CR20220576A - Tratamiento conjunto con pbmc modificadas y un inmunoconjugado - Google Patents

Tratamiento conjunto con pbmc modificadas y un inmunoconjugado

Info

Publication number
CR20220576A
CR20220576A CR20220576A CR20220576A CR20220576A CR 20220576 A CR20220576 A CR 20220576A CR 20220576 A CR20220576 A CR 20220576A CR 20220576 A CR20220576 A CR 20220576A CR 20220576 A CR20220576 A CR 20220576A
Authority
CR
Costa Rica
Prior art keywords
polypeptide
immunoconjugate
common therapy
administering
variant
Prior art date
Application number
CR20220576A
Other languages
English (en)
Inventor
Scott Loughhead
Deak Laura Codarri
Valeria G Nicolini
Pablo Umaña
Christian Klein
Matthew Booty
Christine Trumpfheller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20220576A publication Critical patent/CR20220576A/es

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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N2710/20011—Papillomaviridae
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud proporciona métodos para estimular una respuesta inmunitaria en un individuo que comprende administrar una composición de células nucleadas (por ejemplo, PBMC) que comprende un antígeno exógeno intracelular en conjunto con la administración de un inmunoconjugado que comprende un polipéptido de IL-2 variante y un segundo polipéptido. El polipéptido de IL-2 variante exhibe afinidad reducida a la subunidad a del receptor de IL-2. El segundo polipéptido actúa sobre una célula tumoral o un linfocito T.
CR20220576A 2020-05-11 2021-05-10 Tratamiento conjunto con pbmc modificadas y un inmunoconjugado CR20220576A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063023193P 2020-05-11 2020-05-11
US202063105135P 2020-10-23 2020-10-23
PCT/US2021/031542 WO2021231278A1 (en) 2020-05-11 2021-05-10 Combination therapy with modified pbmcs and an immunoconjugate

Publications (1)

Publication Number Publication Date
CR20220576A true CR20220576A (es) 2022-12-07

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CR20220576A CR20220576A (es) 2020-05-11 2021-05-10 Tratamiento conjunto con pbmc modificadas y un inmunoconjugado

Country Status (15)

Country Link
US (1) US20230181712A1 (es)
EP (1) EP4149524A1 (es)
JP (1) JP2023527690A (es)
KR (1) KR20230010240A (es)
CN (1) CN115551540A (es)
AU (1) AU2021272340A1 (es)
BR (1) BR112022022614A2 (es)
CA (1) CA3177288A1 (es)
CL (1) CL2022003130A1 (es)
CR (1) CR20220576A (es)
IL (1) IL298038A (es)
MX (1) MX2022014134A (es)
PE (1) PE20230387A1 (es)
TW (1) TW202207975A (es)
WO (1) WO2021231278A1 (es)

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WO2021231773A1 (en) 2020-05-13 2021-11-18 Good Therapeutics, Inc. Compositions of protein complexes and methods of use thereof
JP2025534285A (ja) * 2022-09-29 2025-10-15 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト プロテアーゼ活性化ポリペプチド

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