ECSP045335A - Acidos bisfosfonicos para el tratamiento y prevencion de osteoporosis - Google Patents

Acidos bisfosfonicos para el tratamiento y prevencion de osteoporosis

Info

Publication number
ECSP045335A
ECSP045335A EC2004005335A ECSP045335A ECSP045335A EC SP045335 A ECSP045335 A EC SP045335A EC 2004005335 A EC2004005335 A EC 2004005335A EC SP045335 A ECSP045335 A EC SP045335A EC SP045335 A ECSP045335 A EC SP045335A
Authority
EC
Ecuador
Prior art keywords
prevention
treatment
osteoporosis
bisphosphonic acids
bisphosphonic
Prior art date
Application number
EC2004005335A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29414669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP045335(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of ECSP045335A publication Critical patent/ECSP045335A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere al empleo de los ácidos bisfosfónicos o las sales farmacéuticamente aceptables de los mismos, para la elaboración de medicamentos para la prevención o tratamiento de trastornos caracterizados por un aumento patológico de la resorción ósea, especialmente para la prevención y tratamiento de la osteoporosis.
EC2004005335A 2002-05-10 2004-10-01 Acidos bisfosfonicos para el tratamiento y prevencion de osteoporosis ECSP045335A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02010136 2002-05-10

Publications (1)

Publication Number Publication Date
ECSP045335A true ECSP045335A (es) 2004-11-26

Family

ID=29414669

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005335A ECSP045335A (es) 2002-05-10 2004-10-01 Acidos bisfosfonicos para el tratamiento y prevencion de osteoporosis

Country Status (32)

Country Link
US (5) US7410957B2 (es)
EP (4) EP2308563A1 (es)
JP (5) JP2005522526A (es)
KR (7) KR20090106663A (es)
CN (2) CN1939314A (es)
AR (2) AR039978A1 (es)
AT (1) ATE376444T1 (es)
AU (2) AU2003229770B2 (es)
BR (1) BR0308901A (es)
CA (2) CA2481142C (es)
CY (2) CY1108105T1 (es)
DE (1) DE60317061T2 (es)
DK (2) DK1880744T3 (es)
EC (1) ECSP045335A (es)
ES (2) ES2294277T3 (es)
GT (1) GT200300107A (es)
HR (1) HRP20040906B1 (es)
IL (3) IL164371A0 (es)
MX (1) MXPA04009586A (es)
MY (2) MY146809A (es)
NO (2) NO328734B1 (es)
NZ (2) NZ556278A (es)
PA (1) PA8573101A1 (es)
PE (1) PE20040440A1 (es)
PL (2) PL371346A1 (es)
PT (2) PT1506041E (es)
RU (2) RU2387451C2 (es)
SI (2) SI1880744T1 (es)
TW (1) TWI347188B (es)
UY (1) UY27802A1 (es)
WO (1) WO2003095029A1 (es)
ZA (1) ZA200407950B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
CA2469779C (en) * 2001-12-21 2008-02-12 The Procter & Gamble Company Method for the treatment of bone disorders
US20050176685A1 (en) * 2002-04-05 2005-08-11 Daifotis Anastasia G. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
CN1939314A (zh) 2002-05-10 2007-04-04 弗·哈夫曼-拉罗切有限公司 用于治疗和预防骨质疏松症的二膦酸
SI1596870T2 (sl) 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
DE202005021414U1 (de) * 2004-08-23 2008-03-20 Teva Pharmaceutical Industries Ltd. Festes und kristallines Ibandronat-Natrium
WO2006081962A1 (en) * 2005-02-01 2006-08-10 F.Hoffmann-La Roche Ag Ibandronate polymorph b
HUE042316T2 (hu) * 2005-02-01 2019-06-28 Atnahs Pharma Uk Ltd Az Ibandronát A polimorf orvosi alkalmazása
US20070049557A1 (en) * 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
ES2426445T3 (es) * 2006-04-07 2013-10-23 Merrion Research Iii Limited Forma de dosificación oral sólida que contiene un potenciador
BRPI0710512A2 (pt) 2006-04-20 2012-06-05 Hoffmann La Roche moduladores derivados de diazepan de receptores de quimiocinas
JP5290198B2 (ja) * 2006-12-20 2013-09-18 ミラン ファーマシューティカルズ ユーエルシー ホットメルト顆粒化潤滑剤を含んでなる医薬組成物
WO2009137080A1 (en) * 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of gnrh related compounds and processes of preparation
EP2210596A1 (en) 2009-01-22 2010-07-28 Laboratorios Liconsa, S.A. Pharmaceutical composition of ibandronate sodium salt or a hydrate thereof
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
EP2459176B1 (en) 2009-07-31 2017-09-27 Grünenthal GmbH Crystallization method and bioavailability
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
US9089484B2 (en) * 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
US9340565B2 (en) 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
US8802114B2 (en) 2011-01-07 2014-08-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
JP5874545B2 (ja) * 2011-06-20 2016-03-02 アステラス製薬株式会社 経口投与用医薬組成物
JP7211704B2 (ja) 2015-01-29 2023-01-24 ノヴォ ノルディスク アー／エス Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用
US10195218B2 (en) 2016-05-31 2019-02-05 Grunenthal Gmbh Crystallization method and bioavailability
CN114230610B (zh) * 2021-11-26 2023-05-23 西南医科大学附属医院 放射性标记物、其前体化合物、及制法和应用

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US500937A (en) * 1893-07-04 Conduit railway insulator
US124314A (en) * 1872-03-05 Improvement in preparing paper for buildings
DE2405254C2 (de) 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
DE2534391C2 (de) 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2745083C2 (de) 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
US4252742A (en) 1979-07-13 1981-02-24 Ciba-Geigy Corporation Chemical process for the preparation of 2,6-dialkylcyclohexylamines from 2,6-dialkylphenols
DE2943498C2 (de) 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2531088B1 (fr) 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
US4509612A (en) 1982-09-28 1985-04-09 Applied Power Inc. Latch mechanism for a tilt-cab truck
JPS59145179A (ja) 1983-01-11 1984-08-20 Ricoh Co Ltd 補充交換用部品を検知可能にした事務機器
IT1195993B (it) 1984-01-12 1988-11-03 Gentili Ist Spa Forme farmaceutiche a base di difosfonati
DE3428524A1 (de) 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3434667A1 (de) 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4812311A (en) 1984-12-21 1989-03-14 The Procter & Gamble Company Kit for use in the treatment of osteoporosis
DE3512536A1 (de) 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4761406A (en) 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
DE3540150A1 (de) 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3640938A1 (de) 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
US4973576A (en) 1987-03-10 1990-11-27 Yamanouchi Pharmaceutical Co., Ltd. Bisphophonic acid derivatives and pharmaceutical compositions containing the same
CA1339805C (en) 1988-01-20 1998-04-07 Yasuo Isomura (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active
DE3822650A1 (de) 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4958839A (en) 1988-07-12 1990-09-25 Guzik Technical Enterprises, Inc. Disc clamp employing resilient cone for spreading balls
DE3825654A1 (de) * 1988-07-28 1990-02-01 Bosch Gmbh Robert Sicherheitseinrichtung an einer handwerkzeugmaschine
JP2691914B2 (ja) 1988-09-09 1997-12-17 株式会社リコー 画像形成装置
US5018651A (en) 1988-12-27 1991-05-28 Hull Harold L Side or end dump article carrier
US4922077A (en) 1989-01-31 1990-05-01 Raytheon Company Method of laser marking metal packages
DE3917153A1 (de) * 1989-05-26 1990-11-29 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
JP2985205B2 (ja) 1990-01-25 1999-11-29 ミノルタ株式会社 画像形成装置
JPH03226767A (ja) 1990-01-31 1991-10-07 Minolta Camera Co Ltd 画像形成装置管理システム
US5335048A (en) 1990-01-30 1994-08-02 Minolta Camera Kabushiki Kaisha Efficient control system of image forming apparatus
US5356887A (en) 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
JPH04151765A (ja) 1990-10-16 1992-05-25 Fujitsu Ltd ファクシミリ装置の消耗品自動発注方式
CA2122479C (en) * 1991-11-22 1998-08-25 Richard John Dansereau Risedronate delayed-release compositions
CA2124792C (en) * 1991-12-17 2000-07-04 Ann D. Geddes Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
JPH05224479A (ja) 1992-02-10 1993-09-03 Toshiba Corp 画像形成装置
TW237386B (es) 1992-04-15 1995-01-01 Ciba Geigy
CA2138367C (en) 1992-06-30 1998-09-22 Marion David Francis Use of phosphonates for the treatment of osteoporosis
JPH06111039A (ja) 1992-09-25 1994-04-22 Toray Ind Inc 光学読み取り識別マークの記録方法
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
JPH06250802A (ja) 1993-02-22 1994-09-09 Ricoh Co Ltd プリンタ
FR2703590B1 (fr) 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
JPH07239825A (ja) 1994-02-28 1995-09-12 Canon Inc 状態通報方法およびそれを用いたネットワークシステム
US20010007863A1 (en) 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
TW390813B (en) 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
GB9408775D0 (en) 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
US5462932A (en) 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
JPH07325514A (ja) 1994-05-30 1995-12-12 Ricoh Co Ltd サプライ発注システム
UA41909C2 (uk) * 1994-07-22 2001-10-15 Елі Ліллі Енд Компані Використання комбінації сполук для інгібірування остеопорозу, фармацевтичний препарат
JPH08152825A (ja) 1994-11-30 1996-06-11 Mita Ind Co Ltd 画像形成装置の管理システム
JPH08152814A (ja) 1994-11-30 1996-06-11 Mita Ind Co Ltd 画像形成装置の管理システム
FR2727629A1 (fr) 1994-12-06 1996-06-07 Sanofi Sa Trousse pour cycle de traitement de l'osteoporose
JP3261900B2 (ja) 1994-12-13 2002-03-04 村田機械株式会社 ファクシミリ装置
CA2208714C (en) 1994-12-28 2003-10-21 Gador S.A. Bone mass anabolic composition comprising olpadronate
JPH08211792A (ja) 1995-02-03 1996-08-20 Mita Ind Co Ltd 画像形成装置の管理システム
HUP9802066A3 (en) * 1995-02-17 2001-02-28 Merck & Co Inc Use of alendronate for preparing medicament usefull for lessening the risk of non-vertebral bone fractures
US20010051616A1 (en) 1995-02-17 2001-12-13 David B. Karpf Method of lessening the risk of vertebral fractures
JPH08315052A (ja) 1995-05-18 1996-11-29 Ricoh Co Ltd 自動発注システム
JPH08310007A (ja) 1995-05-19 1996-11-26 Oki Data:Kk シリアルプリンタ
JPH09120238A (ja) 1995-10-25 1997-05-06 Canon Inc 出力装置
JPH09156123A (ja) 1995-12-04 1997-06-17 Brother Ind Ltd プリンタ
JPH09185474A (ja) 1995-12-27 1997-07-15 Fuji Xerox Co Ltd 印刷管理装置
JP3363680B2 (ja) 1995-12-28 2003-01-08 ブラザー工業株式会社 カートリッジの真偽判別方法及びそれを利用した出力装置
JPH09259355A (ja) 1996-03-21 1997-10-03 Oki Electric Ind Co Ltd 梱包された商品の確認処理システム
DE19615812A1 (de) 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
US5930553A (en) 1997-04-25 1999-07-27 Hewlett-Packard Company Image forming and office automation device consumable with memory
US5730715A (en) 1996-06-14 1998-03-24 Becton Dickinson And Company Method for the iontophoretic administration of bisphosphonates
JPH1052964A (ja) 1996-08-09 1998-02-24 Canon Inc 画像形成装置および画像形成装置の消耗材管理方法
JP3266002B2 (ja) 1996-08-29 2002-03-18 オムロン株式会社 純正交換部品識別装置及び純正交換部品識別方法
JPH10105011A (ja) 1996-09-25 1998-04-24 Ricoh Co Ltd 記録出力サービス課金装置
US5781405A (en) * 1996-09-30 1998-07-14 Gateway 2000, Inc. Electronic device having rotatably mounted infrared device with a pair of pegs fitting into a pair of holes
JPH10234825A (ja) 1997-02-20 1998-09-08 Cosmo Yakuhin:Kk 配置薬箱システム
JPH10264968A (ja) 1997-03-26 1998-10-06 Funai Electric Co Ltd 梱包構造
US6905701B2 (en) 1997-06-11 2005-06-14 Umd, Inc. Formulations for transmucosal vaginal delivery of bisphosphonates
US6572874B1 (en) 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US6432932B1 (en) 1997-07-22 2002-08-13 Merck & Co., Inc. Method for inhibiting bone resorption
US5994329A (en) * 1997-07-22 1999-11-30 Merck & Co., Inc. Method for inhibiting bone resorption
PT1175904E (pt) * 1997-07-22 2007-04-30 Merck & Co Inc Alendronato para utilização no tratamento da osteoporose
US6015801A (en) 1997-07-22 2000-01-18 Merck & Co., Inc. Method for inhibiting bone resorption
JPH1185657A (ja) 1997-09-10 1999-03-30 Toshiba Corp サーバクライアントシステム及びカード作成装置の消耗品集中管理システム
US6124314A (en) 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
SE9703691D0 (sv) 1997-10-10 1997-10-10 Astra Ab Pharmaceutical compositions
JPH11126008A (ja) 1997-10-24 1999-05-11 Canon Inc カートリッジおよびリサイクルシステム
JPH11239926A (ja) 1997-12-22 1999-09-07 Canon Inc 部品の再利用システム及び分解を容易にした製品及び分解方法
JP3065053B2 (ja) 1998-01-06 2000-07-12 セイコーエプソン株式会社 機器監視システム、ローカル監視装置、統合監視装置、機器監視方法、及び、プログラムを格納したコンピュータ可読媒体
JP4274332B2 (ja) 1998-02-20 2009-06-03 東芝テック株式会社 画像形成装置
JP3919375B2 (ja) 1998-03-20 2007-05-23 キヤノン株式会社 画像形成装置及び画像形成装置の制御方法
JPH11272350A (ja) 1998-03-20 1999-10-08 Canon Inc 課金管理装置及び方法及び印刷装置
JP3720584B2 (ja) 1998-06-05 2005-11-30 株式会社リコー 事務機器の管理システムとそのホストコンピュータ
WO1999067809A1 (en) 1998-06-24 1999-12-29 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
JP2000019803A (ja) 1998-07-01 2000-01-21 Canon Inc 消耗品ユニット及びこれを用いた画像形成装置及びその再利用システムとその方法
US6816968B1 (en) 1998-07-10 2004-11-09 Silverbrook Research Pty Ltd Consumable authentication protocol and system
JP3200037B2 (ja) 1998-07-16 2001-08-20 株式会社ダスキン レンタル商品管理システム
IT1303672B1 (it) 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
JP3476122B2 (ja) 1998-08-26 2003-12-10 株式会社沖データ 状態通知装置
JP2968791B1 (ja) 1998-08-28 1999-11-02 新潟日本電気株式会社 印刷システム
US6494562B1 (en) 1998-09-03 2002-12-17 Hewlett-Packard Company Method and apparatus for identifying a sales channel
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
EP0998932A1 (de) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
EP0998933A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
JP2000206752A (ja) 1998-11-10 2000-07-28 Ricoh Co Ltd 電子写真記録装置
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
BR9915927A (pt) 1998-12-04 2001-08-21 Roche Diagnostics Gmbh Uso de ácido ibandrÈnico ou seus sais ou ésteres fisiologicamente compatìveis
US6229655B1 (en) * 1998-12-22 2001-05-08 Minolta Co., Ltd. Zoom lens system
JP2000194767A (ja) 1998-12-24 2000-07-14 Ricoh Co Ltd 自動発注システム
JP4297579B2 (ja) 1998-12-28 2009-07-15 日立マクセル株式会社 管理システム
EP1151478B1 (de) * 1999-01-11 2002-08-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mos-leistungsbauelement und verfahren zum herstellen desselben
US6204763B1 (en) 1999-03-22 2001-03-20 Jujitsu Limited Household consumable item automatic replenishment system including intelligent refrigerator
WO2000061230A2 (en) 1999-04-09 2000-10-19 Karo Bio Ab Estrogen receptors-beta antagonism and bone diseases
SE9901272D0 (sv) 1999-04-09 1999-04-09 Astra Ab New improved formulation
CA2308532C (en) 1999-05-12 2005-11-29 Gador S.A. Use of bisphosphonates for the treatment of osteogenesis imperfecta
PT1178810E (pt) 1999-05-21 2005-08-31 Novartis Ag Utilizacao de acidos bisfosfonicos para o tratamento de angiogenese
JP2000347503A (ja) 1999-06-04 2000-12-15 Nec Corp 記録装置、記録装置におけるトナーカートリッジの適合性判別方法及びトナーカートリッジ
US6965411B1 (en) 1999-06-24 2005-11-15 Jones Richard A Remote camera positioner
AR024462A1 (es) 1999-07-01 2002-10-02 Merck & Co Inc Tabletas farmaceuticas
US6903836B2 (en) 1999-09-10 2005-06-07 Hewlett-Packard Development Company, L.P. Hard copy cost recovery systems, an apparatus for tracking usage information for a hard copy device, hard copy devices, and a usage accounting method
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6793934B1 (en) * 1999-12-08 2004-09-21 Shire Laboratories, Inc. Solid oral dosage form
JP2001246822A (ja) 1999-12-27 2001-09-11 Canon Inc 印刷装置、印刷装置における報知方法、印刷装置の制御方法、外部装置、外部装置の制御方法、及び記録媒体
US6285060B1 (en) * 1999-12-30 2001-09-04 Siliconix Incorporated Barrier accumulation-mode MOSFET
JP2000325554A (ja) 2000-01-01 2000-11-28 Samii Kk スロットマシン
JP2001228761A (ja) 2000-02-14 2001-08-24 Canon Inc 消耗品管理方法及び消耗品管理システム
JP2001228762A (ja) 2000-02-14 2001-08-24 Canon Inc 消耗品管理システム及び消耗品管理方法
JP2001253827A (ja) 2000-02-15 2001-09-18 Pfizer Prod Inc 骨粗鬆症を治療するための組成物および方法
JP3799210B2 (ja) 2000-03-07 2006-07-19 株式会社リコー 画像形成装置
US20020004218A1 (en) * 2000-03-31 2002-01-10 Rodan Gideon A. Methods for identifying compounds useful for inhibiting geranylgeranyl diphosphate synthase
WO2001076592A1 (en) 2000-04-06 2001-10-18 Acorda Therapeutics, Inc. Compositions and methods for promoting neural regeneration
US6468559B1 (en) 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
JP3302985B2 (ja) 2000-05-12 2002-07-15 株式会社ハイパーマーケティング 消耗品提供システム
GB0012209D0 (en) 2000-05-19 2000-07-12 Novartis Ag Organic compounds
HU228400B1 (en) * 2000-06-20 2013-03-28 Novartis Ag The use of bisphosphonates for treatment of osteoporosis
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
KR100863146B1 (ko) 2000-07-17 2008-10-14 아스텔라스세이야쿠 가부시키가이샤 경구 흡수 개선 의약 조성물
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
US6750213B2 (en) 2000-10-19 2004-06-15 Merck & Co., Inc. Estrogen receptor modulators
SK4772003A3 (en) 2000-10-19 2003-08-05 Merck & Co Inc Estrogen receptor modulators
CA2431515C (en) 2001-01-23 2008-01-22 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
AR034199A1 (es) 2001-02-01 2004-02-04 Riderway Corp Composicion farmacologica liquida para el tratamiento de enfermedades oseas y procedimientos para su elaboracion
DK1365769T3 (da) 2001-02-06 2011-05-16 Sydney Children S Hospitals Network Randwick And Westmead Incorporating The Royal Alexandra Hospital Lægemiddel til behandling af osteonekrose og til behandling af patienter med risiko for at udvikle osteonekrose
KR20030083725A (ko) 2001-03-01 2003-10-30 에미스페어 테크놀로지스, 인코포레이티드 비스포스포네이트 전달용 조성물
AU2002305359B2 (en) 2001-05-10 2005-05-26 Merck & Co., Inc. Estrogen receptor modulators
US6998678B2 (en) * 2001-05-17 2006-02-14 Infineon Technologies Ag Semiconductor arrangement with a MOS-transistor and a parallel Schottky-diode
CA2468687A1 (en) 2001-12-13 2003-06-26 Merck & Co., Inc. Liquid bisphosphonate formulations for bone disorders
US20050070504A1 (en) 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
CA2469779C (en) * 2001-12-21 2008-02-12 The Procter & Gamble Company Method for the treatment of bone disorders
DE10207309B4 (de) * 2002-02-21 2015-07-23 Infineon Technologies Ag MOS-Transistoreinrichtung
US7488496B2 (en) * 2002-03-06 2009-02-10 Christer Rosen Effervescent compositions comprising bisphosphonates and methods related thereto
IL163825A0 (en) * 2002-03-13 2005-12-18 Merck & Co Inc Fluorinated 4-azasteroid derivatives as androgen receptor modulators
US20050176685A1 (en) 2002-04-05 2005-08-11 Daifotis Anastasia G. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
CN1939314A (zh) 2002-05-10 2007-04-04 弗·哈夫曼-拉罗切有限公司 用于治疗和预防骨质疏松症的二膦酸
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
GB0424543D0 (en) * 2004-11-05 2004-12-08 Varintelligent Bvi Ltd Driving method for high frame rate display system

Also Published As

Publication number Publication date
AU2003229770B2 (en) 2009-11-05
TWI347188B (en) 2011-08-21
JP5813911B2 (ja) 2015-11-17
ZA200407950B (en) 2005-12-28
CA2481142C (en) 2012-11-13
US20100197637A1 (en) 2010-08-05
SI1506041T1 (sl) 2008-02-29
US20060166938A1 (en) 2006-07-27
ES2294277T3 (es) 2008-04-01
CN1646193A (zh) 2005-07-27
EP1880744A1 (en) 2008-01-23
NO331024B1 (no) 2011-09-12
AR039978A1 (es) 2005-03-09
KR20140021045A (ko) 2014-02-19
EP2308563A1 (en) 2011-04-13
RU2387451C2 (ru) 2010-04-27
MXPA04009586A (es) 2005-01-11
US20050075319A1 (en) 2005-04-07
EP1506041B1 (en) 2007-10-24
MY146809A (en) 2012-09-28
WO2003095029A1 (en) 2003-11-20
GT200300107A (es) 2006-02-23
KR20040097267A (ko) 2004-11-17
AU2010200438B2 (en) 2012-02-02
US20080249069A1 (en) 2008-10-09
CA2481142A1 (en) 2003-11-20
EP2851105A1 (en) 2015-03-25
KR20090029312A (ko) 2009-03-20
DE60317061D1 (de) 2007-12-06
JP6067466B2 (ja) 2017-01-25
KR100642961B1 (ko) 2006-11-10
PT1506041E (pt) 2007-12-28
DE60317061T2 (de) 2008-07-24
HRP20040906A2 (en) 2005-06-30
CY1108105T1 (el) 2014-02-12
HK1080409A1 (zh) 2006-04-28
KR20060058151A (ko) 2006-05-29
ES2532393T3 (es) 2015-03-26
KR100642961B9 (ko) 2021-11-12
IL205262A (en) 2015-03-31
JP2009132709A (ja) 2009-06-18
KR20120065435A (ko) 2012-06-20
PL371346A1 (en) 2005-06-13
JP5837552B2 (ja) 2015-12-24
IL164371A (en) 2010-11-30
US7410957B2 (en) 2008-08-12
MY140080A (en) 2009-11-30
EP1506041A1 (en) 2005-02-16
PE20040440A1 (es) 2004-08-07
US7718634B2 (en) 2010-05-18
TW200404553A (en) 2004-04-01
CN1939314A (zh) 2007-04-04
AU2010200438A1 (en) 2010-02-25
US7192938B2 (en) 2007-03-20
AU2003229770A1 (en) 2003-11-11
RU2004129324A (ru) 2006-01-27
IL164371A0 (en) 2005-12-18
ATE376444T1 (de) 2007-11-15
KR20090106663A (ko) 2009-10-09
EP1880744B1 (en) 2015-01-21
KR20150053811A (ko) 2015-05-18
PL399493A1 (pl) 2012-11-05
CN100551377C (zh) 2009-10-21
JP2013166773A (ja) 2013-08-29
NO20100477L (no) 2004-10-01
JP2005522526A (ja) 2005-07-28
SI1880744T1 (sl) 2015-04-30
BR0308901A (pt) 2005-01-04
HRP20040906B1 (en) 2013-01-31
RU2329809C2 (ru) 2008-07-27
NZ556278A (en) 2009-06-26
PT1880744E (pt) 2015-02-13
JP2015083592A (ja) 2015-04-30
RU2008103617A (ru) 2009-08-10
NO328734B1 (no) 2010-05-03
DK1880744T3 (en) 2015-02-09
CY1116233T1 (el) 2017-02-08
JP2014058554A (ja) 2014-04-03
DK1506041T3 (da) 2008-01-28
US20030225039A1 (en) 2003-12-04
NO20044195L (no) 2004-10-01
AR061845A2 (es) 2008-09-24
NZ535705A (en) 2007-08-31
CA2763775C (en) 2014-01-07
PA8573101A1 (es) 2004-02-07
CA2763775A1 (en) 2003-11-20
UY27802A1 (es) 2003-11-28

Similar Documents

Publication Publication Date Title
ECSP045335A (es) Acidos bisfosfonicos para el tratamiento y prevencion de osteoporosis
IL213649A0 (en) Prodrugs of gabapentin compounds, compositions and their use in the manufacture of a medicament
ECSP024399A (es) Derivados de benzotiazol
GT200300075AA (es) Compuestos que modulan la actividad ppar y procedimientos para su preparacion (patente fraccionaria no. 1 de la solicitud no. pi-20030075)
CO5570667A2 (es) Compuestos azabiciclico sustituidos condensados con heteroarilo para el tratamiento de enfermedades
CR9937A (es) Composiciones farmaceuticas de galio y metodos
ECSP034744A (es) Antagonistas de nmda/nr2b no arilo-heterociclico n-sustituidos
DK1417975T3 (da) Middel til behandling af sygdomme, med tab af knoglemasse som følge, med EP4-agonist som aktivt indholdsstof
PA8547701A1 (es) Nucleosidos 4 substituidos.
BR0311494A (pt) Novos indóis substituìdos
UY28376A1 (es) Agentes terapéuticos
UY27872A1 (es) Inhibidores de caspasa y usos de los mismos.
UY30377A1 (es) Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa
IS2517B (is) Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki
CO5611124A2 (es) Derivados de benzofurano substituidos utiles en el tratamiento de desordenes hiper-proliferativos
HN2003000379A (es) Derivados de anilinopirazol utiles en el tratamiento de la diabetes
CL2004001372A1 (es) Alendronato monosodico en forma amorfa; proceso de preparacion; composicion farmaceutica que lo comprende; y su uso para inhibir la resorcion osea en el tratamiento de fracturas, osteoporosis, osteoartritis, enfermedad de paget, osteohalisteresis, os
AR044200A1 (es) Composicion de fondaparinux sodico de alta pureza ,un procedimiento de preparacion de esta composicion y composiciones farmaceuticas que la contienen como principio activo
HN2002000110A (es) Uso de (z) - 2 - ciano - 3 - hidroxi - butil - 2 - acido enoico (4' - trifluorometil fenilo) - amida para el tratamiento de la esclerosis multiple.
GT200700097A (es) Nuevos derivados de fenilpiridinilpiperazina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
UY29790A1 (es) Sales de diariloimidazola-4-carboxamidas, composiciones que las contienen, procesos de preparación y aplicaciones
ATE330616T1 (de) Verabreichung von bisphosphonaten durch inhalation zur behandlung von knochenresorption und osteoporosis
UY29741A1 (es) Sales de 1,5- diaril pirazol-3-carboxamidas, procesos de preparación, composeciones farmacéuticas que las contienen, aplicaciones y métodos de uso.
CR7507A (es) Acidos bifosfonicos para el tratamiento y prevencion de osteoporosis
GT200200002A (es) Utilizacion de cromanos