CR20200056A - Novedosos compuestos que activan la ruta nrf2 - Google Patents

Novedosos compuestos que activan la ruta nrf2

Info

Publication number
CR20200056A
CR20200056A CR20200056A CR20200056A CR20200056A CR 20200056 A CR20200056 A CR 20200056A CR 20200056 A CR20200056 A CR 20200056A CR 20200056 A CR20200056 A CR 20200056A CR 20200056 A CR20200056 A CR 20200056A
Authority
CR
Costa Rica
Prior art keywords
novel compounds
nrf2 pathway
compounds activating
activating
compounds
Prior art date
Application number
CR20200056A
Other languages
English (en)
Inventor
Duran Carlos Puig
Casals Laia Miret
Stephen Fiacco
Andrew Davis
Canela Nuria Trallero
Paniagua Carlos Heras
Benitez Miriam Gongora
Tomillero Ivan Ramos
Stefan Geschwindner
Palomera Fernando Albericio
Bas Marta Paradis
Cubero Omar Brun
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of CR20200056A publication Critical patent/CR20200056A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención se refiere a compuestos peptídicos, cuyos compuestos peptídicos son compuestos de fórmula (I)¿, o una sal, o solvato, o N-óxido, o estereoisómero farmacéuticamente aceptable del mismo: Fórmula (I)¿ en la que R1; R2; s; t; u; Aa78 y G1 son como se han definido en el presente documento. Los compuestos peptídicos son útiles para activar la ruta Nrf2.
CR20200056A 2017-08-08 2018-08-08 Novedosos compuestos que activan la ruta nrf2 CR20200056A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17382558 2017-08-08
PCT/EP2018/071536 WO2019030298A1 (en) 2017-08-08 2018-08-08 NEW COMPOUNDS THAT ACTIVATE THE NRF2 PATH

Publications (1)

Publication Number Publication Date
CR20200056A true CR20200056A (es) 2020-03-16

Family

ID=59677167

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20200056A CR20200056A (es) 2017-08-08 2018-08-08 Novedosos compuestos que activan la ruta nrf2

Country Status (24)

Country Link
US (1) US20200255478A1 (es)
EP (1) EP3665182A1 (es)
JP (1) JP2020530022A (es)
KR (1) KR20200035269A (es)
CN (1) CN110997695A (es)
AR (1) AR113100A1 (es)
AU (1) AU2018314833B2 (es)
BR (1) BR112019026306A2 (es)
CA (1) CA3066698A1 (es)
CL (1) CL2020000305A1 (es)
CO (1) CO2020000617A2 (es)
CR (1) CR20200056A (es)
DO (1) DOP2020000017A (es)
EA (1) EA202090432A1 (es)
EC (1) ECSP20008530A (es)
IL (1) IL272467A (es)
JO (1) JOP20200025A1 (es)
MA (1) MA49828A (es)
MX (1) MX2020001481A (es)
PE (1) PE20211460A1 (es)
PH (1) PH12019502852A1 (es)
SG (1) SG11201913161WA (es)
TW (1) TW201919682A (es)
WO (1) WO2019030298A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR128023A1 (es) * 2021-12-17 2024-03-20 3B Pharmaceuticals Gmbh Ligandos de anhidrasa carbónica ix
WO2025248100A1 (en) * 2024-05-31 2025-12-04 Institut National de la Santé et de la Recherche Médicale Nrf2 activators for use in the treatment of vitiligo

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT7920688U1 (it) 1979-02-05 1980-08-05 Chiesi Paolo Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore
ATE23272T1 (de) 1981-07-08 1986-11-15 Draco Ab Pulverinhalator.
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI69963C (fi) 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
DE3927170A1 (de) 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
WO1992003175A1 (en) 1990-08-11 1992-03-05 Fisons Plc Inhalation device
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
ATE209938T1 (de) 1990-09-26 2001-12-15 Pharmachemie Bv Wirbelkammer-pulverinhalator
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
PL173090B1 (pl) 1992-12-18 1998-01-30 Schering Corp Inhalator do sproszkowanych lekarstw
MX9707864A (es) 1995-04-14 1997-11-29 Glaxo Wellcome Inc Inhalador de dosis medida por salmeterol.
CA2378713C (en) 1995-06-21 2003-08-12 Asta Medica Aktiengesellschaft Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
ES2351976T3 (es) 2003-04-29 2011-02-14 Avi Biopharma, Inc. Composiciones para mejorar el transporte y la eficacia antisentido de análogos de ácidos nucleicos en células.
ES2353018T3 (es) 2004-07-16 2011-02-24 Almirall, S.A. Inhalador para la administración de productos farmacéuticos en polvo, y un cartucho de polvo para uso con este inhalador.
ES2478670T3 (es) 2007-02-28 2014-07-22 Leo Pharma A/S Nuevos inhibidores de la fosfodiesterasa
US8575305B2 (en) 2008-06-04 2013-11-05 Medical Research Council Cell penetrating peptides
JP2012051826A (ja) * 2010-08-31 2012-03-15 Toray Ind Inc 環状ペプチド及びその修飾ペプチド並びにＫｅｌｃｈ様ＥＣＨ結合タンパク質１の結合阻害物質のスクリーニング方法
WO2012150960A1 (en) 2011-05-05 2012-11-08 Avi Biopharma, Inc. Peptide oligonucleotide conjugates
WO2013030569A2 (en) 2011-08-30 2013-03-07 Michael John Gait Peptides
JP2015067579A (ja) * 2013-09-30 2015-04-13 国立大学法人東北大学 細胞透過性ペプチド及び当該ペプチドを含む医薬組成物。

Also Published As

Publication number Publication date
JP2020530022A (ja) 2020-10-15
KR20200035269A (ko) 2020-04-02
AU2018314833B2 (en) 2020-03-19
DOP2020000017A (es) 2020-02-28
BR112019026306A2 (pt) 2020-07-14
CO2020000617A2 (es) 2020-05-05
MX2020001481A (es) 2020-03-20
PH12019502852A1 (en) 2020-09-28
AR113100A1 (es) 2020-01-29
AU2018314833A1 (en) 2020-01-02
SG11201913161WA (en) 2020-01-30
US20200255478A1 (en) 2020-08-13
EA202090432A1 (ru) 2020-06-08
MA49828A (fr) 2020-06-17
PE20211460A1 (es) 2021-08-05
CA3066698A1 (en) 2019-02-14
ECSP20008530A (es) 2020-05-29
TW201919682A (zh) 2019-06-01
IL272467A (en) 2020-03-31
CN110997695A (zh) 2020-04-10
JOP20200025A1 (ar) 2020-02-04
EP3665182A1 (en) 2020-06-17
CL2020000305A1 (es) 2020-06-26
WO2019030298A1 (en) 2019-02-14

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