PL1907374T3 - Pochodne benzylopiperazyny użyteczne do leczenia zaburzeń układu pokarmowego - Google Patents

Pochodne benzylopiperazyny użyteczne do leczenia zaburzeń układu pokarmowego

Info

Publication number
PL1907374T3
PL1907374T3 PL06776430T PL06776430T PL1907374T3 PL 1907374 T3 PL1907374 T3 PL 1907374T3 PL 06776430 T PL06776430 T PL 06776430T PL 06776430 T PL06776430 T PL 06776430T PL 1907374 T3 PL1907374 T3 PL 1907374T3
Authority
PL
Poland
Prior art keywords
treatment
gastrointestinal disorders
derivatives useful
benzylpiperazine derivatives
benzylpiperazine
Prior art date
Application number
PL06776430T
Other languages
English (en)
Inventor
Christopher Norbert Johnson
David Timothy Macpherson
Steven James Stanway
Geoffrey Stemp
Mervyn Thompson
Susan Marie Westaway
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0515381A external-priority patent/GB0515381D0/en
Priority claimed from GB0611469A external-priority patent/GB0611469D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PL1907374T3 publication Critical patent/PL1907374T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PL06776430T 2005-07-26 2006-07-24 Pochodne benzylopiperazyny użyteczne do leczenia zaburzeń układu pokarmowego PL1907374T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0515381A GB0515381D0 (en) 2005-07-26 2005-07-26 Compounds
GB0611469A GB0611469D0 (en) 2006-06-09 2006-06-09 Compounds
PCT/EP2006/007390 WO2007012479A2 (en) 2005-07-26 2006-07-24 Benzylpiperazine derivates and their medical use
EP06776430A EP1907374B1 (en) 2005-07-26 2006-07-24 Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders

Publications (1)

Publication Number Publication Date
PL1907374T3 true PL1907374T3 (pl) 2012-12-31

Family

ID=37560776

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06776430T PL1907374T3 (pl) 2005-07-26 2006-07-24 Pochodne benzylopiperazyny użyteczne do leczenia zaburzeń układu pokarmowego

Country Status (28)

Country Link
US (2) US8536182B2 (pl)
EP (2) EP2441763A1 (pl)
JP (1) JP4938777B2 (pl)
KR (1) KR101281435B1 (pl)
AR (1) AR054508A1 (pl)
AU (1) AU2006274212B2 (pl)
BR (1) BRPI0613987A2 (pl)
CA (1) CA2616513C (pl)
CR (1) CR9722A (pl)
CY (1) CY1113257T1 (pl)
DK (1) DK1907374T3 (pl)
EA (1) EA014061B1 (pl)
EG (1) EG26235A (pl)
ES (1) ES2390812T3 (pl)
HR (1) HRP20120833T1 (pl)
IL (1) IL188854A (pl)
JO (1) JO2747B1 (pl)
MA (1) MA29723B1 (pl)
MX (1) MX2008001211A (pl)
MY (1) MY150098A (pl)
NO (1) NO340489B1 (pl)
NZ (1) NZ565062A (pl)
PE (1) PE20070180A1 (pl)
PL (1) PL1907374T3 (pl)
PT (1) PT1907374E (pl)
SI (1) SI1907374T1 (pl)
TW (1) TWI376375B (pl)
WO (1) WO2007012479A2 (pl)

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GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
JO2747B1 (en) * 2005-07-26 2014-03-15 جلاكسو جروب ليمتد Vehicles
GB0524814D0 (en) * 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
CN101448503B (zh) 2006-01-27 2011-04-13 株式会社爱慕知科学 哌啶和哌嗪衍生物
PL2041093T3 (pl) * 2006-06-28 2010-09-30 Glaxo Group Ltd Pochodne piperazynylowe użyteczne w leczeniu zaburzeń, którym pośredniczy receptor GPR38
GB0723317D0 (en) * 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
JP5663743B2 (ja) 2009-02-27 2015-02-04 ラクオリア創薬株式会社 モチリン受容体作動活性を有するオキシインドール誘導体
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
CN113292485B (zh) * 2021-06-08 2023-10-27 河南大学 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用

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GB0723317D0 (en) 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
WO2007012479A2 (en) 2007-02-01
TW200745081A (en) 2007-12-16
DK1907374T3 (da) 2012-10-15
NO340489B1 (no) 2017-05-02
EP1907374B1 (en) 2012-08-22
HK1116477A1 (en) 2008-12-24
IL188854A (en) 2013-08-29
AU2006274212B2 (en) 2011-06-09
EG26235A (en) 2013-05-07
MA29723B1 (fr) 2008-09-01
HRP20120833T1 (hr) 2012-11-30
KR20080037663A (ko) 2008-04-30
IL188854A0 (en) 2008-04-13
PT1907374E (pt) 2012-11-05
NZ565062A (en) 2011-02-25
PE20070180A1 (es) 2007-04-25
CR9722A (es) 2008-04-10
JP2009502842A (ja) 2009-01-29
US20130317041A1 (en) 2013-11-28
NO20081014L (no) 2008-04-10
EA014061B1 (ru) 2010-08-30
EP1907374A2 (en) 2008-04-09
CA2616513A1 (en) 2007-02-01
ES2390812T3 (es) 2012-11-16
TWI376375B (en) 2012-11-11
SI1907374T1 (sl) 2012-11-30
MY150098A (en) 2013-11-29
JP4938777B2 (ja) 2012-05-23
WO2007012479A3 (en) 2007-04-26
US8536182B2 (en) 2013-09-17
JO2747B1 (en) 2014-03-15
AU2006274212A1 (en) 2007-02-01
KR101281435B1 (ko) 2013-07-02
CY1113257T1 (el) 2016-04-13
EP2441763A1 (en) 2012-04-18
EA200800421A1 (ru) 2008-06-30
BRPI0613987A2 (pt) 2011-03-01
US20090054456A1 (en) 2009-02-26
AR054508A1 (es) 2007-06-27
CA2616513C (en) 2013-02-19
MX2008001211A (es) 2008-03-24

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