CR6438A - 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado - Google Patents
2-aminopiridinas que contienen sustituyentes de tipo anillo condensadoInfo
- Publication number
- CR6438A CR6438A CR6438A CR6438A CR6438A CR 6438 A CR6438 A CR 6438A CR 6438 A CR6438 A CR 6438A CR 6438 A CR6438 A CR 6438A CR 6438 A CR6438 A CR 6438A
- Authority
- CR
- Costa Rica
- Prior art keywords
- condensed ring
- aminopiridins
- ring type
- disorders
- containing substitutes
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 150000003930 2-aminopyridines Chemical class 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
Abstract
Se refiere a ciertas 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado que muestran actividad como inhibidores de sintasa de óxido nítrico (NOS), a composiciones farmacéuticas que las contienen, y a su uso en el tratamiento y prevención de trastornos del sistema nervioso central, trastornos inflamatorios, choque séptico, obesidad y otras enfermedades, trastornos y estados
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12159799P | 1999-02-25 | 1999-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR6438A true CR6438A (es) | 2004-02-23 |
Family
ID=22397690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR6438A CR6438A (es) | 1999-02-25 | 2001-08-08 | 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado |
Country Status (44)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) * | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| CN1341099A (zh) * | 1999-02-25 | 2002-03-20 | 辉瑞产品公司 | 含有稠合环取代基的2－氨基吡啶 |
| AU2001249610B2 (en) | 2000-03-31 | 2005-03-24 | Euro-Celtique S.A. | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| CN1745064A (zh) * | 2002-12-06 | 2006-03-08 | 泊达研究基金会 | 用于治疗受损的哺乳动物神经组织的吡啶 |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| US20050192321A1 (en) * | 2003-09-15 | 2005-09-01 | Meythaler Jay M. | Treatment of neuropathy with rapid release aminopyridine |
| WO2014138460A1 (en) | 2013-03-07 | 2014-09-12 | Northwestern University | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9951014B2 (en) | 2014-11-04 | 2018-04-24 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
| US12213973B2 (en) | 2021-10-18 | 2025-02-04 | Northwestern University | Bacterial nitric oxide synthase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996018616A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH101435A (ja) * | 1995-09-14 | 1998-01-06 | Nippon Kayaku Co Ltd | ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤 |
| PT891332E (pt) * | 1996-03-29 | 2004-07-30 | Pfizer | Derivados de 6-fenilpiridil-2-amina |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| YU35699A (sh) * | 1997-02-10 | 2002-06-19 | Pfizer Products Inc. | 2-amino-6-(2-supstituisan-4-fenoksi)-supstituisani piridini |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| CA2334012C (en) * | 1998-06-03 | 2006-05-02 | Pfizer Products Inc. | 2-aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors |
| CN1341099A (zh) * | 1999-02-25 | 2002-03-20 | 辉瑞产品公司 | 含有稠合环取代基的2－氨基吡啶 |
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2000
- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
- 2000-02-02 NZ NZ512912A patent/NZ512912A/en unknown
- 2000-02-02 AT AT00901285T patent/ATE245143T1/de not_active IP Right Cessation
- 2000-02-02 PT PT00901285T patent/PT1155000E/pt unknown
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- 2000-02-02 EE EEP200100454A patent/EE200100454A/xx unknown
- 2000-02-02 KR KR1020017010899A patent/KR20010114213A/ko not_active Ceased
- 2000-02-02 CA CA002364719A patent/CA2364719C/en not_active Expired - Fee Related
- 2000-02-02 BR BR0008569-3A patent/BR0008569A/pt not_active IP Right Cessation
- 2000-02-02 EA EA200100816A patent/EA003941B1/ru not_active IP Right Cessation
- 2000-02-02 HU HU0200163A patent/HUP0200163A3/hu unknown
- 2000-02-02 JP JP2000600983A patent/JP3825636B2/ja not_active Expired - Fee Related
- 2000-02-02 YU YU58301A patent/YU58301A/sh unknown
- 2000-02-02 IL IL14430800A patent/IL144308A0/xx unknown
- 2000-02-02 PL PL00350219A patent/PL350219A1/xx not_active Application Discontinuation
- 2000-02-02 TR TR2001/02481T patent/TR200102481T2/xx unknown
- 2000-02-02 HR HR20010597A patent/HRP20010597A2/hr not_active Application Discontinuation
- 2000-02-02 AP APAP/P/2001/002251A patent/AP2001002251A0/en unknown
- 2000-02-02 CZ CZ20013036A patent/CZ20013036A3/cs unknown
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- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 DK DK00901285T patent/DK1155000T3/da active
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- 2000-02-02 OA OA1200100224A patent/OA11841A/en unknown
- 2000-02-02 WO PCT/IB2000/000109 patent/WO2000050400A1/en not_active Ceased
- 2000-02-02 MX MXPA01008671A patent/MXPA01008671A/es active IP Right Grant
- 2000-02-02 ES ES00901285T patent/ES2200813T3/es not_active Expired - Lifetime
- 2000-02-03 HN HN2000000016A patent/HN2000000016A/es unknown
- 2000-02-15 US US09/504,989 patent/US6211208B1/en not_active Expired - Fee Related
- 2000-02-17 PA PA20008490901A patent/PA8490901A1/es unknown
- 2000-02-23 MA MA25912A patent/MA26721A1/fr unknown
- 2000-02-23 PE PE2000000146A patent/PE20001482A1/es not_active Application Discontinuation
- 2000-02-23 TN TNTNSN00034A patent/TNSN00034A1/fr unknown
- 2000-02-23 DZ DZ000036A patent/DZ3017A1/xx active
- 2000-02-23 CO CO00012733A patent/CO5160241A1/es unknown
- 2000-02-23 AR ARP000100767A patent/AR018979A1/es unknown
- 2000-02-24 SV SV2000000026A patent/SV2002000026A/es not_active Application Discontinuation
- 2000-02-24 GT GT200000021A patent/GT200000021A/es unknown
-
2001
- 2001-02-08 US US09/779,318 patent/US6372768B2/en not_active Expired - Fee Related
- 2001-07-13 IS IS6005A patent/IS6005A/is unknown
- 2001-08-08 CR CR6438A patent/CR6438A/es unknown
- 2001-08-23 ZA ZA200106974A patent/ZA200106974B/en unknown
- 2001-08-23 NO NO20014095A patent/NO20014095L/no not_active Application Discontinuation
- 2001-08-30 BG BG105855A patent/BG105855A/xx unknown
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