CR9937A - Composiciones farmaceuticas de galio y metodos - Google Patents

Composiciones farmaceuticas de galio y metodos

Info

Publication number
CR9937A
CR9937A CR9937A CR9937A CR9937A CR 9937 A CR9937 A CR 9937A CR 9937 A CR9937 A CR 9937A CR 9937 A CR9937 A CR 9937A CR 9937 A CR9937 A CR 9937A
Authority
CR
Costa Rica
Prior art keywords
pharmaceutical compositions
gallium
galio
methods
complexes
Prior art date
Application number
CR9937A
Other languages
English (en)
Inventor
N Julian Thomas
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Publication of CR9937A publication Critical patent/CR9937A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/06—Chelate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a nuevas composiciones farmaceuticas de galio, que incluyen complejos de galio que tienen biodisponibilidad oral incrementada, con relacion a sales de galio no formadas en complejos. Tales composiciones son empleadas en el tratamiento de condiciones y enfermedades en las cuales, la inhibicion de la resorpcion anormalmente incrementada de calcio se desea, que incluye cancer, hipercalcemia, osteoporosis, osteopenia y enfermedad de Paget. Tambien se proporcionan metodos de preparacion.
CR9937A 2005-11-04 2008-04-28 Composiciones farmaceuticas de galio y metodos CR9937A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73338805P 2005-11-04 2005-11-04

Publications (1)

Publication Number Publication Date
CR9937A true CR9937A (es) 2008-06-26

Family

ID=38023756

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9937A CR9937A (es) 2005-11-04 2008-04-28 Composiciones farmaceuticas de galio y metodos

Country Status (13)

Country Link
US (3) US7354952B2 (es)
EP (1) EP1948159A4 (es)
JP (1) JP2009514856A (es)
KR (1) KR20080072830A (es)
CN (1) CN101296694A (es)
AU (1) AU2006312117A1 (es)
BR (1) BRPI0618096A2 (es)
CA (1) CA2626029A1 (es)
CR (1) CR9937A (es)
EA (1) EA200801261A1 (es)
IL (1) IL190239A0 (es)
WO (1) WO2007055885A2 (es)
ZA (1) ZA200803283B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005321803B2 (en) * 2004-12-29 2012-02-09 Emisphere Technologies, Inc. Pharmaceutical formulations of gallium salts
CA2626029A1 (en) * 2005-11-04 2007-05-18 Genta Incorporated Pharmaceutical gallium compositions and methods
WO2009059188A1 (en) * 2007-11-02 2009-05-07 Emisphere Technologies, Inc. Method of treating vitamin b12 deficiency
US20090275654A1 (en) * 2008-04-30 2009-11-05 Genta Incorporated Pharmaceutical Gallium Compositions and Methods
CN102665421A (zh) * 2009-03-30 2012-09-12 尼基制药公司 治疗骨质疏松的方法
EP2416788A4 (en) * 2009-04-07 2012-08-22 Lawrence Bernstein IDENTIFICATION AND TREATMENT OF CANCER
US8153687B2 (en) * 2009-05-05 2012-04-10 Lawrence Richard Bernstein Gallium complexes with polyalcohols and methods of use
KR20130026429A (ko) * 2010-02-24 2013-03-13 에미스페어 테크놀로지스, 인코포레이티드 경구 ｂ12 치료요법
US20120245135A1 (en) * 2011-03-24 2012-09-27 Genta Incorporated Gallium Complexes, Pharmaceutical Compositions And Methods Of Use
US9205108B2 (en) 2012-08-13 2015-12-08 Jan M. Troup Treatment of traumatic brain injury by using gallium compounds to reduce oxidative stress levels
MX368045B (es) * 2012-08-23 2019-09-17 Emisphere Tech Inc Compuestos de diisopropanolamina y dietanolamina de fenoxialquilo para la administracion de agentes activos.
MX2019009510A (es) * 2017-02-10 2019-11-25 Altum Pharmaceuticals Inc Composiciones de complejos de galio (iii) para administracion oral.
US10507218B2 (en) 2018-02-22 2019-12-17 Lipidrisk, Llc Treatment of cardiovascular disease by using gallium compounds to bind calcified lesions
WO2024137849A1 (en) * 2022-12-20 2024-06-27 Northeast Ohio Medical University Gallium-loaded hydrogels for bone treatment

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258376A (en) 1989-11-22 1993-11-02 Bernstein Lawrence R Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
US6004951A (en) * 1989-11-22 1999-12-21 Bernstein; Lawrence Richard Administration of gallium complexes of 3-hydroxy-4-pyrones to provide physiologically active gallium levels in a mammalian individual
US5574027A (en) 1989-11-22 1996-11-12 Bernstein; Lawrence R. Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
WO1991017751A1 (en) 1990-05-24 1991-11-28 Fujisawa, Inc. Orally administrable gallium compositions and methods of treatment therewith
US5196412A (en) 1991-03-06 1993-03-23 Johnson Matthey, Inc. Gallium compounds
GB9111689D0 (en) * 1991-05-31 1991-07-24 Johnson Matthey Plc Gallium compounds
ES2120450T3 (es) 1991-07-25 1998-11-01 Philippe Collery Complejos de galio (iii), su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US7351741B2 (en) 2000-06-29 2008-04-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2003045306A2 (en) 2001-11-13 2003-06-05 Emisphere Technologies, Inc. Phenoxy amine compounds and compositions for delivering active agents
US20050147662A1 (en) 2003-12-19 2005-07-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU2005321803B2 (en) 2004-12-29 2012-02-09 Emisphere Technologies, Inc. Pharmaceutical formulations of gallium salts
CA2626029A1 (en) * 2005-11-04 2007-05-18 Genta Incorporated Pharmaceutical gallium compositions and methods

Also Published As

Publication number Publication date
IL190239A0 (en) 2008-11-03
AU2006312117A1 (en) 2007-05-18
JP2009514856A (ja) 2009-04-09
US7456215B2 (en) 2008-11-25
US7354952B2 (en) 2008-04-08
KR20080072830A (ko) 2008-08-07
BRPI0618096A2 (pt) 2011-08-16
EA200801261A1 (ru) 2008-08-29
WO2007055885A3 (en) 2007-07-12
CN101296694A (zh) 2008-10-29
ZA200803283B (en) 2009-11-25
US20070105953A1 (en) 2007-05-10
US20080160103A1 (en) 2008-07-03
WO2007055885A2 (en) 2007-05-18
EP1948159A2 (en) 2008-07-30
US20080166296A1 (en) 2008-07-10
CA2626029A1 (en) 2007-05-18
US7842724B2 (en) 2010-11-30
EP1948159A4 (en) 2011-10-12

Similar Documents

Publication Publication Date Title
CR9937A (es) Composiciones farmaceuticas de galio y metodos
GT200500060A (es) Compuestos de imidazol para el tratamiento de trastornos neurodegenerativos
ECSP045335A (es) Acidos bisfosfonicos para el tratamiento y prevencion de osteoporosis
CY1120088T1 (el) Παραγωγα τυπου αζαϊνδαζολιου ή διαζαϊνδαζολιου ως φαρμακo
CO6670589A2 (es) Compuestos para reducir la producción de beta-amiloide
BR0307998A (pt) Hidroxietilaminas substituìdas
CO6331340A2 (es) Pirrolo-pirimidinas y pirrolo piridinas
ATE517882T1 (de) Chinolinderivate
BRPI0415288A (pt) composto, composição farmacêutica, método para tratar ou prevenir doenças, e, método para preparar o composto
DOP2010000103A (es) Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas quinasas b
UY30377A1 (es) Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa
SG178975A1 (en) Indenone derivative and pharmaceutical composition comprising same
UY28484A1 (es) Compuestos para el tratamiento de trastornos neurodegenerativos
CY1110401T1 (el) Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσων
PE20251749A1 (es) Sales de obicetrapib y procesos para su fabricacion y productos intermedios de estos
WO2006066067A3 (en) Formulations of bisphosphonate drugs with improved bioavailability
GT200500070A (es) Compuestos de sulfonamidas para el tratamiento de trastornos neurodegenerativos
ATE330616T1 (de) Verabreichung von bisphosphonaten durch inhalation zur behandlung von knochenresorption und osteoporosis
HN2004000518A (es) Proceso para la preparacion de inhibidores de tubulina
BRPI0509881A (pt) combinação terapêutica para tratamento da doença de alzheimer
DE502004001499D1 (de) Verwendung von lornoxicam oder lornoxicam-analoga verbindungen
EA201001097A1 (ru) Фармацевтическая композиция для профилактики и лечения резорбции костной ткани различной этиологии
CR7507A (es) Acidos bifosfonicos para el tratamiento y prevencion de osteoporosis
WO2009134856A3 (en) Pharmaceutical gallium compounds, composition and methods of preparation
EA200801003A1 (ru) Фармацевтически приемлемые соли и гидраты ризедроновой кислоты

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)