CR9574A - Potenciadores del receptor ampa - Google Patents

Potenciadores del receptor ampa

Info

Publication number
CR9574A
CR9574A CR9574A CR9574A CR9574A CR 9574 A CR9574 A CR 9574A CR 9574 A CR9574 A CR 9574A CR 9574 A CR9574 A CR 9574A CR 9574 A CR9574 A CR 9574A
Authority
CR
Costa Rica
Prior art keywords
potentiators
ampa
receiver
ampa receiver
formulations
Prior art date
Application number
CR9574A
Other languages
English (en)
Inventor
Maria Castano Mansanet Ana
Laurent Cordier Frederic
Dominguez-Manzanares Esteban
Eric Hong Jian
Joseph Hornback William
Jiang Delu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR9574A publication Critical patent/CR9574A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a potenciadores del receptor AMPA de formula I: formulaciones que los comprenden, metodos de su uso e intermediarios utiles para su preparacion.
CR9574A 2005-06-06 2007-12-06 Potenciadores del receptor ampa CR9574A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05380117 2005-06-06
EP05380187 2005-08-18
US72420605P 2005-10-06 2005-10-06

Publications (1)

Publication Number Publication Date
CR9574A true CR9574A (es) 2008-05-30

Family

ID=37227734

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9574A CR9574A (es) 2005-06-06 2007-12-06 Potenciadores del receptor ampa

Country Status (13)

Country Link
US (2) US7393868B2 (es)
AR (1) AR057347A1 (es)
CR (1) CR9574A (es)
CY (1) CY1108718T1 (es)
DE (1) DE602006003661D1 (es)
DO (1) DOP2006000124A (es)
EC (1) ECSP077979A (es)
IL (1) IL187157A0 (es)
JO (1) JO2539B1 (es)
MA (1) MA29910B1 (es)
MY (1) MY140858A (es)
NO (1) NO20080079L (es)
PE (1) PE20070107A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006003661D1 (de) * 2005-06-06 2008-12-24 Lilly Co Eli Ampa-rezeptoren-verstärker
JP2010501597A (ja) * 2006-08-31 2010-01-21 ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ 正のアロステリックａｍｐａ受容体モジュレーターを用いて呼吸抑制を阻害する方法
CA2729767A1 (en) * 2008-07-07 2010-01-14 Fasgen, Inc. Novel compounds, pharmaceutical compositions containing same, methods of use for same, and methods for preparing same
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
EP2694472B1 (en) 2011-04-05 2020-03-11 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
US20150011554A1 (en) 2013-06-13 2015-01-08 Veroscience Llc Compositions and Methods for Treating Metabolic Disorders
EP3436021A4 (en) 2016-03-29 2019-11-06 RespireRx Pharmaceuticals Inc. COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
AU5235699A (en) 1998-07-31 2000-02-21 Eli Lilly And Company Sulfonamide derivatives
WO2001042203A1 (en) 1999-12-08 2001-06-14 Eli Lilly And Company Cyclopentyl sulfonamide derivatives
AU2002212959A1 (en) 2000-10-13 2002-04-29 Eli Lilly And Company Cycloalkylfluorosulfonamide derivatives
US20040087604A1 (en) 2001-01-22 2004-05-06 Tatsuo Tsuri Hetero-tricyclic compounds having substituted amino groups
US20040157817A1 (en) 2001-05-30 2004-08-12 Cantell Buddy Eugene Cycloalkenylsulfonamide derivatives
US6881741B2 (en) 2001-06-11 2005-04-19 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections
SE0102616D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
ES2383115T3 (es) 2004-01-09 2012-06-18 Eli Lilly And Company Compuestos de tiofeno y furano
US20070270471A1 (en) 2004-08-09 2007-11-22 Glaxo Group Limited Compounds Which Potentiate Glutamate Receptor and Uses Thereof in Medicine
DE602006003661D1 (de) * 2005-06-06 2008-12-24 Lilly Co Eli Ampa-rezeptoren-verstärker

Also Published As

Publication number Publication date
MY140858A (en) 2010-01-29
US7393868B2 (en) 2008-07-01
JO2539B1 (en) 2010-09-05
CY1108718T1 (el) 2014-04-09
AR057347A1 (es) 2007-11-28
IL187157A0 (en) 2008-02-09
DOP2006000124A (es) 2007-02-15
MA29910B1 (fr) 2008-11-03
DE602006003661D1 (de) 2008-12-24
US7652064B2 (en) 2010-01-26
ECSP077979A (es) 2008-01-23
HK1116182A1 (en) 2008-12-19
US20070142441A1 (en) 2007-06-21
NO20080079L (no) 2008-01-04
PE20070107A1 (es) 2007-02-09
US20060276532A1 (en) 2006-12-07

Similar Documents

Publication Publication Date Title
CR9814A (es) Derivados de carboxamida como antagonistas del receptor muscarinico
CR11241A (es) Compuestos de pirazol y su uso como inhibidores de raf
HN2006016313A (es) Derivados de amida sustituida y metodos de uso
UY32292A (es) Agonistas de s1p1 y métodos de preparación y uso
CR11393A (es) Agonistas novedosos de los receptores de glucocorticoides
SV2011003894A (es) Nuevos compuestos halosustituidos
UY31124A1 (es) Derivados de oxiadazol y su uso como potenciadores del receptor metabotropico de glutamato - 842
CR9574A (es) Potenciadores del receptor ampa
CR8357A (es) Derivados de tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorio
ECSP088151A (es) Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
ECSP088740A (es) Derivados de tetrahidronaftalina, procedimientos para prepararlos y su uso como antiinflamatorios
ECSP088251A (es) Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
PA8657801A1 (es) Aminalcoholes triciclicos, procedimientos para su preparacion
CR11828A (es) Compuestos novedosos activos como antagonistas de receptor muscarínico
CR11506A (es) Uso de derivados de acido tetramico para controlar nematodos
TNSN07462A1 (en) Ampa receptor potentiators
UY29481A1 (es) Derivados de tetrahidronaftalina, procedimientos para su preparación y su uso como antiinflamatorios.
PA8666801A1 (es) Derivado de 5h-bensociclohepteno, procedimiento para su preparacion y su uso como antiinflamatorios
UA92343C2 (en) Ampa receptor potentiators
DOP2006000089A (es) Derivados de tetrahidronaftalina, procedimientos para su preparacion y uso como antiinflamatorios.
CR9435A (es) Uso de un compuesto
CR9140A (es) Potenciadores de receptores de del glutamato
CU23564A3 (es) Derivados de carboxamida como antagonistas del receptor muscarínico
CR8322A (es) Arilindenopiridinas y arilindenopirimidinas y su uso como antagonista del receptor adenosina a2a
CR9104A (es) Potenciadores de receptores de glutamato