CR9244A - AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASA - Google Patents

AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASA

Info

Publication number
CR9244A
CR9244A CR9244A CR9244A CR9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A
Authority
CR
Costa Rica
Prior art keywords
secretasa
imidazolones
inhibition
amino
aminoimidazolone
Prior art date
Application number
CR9244A
Other languages
Spanish (es)
Inventor
Sotirios Malamas Michael
Joseph Erdei James
Suwandi Gunawan Iwan
Nowak Pawel
Lynn Harrison Boyd
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9244A publication Critical patent/CR9244A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion suministra un compuesto de aminoimidazolona de formula I. Tambien se suministran composiciones y metodos para el uso de estos para inhibir B-secretasa (BACE) y tratar depositos B-amiloides y ovillos neurofibrilares.The present invention provides an aminoimidazolone compound of formula I. Compositions and methods for the use of these are also provided to inhibit B-secretase (BACE) and treat B-amyloid deposits and neurofibrillary clews.

CR9244A 2005-01-14 2007-07-12 AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASA CR9244A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64380505P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
CR9244A true CR9244A (en) 2007-09-07

Family

ID=36581776

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9244A CR9244A (en) 2005-01-14 2007-07-12 AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASA

Country Status (20)

Country Link
US (2) US7563796B2 (en)
EP (2) EP2264036A1 (en)
JP (1) JP2008526966A (en)
KR (1) KR20070095948A (en)
CN (1) CN101103034A (en)
AR (1) AR052458A1 (en)
AU (1) AU2006205127A1 (en)
BR (1) BRPI0606690A2 (en)
CA (1) CA2593515A1 (en)
CR (1) CR9244A (en)
GT (1) GT200600009A (en)
IL (1) IL183938A0 (en)
MX (1) MX2007008555A (en)
NO (1) NO20073099L (en)
PA (1) PA8660001A1 (en)
PE (1) PE20060842A1 (en)
RU (1) RU2007126570A (en)
TW (1) TW200637866A (en)
WO (1) WO2006076284A2 (en)
ZA (1) ZA200705783B (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
BRPI0512213A (en) * 2004-06-16 2008-02-19 Wyeth Corp method for treating, preventing or ameliorating a disease or disorder; pharmaceutical composition; process for the preparation of a compound; and use of a compound
RU2006144075A (en) 2004-06-16 2008-07-27 Вайет (Us) DIPHENYLIMIDAZOPYRIMIDINE AND β-IMIDAZOLAMINES AS β-SECRETASE INHIBITORS
CN101111489A (en) * 2005-02-01 2008-01-23 惠氏公司 Amino-pyridines as inhibitors of β-secretase
BRPI0606902A2 (en) * 2005-02-14 2009-07-28 Wyeth Corp compound; method for treating a disease or disorder associated with excessive baceous activity in a patient in need thereof; method for modulating bace activity; pharmaceutical composition
PE20070135A1 (en) 2005-06-14 2007-03-09 Schering Corp HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ASPARTILE PROTEASES
WO2006138265A2 (en) 2005-06-14 2006-12-28 Schering Corporation Heterocyclic aspartyl protease inhibitors, preparation and use thereof
TW200738683A (en) * 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
AU2006266167A1 (en) * 2005-06-30 2007-01-11 Wyeth Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
TW200730523A (en) * 2005-07-29 2007-08-16 Wyeth Corp Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
JP2009509957A (en) * 2005-09-26 2009-03-12 ワイス Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as β-secretase inhibitors
CA2628074C (en) 2005-10-25 2014-01-14 Shionogi & Co., Ltd. Aminodihydrothiazine derivative
AU2006333049A1 (en) * 2005-12-19 2007-07-12 Wyeth 2-amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation
WO2007100536A1 (en) * 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
PE20080155A1 (en) 2006-06-12 2008-03-10 Schering Corp HETEROCYCLIC COMPOUNDS AS ASPARTILE-PROTEASE INHIBITORS
TW200808796A (en) * 2006-06-14 2008-02-16 Astrazeneca Ab New compounds III
TW200815449A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds II
TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
TW200815443A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds I
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
TW200817406A (en) * 2006-08-17 2008-04-16 Wyeth Corp Imidazole amines as inhibitors of β-secretase
WO2008036196A2 (en) * 2006-09-21 2008-03-27 Wyeth Indolylalkylpyridin-2-amines for the inhibition of beta-secretase
WO2008063114A1 (en) * 2006-11-20 2008-05-29 Astrazeneca Ab Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia
JP2010512389A (en) 2006-12-12 2010-04-22 シェーリング コーポレイション Aspartyl protease inhibitor
CL2008000784A1 (en) * 2007-03-20 2008-05-30 Wyeth Corp AMINO-5 COMPOUNDS - [- 4- (DIFLOUROMETOXI) SUBSTITUTED PHENYL] -5-PHENYLMIDAZOLONE, B-SECRETASE INHIBITORS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT ALZHEIMER, COGNITIVE DETERIORATION, DOWN SYNDROME, DECREASE CO
CL2008000791A1 (en) * 2007-03-23 2008-05-30 Wyeth Corp COMPOUNDS DERIVED FROM 2-AMINO-5- (4-DIFLUOROMETOXI-FENIL) -5-FENIL-IMIDAZOLIDIN-4-ONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH EXCESSIVE BACE ACTIVITY, SUCH AS ILLNESS
US8653067B2 (en) 2007-04-24 2014-02-18 Shionogi & Co., Ltd. Pharmaceutical composition for treating Alzheimer's disease
JP5383484B2 (en) 2007-04-24 2014-01-08 塩野義製薬株式会社 Aminodihydrothiazine derivatives substituted with cyclic groups
TW200902499A (en) * 2007-05-15 2009-01-16 Astrazeneca Ab New compounds
CA2723222C (en) 2008-04-22 2013-04-02 Schering Corporation Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use
KR101324426B1 (en) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING β-SECRETASE-INHIBITING ACTIVITY
JP5417860B2 (en) * 2008-08-26 2014-02-19 住友化学株式会社 Method for producing α-hydroxyesters
MY148558A (en) 2008-09-11 2013-04-30 Amgen Inc Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use
CN102186841A (en) 2008-10-22 2011-09-14 盐野义制药株式会社 2-aminopyridin-4-one and 2-aminopyridine derivative both having bace1-inhibiting activity
TW201020244A (en) * 2008-11-14 2010-06-01 Astrazeneca Ab New compounds
EP2281824A1 (en) 2009-08-07 2011-02-09 Noscira, S.A. Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders
UA108363C2 (en) 2009-10-08 2015-04-27 IMINOTIADIASIADIOXIDE OXIDES AS BACE INHIBITORS, COMPOSITIONS THEREOF AND THEIR APPLICATIONS
MX2012006491A (en) 2009-12-11 2012-07-03 Shionogi & Co OXAZINE DERIVATIVES
US8497264B2 (en) 2010-03-15 2013-07-30 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
EP2547685A1 (en) 2010-03-15 2013-01-23 Amgen Inc. Spiro-tetracyclic ring compounds as beta - secretase modulators
MX339640B (en) 2010-06-09 2016-06-01 Janssen Pharmaceutica Nv * 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace).
US8921363B2 (en) 2010-08-05 2014-12-30 Amgen Inc. Derivatives of 1 H-isoindol-3-amine, 1 H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as beta-secretase inhibitors
JP5816630B2 (en) 2010-10-29 2015-11-18 塩野義製薬株式会社 Naphthyridine derivatives
EP2634188A4 (en) * 2010-10-29 2014-05-07 Shionogi & Co Fused aminodihydropyrimidine derivative
EP2643299B1 (en) 2010-11-22 2016-06-22 Noscira, S.A. Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions
US8957083B2 (en) 2010-11-23 2015-02-17 Amgen Inc. Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
EP2655376B1 (en) 2010-12-22 2017-08-23 Janssen Pharmaceutica NV 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
US9346827B2 (en) 2011-02-07 2016-05-24 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
EP2675810A1 (en) 2011-02-15 2013-12-25 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
CN103415519B (en) 2011-03-01 2016-03-02 詹森药业有限公司 As 6,7-dihydro-pyrazol [1, the 5-a] pyrazine-4-yl amine derivatives that beta-secretase (BACE) inhibitor is useful
AU2012224632B2 (en) * 2011-03-09 2016-06-16 Janssen Pharmaceutica Nv 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (BACE)
EP2694489B1 (en) 2011-04-07 2017-09-06 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2694521B1 (en) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
US8883779B2 (en) 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
CN103874496A (en) 2011-08-22 2014-06-18 默沙东公司 2-spiro-substituted iminothiazines as BACE inhibitors and their mono- and dioxide-oxides, compositions and uses thereof
WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
EP2912035A4 (en) 2012-10-24 2016-06-15 Shionogi & Co Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
WO2014078314A1 (en) 2012-11-15 2014-05-22 Amgen Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
MX368326B (en) 2013-06-12 2019-09-27 Janssen Pharmaceutica Nv 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace).
KR102243134B1 (en) 2013-06-12 2021-04-22 얀센 파마슈티카 엔.브이. 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase(bace)
BR112015030597A2 (en) 2013-06-12 2017-07-25 Janssen Pharmaceutica Nv 4-amino-6-phenyl-6,7-dihydro [1,2,3] triazolo [1,5-a] pyrazine derivatives as beta-secretase (bace) inhibitors
CN105272960A (en) 2014-07-18 2016-01-27 上海科胜药物研发有限公司 Preparation method of canagliflozin intermediate 2-(2-methyl-5-bromobenzyl)-5-(4-fluorobenzene)thiophene
ES2768823T3 (en) 2014-12-18 2020-06-23 Janssen Pharmaceutica Nv 2,3,4,5-Tetrahydropyridin-6-amine and 3,4-dihydro-2H-pyrrole-5-amine derivatives useful as beta-secretase inhibitors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45198B1 (en) * 1976-06-05 1982-07-14 Wyeth John & Brother Ltd Guanidine derivatives
DE2901362A1 (en) 1978-01-25 1979-07-26 Sandoz Ag GUANIDE DERIVATIVES, THEIR PRODUCTION AND USE
GB1588096A (en) * 1978-05-20 1981-04-15 Wyeth & Bros Ltd John Pyrrole derivatives
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
ZA967800B (en) 1995-09-20 1997-04-03 Yamanouchi Pharma Co Ltd Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them
GB9611046D0 (en) 1996-05-25 1996-07-31 Wivenhoe Techn Ltd Pharmacological compounds
GB2323841A (en) 1997-04-04 1998-10-07 Ferring Bv Group Holdings Pyridine derivatives with anti-tumor and anti-inflammatory activity
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
US6492408B1 (en) * 1999-07-21 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
DE10024319A1 (en) 2000-05-17 2001-11-22 Merck Patent Gmbh New bis-acylguanidine compounds are subtype-1 cellular sodium ion-proton antiporter inhibitors useful e.g. for treating arrhythmia, angina pectoris, infarction and insulin-independent diabetes mellitus
DE10046993A1 (en) 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament and medicament containing them
AU2002347022A1 (en) 2001-12-20 2003-07-09 Novo Nordisk A/S Benzimidazols and indols as glucagon receptor antagonists/inverse agonisten
US7053220B2 (en) 2002-02-01 2006-05-30 Elan Pharmaceuticals, Inc. Hydroxyalkanoyl aminopyrazoles and related compounds
AU2003229024A1 (en) 2002-05-07 2003-11-11 Elan Pharmaceuticals, Inc. Succinoyl aminopyrazoles and related compounds
GB0223038D0 (en) * 2002-10-04 2002-11-13 Merck Sharp & Dohme Therapeutic compounds
WO2004058727A1 (en) 2002-12-20 2004-07-15 Bayer Pharmaceuticals Corporation Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
KR20060033873A (en) 2003-07-01 2006-04-20 바이엘 크롭사이언스 게엠베하 3-pyridylcarboxamide derivatives as pesticides
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
EP2335701B1 (en) 2003-12-15 2012-07-11 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
BRPI0512213A (en) 2004-06-16 2008-02-19 Wyeth Corp method for treating, preventing or ameliorating a disease or disorder; pharmaceutical composition; process for the preparation of a compound; and use of a compound
RU2006144075A (en) * 2004-06-16 2008-07-27 Вайет (Us) DIPHENYLIMIDAZOPYRIMIDINE AND β-IMIDAZOLAMINES AS β-SECRETASE INHIBITORS
CN101111489A (en) 2005-02-01 2008-01-23 惠氏公司 Amino-pyridines as inhibitors of β-secretase
BRPI0606902A2 (en) 2005-02-14 2009-07-28 Wyeth Corp compound; method for treating a disease or disorder associated with excessive baceous activity in a patient in need thereof; method for modulating bace activity; pharmaceutical composition
WO2006088694A1 (en) 2005-02-14 2006-08-24 Wyeth SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS
WO2006088705A1 (en) 2005-02-14 2006-08-24 Wyeth Terphenyl guanidines as [beta symbol] -secretase inhibitors
TW200738683A (en) 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
AU2006266167A1 (en) 2005-06-30 2007-01-11 Wyeth Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
TW200730523A (en) 2005-07-29 2007-08-16 Wyeth Corp Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
JP2009509957A (en) 2005-09-26 2009-03-12 ワイス Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as β-secretase inhibitors
AU2006333049A1 (en) 2005-12-19 2007-07-12 Wyeth 2-amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation
WO2007100536A1 (en) 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US7700606B2 (en) 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase

Also Published As

Publication number Publication date
ZA200705783B (en) 2008-09-25
TW200637866A (en) 2006-11-01
RU2007126570A (en) 2009-02-20
JP2008526966A (en) 2008-07-24
PE20060842A1 (en) 2006-10-12
EP1836208A2 (en) 2007-09-26
US20060160828A1 (en) 2006-07-20
MX2007008555A (en) 2007-11-21
AU2006205127A1 (en) 2006-07-20
AR052458A1 (en) 2007-03-21
WO2006076284A3 (en) 2007-04-19
US20090253716A1 (en) 2009-10-08
CN101103034A (en) 2008-01-09
CA2593515A1 (en) 2006-07-20
EP2264036A1 (en) 2010-12-22
KR20070095948A (en) 2007-10-01
GT200600009A (en) 2006-08-17
BRPI0606690A2 (en) 2009-07-14
PA8660001A1 (en) 2006-09-08
NO20073099L (en) 2007-07-31
WO2006076284A2 (en) 2006-07-20
IL183938A0 (en) 2007-10-31
US7563796B2 (en) 2009-07-21

Similar Documents

Publication Publication Date Title
CR9244A (en) AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASA
CR9272A (en) AMINO-IMIDAZOLONES FOR THE INHIBITION OF B-SECRETASE
PA8772701A1 (en) "AMINO-5 COMPOUNDS - [- 4- (DIFLUOROMETOXI) REPLACED PHENYL) -5-PHENYLIMIDAZOLONE AS INHIBITORS OF ß-SECRETASE"
CR9830A (en) AMINO-5- [4- (DIFLUOROMETOXI) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF B-SECRETASE
CR9331A (en) VEGF-R2 INHIBITORS AND METHODS
GT200600283A (en) COMPOUNDS OF AMINO-5-HETEROARILO (5 MEMBERS) IMIDAZOLONE AND ITS USE FOR THE MODULATION OF beta-SECRETASE
CY1109911T1 (en) PYRROLOVENZODIAZEPINES
CY1112102T1 (en) Substituted Pyramidodiazepine Uses As Suspensions PLK1
DK1761520T3 (en) kinase inhibitors
EA200701396A1 (en) TRIAZOLOPHTHALASINS AS PDE-2 INHIBITORS
CR20110028A (en) PIRIMIDINE DERIVATIVES AS CINASE INHIBITORS
BRPI0510177B8 (en) compound, pharmaceutical composition and use thereof
MX2009003834A (en) Pyrrolydine derivatives as iap inhibitors.
ECSP066893A (en) APOPTOSIS PROTEIN INHIBITORS (IAP)
SV2011003809A (en) HETEROARILO DERIVATIVES AS DGAT1 INHIBITORS
ECSP10010722A (en) ORGANIC COMPOUNDS
NO20081636L (en) FAP inhibitors
EA200971051A1 (en) INHIBITORS P70 S6 KINASE
ECSP078062A (en) 1,4-DIHYDROPIRIDINE-CONDENSED HETEROCICLES, PROCESSES TO PREPARE THE SAME, USE AND COMPOSITIONS CONTAINING THEM
EA201200891A1 (en) DERIVATIVES 3,4,4A, 10D-TETRAGIDRO-1H-TIOPIRANO [4,3-C] IZOHINOLINA
CL2011001078A1 (en) Compounds derived from spirodihydrotetraazabenzoazulene; preparation procedure; pharmaceutical composition; and its use for the prevention or treatment of dysmenorrhea, sexual dysfunction, hypertension, liver cirrhosis and schizophrenia among others.
DOP2005000010A (en) QUINASE INHIBITORS
EA200901504A1 (en) DERIVATIVES OF PYRAZOLONA, AS PDE4 INHIBITORS
EA200801145A1 (en) SPYROCYCLIC DERIVATIVES OF HINAZOLIN AS PDE7 INHIBITORS
ATE417849T1 (en) PYRAZOLOA4,3-DÜPYRIMIDINE

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)