CR9244A - AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA - Google Patents

AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA

Info

Publication number
CR9244A
CR9244A CR9244A CR9244A CR9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A
Authority
CR
Costa Rica
Prior art keywords
secretasa
imidazolones
inhibition
amino
aminoimidazolone
Prior art date
Application number
CR9244A
Other languages
English (en)
Inventor
Sotirios Malamas Michael
Joseph Erdei James
Suwandi Gunawan Iwan
Nowak Pawel
Lynn Harrison Boyd
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9244A publication Critical patent/CR9244A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion suministra un compuesto de aminoimidazolona de formula I. Tambien se suministran composiciones y metodos para el uso de estos para inhibir B-secretasa (BACE) y tratar depositos B-amiloides y ovillos neurofibrilares.
CR9244A 2005-01-14 2007-07-12 AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA CR9244A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64380505P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
CR9244A true CR9244A (es) 2007-09-07

Family

ID=36581776

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9244A CR9244A (es) 2005-01-14 2007-07-12 AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA

Country Status (20)

Country Link
US (2) US7563796B2 (es)
EP (2) EP2264036A1 (es)
JP (1) JP2008526966A (es)
KR (1) KR20070095948A (es)
CN (1) CN101103034A (es)
AR (1) AR052458A1 (es)
AU (1) AU2006205127A1 (es)
BR (1) BRPI0606690A2 (es)
CA (1) CA2593515A1 (es)
CR (1) CR9244A (es)
GT (1) GT200600009A (es)
IL (1) IL183938A0 (es)
MX (1) MX2007008555A (es)
NO (1) NO20073099L (es)
PA (1) PA8660001A1 (es)
PE (1) PE20060842A1 (es)
RU (1) RU2007126570A (es)
TW (1) TW200637866A (es)
WO (1) WO2006076284A2 (es)
ZA (1) ZA200705783B (es)

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US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
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RU2006144075A (ru) 2004-06-16 2008-07-27 Вайет (Us) ДИФЕНИЛИМИДАЗОПИРИМИДИН И -ИМИДАЗОЛАМИНЫ КАК ИНГИБИТОРЫ β-СЕКРЕТАЗЫ
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BRPI0606902A2 (pt) * 2005-02-14 2009-07-28 Wyeth Corp composto; método para o tratamento de uma doença ou distúrbio associado a atividade excessiva de bace em um paciente que dele necessite; método para modular a atividade de bace; composição farmacêutica
PE20070135A1 (es) 2005-06-14 2007-03-09 Schering Corp Compuestos heterociclicos como inhibidores de aspartil proteasas
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TW200815449A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds II
TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
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CL2008000784A1 (es) * 2007-03-20 2008-05-30 Wyeth Corp Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co
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Also Published As

Publication number Publication date
ZA200705783B (en) 2008-09-25
TW200637866A (en) 2006-11-01
RU2007126570A (ru) 2009-02-20
JP2008526966A (ja) 2008-07-24
PE20060842A1 (es) 2006-10-12
EP1836208A2 (en) 2007-09-26
US20060160828A1 (en) 2006-07-20
MX2007008555A (es) 2007-11-21
AU2006205127A1 (en) 2006-07-20
AR052458A1 (es) 2007-03-21
WO2006076284A3 (en) 2007-04-19
US20090253716A1 (en) 2009-10-08
CN101103034A (zh) 2008-01-09
CA2593515A1 (en) 2006-07-20
EP2264036A1 (en) 2010-12-22
KR20070095948A (ko) 2007-10-01
GT200600009A (es) 2006-08-17
BRPI0606690A2 (pt) 2009-07-14
PA8660001A1 (es) 2006-09-08
NO20073099L (no) 2007-07-31
WO2006076284A2 (en) 2006-07-20
IL183938A0 (en) 2007-10-31
US7563796B2 (en) 2009-07-21

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