ECSP23073998A - Compuestos heterocíclicos de arilo como bloqueadores del canal agitador de potasio kv1.3 - Google Patents

Compuestos heterocíclicos de arilo como bloqueadores del canal agitador de potasio kv1.3

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Publication number
ECSP23073998A
ECSP23073998A ECSENADI202373998A ECDI202373998A ECSP23073998A EC SP23073998 A ECSP23073998 A EC SP23073998A EC SENADI202373998 A ECSENADI202373998 A EC SENADI202373998A EC DI202373998 A ECDI202373998 A EC DI202373998A EC SP23073998 A ECSP23073998 A EC SP23073998A
Authority
EC
Ecuador
Prior art keywords
blockers
potassium
heterocyclic aryl
aryl compounds
agitator channel
Prior art date
Application number
ECSENADI202373998A
Other languages
English (en)
Inventor
Morten Jensen
Vishwanath Jogini
Fabrizio Giordanetto
Roger John Snow
Original Assignee
De Shaw Res Llc
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Filing date
Publication date
Application filed by De Shaw Res Llc filed Critical De Shaw Res Llc
Publication of ECSP23073998A publication Critical patent/ECSP23073998A/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Se describe un compuesto de Fórmula (I), (I'), (II), (II'), (III) o (IV) o una sal farmacéuticamente aceptable de este, en donde los sustituyentes son como se definen en la presente descripción. También se describen composiciones farmacéuticas que comprenden el mismo y el método de uso del mismo.
ECSENADI202373998A 2021-03-30 2023-09-29 Compuestos heterocíclicos de arilo como bloqueadores del canal agitador de potasio kv1.3 ECSP23073998A (es)

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