CR6458A - Composiciones de valdecoxib - Google Patents

Composiciones de valdecoxib

Info

Publication number
CR6458A
CR6458A CR6458A CR6458A CR6458A CR 6458 A CR6458 A CR 6458A CR 6458 A CR6458 A CR 6458A CR 6458 A CR6458 A CR 6458A CR 6458 A CR6458 A CR 6458A
Authority
CR
Costa Rica
Prior art keywords
time
administration
valdecoxib
concentration
reach
Prior art date
Application number
CR6458A
Other languages
English (en)
Inventor
Sreekant Nadrarni
Tugrul T Kararli
Mark J Kontny
Subhash Desai
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR6458(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of CR6458A publication Critical patent/CR6458A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

Un compuesto farmacéutico que incluye partículas de valdecoxib en una cantidad de cerca de 1 mg a 100 mg por dosis y uno o más excipientes farmacéuticos aceptados. En una unidad, una única dosis, por administración vía oral a un sujeto, provee un tiempo de concentración del suero del flujo sanguíneo de valdecoxib con por lo menos uno de los siguientes: a)un tiempo para alcanzar un umbral de concentración para efectos terapéuticos no mayor a cerca de 0.5 h después de su administración, b)un tiempo para alcanzar concentración máxima (Tmax) no mayor a 3 h después de su administración y, c)una concentración máxima (Cmax) no menor a cerca de 100 ng/ml.
CR6458A 1999-12-08 2001-09-11 Composiciones de valdecoxib CR6458A (es)

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US16985699P 1999-12-08 1999-12-08
US18163500P 2000-02-10 2000-02-10
US20226900P 2000-05-05 2000-05-05

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JP2003516353A (ja) 2003-05-13
SK12692001A3 (sk) 2002-04-04
WO2001041762A3 (en) 2001-11-01
AU2005200015A1 (en) 2005-02-03
HUP0200409A3 (en) 2004-07-28
CZ20013163A3 (cs) 2002-06-12
AR027896A1 (es) 2003-04-16
PE20010940A1 (es) 2001-09-12
AU777402B2 (en) 2004-10-14
BG105873A (bg) 2002-04-30
TWI265808B (en) 2006-11-11
KR20020000760A (ko) 2002-01-05
HK1041637A1 (zh) 2002-07-19
US20020013357A1 (en) 2002-01-31
NO20013858D0 (no) 2001-08-08
HUP0200409A2 (en) 2002-06-29
KR20060019639A (ko) 2006-03-03
CN1203852C (zh) 2005-06-01
KR100645866B1 (ko) 2006-11-15
NO20013858L (no) 2001-10-08
BR0008059A (pt) 2002-03-26
KR100664479B1 (ko) 2007-01-04
PL351069A1 (en) 2003-03-10
IS6040A (is) 2001-08-07
IL144763A (en) 2007-09-20
EA003639B1 (ru) 2003-08-28
AU1930301A (en) 2001-06-18
AU1931001A (en) 2001-06-18
CA2362816A1 (en) 2001-06-14
WO2001041762A2 (en) 2001-06-14
IL144763A0 (en) 2002-06-30
EE200100414A (et) 2002-12-16
MY138227A (en) 2009-05-29
NZ513963A (en) 2003-10-31
WO2001041761A2 (en) 2001-06-14
TR200102297T1 (tr) 2002-03-21
CN1679556A (zh) 2005-10-12
EP1165072A2 (en) 2002-01-02
CA2362816C (en) 2007-02-06
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