CR9722A - Derivados de benzilpiperazina y su uso medico - Google Patents

Derivados de benzilpiperazina y su uso medico

Info

Publication number
CR9722A
CR9722A CR9722A CR9722A CR9722A CR 9722 A CR9722 A CR 9722A CR 9722 A CR9722 A CR 9722A CR 9722 A CR9722 A CR 9722A CR 9722 A CR9722 A CR 9722A
Authority
CR
Costa Rica
Prior art keywords
derivatives
benzilpiperazina
medical use
compounds
agonists
Prior art date
Application number
CR9722A
Other languages
English (en)
Inventor
Christopher Norbert Johnson
David Timothy Macpherson
Steven James Stanway
Geoffrey Stemp
Mervyn Thompson
Susan Marie Westaway
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0515381A external-priority patent/GB0515381D0/en
Priority claimed from GB0611469A external-priority patent/GB0611469D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CR9722A publication Critical patent/CR9722A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invencion se refiere a nuevos derivados de bencilpiperazina tal como los compuestos de formula (I), que tienen actividad como agonistas del receptor GPR38 y al uso de dichos compuestos o sus composiciones farmaceuticas en el tratamiento de trastornos gastrointestinales.
CR9722A 2005-07-26 2008-02-11 Derivados de benzilpiperazina y su uso medico CR9722A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0515381A GB0515381D0 (en) 2005-07-26 2005-07-26 Compounds
GB0611469A GB0611469D0 (en) 2006-06-09 2006-06-09 Compounds

Publications (1)

Publication Number Publication Date
CR9722A true CR9722A (es) 2008-04-10

Family

ID=37560776

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9722A CR9722A (es) 2005-07-26 2008-02-11 Derivados de benzilpiperazina y su uso medico

Country Status (28)

Country Link
US (2) US8536182B2 (es)
EP (2) EP2441763A1 (es)
JP (1) JP4938777B2 (es)
KR (1) KR101281435B1 (es)
AR (1) AR054508A1 (es)
AU (1) AU2006274212B2 (es)
BR (1) BRPI0613987A2 (es)
CA (1) CA2616513C (es)
CR (1) CR9722A (es)
CY (1) CY1113257T1 (es)
DK (1) DK1907374T3 (es)
EA (1) EA014061B1 (es)
EG (1) EG26235A (es)
ES (1) ES2390812T3 (es)
HR (1) HRP20120833T1 (es)
IL (1) IL188854A (es)
JO (1) JO2747B1 (es)
MA (1) MA29723B1 (es)
MX (1) MX2008001211A (es)
MY (1) MY150098A (es)
NO (1) NO340489B1 (es)
NZ (1) NZ565062A (es)
PE (1) PE20070180A1 (es)
PL (1) PL1907374T3 (es)
PT (1) PT1907374E (es)
SI (1) SI1907374T1 (es)
TW (1) TWI376375B (es)
WO (1) WO2007012479A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
JP4938777B2 (ja) * 2005-07-26 2012-05-23 グラクソ グループ リミテッド ベンジルピペラジン誘導体およびその医薬使用
GB0524814D0 (en) * 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
PT1976525E (pt) 2006-01-27 2011-02-04 Ms Science Corp Derivados piperidina e piperazina
WO2008000729A1 (en) * 2006-06-28 2008-01-03 Glaxo Group Limited Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
GB0723317D0 (en) 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
BRPI1007962A2 (pt) 2009-02-27 2016-02-23 Raqualia Pharma Inc composto de fórmula (i), composição farmacêutica contendo o mesmo, uso do mesmo ou de seu sal farmaceuticamente aceitável e método para o tratamento de uma doença mediada pela atividade agonística de receptor de motilina, em um indíviduo mamífero, incluindo um ser humano.
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
CN113292485B (zh) * 2021-06-08 2023-10-27 河南大学 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用

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Also Published As

Publication number Publication date
IL188854A (en) 2013-08-29
HRP20120833T1 (hr) 2012-11-30
JO2747B1 (en) 2014-03-15
CA2616513A1 (en) 2007-02-01
HK1116477A1 (en) 2008-12-24
IL188854A0 (en) 2008-04-13
CY1113257T1 (el) 2016-04-13
EA200800421A1 (ru) 2008-06-30
TW200745081A (en) 2007-12-16
AU2006274212A1 (en) 2007-02-01
JP2009502842A (ja) 2009-01-29
CA2616513C (en) 2013-02-19
KR101281435B1 (ko) 2013-07-02
DK1907374T3 (da) 2012-10-15
EP1907374B1 (en) 2012-08-22
AU2006274212B2 (en) 2011-06-09
PE20070180A1 (es) 2007-04-25
NZ565062A (en) 2011-02-25
EG26235A (en) 2013-05-07
MA29723B1 (fr) 2008-09-01
US20090054456A1 (en) 2009-02-26
US8536182B2 (en) 2013-09-17
EP2441763A1 (en) 2012-04-18
EA014061B1 (ru) 2010-08-30
MX2008001211A (es) 2008-03-24
NO20081014L (no) 2008-04-10
PL1907374T3 (pl) 2012-12-31
TWI376375B (en) 2012-11-11
MY150098A (en) 2013-11-29
PT1907374E (pt) 2012-11-05
AR054508A1 (es) 2007-06-27
WO2007012479A2 (en) 2007-02-01
WO2007012479A3 (en) 2007-04-26
JP4938777B2 (ja) 2012-05-23
KR20080037663A (ko) 2008-04-30
EP1907374A2 (en) 2008-04-09
NO340489B1 (no) 2017-05-02
BRPI0613987A2 (pt) 2011-03-01
ES2390812T3 (es) 2012-11-16
SI1907374T1 (sl) 2012-11-30
US20130317041A1 (en) 2013-11-28

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