CR20210184A - Derivados de 4 pirazin 2 ilmetil-morfolina y su uso como medicamento - Google Patents

Derivados de 4 pirazin 2 ilmetil-morfolina y su uso como medicamento

Info

Publication number
CR20210184A
CR20210184A CR20210184A CR20210184A CR20210184A CR 20210184 A CR20210184 A CR 20210184A CR 20210184 A CR20210184 A CR 20210184A CR 20210184 A CR20210184 A CR 20210184A CR 20210184 A CR20210184 A CR 20210184A
Authority
CR
Costa Rica
Prior art keywords
pyrazin
ylmethyl
medicament
morpholine derivatives
strong
Prior art date
Application number
CR20210184A
Other languages
English (en)
Inventor
Cornelia Dorner-Ciossek
Roland Pfau
Riccardo Giovannini
Angelo Ceci
Dieter Wiedenmayer
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CR20210184A publication Critical patent/CR20210184A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se refiere a 4-pirazin-2-ilmetil-morfolinas novedosas de la Fórmula general <strong>A, procesos para su preparación, composiciones farmacéuticas que las contienen y su uso en tratamientos, particularmente, en el tratamiento o la prevención de afecciones que tienen una relación con las propiedades de modulación alostérica negativa de NR2B</strong>
CR20210184A 2018-10-17 2019-10-16 Derivados de 4 pirazin 2 ilmetil-morfolina y su uso como medicamento CR20210184A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18200943 2018-10-17
PCT/EP2019/078027 WO2020079039A1 (en) 2018-10-17 2019-10-16 4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament

Publications (1)

Publication Number Publication Date
CR20210184A true CR20210184A (es) 2021-05-26

Family

ID=63878518

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210184A CR20210184A (es) 2018-10-17 2019-10-16 Derivados de 4 pirazin 2 ilmetil-morfolina y su uso como medicamento

Country Status (38)

Country Link
US (3) US11166958B2 (es)
EP (1) EP3867244B1 (es)
JP (1) JP7093468B2 (es)
KR (1) KR102840105B1 (es)
CN (1) CN112888685B (es)
AR (1) AR116711A1 (es)
AU (1) AU2019362330B2 (es)
BR (1) BR112021004993A2 (es)
CA (1) CA3113308A1 (es)
CL (1) CL2021000858A1 (es)
CO (1) CO2021004612A2 (es)
CR (1) CR20210184A (es)
DK (1) DK3867244T3 (es)
DO (1) DOP2021000069A (es)
EA (1) EA202191014A1 (es)
EC (1) ECSP21027009A (es)
ES (1) ES2940184T3 (es)
FI (1) FI3867244T3 (es)
HR (1) HRP20230249T1 (es)
HU (1) HUE061891T2 (es)
IL (1) IL282142B2 (es)
JO (1) JOP20210075B1 (es)
LT (1) LT3867244T (es)
MA (1) MA53898B1 (es)
MX (1) MX2021004418A (es)
MY (1) MY205127A (es)
NZ (1) NZ773672A (es)
PE (1) PE20211278A1 (es)
PH (1) PH12021550834A1 (es)
PL (1) PL3867244T3 (es)
PT (1) PT3867244T (es)
RS (1) RS63988B1 (es)
SA (1) SA521421756B1 (es)
SG (1) SG11202103806VA (es)
SI (1) SI3867244T1 (es)
TW (1) TWI828779B (es)
UA (1) UA128408C2 (es)
WO (1) WO2020079039A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11376258B2 (en) * 2019-06-04 2022-07-05 Boehringer Ingelheim International Gmbh Purine derivatives and the use thereof as medicament
WO2025233259A1 (en) 2024-05-07 2025-11-13 Boehringer Ingelheim International Gmbh Compound for use in the treatment of depression, obsessive-compulsive disorder, post-traumatic stress disorder and/or borderline personality disorder

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
CA2443108A1 (en) 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
CA2453383C (en) * 2001-07-24 2010-04-06 Richter Gedeon Vegyeszeti Gyar Rt Piperidine derivatives as nmda receptor antagonists
AU2006322067A1 (en) * 2005-12-06 2007-06-14 Merck Sharp & Dohme Corp. Morpholine carboxamide prokineticin receptor antagonists
US20110319416A1 (en) * 2009-01-28 2011-12-29 Emory University Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions
WO2012128582A2 (en) 2011-03-23 2012-09-27 Hyundai Pharm Co., Ltd. A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
WO2014060398A1 (en) * 2012-10-18 2014-04-24 F. Hoffmann-La Roche Ag Ethynyl derivatives as modulators of mglur5 receptor activity
CA2936886A1 (en) * 2014-02-27 2015-08-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof
US10913736B2 (en) 2014-08-22 2021-02-09 University Of Washington Specific inhibitors of methionyl-tRNA synthetase
BR112018007181A2 (pt) * 2015-10-14 2018-10-16 Bristol-Myers Squibb Company antagonistas de nr2b seletivos

Also Published As

Publication number Publication date
EP3867244A1 (en) 2021-08-25
KR102840105B1 (ko) 2025-07-31
CA3113308A1 (en) 2020-04-23
SG11202103806VA (en) 2021-05-28
CN112888685B (zh) 2023-09-22
US20210393644A1 (en) 2021-12-23
IL282142B1 (en) 2023-12-01
WO2020079039A1 (en) 2020-04-23
ES2940184T3 (es) 2023-05-04
DK3867244T3 (da) 2023-05-01
JP7093468B2 (ja) 2022-06-29
MX2021004418A (es) 2021-07-06
JOP20210075B1 (ar) 2024-12-22
DOP2021000069A (es) 2021-05-31
PT3867244T (pt) 2023-02-22
MA53898A (fr) 2022-01-26
AR116711A1 (es) 2021-06-02
CN112888685A (zh) 2021-06-01
US20200121691A1 (en) 2020-04-23
RS63988B1 (sr) 2023-03-31
MY205127A (en) 2024-10-03
IL282142A (en) 2021-05-31
AU2019362330B2 (en) 2024-03-28
EP3867244B1 (en) 2023-01-18
PH12021550834A1 (en) 2021-10-04
IL282142B2 (en) 2024-04-01
HRP20230249T1 (hr) 2023-04-14
JOP20210075A1 (ar) 2023-01-30
MA53898B1 (fr) 2023-03-31
AU2019362330A1 (en) 2021-04-08
SI3867244T1 (sl) 2023-04-28
TW202031262A (zh) 2020-09-01
CL2021000858A1 (es) 2021-10-01
TWI828779B (zh) 2024-01-11
NZ773672A (en) 2024-12-20
US20250345341A1 (en) 2025-11-13
ECSP21027009A (es) 2021-05-31
HUE061891T2 (hu) 2023-09-28
BR112021004993A2 (pt) 2021-06-08
US11166958B2 (en) 2021-11-09
JP2022505080A (ja) 2022-01-14
SA521421756B1 (ar) 2023-02-12
UA128408C2 (uk) 2024-07-03
PL3867244T3 (pl) 2023-05-22
KR20210079325A (ko) 2021-06-29
CO2021004612A2 (es) 2021-04-30
PE20211278A1 (es) 2021-07-19
EA202191014A1 (ru) 2021-11-09
FI3867244T3 (fi) 2023-03-20
LT3867244T (lt) 2023-03-10

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