CR20250058A - Derivados novedosos deuterados de pirimidin-2-il sulfonamida - Google Patents
Derivados novedosos deuterados de pirimidin-2-il sulfonamidaInfo
- Publication number
- CR20250058A CR20250058A CR20250058A CR20250058A CR20250058A CR 20250058 A CR20250058 A CR 20250058A CR 20250058 A CR20250058 A CR 20250058A CR 20250058 A CR20250058 A CR 20250058A CR 20250058 A CR20250058 A CR 20250058A
- Authority
- CR
- Costa Rica
- Prior art keywords
- deuterated
- pyrimidin
- sulfonamide derivatives
- zhunfmrgslweharesmyu
- xubnmzf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a compuestos novedosos que tienen la fórmula general (I) <img alt="" src="data:image/png;base64,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 (***)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22192252 | 2022-08-26 | ||
| PCT/EP2023/073189 WO2024042147A2 (en) | 2022-08-26 | 2023-08-24 | Novel deuterated pyrimidin-2-yl sulfonamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20250058A true CR20250058A (es) | 2025-05-09 |
Family
ID=83081337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20250058A CR20250058A (es) | 2022-08-26 | 2023-08-24 | Derivados novedosos deuterados de pirimidin-2-il sulfonamida |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20250188061A1 (es) |
| EP (1) | EP4577538A2 (es) |
| JP (1) | JP2025527937A (es) |
| KR (1) | KR20250052376A (es) |
| CN (1) | CN119731168A (es) |
| AR (1) | AR130300A1 (es) |
| AU (1) | AU2023329097A1 (es) |
| CA (1) | CA3262954A1 (es) |
| CL (1) | CL2025000484A1 (es) |
| CO (1) | CO2025003256A2 (es) |
| CR (1) | CR20250058A (es) |
| IL (1) | IL318162A (es) |
| MX (1) | MX2025001765A (es) |
| PE (1) | PE20251077A1 (es) |
| TW (1) | TW202417424A (es) |
| WO (1) | WO2024042147A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2700773A (en) | 2024-05-23 | 2026-03-11 | Pheno Therapeutics Ltd | Compounds |
| GB2701173A (en) | 2024-05-23 | 2026-04-22 | Pheno Therapeutics Ltd | Compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI857957B (zh) * | 2018-06-19 | 2024-10-11 | 德商Ｕｃｂ製藥有限公司 | 吡啶基及吡基-（氮）吲哚磺醯胺 |
| EP3584244A1 (en) * | 2018-06-20 | 2019-12-25 | UCB Pharma GmbH | Substituted alkoxypyridinyl indolsulfonamides |
| JP2022517797A (ja) * | 2019-01-17 | 2022-03-10 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
-
2023
- 2023-08-24 CR CR20250058A patent/CR20250058A/es unknown
- 2023-08-24 AR ARP230102255A patent/AR130300A1/es unknown
- 2023-08-24 AU AU2023329097A patent/AU2023329097A1/en active Pending
- 2023-08-24 CA CA3262954A patent/CA3262954A1/en active Pending
- 2023-08-24 CN CN202380059353.6A patent/CN119731168A/zh active Pending
- 2023-08-24 EP EP23758659.9A patent/EP4577538A2/en active Pending
- 2023-08-24 JP JP2025511827A patent/JP2025527937A/ja active Pending
- 2023-08-24 IL IL318162A patent/IL318162A/en unknown
- 2023-08-24 WO PCT/EP2023/073189 patent/WO2024042147A2/en not_active Ceased
- 2023-08-24 KR KR1020257005076A patent/KR20250052376A/ko active Pending
- 2023-08-24 PE PE2025000390A patent/PE20251077A1/es unknown
- 2023-08-25 TW TW112132038A patent/TW202417424A/zh unknown
-
2025
- 2025-02-12 MX MX2025001765A patent/MX2025001765A/es unknown
- 2025-02-20 CL CL2025000484A patent/CL2025000484A1/es unknown
- 2025-02-21 US US19/059,580 patent/US20250188061A1/en active Pending
- 2025-03-13 CO CONC2025/0003256A patent/CO2025003256A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR130300A1 (es) | 2024-11-27 |
| CL2025000484A1 (es) | 2025-06-27 |
| KR20250052376A (ko) | 2025-04-18 |
| PE20251077A1 (es) | 2025-04-10 |
| WO2024042147A3 (en) | 2024-05-16 |
| TW202417424A (zh) | 2024-05-01 |
| US20250188061A1 (en) | 2025-06-12 |
| JP2025527937A (ja) | 2025-08-25 |
| CN119731168A (zh) | 2025-03-28 |
| IL318162A (en) | 2025-03-01 |
| MX2025001765A (es) | 2025-05-02 |
| CA3262954A1 (en) | 2024-02-29 |
| AU2023329097A1 (en) | 2024-11-21 |
| WO2024042147A2 (en) | 2024-02-29 |
| CO2025003256A2 (es) | 2025-04-16 |
| EP4577538A2 (en) | 2025-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR20250058A (es) | Derivados novedosos deuterados de pirimidin-2-il sulfonamida | |
| CR20220252A (es) | Nuevos inhibidores de braf como rompedores de la paradoja | |
| Mari et al. | Autoprogettazione? | |
| BRPI0906963A8 (pt) | método de rastreamento de localização em tempo real de clientes de loja usando uma multirrede de comunicação | |
| CY1117681T1 (el) | Ρυθμιστες 2,3-διοξυγενασης ινδολοαμινης και μεθοδοι χρησης αυτων | |
| MX2025003905A (es) | Tiosulfato de sodio anhidro y formulaciones de este | |
| EA201070619A1 (ru) | Карбоксамидные, сульфонамидные и аминовые соединения от метаболических нарушений | |
| CY1114504T1 (el) | Συνθεσεις τιγεκυκλινης και μεθοδοι παρασκευης | |
| MA38248A1 (fr) | Compositions pesticides et procédés associés | |
| UA107557C2 (xx) | Композиція антитіла офатумумабу | |
| EA200802380A1 (ru) | Совместные кристаллы пирролидинонов | |
| EA201070186A1 (ru) | Способы и соединения, предназначенные для получения ингибиторов котранспортера натрий-глюкозы 2 типа | |
| BR112014012275A2 (pt) | purificação de proteína com a utilização de tampão bis-tris | |
| CY1111269T1 (el) | Ρυθμιστες βενζιμιδαζολης του vr1 | |
| CY1119077T1 (el) | Παραγωγα πυραζολυλαμινοπυριδινης χρησιμα ως αναστολεις κινασων | |
| BR0212894A (pt) | Derivados de sulfeto de diarila, sais resultantes e agentes imunosupressores utilizando os mesmos | |
| BR112014012955A2 (pt) | sistema de planejamento, sistema tendo portas de visualização acopladas operatoriamente, método para o planejamento de um procedimento, e, método para o acoplamento operacional de portas de visualização | |
| BR112023017376A2 (pt) | Soluções oftálmicas | |
| BRPI0814957B8 (pt) | composto, agente farmacêutico, e, uso do composto | |
| BRPI0518904A2 (pt) | formulaÇÕes de nepafenac tàpicas | |
| AR062098A1 (es) | Metodo para analizar datos que tienen propiedades compartidas y distintas | |
| BR0314058A (pt) | Composições para cuidados pessoais a base de álcool ramificado | |
| CR20250018A (es) | Derivados novedosos de indol sulfonamida 7 sustituidos | |
| BR112014031048A2 (pt) | composições para controle de artrópodes nocivos e método para controle de artrópodes nocivos | |
| BR112012021657A2 (pt) | composto, agentes farmacêutico, agonístico de casr, e agente para conferir kokumi, e, temperos |