CR7869A - Agonistas morfolinicos de la dopamina - Google Patents

Agonistas morfolinicos de la dopamina

Info

Publication number
CR7869A
CR7869A CR7869A CR7869A CR7869A CR 7869 A CR7869 A CR 7869A CR 7869 A CR7869 A CR 7869A CR 7869 A CR7869 A CR 7869A CR 7869 A CR7869 A CR 7869A
Authority
CR
Costa Rica
Prior art keywords
morpholinic
dopamine
agonists
alkyl
conh2
Prior art date
Application number
CR7869A
Other languages
English (en)
Inventor
Moria Norfor Allerton Charlotte
Douglas Baxter Andrew
Simon Cook Andrew
Hepworth David
Kwok-Fung Stephen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0228787A external-priority patent/GB0228787D0/en
Priority claimed from GB0308460A external-priority patent/GB0308460D0/en
Priority claimed from GB0313606A external-priority patent/GB0313606D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of CR7869A publication Critical patent/CR7869A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona compuestos de las formulas (I), (Ia) y (Ib) en las que A se selecciona entre C-X y N, B se selecciona entre C- Y y N, R1 se selecciona entre H y alquilo C1-C6, R2 se selecciona entre H y alquilo C1-C6, X se selecciona entre H, HO, C (O) NH2, NH2, Y se selecciona entre H, HO, NH2, Br, CI y F, Z se selecciona entre H, HO, F, CONH2 y CN; y sus sales, solvatos y profarmacos farmaceuticamente aceptables.
CR7869A 2002-12-10 2005-06-10 Agonistas morfolinicos de la dopamina CR7869A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0228787A GB0228787D0 (en) 2002-12-10 2002-12-10 Morpholine dopamine agonists
GB0308460A GB0308460D0 (en) 2003-04-11 2003-04-11 Morpholine dopamine agonists
GB0313606A GB0313606D0 (en) 2003-06-12 2003-06-12 Morpholine dopamine agonists

Publications (1)

Publication Number Publication Date
CR7869A true CR7869A (es) 2005-07-08

Family

ID=32512061

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7869A CR7869A (es) 2002-12-10 2005-06-10 Agonistas morfolinicos de la dopamina

Country Status (36)

Country Link
EP (1) EP1572214B1 (es)
JP (3) JP3889775B2 (es)
KR (1) KR100796102B1 (es)
AP (1) AP2005003325A0 (es)
AR (1) AR042339A1 (es)
AT (1) ATE460938T1 (es)
AU (1) AU2003302878B2 (es)
CA (1) CA2508262C (es)
CO (1) CO5700781A2 (es)
CR (1) CR7869A (es)
CY (1) CY1110130T1 (es)
DE (1) DE60331769D1 (es)
DK (1) DK1572214T3 (es)
EA (1) EA009589B1 (es)
EC (1) ECSP055850A (es)
ES (1) ES2339767T3 (es)
GE (1) GEP20074272B (es)
HN (1) HN2003000401A (es)
HR (1) HRP20050523A2 (es)
IS (1) IS7843A (es)
MA (1) MA27605A1 (es)
MX (1) MXPA05006151A (es)
MY (1) MY144338A (es)
NL (1) NL1024983C2 (es)
NO (1) NO330143B1 (es)
NZ (1) NZ540505A (es)
OA (1) OA13014A (es)
PA (1) PA8591601A1 (es)
PE (1) PE20040906A1 (es)
PL (1) PL377480A1 (es)
PT (1) PT1572214E (es)
RS (1) RS51442B (es)
SI (1) SI1572214T1 (es)
TW (1) TW200423944A (es)
UY (1) UY28117A1 (es)
WO (1) WO2004052372A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2006003823A0 (en) * 2004-05-26 2006-12-31 Pfizer Indazole and indolone derivatives and their use aspharmaceuticals
AU2005247699A1 (en) * 2004-05-27 2005-12-08 Pfizer Inc. Aminopyridine derivatives as selective dopamine D3 agonists
GB0502509D0 (en) * 2005-02-07 2005-03-16 Pfizer Ltd Novel salt form of a dopamine agonist
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
GB0700786D0 (en) * 2007-01-15 2007-02-21 Pfizer Ltd Morpholine dopamine agonists for the treatment of pain
WO2011146821A2 (en) 2010-05-21 2011-11-24 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
JP2013526583A (ja) 2010-05-21 2013-06-24 リサーチ・トライアングル・インスティチュート フェニルモルホリンおよびその類似体
CA2932003A1 (en) * 2013-12-11 2015-06-18 F. Hoffmann-La Roche Ag Process for the preparation of chiral 2-aryl morpholines
GB2543296A (en) * 2015-10-13 2017-04-19 Indivior Uk Ltd Dopamine D3 receptor antagonists having a morpholine moiety
AU2020270992B2 (en) 2019-04-12 2025-10-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services D3 receptor agonist compounds; methods of preparation; intermediates thereof; and methods of use thereof
EP3725768A1 (en) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives
CN118684636B (zh) * 2024-05-31 2025-03-11 上海优合贝德医药科技有限公司 一种4-吗啉-1-苯基巯基-2-丁酮的合成工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB851311A (en) * 1958-04-02 1960-10-12 Geigy Ag J R Morpholine compounds and their production
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction

Also Published As

Publication number Publication date
MA27605A1 (fr) 2005-11-01
HK1081850A1 (zh) 2006-05-26
JP4624341B2 (ja) 2011-02-02
PA8591601A1 (es) 2004-12-16
JP2007084575A (ja) 2007-04-05
WO2004052372A1 (en) 2004-06-24
CY1110130T1 (el) 2015-01-14
NO330143B1 (no) 2011-02-21
ATE460938T1 (de) 2010-04-15
DE60331769D1 (de) 2010-04-29
NL1024983A1 (nl) 2004-06-11
NL1024983C2 (nl) 2005-02-01
IS7843A (is) 2005-05-12
NO20052557L (no) 2005-09-06
CA2508262A1 (en) 2004-06-24
SI1572214T1 (sl) 2010-07-30
EA009589B1 (ru) 2008-02-28
CO5700781A2 (es) 2006-11-30
TW200423944A (en) 2004-11-16
ES2339767T3 (es) 2010-05-25
MY144338A (en) 2011-08-29
UY28117A1 (es) 2004-07-30
JP2006232857A (ja) 2006-09-07
PE20040906A1 (es) 2005-01-24
EA200500801A1 (ru) 2005-12-29
AP2005003325A0 (en) 2005-06-30
AR042339A1 (es) 2005-06-15
EP1572214A1 (en) 2005-09-14
RS51442B (sr) 2011-04-30
DK1572214T3 (da) 2010-06-07
JP3889775B2 (ja) 2007-03-07
PT1572214E (pt) 2010-05-06
RS20050445A (sr) 2007-04-10
OA13014A (en) 2006-11-10
KR20050094813A (ko) 2005-09-28
JP2006511599A (ja) 2006-04-06
KR100796102B1 (ko) 2008-01-21
JP3920908B2 (ja) 2007-05-30
GEP20074272B (en) 2007-12-25
AU2003302878A1 (en) 2004-06-30
ECSP055850A (es) 2005-09-20
CA2508262C (en) 2009-12-01
NZ540505A (en) 2007-02-23
HRP20050523A2 (en) 2005-08-31
EP1572214B1 (en) 2010-03-17
MXPA05006151A (es) 2005-08-26
PL377480A1 (pl) 2006-02-06
HN2003000401A (es) 2004-11-23
AU2003302878B2 (en) 2009-04-23
NO20052557D0 (no) 2005-05-26

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