BRPI0414377A - processo para a sìntese de 6-amino-4-(3-cloro-4-flúor-fenilamino)-7-etóxi-quinoli na-3-carbonitrila - Google Patents

processo para a sìntese de 6-amino-4-(3-cloro-4-flúor-fenilamino)-7-etóxi-quinoli na-3-carbonitrila

Info

Publication number
BRPI0414377A
BRPI0414377A BRPI0414377-9A BRPI0414377A BRPI0414377A BR PI0414377 A BRPI0414377 A BR PI0414377A BR PI0414377 A BRPI0414377 A BR PI0414377A BR PI0414377 A BRPI0414377 A BR PI0414377A
Authority
BR
Brazil
Prior art keywords
phenylamino
amino
carbonitrile
quinoline
fluoro
Prior art date
Application number
BRPI0414377-9A
Other languages
English (en)
Inventor
Sylvain Daigneault
Ronald Stanley Michalak
Michel Bernatchez
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0414377A publication Critical patent/BRPI0414377A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE 6-AMINO-4-(3CLORO-4-FLúOR-FENILAMINO)-7-ETóXI-QUINOLI NA-3-CARBONITRILA". A presente invenção refere-se a um processo para a preparação de 6-amino-4-(3-cloro-4-flúor-fenilamino)-7-etóxi-quínolina-3-carbonitrila compreendendo as etapas e produtos expostos nessa aplicação.
BRPI0414377-9A 2003-09-15 2004-09-15 processo para a sìntese de 6-amino-4-(3-cloro-4-flúor-fenilamino)-7-etóxi-quinoli na-3-carbonitrila BRPI0414377A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50310603P 2003-09-15 2003-09-15
PCT/US2004/030219 WO2005028421A2 (en) 2003-09-15 2004-09-15 Process for the synthesis of 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxy-quinoline-3-carbonitrile

Publications (1)

Publication Number Publication Date
BRPI0414377A true BRPI0414377A (pt) 2007-04-10

Family

ID=34375310

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414377-9A BRPI0414377A (pt) 2003-09-15 2004-09-15 processo para a sìntese de 6-amino-4-(3-cloro-4-flúor-fenilamino)-7-etóxi-quinoli na-3-carbonitrila

Country Status (19)

Country Link
US (2) US7365203B2 (pt)
EP (1) EP1663951A2 (pt)
JP (1) JP2007505910A (pt)
KR (1) KR20060079217A (pt)
CN (2) CN100395231C (pt)
AU (1) AU2004274450A1 (pt)
BR (1) BRPI0414377A (pt)
CA (1) CA2536439A1 (pt)
CO (1) CO5670368A2 (pt)
CR (1) CR8277A (pt)
EC (1) ECSP066423A (pt)
IL (1) IL173750A0 (pt)
MX (1) MXPA06002796A (pt)
NO (1) NO20060767L (pt)
RU (1) RU2006105263A (pt)
SG (1) SG146645A1 (pt)
UA (1) UA87474C2 (pt)
WO (1) WO2005028421A2 (pt)
ZA (1) ZA200602149B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500008A (es) * 2004-01-16 2005-08-16 Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos
CN101203494A (zh) * 2005-05-25 2008-06-18 惠氏公司 合成经取代3-氰基喹啉和其中间物的方法
EP1984325A4 (en) * 2006-02-03 2011-08-10 Univ Ohio State Res Found SULFONANILID ANALOGUE AS SELECTIVE AROMATASE MODULATORS
JP2008102489A (ja) * 2006-09-19 2008-05-01 Ricoh Co Ltd 現像剤搬送装置、現像装置、プロセスユニット及び画像形成装置
CN102070524A (zh) * 2011-01-12 2011-05-25 无锡好芳德药业有限公司 一种3-氰基-4-卤代喹啉衍生物的制备方法
CN103275002A (zh) * 2013-06-14 2013-09-04 苏州明锐医药科技有限公司 培利替尼的制备方法
CN108675958A (zh) * 2018-03-23 2018-10-19 孙金霞 一种抗肿瘤药物培利替尼中间体的清洁生产方法
CN111848581B (zh) * 2020-08-19 2021-08-10 昆明学院 3-氰基-4-苯胺基-6-氨基喹啉衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6384051B1 (en) * 2000-03-13 2002-05-07 American Cyanamid Company Method of treating or inhibiting colonic polyps
AR035851A1 (es) * 2000-03-28 2004-07-21 Wyeth Corp 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas
AR037438A1 (es) * 2001-11-27 2004-11-10 Wyeth Corp 3-cianoquinolinas como inhibidores de egf-r y her2 quinasas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos

Also Published As

Publication number Publication date
SG146645A1 (en) 2008-10-30
CN101318908A (zh) 2008-12-10
KR20060079217A (ko) 2006-07-05
ECSP066423A (es) 2006-09-18
WO2005028421A3 (en) 2005-05-19
JP2007505910A (ja) 2007-03-15
CO5670368A2 (es) 2006-08-31
AU2004274450A1 (en) 2005-03-31
ZA200602149B (en) 2009-09-30
IL173750A0 (en) 2006-07-05
US7365203B2 (en) 2008-04-29
EP1663951A2 (en) 2006-06-07
NO20060767L (no) 2006-06-07
WO2005028421A2 (en) 2005-03-31
CN100395231C (zh) 2008-06-18
CA2536439A1 (en) 2005-03-31
CN1849299A (zh) 2006-10-18
RU2006105263A (ru) 2007-11-10
US20080161575A1 (en) 2008-07-03
US20050065181A1 (en) 2005-03-24
CR8277A (es) 2006-07-14
WO2005028421A8 (en) 2005-06-16
MXPA06002796A (es) 2006-06-14
UA87474C2 (ru) 2009-07-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.