CR8862A - Derivados de polisacaridos y sus usos en la induccion de una respuesta inmune - Google Patents

Derivados de polisacaridos y sus usos en la induccion de una respuesta inmune

Info

Publication number
CR8862A
CR8862A CR8862A CR8862A CR8862A CR 8862 A CR8862 A CR 8862A CR 8862 A CR8862 A CR 8862A CR 8862 A CR8862 A CR 8862A CR 8862 A CR8862 A CR 8862A
Authority
CR
Costa Rica
Prior art keywords
acetylated
derivatives
derivative
polisacarids
induction
Prior art date
Application number
CR8862A
Other languages
English (en)
Inventor
R Moe Gregory
M Granoff Dan
Original Assignee
Childrens Hosp & Res Ct Oak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hosp & Res Ct Oak filed Critical Childrens Hosp & Res Ct Oak
Publication of CR8862A publication Critical patent/CR8862A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/36—Neisseria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion en general proporciona composiciones que presentan un derivado de polisacarido, y metodos para su preparacion y uso para la prevencion o tratamiento de enfermedades causadas por bacterias Neisseria meningitidis, particularmente cepas (NmB) del grupo B, y por E.coIi Kl. La invencion proporciona un derivado PS des-N-acetilado en el cual uno o mas residuos de PS han sido modificados por la de-N-acetilacion. La invencion tambien incluye derivadas en los cuales uno o mas de los grupos N-acetilo de PS que contienen los PS de-N-acetilados se reemplazan con otros grupos N-acilo, usualmente un grupo acilo menor con 2 o 3 atomos de carbono. Ademas la invencion incluye los derivados de PS des-Nacetilados que contienen hidrocarburos de cadena larga asi como conjugados en los cuales el derivado de PS des-N-acetilados se liga a un portador, por ejemplo una proteina portadora.
CR8862A 2004-06-23 2007-01-18 Derivados de polisacaridos y sus usos en la induccion de una respuesta inmune CR8862A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58267204P 2004-06-23 2004-06-23

Publications (1)

Publication Number Publication Date
CR8862A true CR8862A (es) 2007-07-24

Family

ID=35782376

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8862A CR8862A (es) 2004-06-23 2007-01-18 Derivados de polisacaridos y sus usos en la induccion de una respuesta inmune

Country Status (14)

Country Link
US (2) US7595307B2 (es)
EP (1) EP1784428A2 (es)
JP (1) JP2008509886A (es)
KR (1) KR20070060069A (es)
AU (1) AU2005258301A1 (es)
BR (1) BRPI0512413A (es)
CA (1) CA2568982A1 (es)
CR (1) CR8862A (es)
EC (1) ECSP077129A (es)
IL (1) IL179642A0 (es)
MX (1) MXPA06015107A (es)
NO (1) NO20070434L (es)
RU (1) RU2404995C2 (es)
WO (1) WO2006002402A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006002402A2 (en) 2004-06-23 2006-01-05 Children's Hospital & Research Center At Oakland Polysaccharide derivatives and uses in induction of an immune response
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
WO2007023386A2 (en) * 2005-08-24 2007-03-01 Novartis Vaccines And Diagnostics Srl Zwitterionization of capsular saccharides
BRPI0620453A2 (pt) * 2005-12-23 2011-11-08 Children's Hospital & Research Center At Oakland composições farmaceuticas compreendendo antìgenos de ácido siálico de-n-acetila e anticorpos para os mesmos, e seus usos
CN105267974A (zh) * 2007-06-20 2016-01-27 辉瑞爱尔兰制药公司 用于缀合疫苗的经过修饰的多糖
US8999954B2 (en) 2007-07-03 2015-04-07 Childern's Hospital & Research Center at Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
JP5523313B2 (ja) * 2007-07-03 2014-06-18 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用
JP5702600B2 (ja) * 2007-07-03 2015-04-15 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド オリゴシアル酸誘導体、製造方法および免疫学的使用
WO2011133227A2 (en) 2010-04-23 2011-10-27 Ancora Pharmaceuticals Inc. Synthetic oligosaccharides for staphyloccocus vaccine
WO2011137181A1 (en) 2010-04-27 2011-11-03 Ancora Pharmaceuticals Inc. Synthetic oligosaccharides for moraxella vaccine
WO2011149778A1 (en) 2010-05-26 2011-12-01 Ancora Pharmaceuticals Inc. Synthetic oligosaccharides for neisseria meningitis vaccine
CN109182423B (zh) * 2018-09-26 2020-07-07 武汉中科光谷绿色生物技术有限公司 促进大肠杆菌发酵生产聚唾液酸的方法
CN112795583A (zh) * 2020-11-16 2021-05-14 上海大学 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法
CN114539333B (zh) * 2022-03-01 2023-12-22 德元堂(上海)健康科技发展有限公司 一种唾液酸的循环生产工艺
CN114507262B (zh) * 2022-03-01 2023-12-19 德元堂(上海)健康科技发展有限公司 一种聚唾液酸的水解工艺

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US4314999A (en) * 1978-07-31 1982-02-09 Proter S.P.A. N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
US4216208A (en) * 1978-07-31 1980-08-05 Proter S.P.A. N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity
US4727136A (en) 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
US4722136A (en) * 1985-10-28 1988-02-02 Leviton Manufacturing Company, Inc. Snap-in convenience electrical connector system and method of assembly
JPS6344590A (ja) * 1986-08-12 1988-02-25 Mect Corp シアル酸誘導体の製造方法
WO1991008772A1 (en) * 1989-12-14 1991-06-27 National Research Council Of Canada Improved meningococcal polysaccharide conjugate vaccine
US5846951A (en) * 1991-06-06 1998-12-08 The School Of Pharmacy, University Of London Pharmaceutical compositions
GB9116896D0 (en) * 1991-08-06 1991-09-18 Erba Carlo Spa 3-deoxymannosamine derivatives and process for their preparation
US5811102A (en) * 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
JPH101397A (ja) * 1996-06-14 1998-01-06 Mitsubishi Gas Chem Co Inc 磁気光学素子の基板用ガーネット結晶及びその製造法
JP4162267B2 (ja) * 1996-08-27 2008-10-08 カイロン コーポレイション Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ複合糖質およびその使用法
EP0922059B1 (en) * 1996-08-27 2003-10-22 Chiron Corporation Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions
PT1630168E (pt) 1997-08-27 2011-07-20 Novartis Vaccines & Diagnostic Compostos miméticos moleculares de péptidos de meningococos do serogrupo b
US6274568B1 (en) * 1998-08-06 2001-08-14 Ronald L. Schnaar Compounds for altering cell surface sialic acids and methods of use therefor
CA2279134A1 (en) 1999-07-29 2001-01-29 Tianmin Liu Novel strategy for carbohydrate-based therapeutic vaccines
WO2002009744A2 (en) * 2000-07-28 2002-02-07 National Research Council Of Canada Modified sialic acid vaccines
WO2006002402A2 (en) 2004-06-23 2006-01-05 Children's Hospital & Research Center At Oakland Polysaccharide derivatives and uses in induction of an immune response

Also Published As

Publication number Publication date
US20070010482A1 (en) 2007-01-11
JP2008509886A (ja) 2008-04-03
CA2568982A1 (en) 2006-01-05
MXPA06015107A (es) 2007-03-26
RU2404995C2 (ru) 2010-11-27
IL179642A0 (en) 2007-05-15
US20100068728A1 (en) 2010-03-18
US7595307B2 (en) 2009-09-29
BRPI0512413A (pt) 2008-03-04
AU2005258301A1 (en) 2006-01-05
RU2007102255A (ru) 2008-07-27
KR20070060069A (ko) 2007-06-12
WO2006002402A3 (en) 2006-05-04
ECSP077129A (es) 2007-02-28
EP1784428A2 (en) 2007-05-16
WO2006002402A2 (en) 2006-01-05
NO20070434L (no) 2007-03-20

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)