CR20230465A - Compuestos heterocíclicos de arilo como bloqueadores del canal agitador de potasio kv1.3 - Google Patents

Compuestos heterocíclicos de arilo como bloqueadores del canal agitador de potasio kv1.3

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Publication number
CR20230465A
CR20230465A CR20230465A CR20230465A CR20230465A CR 20230465 A CR20230465 A CR 20230465A CR 20230465 A CR20230465 A CR 20230465A CR 20230465 A CR20230465 A CR 20230465A CR 20230465 A CR20230465 A CR 20230465A
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CR
Costa Rica
Prior art keywords
potassium
heterocyclic compounds
channel blockers
aryl heterocyclic
shaker channel
Prior art date
Application number
CR20230465A
Other languages
English (en)
Inventor
Vishwanath Jogini
Morten Østergaard Jensen
Roger John Snow
Fabrizio Giordanetto
Original Assignee
De Shaw Res Llc
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Filing date
Publication date
Application filed by De Shaw Res Llc filed Critical De Shaw Res Llc
Publication of CR20230465A publication Critical patent/CR20230465A/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un compuesto de Fórmula I ( ), I’ ( ), II ( ), II’ ( ), III ( ) o IV ( ) o una sal farmacéuticamente aceptable de este, en donde los sustituyentes son como se definen en la presente descripción. También se describen composiciones farmacéuticas que comprenden el mismo y el método de uso del mismo.
CR20230465A 2021-03-30 2022-03-29 Compuestos heterocíclicos de arilo como bloqueadores del canal agitador de potasio kv1.3 CR20230465A (es)

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