CR8465A - Hormonas de administracion transdermica que no necesitan potenciadores de penetracion - Google Patents
Hormonas de administracion transdermica que no necesitan potenciadores de penetracionInfo
- Publication number
- CR8465A CR8465A CR8465A CR8465A CR8465A CR 8465 A CR8465 A CR 8465A CR 8465 A CR8465 A CR 8465A CR 8465 A CR8465 A CR 8465A CR 8465 A CR8465 A CR 8465A
- Authority
- CR
- Costa Rica
- Prior art keywords
- patch
- hormones
- potentiators
- transdermal administration
- need
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title abstract 3
- 239000005556 hormone Substances 0.000 title abstract 3
- 230000035515 penetration Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- 230000036470 plasma concentration Effects 0.000 abstract 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229960002568 ethinylestradiol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invencion se refiere a un parche que comprende una capa de droga con un bajo contenido de hormonas, como por ejemplo gestodeno, y opcionalmente un estrogeno (por ejemplo etinilestradiol). Al aplicar el parche a una mujer, se consiguen niveles de plasma de al menos 1,0ng/ml de gestodeno en condiciones de estado estacionario sin necesidad de incorporar potenciadores de penetracion ni mejoradores de permeacion en la capa que contiene droga. Tambien son satisfactorios los niveles en plasma de las hormonas que se consiguen durante todo un periodo de al menos una semana, haciendo que el parche se pueda aplicar para utilizarlo en anticoncepcion femenina con el concepto de aplicar el parche una vez a la semana.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52871803P | 2003-12-12 | 2003-12-12 | |
| EP03078881 | 2003-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR8465A true CR8465A (es) | 2007-06-06 |
Family
ID=34924031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR8465A CR8465A (es) | 2003-12-12 | 2006-06-20 | Hormonas de administracion transdermica que no necesitan potenciadores de penetracion |
Country Status (23)
| Country | Link |
|---|---|
| EP (2) | EP1541137B1 (es) |
| CN (1) | CN101843603B (es) |
| AR (1) | AR046762A1 (es) |
| AT (1) | ATE457168T1 (es) |
| CR (1) | CR8465A (es) |
| CY (2) | CY1110637T1 (es) |
| DE (1) | DE602004025444D1 (es) |
| DK (2) | DK1541137T3 (es) |
| ES (2) | ES2445690T3 (es) |
| GT (1) | GT200400262A (es) |
| HN (1) | HN2004000526A (es) |
| HR (2) | HRP20100254T1 (es) |
| JO (1) | JO2606B1 (es) |
| ME (1) | ME01069B (es) |
| MY (2) | MY144053A (es) |
| PE (1) | PE20051035A1 (es) |
| PL (2) | PL2138169T3 (es) |
| PT (2) | PT2138169E (es) |
| RS (2) | RS53182B (es) |
| SI (2) | SI1541137T1 (es) |
| SV (1) | SV2006001970A (es) |
| TW (1) | TWI257299B (es) |
| UA (1) | UA89766C2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ541807A (en) | 2003-02-21 | 2009-07-31 | Bayer Schering Pharma Ag | UV stable transdermal therapeutic plaster |
| US8668925B2 (en) | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
| US8962013B2 (en) | 2005-05-02 | 2015-02-24 | Bayer Intellectual Property Gmbh | Multi-layered transdermal system with triazine UV absorber |
| DE102005050729A1 (de) * | 2005-10-19 | 2007-04-26 | Schering Ag | Verfahren zur präventiven bedarfsweisen hormonalen Kontrazeption |
| WO2010042607A1 (en) | 2008-10-08 | 2010-04-15 | Agile Therapeutics, Inc | Transdermal delivery |
| US9192614B2 (en) | 2008-10-08 | 2015-11-24 | Agile Therapeutics, Inc. | Contraceptive transdermal delivery of hormones |
| EP2343979B1 (en) | 2008-10-08 | 2020-04-08 | Agile Therapeutics, Inc. | Transdermal delivery |
| WO2010111488A1 (en) | 2009-03-27 | 2010-09-30 | Agile Therapeutics, Inc. | Transdermal delivery |
| WO2012031999A2 (en) | 2010-09-06 | 2012-03-15 | Bayer Pharma Aktiengesellschaft | Low-dose transdermal patches with high drug release |
| AU2015203180B2 (en) * | 2010-09-06 | 2016-06-30 | Bayer Intellectual Property Gmbh | Transdermal therapeutic systems with crystallization-inhibiting protective film (release liner) |
| DE102010040299A1 (de) * | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
| AU2013212005A1 (en) * | 2012-01-27 | 2014-07-31 | Agile Therapeutics, Inc. | Transdermal hormone delivery |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4081537A (en) | 1975-10-10 | 1978-03-28 | Schering Aktiengesellschaft | Δ15 -Steroids and pharmaceutical compositions thereof |
| WO1990004397A1 (de) * | 1988-10-27 | 1990-05-03 | Schering Aktiengesellschaft Berlin Und Bergkamen | Mittel zur transdermalen applikation enthaltend gestoden |
| US5512292A (en) * | 1990-10-29 | 1996-04-30 | Alza Corporation | Transdermal contraceptive formulations methods and devices |
| EP0555360A1 (en) * | 1990-10-29 | 1993-08-18 | Alza Corporation | Transdermal contraceptive formulations, methods and devices |
| DE4336557C2 (de) | 1993-05-06 | 1997-07-17 | Lohmann Therapie Syst Lts | Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung |
| DE4329242A1 (de) * | 1993-08-26 | 1995-03-02 | Schering Ag | Mittel zur transdermalen Applikation enthaltend Gestodenester |
| DE4405898A1 (de) * | 1994-02-18 | 1995-08-24 | Schering Ag | Transdermale therapeutische Systeme enthaltend Sexualsteroide |
| US5762956A (en) | 1996-04-24 | 1998-06-09 | Rutgers, The State University Of New Jersey | Transdermal contraceptive delivery system and process |
| DE19906152B4 (de) | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| AU784196B2 (en) | 1999-11-24 | 2006-02-23 | Agile Therapeutics, Inc. | Improved transdermal contraceptive delivery system and process |
| DE10053375C1 (de) * | 2000-10-27 | 2002-01-24 | Lohmann Therapie Syst Lts | Transdermale therapeutische Systeme mit lichtempfindlichen Wirkstoffen |
| WO2002045701A2 (en) * | 2000-12-05 | 2002-06-13 | Noven Pharmaceuticals, Inc. | Crystallization inhibition of drugs in transdermal drug delivery systems |
-
2004
- 2004-10-12 UA UAA200607580A patent/UA89766C2/ru unknown
- 2004-11-18 JO JO2004159A patent/JO2606B1/en active
- 2004-12-10 ME MEP-2010-79A patent/ME01069B/me unknown
- 2004-12-10 PE PE2004001230A patent/PE20051035A1/es active IP Right Grant
- 2004-12-10 HN HN2004000526A patent/HN2004000526A/es unknown
- 2004-12-10 ES ES09173898.9T patent/ES2445690T3/es not_active Expired - Lifetime
- 2004-12-10 SI SI200431404T patent/SI1541137T1/sl unknown
- 2004-12-10 PT PT91738989T patent/PT2138169E/pt unknown
- 2004-12-10 CN CN2010101564978A patent/CN101843603B/zh not_active Expired - Lifetime
- 2004-12-10 EP EP04078365A patent/EP1541137B1/en not_active Expired - Lifetime
- 2004-12-10 PL PL09173898T patent/PL2138169T3/pl unknown
- 2004-12-10 EP EP09173898.9A patent/EP2138169B1/en not_active Expired - Lifetime
- 2004-12-10 AR ARP040104605A patent/AR046762A1/es not_active Application Discontinuation
- 2004-12-10 PT PT04078365T patent/PT1541137E/pt unknown
- 2004-12-10 RS YU20140050A patent/RS53182B/sr unknown
- 2004-12-10 RS RSP-2010/0202A patent/RS51260B/sr unknown
- 2004-12-10 AT AT04078365T patent/ATE457168T1/de active
- 2004-12-10 SI SI200432127T patent/SI2138169T1/sl unknown
- 2004-12-10 PL PL04078365T patent/PL1541137T3/pl unknown
- 2004-12-10 MY MYPI20045107A patent/MY144053A/en unknown
- 2004-12-10 DK DK04078365.6T patent/DK1541137T3/da active
- 2004-12-10 DE DE602004025444T patent/DE602004025444D1/de not_active Expired - Lifetime
- 2004-12-10 DK DK09173898.9T patent/DK2138169T3/da active
- 2004-12-10 SV SV2004001970A patent/SV2006001970A/es not_active Application Discontinuation
- 2004-12-10 ES ES04078365T patent/ES2340925T3/es not_active Expired - Lifetime
- 2004-12-10 TW TW093138443A patent/TWI257299B/zh not_active IP Right Cessation
- 2004-12-10 GT GT200400262A patent/GT200400262A/es unknown
-
2006
- 2006-06-20 CR CR8465A patent/CR8465A/es unknown
-
2010
- 2010-03-31 MY MYPI2010001448 patent/MY152750A/en unknown
- 2010-05-04 HR HR20100254T patent/HRP20100254T1/hr unknown
- 2010-05-07 CY CY20101100401T patent/CY1110637T1/el unknown
-
2014
- 2014-01-24 HR HRP20140077TT patent/HRP20140077T1/hr unknown
- 2014-02-06 CY CY20141100099T patent/CY1115064T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CU20100143A7 (es) | Hormonas de administración transdérmica que no necesitan potenciadores de penetración | |
| CY1115064T1 (el) | Διαδερμικο συστημα παραδοσης ορμονων χωρις ενισχυτες διεισδυσης | |
| EE03805B1 (et) | Peroraalselt manustatava farmatseutilise kompositsiooni kasutamine meeste erektiilse talitlushäire raviks ettenähtud ravimi valmistamiseks | |
| DK0836506T4 (da) | Transdermalt plaster til indgivelse af 17-deacetyl norgestimat alene eller i kombination med et østrogen | |
| MXPA04005211A (es) | Sistemas terapeuticos transdermicos que contienen hormona esteroides y monocaprilato de propilenglicol. | |
| EA200900491A1 (ru) | Применение эстрадиола валерата или 17в-эстрадиола в комбинации с диеногестом для перорального лечения для поддержания и/или повышения полового влечения у особи женского пола | |
| HUP9900301A2 (hu) | Hormontapasz | |
| BR0312007A (pt) | Controle de taxa de administração transcutânea usando composições farmacêuticas amorfas | |
| CR7610A (es) | Uso de derivados de thio-oxindol en el tratamiento de condiciones realcionadas con la hormona | |
| PE20060467A1 (es) | Tratamiento de la hemorragia de disrupcion en regimenes anticonceptivos extendidos | |
| AR021459A1 (es) | PARCHE QUE CONTIENE ESTRADIOL PARA LA APLICACIoN PERCUTÁNEA DE HORMONAS. | |
| PE20040068A1 (es) | Decanoato, undecanoato y dodecanoato de etonogestrel | |
| CR10289A (es) | "estratrienos 9-alfa-sustituidos como estrogenos de eficacia selectiva"(divisional) | |
| UY28668A1 (es) | Hormonas de administración transdérmica que no necesitan potenciadores de penetración | |
| CU20060121A7 (es) | Hormonas de administración transdérmica que no necesitan potenciadores de penetración | |
| CR8059A (es) | Composicion farmaceutica en forma de hidrogel para administracion transdermica de sustancias activas | |
| PE20070119A1 (es) | Nuevos regimenes para dispositivos de suministro controlado de farmacos para la anticoncepcion | |
| YU13902A (sh) | Mezoprogestini (progesteron receptor modulatori) kao komponente kontraceptivnih sredstava za žene | |
| HN2004000525A (es) | Forma de administracion transdermica liquida o semis lida que contiene sustancia activa sensible a la luz, estable a los rayos ultravioletas | |
| DE69918124D1 (de) | Formulierungen zur transdermalen verabreichung von fenoldopam | |
| Lewis | Treatment of Erectile Dysfunction: Today and Tomorrow |