CR8277A - Procedimiento para la sintesis de 6-amino- 4-[(3-cloro-4-fluorofenil)amino]-7-etoxiquinolin-3-carbonitrilo - Google Patents

Procedimiento para la sintesis de 6-amino- 4-[(3-cloro-4-fluorofenil)amino]-7-etoxiquinolin-3-carbonitrilo

Info

Publication number
CR8277A
CR8277A CR8277A CR8277A CR8277A CR 8277 A CR8277 A CR 8277A CR 8277 A CR8277 A CR 8277A CR 8277 A CR8277 A CR 8277A CR 8277 A CR8277 A CR 8277A
Authority
CR
Costa Rica
Prior art keywords
amino
carbonitrile
fluorophenyl
chloro
procedure
Prior art date
Application number
CR8277A
Other languages
English (en)
Inventor
Stanley Michalak Ronald
Bernatchez Michel
Daigneault Sylvain
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8277A publication Critical patent/CR8277A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Proporciona un procedimiento para la preparacion de 6-AMINO- 4-[(3-CLORO-4-FLUOROFENIL)AMINO]-7-ETOXIQUINOLIN-3-CARBONITRILO, que comprende las etapas y productos que se describen dentro de esta solicitud.
CR8277A 2003-09-15 2006-03-06 Procedimiento para la sintesis de 6-amino- 4-[(3-cloro-4-fluorofenil)amino]-7-etoxiquinolin-3-carbonitrilo CR8277A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50310603P 2003-09-15 2003-09-15

Publications (1)

Publication Number Publication Date
CR8277A true CR8277A (es) 2006-07-14

Family

ID=34375310

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8277A CR8277A (es) 2003-09-15 2006-03-06 Procedimiento para la sintesis de 6-amino- 4-[(3-cloro-4-fluorofenil)amino]-7-etoxiquinolin-3-carbonitrilo

Country Status (19)

Country Link
US (2) US7365203B2 (es)
EP (1) EP1663951A2 (es)
JP (1) JP2007505910A (es)
KR (1) KR20060079217A (es)
CN (2) CN101318908A (es)
AU (1) AU2004274450A1 (es)
BR (1) BRPI0414377A (es)
CA (1) CA2536439A1 (es)
CO (1) CO5670368A2 (es)
CR (1) CR8277A (es)
EC (1) ECSP066423A (es)
IL (1) IL173750A0 (es)
MX (1) MXPA06002796A (es)
NO (1) NO20060767L (es)
RU (1) RU2006105263A (es)
SG (1) SG146645A1 (es)
UA (1) UA87474C2 (es)
WO (1) WO2005028421A2 (es)
ZA (1) ZA200602149B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2553729A1 (en) * 2004-01-16 2005-08-04 Wyeth Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
BRPI0610147A2 (pt) * 2005-05-25 2010-06-01 Wyeth Corp método para preparar e sintetizar 3-cianoquinolinas substituìdas e 4-amino-3-cianoquinolinas
EP1984325A4 (en) * 2006-02-03 2011-08-10 Univ Ohio State Res Found SULFONANILID ANALOGUE AS SELECTIVE AROMATASE MODULATORS
JP2008102489A (ja) * 2006-09-19 2008-05-01 Ricoh Co Ltd 現像剤搬送装置、現像装置、プロセスユニット及び画像形成装置
CN102070524A (zh) * 2011-01-12 2011-05-25 无锡好芳德药业有限公司 一种3-氰基-4-卤代喹啉衍生物的制备方法
CN103275002A (zh) * 2013-06-14 2013-09-04 苏州明锐医药科技有限公司 培利替尼的制备方法
CN108675958A (zh) * 2018-03-23 2018-10-19 孙金霞 一种抗肿瘤药物培利替尼中间体的清洁生产方法
CN111848581B (zh) * 2020-08-19 2021-08-10 昆明学院 3-氰基-4-苯胺基-6-氨基喹啉衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6384051B1 (en) * 2000-03-13 2002-05-07 American Cyanamid Company Method of treating or inhibiting colonic polyps
AR035851A1 (es) * 2000-03-28 2004-07-21 Wyeth Corp 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas
IL161921A0 (en) * 2001-11-27 2005-11-20 Wyeth Corp 3-Cyanoquinolines as inhibitors of egf-r and her2 kinases

Also Published As

Publication number Publication date
RU2006105263A (ru) 2007-11-10
CN100395231C (zh) 2008-06-18
KR20060079217A (ko) 2006-07-05
CO5670368A2 (es) 2006-08-31
US20080161575A1 (en) 2008-07-03
AU2004274450A1 (en) 2005-03-31
WO2005028421A2 (en) 2005-03-31
JP2007505910A (ja) 2007-03-15
SG146645A1 (en) 2008-10-30
EP1663951A2 (en) 2006-06-07
CA2536439A1 (en) 2005-03-31
CN101318908A (zh) 2008-12-10
IL173750A0 (en) 2006-07-05
MXPA06002796A (es) 2006-06-14
UA87474C2 (ru) 2009-07-27
US20050065181A1 (en) 2005-03-24
NO20060767L (no) 2006-06-07
CN1849299A (zh) 2006-10-18
BRPI0414377A (pt) 2007-04-10
WO2005028421A8 (en) 2005-06-16
ZA200602149B (en) 2009-09-30
US7365203B2 (en) 2008-04-29
ECSP066423A (es) 2006-09-18
WO2005028421A3 (en) 2005-05-19

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Legal Events

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FA Abandonment or withdrawal (granting procedure)