PL2114951T3 - Nowe inhibitory fosfodiesterazy - Google Patents
Nowe inhibitory fosfodiesterazyInfo
- Publication number
- PL2114951T3 PL2114951T3 PL08706922T PL08706922T PL2114951T3 PL 2114951 T3 PL2114951 T3 PL 2114951T3 PL 08706922 T PL08706922 T PL 08706922T PL 08706922 T PL08706922 T PL 08706922T PL 2114951 T3 PL2114951 T3 PL 2114951T3
- Authority
- PL
- Poland
- Prior art keywords
- phosphodiesterase inhibitors
- novel phosphodiesterase
- novel
- inhibitors
- phosphodiesterase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90384907P | 2007-02-28 | 2007-02-28 | |
| US94684907P | 2007-06-28 | 2007-06-28 | |
| PCT/DK2008/000080 WO2008104175A2 (en) | 2007-02-28 | 2008-02-26 | Novel phosphodiesterase inhibitors |
| EP08706922.5A EP2114951B9 (en) | 2007-02-28 | 2008-02-26 | Novel phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2114951T3 true PL2114951T3 (pl) | 2014-10-31 |
Family
ID=39415336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08706922T PL2114951T3 (pl) | 2007-02-28 | 2008-02-26 | Nowe inhibitory fosfodiesterazy |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8338431B2 (pl) |
| EP (1) | EP2114951B9 (pl) |
| JP (1) | JP5501770B2 (pl) |
| KR (1) | KR101571654B1 (pl) |
| AU (1) | AU2008221121B2 (pl) |
| BR (1) | BRPI0807749B8 (pl) |
| CA (1) | CA2676933C (pl) |
| CY (1) | CY1115227T1 (pl) |
| DK (1) | DK2114951T3 (pl) |
| ES (1) | ES2478670T3 (pl) |
| HR (1) | HRP20140585T1 (pl) |
| IL (1) | IL200153A (pl) |
| MX (1) | MX2009009238A (pl) |
| MY (1) | MY150075A (pl) |
| NZ (1) | NZ578804A (pl) |
| PL (1) | PL2114951T3 (pl) |
| PT (1) | PT2114951E (pl) |
| RS (1) | RS53407B (pl) |
| RU (1) | RU2495043C2 (pl) |
| SI (1) | SI2114951T1 (pl) |
| WO (1) | WO2008104175A2 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012007234A (es) | 2009-12-22 | 2012-07-30 | Leo Pharma As | Nanocristales de monohidrato de calciprotiol. |
| NZ601001A (en) | 2009-12-22 | 2014-07-25 | Leo Pharma As | Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue |
| BR112012015433B8 (pt) | 2009-12-22 | 2020-03-03 | Leo Pharma As | composição farmacêutica substancialmente anidra para aplicação cutânea |
| SI3070091T1 (sl) | 2010-06-24 | 2019-08-30 | Leo Pharma A/S | Derivati benzodioksola kot zaviralci fosfodiesteraze |
| WO2013122855A1 (en) * | 2012-02-14 | 2013-08-22 | University Of Rochester | Methods of increasing lymphatic transport |
| RU2637945C2 (ru) * | 2012-06-04 | 2017-12-08 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы |
| EP2925364A1 (en) * | 2012-11-30 | 2015-10-07 | Leo Pharma A/S | A method of inhibiting the expression of il-22 in activated t-cells |
| MX2016016378A (es) * | 2014-06-23 | 2017-10-16 | Leo Pharma As | Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. |
| WO2016205482A1 (en) | 2015-06-19 | 2016-12-22 | Bristol-Myers Squibb Company | Diamide macrocycles as factor xia inhibitors |
| DK3390407T3 (da) * | 2015-12-18 | 2023-11-06 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| WO2018108231A1 (en) * | 2016-12-12 | 2018-06-21 | Leo Pharma A/S | Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors |
| JP6850886B2 (ja) * | 2016-12-12 | 2021-03-31 | レオ ファーマ アクティーゼルスカブ | 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
| EP3551632B1 (en) * | 2016-12-12 | 2024-06-12 | UNION therapeutics A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| DK3642210T3 (da) | 2017-06-20 | 2024-12-09 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| TW201919682A (zh) | 2017-08-08 | 2019-06-01 | 西班牙商阿爾米雷爾有限公司 | 活化Ｎｒｆ２路徑的新穎化合物 |
| PT3724196T (pt) | 2017-12-15 | 2023-01-13 | Union Therapeutics As | Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
| ATE325110T1 (de) | 1995-05-19 | 2006-06-15 | Kyowa Hakko Kogyo Kk | Sauerstoff enthaltende heterocyclische verbindungen |
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| CN1219171A (zh) * | 1996-05-20 | 1999-06-09 | 达尔文发现有限公司 | 苯并呋喃甲酰胺及其治疗用途 |
| CN1105723C (zh) * | 1996-08-28 | 2003-04-16 | 普罗克特和甘保尔公司 | 螺环金属蛋白酶抑制剂 |
| WO1998022455A1 (en) * | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygenic heterocyclic compounds |
| JP4219554B2 (ja) | 1997-10-01 | 2009-02-04 | 協和発酵キリン株式会社 | ベンゾフラン誘導体 |
-
2008
- 2008-02-26 CA CA2676933A patent/CA2676933C/en active Active
- 2008-02-26 KR KR1020097018073A patent/KR101571654B1/ko active Active
- 2008-02-26 ES ES08706922.5T patent/ES2478670T3/es active Active
- 2008-02-26 BR BRPI0807749A patent/BRPI0807749B8/pt not_active IP Right Cessation
- 2008-02-26 MY MYPI20093168A patent/MY150075A/en unknown
- 2008-02-26 US US12/528,649 patent/US8338431B2/en active Active
- 2008-02-26 PT PT87069225T patent/PT2114951E/pt unknown
- 2008-02-26 JP JP2009551915A patent/JP5501770B2/ja not_active Expired - Fee Related
- 2008-02-26 WO PCT/DK2008/000080 patent/WO2008104175A2/en not_active Ceased
- 2008-02-26 MX MX2009009238A patent/MX2009009238A/es active IP Right Grant
- 2008-02-26 RS RS20140365A patent/RS53407B/sr unknown
- 2008-02-26 PL PL08706922T patent/PL2114951T3/pl unknown
- 2008-02-26 DK DK08706922.5T patent/DK2114951T3/da active
- 2008-02-26 RU RU2009135810/04A patent/RU2495043C2/ru active
- 2008-02-26 SI SI200831224T patent/SI2114951T1/sl unknown
- 2008-02-26 HR HRP20140585AT patent/HRP20140585T1/hr unknown
- 2008-02-26 NZ NZ578804A patent/NZ578804A/en not_active IP Right Cessation
- 2008-02-26 EP EP08706922.5A patent/EP2114951B9/en active Active
- 2008-02-26 AU AU2008221121A patent/AU2008221121B2/en not_active Ceased
-
2009
- 2009-07-30 IL IL200153A patent/IL200153A/en active IP Right Grant
-
2014
- 2014-06-17 CY CY20141100437T patent/CY1115227T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008221121A1 (en) | 2008-09-04 |
| US20100099688A1 (en) | 2010-04-22 |
| EP2114951B1 (en) | 2014-04-09 |
| BRPI0807749B1 (pt) | 2021-01-05 |
| EP2114951A2 (en) | 2009-11-11 |
| BRPI0807749B8 (pt) | 2022-09-06 |
| RU2495043C2 (ru) | 2013-10-10 |
| KR101571654B1 (ko) | 2015-11-25 |
| CA2676933C (en) | 2015-09-29 |
| JP2010519332A (ja) | 2010-06-03 |
| KR20090126252A (ko) | 2009-12-08 |
| CA2676933A1 (en) | 2008-09-04 |
| DK2114951T3 (da) | 2014-06-23 |
| RU2009135810A (ru) | 2011-04-10 |
| US8338431B2 (en) | 2012-12-25 |
| MY150075A (en) | 2013-11-29 |
| MX2009009238A (es) | 2009-09-08 |
| WO2008104175A2 (en) | 2008-09-04 |
| HK1138262A1 (en) | 2010-08-20 |
| HRP20140585T1 (hr) | 2014-09-12 |
| BRPI0807749A2 (pt) | 2014-06-17 |
| ES2478670T3 (es) | 2014-07-22 |
| WO2008104175A3 (en) | 2009-01-29 |
| RS53407B (sr) | 2014-10-31 |
| EP2114951B9 (en) | 2015-09-02 |
| SI2114951T1 (sl) | 2014-08-29 |
| PT2114951E (pt) | 2014-07-17 |
| IL200153A0 (en) | 2010-04-15 |
| IL200153A (en) | 2016-11-30 |
| AU2008221121B2 (en) | 2013-10-03 |
| CY1115227T1 (el) | 2017-01-04 |
| NZ578804A (en) | 2012-04-27 |
| JP5501770B2 (ja) | 2014-05-28 |
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