CR9244A - AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA - Google Patents

AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA

Info

Publication number
CR9244A
CR9244A CR9244A CR9244A CR9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A CR 9244 A CR9244 A CR 9244A
Authority
CR
Costa Rica
Prior art keywords
secretasa
imidazolones
inhibition
amino
aminoimidazolone
Prior art date
Application number
CR9244A
Other languages
English (en)
Inventor
Sotirios Malamas Michael
Joseph Erdei James
Suwandi Gunawan Iwan
Nowak Pawel
Lynn Harrison Boyd
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9244A publication Critical patent/CR9244A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion suministra un compuesto de aminoimidazolona de formula I. Tambien se suministran composiciones y metodos para el uso de estos para inhibir B-secretasa (BACE) y tratar depositos B-amiloides y ovillos neurofibrilares.
CR9244A 2005-01-14 2007-07-12 AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA CR9244A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64380505P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
CR9244A true CR9244A (es) 2007-09-07

Family

ID=36581776

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9244A CR9244A (es) 2005-01-14 2007-07-12 AMINO-IMIDAZOLONAS PARA LA INHIBICION DE ß-SECRETASA

Country Status (20)

Country Link
US (2) US7563796B2 (es)
EP (2) EP2264036A1 (es)
JP (1) JP2008526966A (es)
KR (1) KR20070095948A (es)
CN (1) CN101103034A (es)
AR (1) AR052458A1 (es)
AU (1) AU2006205127A1 (es)
BR (1) BRPI0606690A2 (es)
CA (1) CA2593515A1 (es)
CR (1) CR9244A (es)
GT (1) GT200600009A (es)
IL (1) IL183938A0 (es)
MX (1) MX2007008555A (es)
NO (1) NO20073099L (es)
PA (1) PA8660001A1 (es)
PE (1) PE20060842A1 (es)
RU (1) RU2007126570A (es)
TW (1) TW200637866A (es)
WO (1) WO2006076284A2 (es)
ZA (1) ZA200705783B (es)

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* Cited by examiner, † Cited by third party
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US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
ATE444962T1 (de) * 2004-06-16 2009-10-15 Wyeth Corp Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung
JP2008503460A (ja) * 2004-06-16 2008-02-07 ワイス β−セクレターゼのインヒビターとしてのジフェニルイミダゾピリミジンおよびイミダゾールアミン
BRPI0607094A2 (pt) * 2005-02-01 2009-08-04 Wyeth Corp composto da fórmula i; uso do composto para o tratamento de uma doença ou distúrbio associado à atividade excessiva de bace em um paciente que dele necessita; uso do composto para modular a atividade de bace; e composição farmacêutica
CN101146769A (zh) 2005-02-14 2008-03-19 惠氏公司 作为β-分泌酶抑制剂的唑基酰基胍
SG162790A1 (en) 2005-06-14 2010-07-29 Schering Corp Aspartyl protease inhibitors
EP1896032B1 (en) 2005-06-14 2012-10-31 Merck Sharp & Dohme Corp. The preparation and use of compounds as protease inhibitors
TW200738683A (en) * 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
JP2009500329A (ja) * 2005-06-30 2009-01-08 ワイス アミノ−５−（６員）ヘテロアリールイミダゾロン化合物およびβ−セレクターゼ調節のためのその使用
TW200730523A (en) * 2005-07-29 2007-08-16 Wyeth Corp Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
AU2006294620A1 (en) * 2005-09-26 2007-04-05 Wyeth Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace)
CN101346357B (zh) 2005-10-25 2014-04-02 盐野义制药株式会社 氨基二氢噻嗪衍生物
JP2009520027A (ja) * 2005-12-19 2009-05-21 ワイス ２−アミノ−５−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用
WO2007100536A1 (en) * 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US8168641B2 (en) 2006-06-12 2012-05-01 Schering Corporation Aspartyl protease inhibitors
TW200815449A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds II
TW200815443A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds I
TW200808796A (en) * 2006-06-14 2008-02-16 Astrazeneca Ab New compounds III
TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
TW200817406A (en) * 2006-08-17 2008-04-16 Wyeth Corp Imidazole amines as inhibitors of β-secretase
MX2009003102A (es) * 2006-09-21 2009-04-01 Wyeth Corp INDOLILALQUILPIRIDIN-2-AMINAS PARA LA INHIBICION DE ß-SECRETASA.
WO2008063114A1 (en) * 2006-11-20 2008-05-29 Astrazeneca Ab Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia
MX2009006228A (es) 2006-12-12 2009-06-22 Schering Corp Inhibidores de aspartil proteasa.
CL2008000784A1 (es) * 2007-03-20 2008-05-30 Wyeth Corp Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co
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JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
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KR101730937B1 (ko) 2010-06-09 2017-04-27 얀센 파마슈티카 엔.브이. 베타-세크레타아제(ｂａｃｅ) 저해제로 유용한 5,6-디하이드로-2ｈ-[1,4]옥사진-3-일-아민 유도체
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EP2634188A4 (en) * 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
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Also Published As

Publication number Publication date
US20090253716A1 (en) 2009-10-08
WO2006076284A2 (en) 2006-07-20
CN101103034A (zh) 2008-01-09
IL183938A0 (en) 2007-10-31
WO2006076284A3 (en) 2007-04-19
TW200637866A (en) 2006-11-01
ZA200705783B (en) 2008-09-25
BRPI0606690A2 (pt) 2009-07-14
AU2006205127A1 (en) 2006-07-20
JP2008526966A (ja) 2008-07-24
RU2007126570A (ru) 2009-02-20
CA2593515A1 (en) 2006-07-20
PE20060842A1 (es) 2006-10-12
KR20070095948A (ko) 2007-10-01
US20060160828A1 (en) 2006-07-20
NO20073099L (no) 2007-07-31
PA8660001A1 (es) 2006-09-08
US7563796B2 (en) 2009-07-21
GT200600009A (es) 2006-08-17
EP1836208A2 (en) 2007-09-26
EP2264036A1 (en) 2010-12-22
AR052458A1 (es) 2007-03-21
MX2007008555A (es) 2007-11-21

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