogenic compounds
EP3303326B1 (en) 2015-05-26 2020-12-16 H. Hoffnabb-La Roche Ag Heterocyclic estrogen receptor modulators and uses thereof
KR20180012853A (ko) * 2015-06-16 2018-02-06 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피페리딘 유도체 및 이의 제조 방법 및 약학적 용도
CN106518768B (zh) 2015-09-15 2021-07-02 江苏恒瑞医药股份有限公司 丙烯酸类衍生物、其制备方法及其在医药上的应用
KR102710603B1 (ko) 2015-10-01 2024-09-27 올레마 파마슈티컬스 인코포레이티드 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물
US10399939B2 (en) 2015-11-09 2019-09-03 Genentech, Inc. Tetrahydronaphthalene estrogen receptor modulators and uses thereof
US10519148B2 (en) 2015-11-12 2019-12-31 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
MX2018007844A (es) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo.
US9969732B2 (en) * 2016-04-08 2018-05-15 Genentech, Inc. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof
US10125135B2 (en) 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
WO2017182495A1 (en) 2016-04-20 2017-10-26 Astrazeneca Ab Indazole derivatives that down-regulate the estrogen receptor and possess anti-cancer activity
WO2017192991A1 (en) 2016-05-06 2017-11-09 Xavier University Of Louisiana Selective estrogen receptor down-regulators (serds)
WO2018001232A1 (zh) 2016-06-29 2018-01-04 浙江海正药业股份有限公司 丙烯酸类衍生物及其制备方法和其在医药上的用途
WO2018019793A1 (en) 2016-07-25 2018-02-01 Astrazeneca Ab N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer
CN107814798B (zh) 2016-09-14 2020-11-03 四川科伦博泰生物医药股份有限公司 3-取代丙烯酸类化合物及其制备方法和用途
WO2018053354A1 (en) 2016-09-15 2018-03-22 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
TWI735681B (zh) 2016-10-24 2021-08-11 瑞典商阿斯特捷利康公司 化合物
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono
EP3555064B9 (en) 2016-12-16 2023-03-01 Pfizer Inc. Glp-1 receptor agonists and uses thereof
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
KR102276022B1 (ko) 2016-12-16 2021-07-13 일라이 릴리 앤드 캄파니 돌연변이체 idh1 및 idh2 억제제로서의 7-페닐에틸아미노-4h-피리미도[4,5-d][1,3]옥사진-2-온 화합물
LT3555097T (lt) 2016-12-16 2022-08-25 Janssen Pharmaceutica Nv Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
CA3045224A1 (en) 2016-12-16 2018-06-21 Basf Se Pesticidal compounds
ES2866152T3 (es) 2017-01-30 2021-10-19 Chiesi Farm Spa Derivados de tirosina amida como inhibidores de la Rho-quinasa

Also Published As

Publication number Publication date
NI201900039A (es) 2020-05-15
JP6744489B2 (ja) 2020-08-19
DOP2019000104A (es) 2019-05-15
IL266245A (en) 2019-06-30
CL2019001077A1 (es) 2019-06-21
HUE057524T2 (hu) 2022-05-28
NZ753459A (en) 2023-01-27
PT3640251T (pt) 2022-02-22
PH12019500830A1 (en) 2019-07-24
US10961241B2 (en) 2021-03-30
US20240383895A1 (en) 2024-11-21
CN114656464A (zh) 2022-06-24
LT3433256T (lt) 2019-11-11
DK3640251T3 (da) 2022-03-07
SG11201903182XA (en) 2019-05-30
DK3433256T3 (da) 2019-10-28
HUE045714T2 (hu) 2020-01-28
SMT202200098T1 (it) 2022-03-21
EP3640251A1 (en) 2020-04-22
WO2018077630A1 (en) 2018-05-03
PL3433256T3 (pl) 2020-01-31
RS59445B1 (sr) 2019-11-29
SI3640251T1 (sl) 2022-04-29
PE20191078A1 (es) 2019-08-20
US20180111931A1 (en) 2018-04-26
ME03547B (me) 2020-07-20
ES2907759T3 (es) 2022-04-26
JOP20190090A1 (ar) 2019-04-23
AU2017349797A1 (en) 2019-05-30
ES2751902T3 (es) 2020-04-02
US20210284636A1 (en) 2021-09-16
MX382331B (es) 2025-03-13
HRP20220255T1 (hr) 2022-04-29
CN109843888A (zh) 2019-06-04
IL266245B (en) 2021-05-31
EP3433256B1 (en) 2019-08-07
JP6993477B2 (ja) 2022-01-13
ZA201900694B (en) 2024-09-25
JP2019537570A (ja) 2019-12-26
SMT201900602T1 (it) 2019-11-13
AU2017349797B2 (en) 2020-05-21
MX2019004685A (es) 2019-08-21
US12077530B2 (en) 2024-09-03
US10590130B2 (en) 2020-03-17
CN114656464B (zh) 2024-10-15
KR102178692B1 (ko) 2020-11-13
JP2020186250A (ja) 2020-11-19
JOP20190090B1 (ar) 2023-03-28
TW201829403A (zh) 2018-08-16
CN109843888B (zh) 2022-03-01
US20190100520A1 (en) 2019-04-04
US10131663B2 (en) 2018-11-20
MY205300A (en) 2024-10-11
CY1122566T1 (el) 2021-01-27
EP3433256A1 (en) 2019-01-30
EP3640251B1 (en) 2021-12-08
TWI735681B (zh) 2021-08-11
SI3433256T1 (sl) 2019-11-29
ECSP19028657A (es) 2019-04-30
CO2019003950A2 (es) 2019-04-30
CY1125292T1 (el) 2024-02-16
LT3640251T (lt) 2022-03-10
KR20190066054A (ko) 2019-06-12
US20200239467A1 (en) 2020-07-30
BR112019007393A2 (pt) 2019-07-02
PL3640251T3 (pl) 2022-04-11
CA3040040A1 (en) 2018-05-03
UA125824C2 (uk) 2022-06-15
PT3433256T (pt) 2019-10-31

Similar Documents

Publication Publication Date Title
NI201900039A (es) Derivados de 6, 7, 8, 9-tetrahidro-3h-pirazolo[4, 3-f] isoquinolina útiles en el tratamiento del cáncer
ECSP20070854A (es) Compuestos heteroaril tetracíclicos
DOP2021000183A (es) Compuestos tricíclicos condensados útiles como agentes anticancerígenos
UY38001A (es) Compuestos que inhiben las proteínas ras mutantes g12c
ECSP24028270A (es) Compuestos espirocíclicos
CO2018004857A2 (es) Derivados de dihidroimidazopirazinona usados en el tratamiento del cáncer
NI201200184A (es) Morfolinopirimidinas y su uso en terapia
UY35590A (es) Nuevos compuestos para el tratamiento del cáncer
UY35275A (es) Derivados de aminopirazina
CO2019008941A2 (es) Moduladores del receptor de estrógeno
CL2020001277A1 (es) Derivados de piridinona y su uso como inhibidores selectivos de alk-2.
ECSP18056196A (es) Derivados de indano
UY36958A (es) Compuestos para administración intracelular