CS126692A3 - Heterocyclically substituted derivatives of phenylacetic acid, process oftheir preparation and their use in medicaments - Google Patents

Heterocyclically substituted derivatives of phenylacetic acid, process oftheir preparation and their use in medicaments

Info

Publication number: CS126692A3
Authority: CS; Czechoslovakia
Prior art keywords: alkyl; phenyl; substd; opt; halo
Prior art date: 1991-04-26

Application number

CS921266A

Other languages

English (en)

Inventor

Ulrich Dr Muller

Klaus Dr Mohrs

Jurgen Dr Dressel

Rudolf Dr Hanko

Walter Dr Hubsch

Michael Dr Matzke

Ulrich Dr Niewohner

Siegfried Dr Raddatz

Thomas Dr Kramer

Matthias Dr Muller-Gliemann

Hans-Peter Dr Bellemann

Martin Dr Beuck

Stanislav Prof Dr Kazda

Stefan Dr Wohlfeil

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-26

Filing date

1992-04-24

Publication date

1992-12-16

1992-04-24 Application filed by Bayer Ag filed Critical Bayer Ag

1992-12-16 Publication of CS126692A3 publication Critical patent/CS126692A3/cs

Links

WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical class O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 6
125000005843 halogen group Chemical group 0.000 abstract 6
125000002252 acyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 2
125000003831 tetrazolyl group Chemical group 0.000 abstract 2
-1 2-phenylvinyl Chemical group 0.000 abstract 1
101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
229960003424 phenylacetic acid Drugs 0.000 abstract 1
239000003279 phenylacetic acid Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Pyridine Compounds (AREA)
Paper (AREA)

CS921266A 1991-04-26 1992-04-24 Heterocyclically substituted derivatives of phenylacetic acid, process oftheir preparation and their use in medicaments CS126692A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4113693		1991-04-26
DE4200954A DE4200954A1 (de)	1991-04-26	1992-01-16	Heterocyclisch substituierte phenylessigsaeurederivate

Publications (1)

Publication Number	Publication Date
CS126692A3 true CS126692A3 (en)	1992-12-16

Family

ID=25903177

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS921266A CS126692A3 (en)	1991-04-26	1992-04-24	Heterocyclically substituted derivatives of phenylacetic acid, process oftheir preparation and their use in medicaments

Country Status (15)

Country	Link
US (2)	US5521206A (cs)
EP (2)	EP0513533B1 (cs)
JP (1)	JP3225086B2 (cs)
KR (1)	KR920019758A (cs)
CN (1)	CN1031339C (cs)
AT (1)	ATE209188T1 (cs)
AU (1)	AU643885B2 (cs)
CA (1)	CA2066943C (cs)
CS (1)	CS126692A3 (cs)
DE (2)	DE4200954A1 (cs)
HU (1)	HUT61283A (cs)
IE (1)	IE921335A1 (cs)
IL (1)	IL101676A0 (cs)
NZ (1)	NZ242477A (cs)
TW (1)	TW199163B (cs)

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DE4208051A1 (de) *	1992-03-13	1993-09-16	Bayer Ag	Substituierte phenylessigsaeureamide
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GB9218449D0 (en)	1992-08-29	1992-10-14	Boots Co Plc	Therapeutic agents
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DE19615265A1 (de) *	1996-04-18	1997-12-04	Bayer Ag	Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
US5956737A (en)	1996-09-09	1999-09-21	Design Intelligence, Inc.	Design engine for fitting content to a medium
JP2001506997A (ja) *	1996-12-16	2001-05-29	オントジエン・コーポレイシヨン	ホスホチロシン認識ユニットを有する蛋白質の修飾物質
US6034251A (en) *	1997-11-07	2000-03-07	Schering Corporation	Phenyl-alkyl-imidazoles
JP2000053651A (ja) *	1998-06-18	2000-02-22	Lonza Ag	ホルミルイミダゾ―ル類の製造方法
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
AU7447500A (en) *	1999-09-30	2001-04-30	Mitsubishi Chemical Corporation	Acylsulfonamide derivatives
US6987131B1 (en)	2000-06-26	2006-01-17	Burzynski Stanislaw R	Phenylacetic acid compositions for treating or preventing hypercholesterolemia
DE10050995A1 (de) *	2000-10-14	2002-04-18	Boehringer Ingelheim Pharma	Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6852728B2 (en)	2000-10-14	2005-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
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CN107325052B (zh) *	2017-06-19	2020-01-10	广东药科大学	一类具有抗癌活性的咪唑酯类化合物及其衍生物
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US5164407A (en) *	1989-07-03	1992-11-17	Merck & Co., Inc.	Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
US5449682A (en) *	1990-02-13	1995-09-12	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted benzyl element
WO1991012002A1 (en) *	1990-02-13	1991-08-22	Merck & Co., Inc.	Imidazole angiotensin ii antagonists incorporating a substituted benzyl element
US5183810A (en) *	1990-02-13	1993-02-02	Merck & Co., Inc.	Imidazole angiotensin II antagonists incorporating a substituted benzyl element
FR2658511B1 (fr) *	1990-02-16	1992-06-19	Union Pharma Scient Appl	Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4036645A1 (de) *	1990-11-16	1992-05-21	Hoechst Ag	Substituierte azole, verfahren zu deren herstellung, deren enthaltende mittel und deren verwendung

1992
- 1992-01-16 DE DE4200954A patent/DE4200954A1/de not_active Withdrawn
- 1992-03-30 AU AU13907/92A patent/AU643885B2/en not_active Ceased
- 1992-04-13 EP EP92106345A patent/EP0513533B1/de not_active Expired - Lifetime
- 1992-04-13 AT AT92106345T patent/ATE209188T1/de not_active IP Right Cessation
- 1992-04-13 DE DE59209934T patent/DE59209934D1/de not_active Expired - Fee Related
- 1992-04-13 EP EP01110080A patent/EP1127880A3/de not_active Withdrawn
- 1992-04-14 TW TW081102878A patent/TW199163B/zh active
- 1992-04-23 IL IL101676A patent/IL101676A0/xx unknown
- 1992-04-23 CA CA002066943A patent/CA2066943C/en not_active Expired - Fee Related
- 1992-04-24 IE IE133592A patent/IE921335A1/en not_active Application Discontinuation
- 1992-04-24 HU HU9201388A patent/HUT61283A/hu unknown
- 1992-04-24 CS CS921266A patent/CS126692A3/cs unknown
- 1992-04-24 JP JP13177092A patent/JP3225086B2/ja not_active Expired - Fee Related
- 1992-04-24 NZ NZ242477A patent/NZ242477A/en unknown
- 1992-04-25 CN CN92103141A patent/CN1031339C/zh not_active Expired - Lifetime
- 1992-04-25 KR KR1019920007042A patent/KR920019758A/ko not_active Withdrawn
1994
- 1994-04-15 US US08/227,913 patent/US5521206A/en not_active Expired - Fee Related
1996
- 1996-03-01 US US08/609,366 patent/US5776964A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2066943A1 (en)	1992-10-27
IL101676A0 (en)	1992-12-30
EP0513533B1 (de)	2001-11-21
NZ242477A (en)	1994-10-26
EP1127880A3 (de)	2003-10-29
DE4200954A1 (de)	1992-10-29
ATE209188T1 (de)	2001-12-15
IE921335A1 (en)	1992-11-04
AU643885B2 (en)	1993-11-25
TW199163B (cs)	1993-02-01
CN1031339C (zh)	1996-03-20
DE59209934D1 (de)	2002-01-03
CN1066065A (zh)	1992-11-11
US5776964A (en)	1998-07-07
EP1127880A2 (de)	2001-08-29
EP0513533A2 (de)	1992-11-19
HUT61283A (en)	1992-12-28
EP0513533A3 (de)	1992-12-02
HU9201388D0 (en)	1992-07-28
CA2066943C (en)	2002-10-15
JPH05208954A (ja)	1993-08-20
JP3225086B2 (ja)	2001-11-05
KR920019758A (ko)	1992-11-19
US5521206A (en)	1996-05-28
AU1390792A (en)	1992-10-29

Publication	Publication Date	Title
CS126692A3 (en)	1992-12-16	Heterocyclically substituted derivatives of phenylacetic acid, process oftheir preparation and their use in medicaments
EE9500071A (et)	1996-04-15	Tsükloalkanindool- ja asaindoolderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud derivaate sisaldavad ravimid ning karboksüülhapped kui vaheühendid nimetatud tsükloalkaanindool- ja asaindoolderivaatide valmistamiseks
HUT70423A (en)	1995-10-30	Oxazolidine derivatives, process for preparing them and pharmaceutical compositions containing them
NO954507L (no)	1992-08-24	1-bifenylmetylimidazolderivater, fremgangsmåte til fremstilling og anvendelse derav
EE9600043A (et)	1996-12-16	Heteroaatomit sisaldavad bensotsüklopentaanoksasolidinoonid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
PT77619A (en)	1983-12-01	Process for the preparation of a fungicidal composition contai-ning new heterocyclically substituted hydroxyalkyl-azolyl deri-vatives
GR3004789T3 (cs)	1993-04-28
ES8601978A1 (es)	1985-11-16	Procedimiento para preparar derivados de isoquinoleina
IL98840A0 (en)	1992-07-15	Bisguanidine derivatives and their use as fungicides
NZ237276A (en)	1993-04-28	13-hydroxymilbemycin ether derivatives: pharmaceuticals, veterinary and pesticidal compositions
EP0551527A4 (cs)	1994-08-31
ES8604150A1 (es)	1986-01-16	Un procedimiento para la preparacion de medicamentos a base de derivados de la 1,4-dihidropiridina
HU9501792D0 (en)	1995-08-28	Benzoylguanidine derivatives, substituted with heterocyclic groups bonded through oxygene
GR3032686T3 (en)	2000-06-30	2-Cyano-3,5-dihydroxy-hex-2-ene carboxamide derivatives, process for their preparation and their use as medicaments
CN218927060U (zh)	2023-04-28	绝缘端板用模具加工设备
IT1111676B (it)	1986-01-13	Derivati della 2-fenossimetil-morfolina
ES457473A1 (es)	1978-07-01	Un procedimiento para preparar derivados de cefalosporina.
FR2273532A1 (fr)	1976-01-02	Nouveaux derives du thienyl-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent
IT1177773B (it)	1987-08-26	Procedimento per produrre alcool alfa,beta-insaturi,otticamente attivi,utili come diserbanti,fungicidi,regolatori di crescita delle piante e simili e prodotti ottenuti
ATA502477A (de)	1978-03-15	Verfahren zur herstellung von neuen n-acylamino-alfa-arylacetamidocephalosporinderivaten und deren salzen
GB891189A (en)	1962-03-14	Appliance for milling hinge mortises in casements, frames, doors and the like
HUT42677A (en)	1987-08-28	Herbicidal compositions comprising alpha-substituted acetophenone derivatives as active substance and process for preparing the active substances
HUT60742A (en)	1992-10-28	Method for producing imidqzo-benzodiazepine-2-(1h)-one derivatives and pharmaceutical preparatives containing them
ES2029163A6 (es)	1992-07-16	Procedimiento para la preparacion de nuevos derivados de piperacina.
GB1085422A (en)	1967-10-04	Apparatus for winding rotating bodies