CR20190589A - Sensor y sistema de detección - Google Patents

Sensor y sistema de detección

Info

Publication number
CR20190589A
CR20190589A CR20190589A CR20190589A CR20190589A CR 20190589 A CR20190589 A CR 20190589A CR 20190589 A CR20190589 A CR 20190589A CR 20190589 A CR20190589 A CR 20190589A CR 20190589 A CR20190589 A CR 20190589A
Authority
CR
Costa Rica
Prior art keywords
electrodes
polynucleotide chains
nucleic acid
stranded nucleic
acid polymer
Prior art date
Application number
CR20190589A
Other languages
English (en)
Inventor
John Moon
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of CR20190589A publication Critical patent/CR20190589A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Burglar Alarm Systems (AREA)
  • Geophysics And Detection Of Objects (AREA)

Abstract

Un sensor incluye dos electrodos y un canal modulable conductor de electricidad unido a los dos electrodos. El canal modulable conductor de electricidad incluye un polímero de ácido nucleico parcialmente bicatenario modificado, polímero de ácido nucleico parcialmente bicatenario conectado eléctricamente a los dos electrodos y uniendo el espacio entre los dos electrodos. El polímero de ácido nucleico parcialmente bicatenario modificado incluye dos cadenas polinucleotídicas parcialmente unidas entre sí, un hueco en una primera cadena de las cadenas polinucleotídicas en las que faltan bases nucleotídicas y una pluralidad de bases nucleotídicas de una segunda cadena de las cadenas polinucleotídicas expuestas en el hueco en la primera de las cadenas polinucleotídicas.
CR20190589A 2018-06-29 2019-06-13 Sensor y sistema de detección CR20190589A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862692468P 2018-06-29 2018-06-29
NL2021376A NL2021376B1 (en) 2018-06-29 2018-07-23 Sensor and sensing system
PCT/US2019/036979 WO2020005557A1 (en) 2018-06-29 2019-06-13 Sensor and sensing system

Publications (1)

Publication Number Publication Date
CR20190589A true CR20190589A (es) 2020-02-26

Family

ID=67001730

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190589A CR20190589A (es) 2018-06-29 2019-06-13 Sensor y sistema de detección

Country Status (21)

Country Link
US (2) US11332786B2 (es)
EP (1) EP3587591B1 (es)
JP (1) JP7034185B2 (es)
KR (2) KR20200026214A (es)
CN (2) CN110656035B (es)
AU (1) AU2019279958B2 (es)
BR (1) BR112019028107A2 (es)
CA (1) CA3064903C (es)
CL (1) CL2019003785A1 (es)
CO (1) CO2019014758A2 (es)
CR (1) CR20190589A (es)
IL (1) IL271292A (es)
MX (1) MX2019015851A (es)
NL (1) NL2021376B1 (es)
PE (1) PE20220582A1 (es)
PH (1) PH12019502904A1 (es)
RU (1) RU2747795C1 (es)
SG (1) SG11201913460RA (es)
TW (1) TWI699528B (es)
WO (1) WO2020005557A1 (es)
ZA (1) ZA201908277B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2021376B1 (en) * 2018-06-29 2020-01-06 Illumina Inc Sensor and sensing system
TWI803855B (zh) * 2020-04-21 2023-06-01 美商西方數位科技公司 用於定序核酸之系統及裝置、定序複數個ｓ個核酸股之方法及減輕由於使用單分子感測器陣列之核酸定序程序而產生之定序資料之錯誤之方法
US20230175059A1 (en) * 2020-05-04 2023-06-08 Illumina, Inc. Compositions and methods for sequencing using polymer bridges
CN115698329A (zh) 2020-05-11 2023-02-03 伊鲁米纳公司 包括偶联至电极的颗粒的装置及其制造和使用方法
CA3182087A1 (en) * 2020-06-30 2022-01-06 Illumina, Inc. Compositions and methods for sequencing using at least electrical characteristics
KR20230030582A (ko) * 2020-06-30 2023-03-06 일루미나, 싱가포르 피티이 엘티디 전극들 사이의 브리지들의 전기적 특성들을 적어도 변경하는 것을 사용하여 서열분석하기 위한 조성물들 및 방법들
CN112525961A (zh) * 2020-10-28 2021-03-19 重庆第二师范学院 一种基于纳米复合材料的生物传感器及其构建方法
US12385873B2 (en) 2020-12-25 2025-08-12 Aurangzeb Nafees Nagy Detection of target nucleic acid molecules
EP4314333A1 (en) * 2021-03-30 2024-02-07 Illumina, Inc. Compositions and methods for sequencing using polymers with metal-coated regions and exposed regions
US12493024B2 (en) 2021-03-31 2025-12-09 Illumina, Inc. Scalable circuit for molecular detection

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US6399303B1 (en) * 1999-04-07 2002-06-04 Integrated Nano-Technologies, Llc High resolution DNA detection methods and devices
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US20020072054A1 (en) 2000-12-13 2002-06-13 The Regents Of The University Of California Sensor using impedance change to detect the end-point for PCR DNA amplification
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WO2010132727A1 (en) * 2009-05-13 2010-11-18 University Of Southern California Electrical wiring of polynucleotides for nanoelectronic applications
KR101220869B1 (ko) * 2010-01-05 2013-01-11 한국생명공학연구원 Ｄｎａ를 이용한 금속 나노와이어 제조 및 ｄｎａ 측정 방법
CN102384934A (zh) * 2011-09-23 2012-03-21 东南大学 在纳米孔表面制备纳米间隙电极的方法
KR101974577B1 (ko) * 2012-05-21 2019-05-02 삼성전자주식회사 나노입자 제작용 주형 및 이를 이용한 나노입자의 제조 방법
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NL2021376B1 (en) * 2018-06-29 2020-01-06 Illumina Inc Sensor and sensing system

Also Published As

Publication number Publication date
TW202001237A (zh) 2020-01-01
JP7034185B2 (ja) 2022-03-11
IL271292A (en) 2020-01-30
JP2021501562A (ja) 2021-01-21
US20220259650A1 (en) 2022-08-18
BR112019028107A2 (pt) 2020-07-14
PE20220582A1 (es) 2022-04-20
RU2747795C1 (ru) 2021-05-14
CN110656035A (zh) 2020-01-07
AU2019279958A1 (en) 2020-01-16
US11332786B2 (en) 2022-05-17
SG11201913460RA (en) 2020-01-30
ZA201908277B (en) 2022-07-27
CA3064903A1 (en) 2019-12-29
NL2021376B1 (en) 2020-01-06
CL2019003785A1 (es) 2020-07-10
EP3587591B1 (en) 2022-10-05
KR20210135345A (ko) 2021-11-12
TWI699528B (zh) 2020-07-21
CN212199257U (zh) 2020-12-22
US20200002758A1 (en) 2020-01-02
WO2020005557A1 (en) 2020-01-02
CO2019014758A2 (es) 2020-01-17
KR20200026214A (ko) 2020-03-10
CA3064903C (en) 2023-07-25
MX2019015851A (es) 2020-08-17
AU2019279958B2 (en) 2022-03-10
KR102530252B1 (ko) 2023-05-09
EP3587591A1 (en) 2020-01-01
PH12019502904A1 (en) 2020-09-14
CN110656035B (zh) 2024-12-31

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