CS131891A3 - Vaccine - Google Patents

Vaccine Download PDF

Info

Publication number: CS131891A3
Authority: CS; Czechoslovakia
Prior art keywords: group; composition; amino acid; polypeptide; composition according
Prior art date: 1990-05-07

Application number

CS911318A

Other languages

Czech (cs)

English (en)

Inventor

Christopher L Penny

Original Assignee

North American Vaccine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-07

Filing date

1991-05-06

Publication date

1992-02-19

1991-05-06 Application filed by North American Vaccine filed Critical North American Vaccine

1992-02-19 Publication of CS131891A3 publication Critical patent/CS131891A3/cs

Links

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229960001269 glycine hydrochloride Drugs 0.000 description 1
108010010096 glycyl-glycyl-tyrosine Proteins 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
108060003552 hemocyanin Proteins 0.000 description 1
229960002520 hepatitis vaccine Drugs 0.000 description 1
230000007236 host immunity Effects 0.000 description 1
230000000984 immunochemical effect Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
229960001438 immunostimulant agent Drugs 0.000 description 1
239000003022 immunostimulating agent Substances 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
229940044173 iodine-125 Drugs 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
210000003127 knee Anatomy 0.000 description 1
BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000035772 mutation Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
UHGIMQLJWRAPLT-UHFFFAOYSA-N octadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCCCOP(O)(O)=O UHGIMQLJWRAPLT-UHFFFAOYSA-N 0.000 description 1
244000045947 parasite Species 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
239000013641 positive control Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000008569 process Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
239000003566 sealing material Substances 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940054269 sodium pyruvate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000894007 species Species 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
230000008280 toxic mechanism Effects 0.000 description 1
238000001890 transfection Methods 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1
108010005834 tyrosyl-alanyl-glycine Proteins 0.000 description 1
239000012646 vaccine adjuvant Substances 0.000 description 1
229940124931 vaccine adjuvant Drugs 0.000 description 1
229940125575 vaccine candidate Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Oscillators With Electromechanical Resonators (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CS911318A 1990-05-07 1991-05-06 Vaccine CS131891A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US51846090A	1990-05-07	1990-05-07

Publications (1)

Publication Number	Publication Date
CS131891A3 true CS131891A3 (en)	1992-02-19

Family

ID=24064028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS911318A CS131891A3 (en)	1990-05-07	1991-05-06	Vaccine

Country Status (22)

Country	Link
EP (1)	EP0597838B1 (fr)
JP (1)	JPH05506234A (fr)
CN (1)	CN1056816A (fr)
AT (1)	ATE173936T1 (fr)
AU (1)	AU7777991A (fr)
CA (1)	CA2082425A1 (fr)
CS (1)	CS131891A3 (fr)
DE (1)	DE69130576T2 (fr)
DK (1)	DK0597838T3 (fr)
ES (1)	ES2124701T3 (fr)
FI (1)	FI925032A7 (fr)
HR (1)	HRP930658A2 (fr)
HU (1)	HUT65493A (fr)
IE (1)	IE911527A1 (fr)
IL (1)	IL97985A0 (fr)
MX (1)	MX172210B (fr)
NO (1)	NO924271L (fr)
NZ (1)	NZ238042A (fr)
TW (1)	TW221676B (fr)
WO (1)	WO1991016926A1 (fr)
YU (1)	YU79691A (fr)
ZA (1)	ZA913214B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA22842A1 (fr) *	1992-03-27	1993-10-01	Smithkline Beecham Biolog	Procede de preparation de compositions de vaccin.
US6620414B2 (en)	1992-03-27	2003-09-16	Smithkline Beecham Biologicals (S.A.)	Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
WO1996007102A1 (fr) *	1994-09-01	1996-03-07	Wisconsin Alumni Research Foundation	Remodelage therapeutique dans le traitement du sida
FR2726471B1 (fr) *	1994-11-07	1997-01-31	Pf Medicament	Procede pour ameliorer l'immunogenicite d'un compose immunogene ou d'un haptene et application a la preparation de vaccins
US6027731A (en) *	1998-11-17	2000-02-22	Wisconsin Alumni Research Foundation	Pertussis toxin induced lymphocytosis
CA2360347C (fr)	1998-12-31	2013-05-07	Chiron Corporation	Expression amelioree de polypeptides hiv et production de particules de type viral
AU2487300A (en)	1998-12-31	2000-07-31	Chiron Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
JP4776075B2 (ja)	1998-12-31	2011-09-21	ノバルティスバクシンズアンドダイアグノスティックス，インコーポレーテッド	改変ｈｉｖｅｎｖポリペプチド
AU2002320314A1 (en)	2001-07-05	2003-01-21	Chiron, Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US20030170614A1 (en)	2001-08-31	2003-09-11	Megede Jan Zur	Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
NZ539106A (en) *	2002-10-10	2007-02-23	Yeda Res & Dev	Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1138773A (fr) *	1979-04-18	1983-01-04	Connaught Laboratories Limited	Adjuvants synthetiques pour la stimulation de reactions antigeniques
US4639371A (en) *	1984-10-02	1987-01-27	New York Blood Center, Inc.	Hepatitis B antigenic compositions and vaccines against hepatitis B derived therefrom
GB8807860D0 (en) *	1988-04-05	1988-05-05	Connaught Lab	Pertussis vaccine
NZ230424A (en) *	1988-08-25	1992-05-26	Liposome Co Inc	Liposomal composition comprising an externally disposed antigen

1991
- 1991-04-28 IL IL97985A patent/IL97985A0/xx unknown
- 1991-04-29 ZA ZA913214A patent/ZA913214B/xx unknown
- 1991-05-01 FI FI925032A patent/FI925032A7/fi not_active Application Discontinuation
- 1991-05-01 AT AT91908598T patent/ATE173936T1/de not_active IP Right Cessation
- 1991-05-01 HU HU9203480A patent/HUT65493A/hu unknown
- 1991-05-01 AU AU77779/91A patent/AU7777991A/en not_active Abandoned
- 1991-05-01 CA CA002082425A patent/CA2082425A1/fr not_active Abandoned
- 1991-05-01 WO PCT/CA1991/000144 patent/WO1991016926A1/fr not_active Ceased
- 1991-05-01 DK DK91908598T patent/DK0597838T3/da active
- 1991-05-01 EP EP91908598A patent/EP0597838B1/fr not_active Expired - Lifetime
- 1991-05-01 JP JP91508106A patent/JPH05506234A/ja active Pending
- 1991-05-01 DE DE69130576T patent/DE69130576T2/de not_active Expired - Fee Related
- 1991-05-01 ES ES91908598T patent/ES2124701T3/es not_active Expired - Lifetime
- 1991-05-03 NZ NZ238042A patent/NZ238042A/xx unknown
- 1991-05-06 CS CS911318A patent/CS131891A3/cs unknown
- 1991-05-06 MX MX025669A patent/MX172210B/es unknown
- 1991-05-06 IE IE152791A patent/IE911527A1/en unknown
- 1991-05-07 YU YU79691A patent/YU79691A/sh unknown
- 1991-05-07 CN CN91102899A patent/CN1056816A/zh active Pending
- 1991-07-15 TW TW080105479A patent/TW221676B/zh active
1992
- 1992-11-06 NO NO92924271A patent/NO924271L/no unknown
1993
- 1993-04-01 HR HRP-796/91A patent/HRP930658A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL97985A0 (en)	1992-06-21
NZ238042A (en)	1993-12-23
FI925032L (fi)	1992-11-06
NO924271D0 (no)	1992-11-06
TW221676B (fr)	1994-03-11
HRP930658A2 (en)	1997-12-31
FI925032A0 (fi)	1992-11-06
ES2124701T3 (es)	1999-02-16
JPH05506234A (ja)	1993-09-16
CN1056816A (zh)	1991-12-11
YU79691A (sh)	1994-06-10
DE69130576D1 (de)	1999-01-14
WO1991016926A1 (fr)	1991-11-14
DE69130576T2 (de)	1999-07-29
NO924271L (no)	1993-01-07
EP0597838A1 (fr)	1994-05-25
EP0597838B1 (fr)	1998-12-02
IE911527A1 (en)	1991-11-20
HU9203480D0 (en)	1993-01-28
FI925032A7 (fi)	1992-11-06
HUT65493A (en)	1994-06-28
ATE173936T1 (de)	1998-12-15
ZA913214B (en)	1992-09-30
AU7777991A (en)	1991-11-27
DK0597838T3 (da)	1999-08-16
CA2082425A1 (fr)	1991-11-08
MX172210B (es)	1993-12-07

Publication	Publication Date	Title
CA1329766C (fr)	1994-05-24	Epitopes d'une proteine de la capside nucleique du virus de l'hepatite b stimulant les lymphocytes t
KR100290632B1 (ko)	2001-09-17	면역성이약한항원공액체와이를포함하는합성펩티드담체와백신
US5837250A (en)	1998-11-17	Adjuvant compositions
JP4031201B2 (ja)	2008-01-09	アレルギー治療用免疫原としてのペプチド組成物
CA2793087C (fr)	2019-07-23	Peptides, conjugues et procede permettant d'augmenter l'immunogenicite d'un vaccin
CS283991A3 (en)	1992-04-15	Vaccine
JPH09510975A (ja)	1997-11-04	アレルギー治療用合成ペプチドベース免疫原
WO1999050303A2 (fr)	1999-10-07	Complexe d'alpha-2 macroglobuline modulateur de la reponse immunitaire
CN104507496B (zh)	2018-08-03	包含与crm197载体蛋白偶联的hiv gp41肽的免疫原性化合物
CS131891A3 (en)	1992-02-19	Vaccine
US4919930A (en)	1990-04-24	Synthetic M proteins-streptococci type 5
Robinson et al.	1992	Palmitic acid conjugation of a protein antigen enhances major histocompatibility complex class II-restricted presentation to T cells
EP0166548A2 (fr)	1986-01-02	Vaccin à spectre large contre la gonorrhée
US6290971B1 (en)	2001-09-18	Adjuvant compositions comprising a mineral salt and another immunostimulating compound
AU754988B2 (en)	2002-11-28	Immune response modulator alpha-2 macroglobulin complex
Wang	1993	B cell & T cell epitope orientation and adjuvant-free immunization in synthetic vaccine design
HUT71776A (en)	1996-01-29	Antibody conjugates with improved properties
EP0674907A2 (fr)	1995-10-04	Conjugués d'un anticorps et d'une protéine porteuse, utiles dans l'immunothérapie active