MA26721A1 - Derives de 2-aminopyridine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives de 2-aminopyridine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
MA26721A1
MA26721A1 MA25912A MA25912A MA26721A1 MA 26721 A1 MA26721 A1 MA 26721A1 MA 25912 A MA25912 A MA 25912A MA 25912 A MA25912 A MA 25912A MA 26721 A1 MA26721 A1 MA 26721A1
Authority
MA
Morocco
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel
aminopyridine derivatives
Prior art date
Application number
MA25912A
Other languages
English (en)
Inventor
Adams Lowe John Iii
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA26721A1 publication Critical patent/MA26721A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)

Abstract

L'INVENTION CONCERNE DES DÉRIVÉS DE 2-AMINOPYRIDINE DE FORMULE 1 : DANS LAQUELLE A, B, X, Y ET R1 REPRÉSENTENT DIVERS RADICAUX. ELLE CONCERNE ÉGALEMENT UN PROCÉDÉ POUR LEUR PRÉPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSÉS ET COMPOSITIONS, INHIBANT L'ACTIVITÉ DES OXYDE NITRIQUES-SYNTHASES (NOS) , POUR LE TRAITEMENT DE DIVERSES MALADIES, NOTAMMENT DU SYSTèME NERVEUX CENTRAL.
MA25912A 1999-02-25 2000-02-23 Derives de 2-aminopyridine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant MA26721A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12159799P 1999-02-25 1999-02-25

Publications (1)

Publication Number Publication Date
MA26721A1 true MA26721A1 (fr) 2004-12-20

Family

ID=22397690

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25912A MA26721A1 (fr) 1999-02-25 2000-02-23 Derives de 2-aminopyridine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (44)

Country Link
US (2) US6211208B1 (fr)
EP (1) EP1155000B1 (fr)
JP (1) JP3825636B2 (fr)
KR (1) KR20010114213A (fr)
CN (1) CN1341099A (fr)
AP (1) AP2001002251A0 (fr)
AR (1) AR018979A1 (fr)
AT (1) ATE245143T1 (fr)
AU (1) AU767593B2 (fr)
BG (1) BG105855A (fr)
BR (1) BR0008569A (fr)
CA (1) CA2364719C (fr)
CO (1) CO5160241A1 (fr)
CR (1) CR6438A (fr)
CZ (1) CZ20013036A3 (fr)
DE (1) DE60003893T2 (fr)
DK (1) DK1155000T3 (fr)
DZ (1) DZ3017A1 (fr)
EA (1) EA003941B1 (fr)
EE (1) EE200100454A (fr)
ES (1) ES2200813T3 (fr)
GT (1) GT200000021A (fr)
HN (1) HN2000000016A (fr)
HR (1) HRP20010597A2 (fr)
HU (1) HUP0200163A3 (fr)
ID (1) ID29892A (fr)
IL (1) IL144308A0 (fr)
IS (1) IS6005A (fr)
MA (1) MA26721A1 (fr)
MX (1) MXPA01008671A (fr)
NO (1) NO20014095L (fr)
NZ (1) NZ512912A (fr)
OA (1) OA11841A (fr)
PA (1) PA8490901A1 (fr)
PE (1) PE20001482A1 (fr)
PL (1) PL350219A1 (fr)
PT (1) PT1155000E (fr)
SK (1) SK12022001A3 (fr)
SV (1) SV2002000026A (fr)
TN (1) TNSN00034A1 (fr)
TR (1) TR200102481T2 (fr)
WO (1) WO2000050400A1 (fr)
YU (1) YU58301A (fr)
ZA (1) ZA200106974B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049379A1 (en) * 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
CA2364719C (fr) * 1999-02-25 2006-07-04 Pfizer Products Inc. 2-aminopyridines contenant des substituants a cycles condenses
JP2003529589A (ja) 2000-03-31 2003-10-07 ユーロ−セルティック エス． ア． アミノピリジンならびにこれらの鎮痙薬およびナトリウムチャンネル遮断薬としての使用
US20040092741A1 (en) * 2002-11-08 2004-05-13 Pfizer Inc Substituted pyridines via boronic acid coupling
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
CA2508165C (fr) * 2002-12-06 2014-05-06 Purdue Research Foundation Pyridines destinees au traitement de tissus nerveux mammaliens leses
US20050192321A1 (en) * 2003-09-15 2005-09-01 Meythaler Jay M. Treatment of neuropathy with rapid release aminopyridine
WO2014138460A1 (fr) 2013-03-07 2014-09-12 Northwestern University Inhibiteurs de l'oxyde nitrique synthase neuronaux sélectifs à base de 2-aminopyridine
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
WO2016073623A2 (fr) 2014-11-04 2016-05-12 Northwestern University Inhibiteurs d'oxyde nitrique synthase d'origine bactérienne et mammalienne
US20170038184A1 (en) 2015-08-06 2017-02-09 Charles E. Ankner Formulation delivery system
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
US12213973B2 (en) 2021-10-18 2025-02-04 Northwestern University Bacterial nitric oxide synthase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4515696A (en) * 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH101435A (ja) * 1995-09-14 1998-01-06 Nippon Kayaku Co Ltd ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤
NZ326874A (en) * 1996-03-29 2000-01-28 Pfizer 6-phenylpyridyl-2-amine derivatives
HN1997000027A (es) 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina
DK0958282T3 (da) * 1997-02-10 2004-11-29 Pfizer Prod Inc 2-Amino-6-(2-substitueret-4-phenoxy)-substitueret-pyridiner
HN1998000118A (es) * 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) * 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
CN1303379A (zh) * 1998-06-03 2001-07-11 辉瑞产品公司 作为氧化氮合酶抑制剂的含稠环取代基的2－氨基吡啶
CA2364719C (fr) * 1999-02-25 2006-07-04 Pfizer Products Inc. 2-aminopyridines contenant des substituants a cycles condenses

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PT1155000E (pt) 2003-10-31
OA11841A (en) 2005-08-22
BG105855A (en) 2002-04-30
CO5160241A1 (es) 2002-05-30
US6211208B1 (en) 2001-04-03
EA200100816A1 (ru) 2001-12-24
PE20001482A1 (es) 2001-01-03
GT200000021A (es) 2001-08-17
SK12022001A3 (sk) 2002-07-02
IL144308A0 (en) 2002-05-23
YU58301A (sh) 2004-05-12
US20010014689A1 (en) 2001-08-16
NO20014095D0 (no) 2001-08-23
DE60003893D1 (de) 2003-08-21
ATE245143T1 (de) 2003-08-15
SV2002000026A (es) 2002-02-05
PL350219A1 (en) 2002-11-18
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AU2124300A (en) 2000-09-14
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