CL2022003130A1 - Tratamiento conjunto con pbmc modificadas y un inmunoconjugado. - Google Patents

Tratamiento conjunto con pbmc modificadas y un inmunoconjugado.

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Publication number
CL2022003130A1
CL2022003130A1 CL2022003130A CL2022003130A CL2022003130A1 CL 2022003130 A1 CL2022003130 A1 CL 2022003130A1 CL 2022003130 A CL2022003130 A CL 2022003130A CL 2022003130 A CL2022003130 A CL 2022003130A CL 2022003130 A1 CL2022003130 A1 CL 2022003130A1
Authority
CL
Chile
Prior art keywords
polypeptide
immunoconjugate
joint treatment
pbmc
administering
Prior art date
Application number
CL2022003130A
Other languages
English (en)
Inventor
Christian Klein
Scott Loughhead
Matthew Booty
Pablo Umaña
Christine Trumpfheller
Valeria G Nicolini
Deak Laura Codarri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2022003130A1 publication Critical patent/CL2022003130A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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Abstract

La presente solicitud proporciona métodos para estimular una respuesta inmunitaria en un individuo que comprende administrar una composición de células nucleadas (por ejemplo, PBMC) que comprende un antígeno exógeno intracelular en conjunto con la administración de un inmunoconjugado que comprende un polipéptido de IL-2 variante y un segundo polipéptido. El polipéptido de IL-2 variante exhibe afinidad reducida a la subunidad α del receptor de IL-2. El segundo polipéptido actúa sobre una célula tumoral o un linfocito T.
CL2022003130A 2020-05-11 2022-11-10 Tratamiento conjunto con pbmc modificadas y un inmunoconjugado. CL2022003130A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063023193P 2020-05-11 2020-05-11
US202063105135P 2020-10-23 2020-10-23

Publications (1)

Publication Number Publication Date
CL2022003130A1 true CL2022003130A1 (es) 2023-05-19

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CL2022003130A CL2022003130A1 (es) 2020-05-11 2022-11-10 Tratamiento conjunto con pbmc modificadas y un inmunoconjugado.

Country Status (15)

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US (1) US20230181712A1 (es)
EP (1) EP4149524A1 (es)
JP (1) JP2023527690A (es)
KR (1) KR20230010240A (es)
CN (1) CN115551540A (es)
AU (1) AU2021272340A1 (es)
BR (1) BR112022022614A2 (es)
CA (1) CA3177288A1 (es)
CL (1) CL2022003130A1 (es)
CR (1) CR20220576A (es)
IL (1) IL298038A (es)
MX (1) MX2022014134A (es)
PE (1) PE20230387A1 (es)
TW (1) TW202207975A (es)
WO (1) WO2021231278A1 (es)

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JP2023526282A (ja) 2020-05-13 2023-06-21 ボナム セラピューティクス，インク． タンパク質複合体の組成物及びその使用方法
CN119948048A (zh) * 2022-09-29 2025-05-06 豪夫迈·罗氏有限公司 蛋白酶活化的多肽

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