PL2114951T3 - Nowe inhibitory fosfodiesterazy - Google Patents
Nowe inhibitory fosfodiesterazyInfo
- Publication number
- PL2114951T3 PL2114951T3 PL08706922T PL08706922T PL2114951T3 PL 2114951 T3 PL2114951 T3 PL 2114951T3 PL 08706922 T PL08706922 T PL 08706922T PL 08706922 T PL08706922 T PL 08706922T PL 2114951 T3 PL2114951 T3 PL 2114951T3
- Authority
- PL
- Poland
- Prior art keywords
- phosphodiesterase inhibitors
- novel phosphodiesterase
- novel
- inhibitors
- phosphodiesterase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90384907P | 2007-02-28 | 2007-02-28 | |
| US94684907P | 2007-06-28 | 2007-06-28 | |
| EP08706922.5A EP2114951B9 (en) | 2007-02-28 | 2008-02-26 | Novel phosphodiesterase inhibitors |
| PCT/DK2008/000080 WO2008104175A2 (en) | 2007-02-28 | 2008-02-26 | Novel phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2114951T3 true PL2114951T3 (pl) | 2014-10-31 |
Family
ID=39415336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08706922T PL2114951T3 (pl) | 2007-02-28 | 2008-02-26 | Nowe inhibitory fosfodiesterazy |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8338431B2 (pl) |
| EP (1) | EP2114951B9 (pl) |
| JP (1) | JP5501770B2 (pl) |
| KR (1) | KR101571654B1 (pl) |
| AU (1) | AU2008221121B2 (pl) |
| BR (1) | BRPI0807749B8 (pl) |
| CA (1) | CA2676933C (pl) |
| CY (1) | CY1115227T1 (pl) |
| DK (1) | DK2114951T3 (pl) |
| ES (1) | ES2478670T3 (pl) |
| HR (1) | HRP20140585T1 (pl) |
| IL (1) | IL200153A (pl) |
| MX (1) | MX2009009238A (pl) |
| MY (1) | MY150075A (pl) |
| NZ (1) | NZ578804A (pl) |
| PL (1) | PL2114951T3 (pl) |
| PT (1) | PT2114951E (pl) |
| RS (1) | RS53407B (pl) |
| RU (1) | RU2495043C2 (pl) |
| SI (1) | SI2114951T1 (pl) |
| WO (1) | WO2008104175A2 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012007225A (es) | 2009-12-22 | 2012-07-30 | Leo Pharma As | Composicion farmaceutica que comprende mezcla de solventes y derivado o analogo de vitamina d. |
| MX2012007234A (es) | 2009-12-22 | 2012-07-30 | Leo Pharma As | Nanocristales de monohidrato de calciprotiol. |
| RU2560677C2 (ru) | 2009-12-22 | 2015-08-20 | Лео Фарма А/С | Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ |
| JP6174997B2 (ja) * | 2010-06-24 | 2017-08-02 | レオ ファーマ アクティーゼルスカブ | ホスホジエステラーゼ阻害剤としてのベンゾジオキソールまたはベンゾジオキセピンヘテロ環化合物 |
| WO2013122855A1 (en) * | 2012-02-14 | 2013-08-22 | University Of Rochester | Methods of increasing lymphatic transport |
| KR20150022789A (ko) * | 2012-06-04 | 2015-03-04 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 |
| WO2014083099A1 (en) * | 2012-11-30 | 2014-06-05 | Leo Pharma A/S | A method of inhibiting the expression of il-22 in activated t-cells |
| JP6785666B2 (ja) | 2014-06-23 | 2020-11-18 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環化合物の調製方法 |
| US10160750B2 (en) | 2015-06-19 | 2018-12-25 | Bristol-Myers Squibb Company | Diamide macrocycles as factor XIa inhibitors |
| DK3390407T3 (da) * | 2015-12-18 | 2023-11-06 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| CN110088108B (zh) * | 2016-12-12 | 2024-06-14 | 联合疗法公司 | 取代的吡唑并氮杂䓬-4-酮类及其作为磷酸二酯酶抑制剂的用途 |
| US11065257B2 (en) * | 2016-12-12 | 2021-07-20 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| ES2874632T3 (es) * | 2016-12-12 | 2021-11-05 | Union Therapeutics As | Pirazoloazepin-8-onas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| AU2018286964B2 (en) | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| TW201919682A (zh) | 2017-08-08 | 2019-06-01 | 西班牙商阿爾米雷爾有限公司 | 活化Ｎｒｆ２路徑的新穎化合物 |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
| HK1000785A1 (en) | 1995-05-19 | 2006-06-30 | Kyowa Hakko Kogyo Co., Ltd | Oxygen-containing heterocyclic compounds |
| US6514996B2 (en) * | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| HUP0100042A3 (en) * | 1996-05-20 | 2003-01-28 | Darwin Discovery Ltd Cambridge | Benzofuran carboxamides medicaments containing the same and their therapeutic use |
| TR199900429T2 (xx) * | 1996-08-28 | 1999-05-21 | The Procter & Gamble Company | Spirosiklik metaloproteaz inhibit�rleri. |
| AU4967697A (en) * | 1996-11-19 | 1998-06-10 | Kyowa Hakko Kogyo Co. Ltd. | Oxygenic heterocyclic compounds |
| EP1029860B1 (en) * | 1997-10-01 | 2003-04-16 | Kyowa Hakko Kogyo Co., Ltd. | Benzofuran derivatives |
-
2008
- 2008-02-26 PL PL08706922T patent/PL2114951T3/pl unknown
- 2008-02-26 NZ NZ578804A patent/NZ578804A/en not_active IP Right Cessation
- 2008-02-26 HR HRP20140585AT patent/HRP20140585T1/hr unknown
- 2008-02-26 RS RS20140365A patent/RS53407B/sr unknown
- 2008-02-26 BR BRPI0807749A patent/BRPI0807749B8/pt not_active IP Right Cessation
- 2008-02-26 SI SI200831224T patent/SI2114951T1/sl unknown
- 2008-02-26 DK DK08706922.5T patent/DK2114951T3/da active
- 2008-02-26 KR KR1020097018073A patent/KR101571654B1/ko active Active
- 2008-02-26 US US12/528,649 patent/US8338431B2/en active Active
- 2008-02-26 JP JP2009551915A patent/JP5501770B2/ja not_active Expired - Fee Related
- 2008-02-26 RU RU2009135810/04A patent/RU2495043C2/ru active
- 2008-02-26 PT PT87069225T patent/PT2114951E/pt unknown
- 2008-02-26 MY MYPI20093168A patent/MY150075A/en unknown
- 2008-02-26 MX MX2009009238A patent/MX2009009238A/es active IP Right Grant
- 2008-02-26 CA CA2676933A patent/CA2676933C/en active Active
- 2008-02-26 WO PCT/DK2008/000080 patent/WO2008104175A2/en not_active Ceased
- 2008-02-26 ES ES08706922.5T patent/ES2478670T3/es active Active
- 2008-02-26 EP EP08706922.5A patent/EP2114951B9/en active Active
- 2008-02-26 AU AU2008221121A patent/AU2008221121B2/en not_active Ceased
-
2009
- 2009-07-30 IL IL200153A patent/IL200153A/en active IP Right Grant
-
2014
- 2014-06-17 CY CY20141100437T patent/CY1115227T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2478670T3 (es) | 2014-07-22 |
| JP5501770B2 (ja) | 2014-05-28 |
| IL200153A0 (en) | 2010-04-15 |
| US20100099688A1 (en) | 2010-04-22 |
| CY1115227T1 (el) | 2017-01-04 |
| AU2008221121B2 (en) | 2013-10-03 |
| RU2009135810A (ru) | 2011-04-10 |
| PT2114951E (pt) | 2014-07-17 |
| HRP20140585T1 (hr) | 2014-09-12 |
| BRPI0807749B1 (pt) | 2021-01-05 |
| EP2114951B9 (en) | 2015-09-02 |
| HK1138262A1 (en) | 2010-08-20 |
| AU2008221121A1 (en) | 2008-09-04 |
| MY150075A (en) | 2013-11-29 |
| WO2008104175A2 (en) | 2008-09-04 |
| CA2676933A1 (en) | 2008-09-04 |
| SI2114951T1 (sl) | 2014-08-29 |
| RS53407B (sr) | 2014-10-31 |
| RU2495043C2 (ru) | 2013-10-10 |
| BRPI0807749B8 (pt) | 2022-09-06 |
| JP2010519332A (ja) | 2010-06-03 |
| KR20090126252A (ko) | 2009-12-08 |
| IL200153A (en) | 2016-11-30 |
| CA2676933C (en) | 2015-09-29 |
| NZ578804A (en) | 2012-04-27 |
| MX2009009238A (es) | 2009-09-08 |
| EP2114951A2 (en) | 2009-11-11 |
| DK2114951T3 (da) | 2014-06-23 |
| US8338431B2 (en) | 2012-12-25 |
| WO2008104175A3 (en) | 2009-01-29 |
| KR101571654B1 (ko) | 2015-11-25 |
| EP2114951B1 (en) | 2014-04-09 |
| BRPI0807749A2 (pt) | 2014-06-17 |
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