CR20250058A - Derivados novedosos deuterados de pirimidin-2-il sulfonamida - Google Patents

Derivados novedosos deuterados de pirimidin-2-il sulfonamida

Info

Publication number
CR20250058A
CR20250058A CR20250058A CR20250058A CR20250058A CR 20250058 A CR20250058 A CR 20250058A CR 20250058 A CR20250058 A CR 20250058A CR 20250058 A CR20250058 A CR 20250058A CR 20250058 A CR20250058 A CR 20250058A
Authority
CR
Costa Rica
Prior art keywords
deuterated
pyrimidin
sulfonamide derivatives
zhunfmrgslweharesmyu
xubnmzf
Prior art date
Application number
CR20250058A
Other languages
English (en)
Inventor
Wolfgang Guba
Emmanuel Pinard
Luca Claudio Gobbi
Guido Galley
Dmitry Mazunin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20250058A publication Critical patent/CR20250058A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a compuestos novedosos que tienen la fórmula general (I) <img alt="" src="data:image/png;base64,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 (***)
CR20250058A 2022-08-26 2023-08-24 Derivados novedosos deuterados de pirimidin-2-il sulfonamida CR20250058A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22192252 2022-08-26
PCT/EP2023/073189 WO2024042147A2 (en) 2022-08-26 2023-08-24 Novel deuterated pyrimidin-2-yl sulfonamide derivatives

Publications (1)

Publication Number Publication Date
CR20250058A true CR20250058A (es) 2025-05-09

Family

ID=83081337

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20250058A CR20250058A (es) 2022-08-26 2023-08-24 Derivados novedosos deuterados de pirimidin-2-il sulfonamida

Country Status (16)

Country Link
US (1) US20250188061A1 (es)
EP (1) EP4577538A2 (es)
JP (1) JP2025527937A (es)
KR (1) KR20250052376A (es)
CN (1) CN119731168A (es)
AR (1) AR130300A1 (es)
AU (1) AU2023329097A1 (es)
CA (1) CA3262954A1 (es)
CL (1) CL2025000484A1 (es)
CO (1) CO2025003256A2 (es)
CR (1) CR20250058A (es)
IL (1) IL318162A (es)
MX (1) MX2025001765A (es)
PE (1) PE20251077A1 (es)
TW (1) TW202417424A (es)
WO (1) WO2024042147A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025243044A1 (en) 2024-05-23 2025-11-27 Pheno Therapeutics Limited Compounds
GB2700773A (en) 2024-05-23 2026-03-11 Pheno Therapeutics Ltd Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI857957B (zh) * 2018-06-19 2024-10-11 德商Ｕｃｂ製藥有限公司 吡啶基及吡基-（氮）吲哚磺醯胺
EP3584244A1 (en) * 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides
JP2022517797A (ja) * 2019-01-17 2022-03-10 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物

Also Published As

Publication number Publication date
CA3262954A1 (en) 2024-02-29
KR20250052376A (ko) 2025-04-18
WO2024042147A3 (en) 2024-05-16
JP2025527937A (ja) 2025-08-25
MX2025001765A (es) 2025-05-02
IL318162A (en) 2025-03-01
US20250188061A1 (en) 2025-06-12
CL2025000484A1 (es) 2025-06-27
CN119731168A (zh) 2025-03-28
AU2023329097A1 (en) 2024-11-21
EP4577538A2 (en) 2025-07-02
PE20251077A1 (es) 2025-04-10
TW202417424A (zh) 2024-05-01
WO2024042147A2 (en) 2024-02-29
CO2025003256A2 (es) 2025-04-16
AR130300A1 (es) 2024-11-27

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